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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE265866 microRNA396 is a coordinative regulator that can be modulated to reconcile the reverse relationship between fruit size and quality in tomato April 30, 2025Contributors : Haiping Liu ; Tianbao Yang ; Xudong ZhuSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Solanum lycopersicumThe microRNA396 (miR396) family is a group of small, non-coding RNA molecules that regulates expression of growth-regulating factors (GRFs) in plants. In this study, the researchers used short tandem target […]
- GSE278425 Genome-wide DNA methylation profiles of well-differentiated liposarcomas (WDLPS), dedifferentiated liposarcomas (DDLPS), and normal adipose tissues II April 30, 2025Contributors : Naoko Hattori ; Satoshi Yamashita ; Toshikazu UshijimaSeries Type : Methylation profiling by arrayOrganism : Homo sapiensLiposarcoma (LPS) is the most common soft-tissue sarcoma in adults, and well-differentiated LPS (WDLPS) and dedifferentiated LPS (DDLPS) are the most frequent subtypes. These LPSs are considered to develop due to disturbance […]
- GSE266339 miR-181a-5p mediates the effects of BMP4 on intestinal cell proliferation and differentiation April 30, 2025Series Type : Non-coding RNA profiling by high throughput sequencingOrganism : Mus musculusThe intestinal mucosa undergoes a dynamic process of continual proliferation, differentiation and apoptosis. Delineating the mechanisms involved in intestinal epithelial cell (IEC) differentiation is crucial to our understanding of not only normal gut adaptation but al […]
- GSE226482 Single cell RNA sequencing of spinal motor neurons and interneurons differentiated from isogenic FUS and TARDBP human induced pluripotent stem cell lines harbouring ALS-causative mutations April 30, 2025Contributors : Eva Hedlund ; Christoph Schweingruber ; Jik Nijssen ; Irene Mei ; Julio AguilaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAmyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease that can be inherited with genetic mutations in > 25 different genes including e.g. FUS, TARDBP, and C9ORF72. […]
- GSE295789 Arabidopsis GH3.10 conjugates jasmonates April 30, 2025Contributors : Benedikt Ni ; Moritz Klein ; Ben M Hoßbach ; Kirstin Feussner ; Ellen Hornung ; Cornelia Herrfurth ; Mats Hamberg ; Ivo FeussnerSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaJasmonates regulate plant development and defence. In angiosperms, the canonical bioactive jasmonate is jasmonoyl-isoleuci […]
- GSE252182 Genome-wide DNA methylation profiles of well-differentiated liposarcomas (WDLPS), dedifferentiated liposarcomas (DDLPS), and normal adipose tissues April 30, 2025Contributors : Naoko Hattori ; Toshikazu UshijimaSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensLiposarcoma (LPS) is the most common soft-tissue sarcoma in adults, and well-differentiated LPS (WDLPS) and dedifferentiated LPS (DDLPS) are the most frequent subtypes. These LPSs are considered to develop due to disturbances in t […]
- GSE231456 RNA sequencing of HTNV NP and Gc proteins expressing cells April 30, 2025Contributors : Quan Liu ; Yinghua Zhao ; Lihe CheSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHantavirus infection has become a public health concern worldwide due to its ability to cause severe diseases in humans. The virulence of Hantavirus is determined by their ability to restrain host innate immune responses, su […]
- GSE295447 On target: Transcriptomic analysis of 12 human iPSC-derived cell phenotypes shows precision in an extensive pharmacological investigation [set 2] April 30, 2025Contributors : Frank Wessely ; Anja Wilmes ; Rory Bowden ; Sally A Cowley ; Paul Jennings ; Caleb Webber ; Zameel CaderSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe specificity of action of a pharmaceutical compound to a particular target cell type is desirable to mitigate undesired effects in off target cell type […]
- GSE295444 On target: Transcriptomic analysis of 12 human iPSC-derived cell phenotypes shows precision in an extensive pharmacological investigation [set 1] April 30, 2025Contributors : Frank Wessely ; Anja Wilmes ; Rory Bowden ; Sally A Cowley ; Paul Jennings ; Caleb Webber ; Zameel CaderSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe specificity of action of a pharmaceutical compound to a particular target cell type is desirable to mitigate undesired effects in off target cell type […]
- GSE295520 Targeting Glucose Metabolism: Synergistic Strategies to Enhance Apoptosis and Immune Activation in Hepatocellular Carcinoma Treatment April 30, 2025Contributors : Yunching Chen ; Yen-Nhi Ngoc TaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusExploiting the dependency of cancer cells on glycolysis offers a promising avenue to enhance therapeutic strategies for hepatocellular carcinoma (HCC). In our study, we employ glucose oxidase (GOx) as a glucose metabolism modul […]
- GSE295463 Single-cell sequencing-based technology reveals differences in four animal models of pulmonary fibrosis April 30, 2025Contributors : Shan Zhao ; Weibin Qian ; Xinrui CaiSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusPulmonary fibrosis is a progressive interstitial lung disease characterised by a progressive loss of lung function. It can occur as a result of occupational or medical exposures, genetic defects, trauma or acute lung […]
- GSE295544 Designed NGF mimetics with reduced nociceptive signatures in neurons April 30, 2025Contributors : Thomas Schlichthaerle ; Aerin Yang ; Damien Detraux ; David E. Johnson ; Chloe J. Peach ; Natasha I. Edman ; Catherine Sniezek ; Charles A. Williams ; Sonali Arora ; Neerja Katiyar ; Irene Chen ; Ali Etemadi ; Andrew Favor ; David Lee ; Connor Kubo ; Brian Coventry ; Buwei Huang ; Nathan Ennist ; Lukas Milles ; Banumathi Sankaran ; Alex Kang ; […]
- GSE295620 Single-nucleus and spatial transcriptome identify brain landscape of gene regulatory networks associated with behavioral maturation in honeybees April 30, 2025Contributors : Xiaohuan Mu ; Jie Ma ; Qun Liu ; Zijing Zhang ; Yating QinSeries Type : Expression profiling by high throughput sequencingOrganism : Apis melliferaAnimal behavior is linked to the gene regulatory network (GRN) coordinating gene expression in the brain. Eusocial honeybees, with their natural behavioral plasticity, provide an excellent model for […]
- GSE295781 Transcriptomics of Pseudomonas aeruginosa PA14 upon deletion of the sigma factor RpoS April 30, 2025Contributors : Luis Mauricio Salazar-Garcia ; Jose Manuel Villalobos-EscobedoSeries Type : Expression profiling by high throughput sequencingOrganism : Pseudomonas aeruginosaWe report RNA-seq data of Pseudomonas aeruginosa PA14 (UCBPP-PA14) and an isogenic rpoS-STOP mutant generated using CRISPR/Cas9 base editing. Transcriptomic profiling during exponential […]
- GSE264711 Sustained-release anti-JUN therapeutic abrogates post-operative adhesions [scRNA-Seq] April 30, 2025Contributors : Michael Januszyk ; Michelle GriffinSeries Type : Expression profiling by high throughput sequencingOrganism : Sus scrofaRadiation therapy is an important treatment component for a majority of cancer patients but involves significant side effects. In this study, we establish a large animal (porcine) irradiation model that recapitulates key clin […]