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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE272373 Soluble epoxide hydrolase inhibition confers neuroprotective and anti-inflammatory effect in a tauopathy mouse model April 30, 2025Contributor : Hui ZhengSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusInhibition of soluble epoxide hydrolase (sEH) has been shown to suppress neuroinflammation through stabilizing epoxy fatty acids. Here we examined the role of sEH inhibitor TPPU in PS19 tauopathy mouse model by treating the 6-month-old wild-type and […]
- GSE200163 ChIP-Seq of MYC in MCF-7 cells treated with AM (Actinomycin D and MG132) or DMSO. April 30, 2025Contributors : Sihan Li ; Zehua Wang ; Da YangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensMYC has been known to bind to thousands of promoters and exert an amplification effect on expression of most genes. Meanwhile, MYC drives tumorigenesis through the regulation of a unique set of cancer-specific tar […]
- GSE274394 Temporal and spatial niche partitioning in a retrotransposon community of the Drosophila melanogaster genome April 30, 2025Contributors : Marion Varoqui ; Mourdas Mohamed ; Bruno Mugat ; Daniel Gourion ; Maëlys Lemoine ; Alain Pélisson ; Charlotte Grimaud ; Séverine ChambeyronSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Non-coding RNA profiling by high throughput sequencingOrganism : Drosophila melanogasterTransposable elements (TEs) are genet […]
- GSE245139 Long circulating RNAs identified as biomarker candidates for risk stratification in childhood acute lymphoblastic leukemia April 30, 2025Contributors : Lucas Poncelet ; Daniel SinnettSeries Type : Expression profiling by high throughput sequencing ; Third-party reanalysisOrganism : Homo sapiensAnalysis of tumoral RNA is essential for childhood acute lymphoblastic leukemia (ALL) diagnosis and prognosis to detect mutations, cryptic fusions and gene expression patterns. Small vesicles circulatin […]
- GSE230042 Cardiac Piezo1 Exacerbates Lethal Ventricular Arrhythmogenesis by Linking Mechanical Stress with Ca2+ Handling after Myocardial Infarction April 30, 2025Contributors : Sheng-an Su ; Yuhao Zhang ; Wudi Li ; Yutao Xi ; Yunrui Lu ; Jian Shen ; Yuankun Ma ; Yaping Wang ; Yimin Shen ; Lan Xie ; Yao Xie ; Hong Ma ; Meixiang XiangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAims: Ventricular arrhythmogenesis is a key cause of sudden cardiac death following myocardial infarc […]
- GSE265866 microRNA396 is a coordinative regulator that can be modulated to reconcile the reverse relationship between fruit size and quality in tomato April 30, 2025Contributors : Haiping Liu ; Tianbao Yang ; Xudong ZhuSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Solanum lycopersicumThe microRNA396 (miR396) family is a group of small, non-coding RNA molecules that regulates expression of growth-regulating factors (GRFs) in plants. In this study, the researchers used short tandem target […]
- GSE261468 MACE-seq transcriptomic analysis of MtCLE35 overexpressing roots of M. truncatula without rhizobia inoculation and at 11 dpi after inoculation with S. meliloti. April 30, 2025Contributor : Maria LebedevaSeries Type : Expression profiling by high throughput sequencingOrganism : Medicago truncatulaCLE (CLAVATA3/ENDOSPERM SURROUNDING REGION-related) peptides are systemic regulators of legume-rhizobium symbiosis that negatively control the number of nitrogen-fixing nodules. In Medicago truncatula, the expression of the MtCLE35 gene i […]
- GSE295620 Single-nucleus and spatial transcriptome identify brain landscape of gene regulatory networks associated with behavioral maturation in honeybees April 30, 2025Contributors : Xiaohuan Mu ; Jie Ma ; Qun Liu ; Zijing Zhang ; Yating QinSeries Type : Expression profiling by high throughput sequencingOrganism : Apis melliferaAnimal behavior is linked to the gene regulatory network (GRN) coordinating gene expression in the brain. Eusocial honeybees, with their natural behavioral plasticity, provide an excellent model for […]
- GSE295544 Designed NGF mimetics with reduced nociceptive signatures in neurons April 30, 2025Contributors : Thomas Schlichthaerle ; Aerin Yang ; Damien Detraux ; David E. Johnson ; Chloe J. Peach ; Natasha I. Edman ; Catherine Sniezek ; Charles A. Williams ; Sonali Arora ; Neerja Katiyar ; Irene Chen ; Ali Etemadi ; Andrew Favor ; David Lee ; Connor Kubo ; Brian Coventry ; Buwei Huang ; Nathan Ennist ; Lukas Milles ; Banumathi Sankaran ; Alex Kang ; […]
- GSE295789 Arabidopsis GH3.10 conjugates jasmonates April 30, 2025Contributors : Benedikt Ni ; Moritz Klein ; Ben M Hoßbach ; Kirstin Feussner ; Ellen Hornung ; Cornelia Herrfurth ; Mats Hamberg ; Ivo FeussnerSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaJasmonates regulate plant development and defence. In angiosperms, the canonical bioactive jasmonate is jasmonoyl-isoleuci […]
- GSE295781 Transcriptomics of Pseudomonas aeruginosa PA14 upon deletion of the sigma factor RpoS April 30, 2025Contributors : Luis Mauricio Salazar-Garcia ; Jose Manuel Villalobos-EscobedoSeries Type : Expression profiling by high throughput sequencingOrganism : Pseudomonas aeruginosaWe report RNA-seq data of Pseudomonas aeruginosa PA14 (UCBPP-PA14) and an isogenic rpoS-STOP mutant generated using CRISPR/Cas9 base editing. Transcriptomic profiling during exponential […]
- GSE295799 Therapeutic base editing alleviates restrictive cardiomyopathy April 30, 2025Contributors : Chong Chang ; Xiulin Zhang ; Geng LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRestrictive cardiomyopathy (RCM) is a severe cardiac disorder characterized by impaired ventricular filling and diastolic dysfunction, with mutations in sarcomeric proteins representing major causative factors. Mutations o […]
- GSE296021 Din oversees MSC homeostasis in mouse incisors April 30, 2025Contributors : Dong Changchun ; Lamichhane Bikash ; Wang XiaofangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe murine incisor presents an excellent model for investigating stem cell homeostasis due to its regenerative capacity and continuous growth throughout the lifetime. Proper homeostasis of the dental mesenchy […]
- GSE296025 Spatial distribution and chromatin accessibility determine the therapeutic capacity of microglial subsets during neurodegeneration [ATAC-seq] April 30, 2025Contributors : Emile Wogram ; Omar Mossad ; Fang Wang ; Nicola Iovino ; Samuel Wald ; Sebastian Preissl ; Marco PrinzSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusMicroglial spatial heterogeneity remains a crucial yet poorly studied question in light of potential cell-directed therapies for Alzheimer`s d […]
- GSE270202 Geographic variation in epigenetic responses to hypoxia in deer mice (Peromyscus maniculatus) distributed along an elevational gradient April 30, 2025Contributors : Dhriti Tandon ; Shane Campbell ; Zac Cheviron ; Bridgett vonHoldtSeries Type : Methylation profiling by high throughput sequencingOrganism : Peromyscus maniculatusSpatially varying environments can pose distinct costs and benefits on traits under selection, such that a beneficial trait in one environment may be counter-productive in another. A […]