Quick Links : Search PubMed , Finding Full Text , PubMed Advanced Search , Clinical Queries , Single Citation Matcher , FAQs & User Guide , Explore MeSH Database , Explore PubMed Journals
Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE262881 A single-cell transcriptomic atlas of all cell types in the entire 5xFAD mouse brain in response to dietary inulin supplementation April 28, 2025Contributors : Xiaoyan Wang ; Houyu Zhang ; Zhou Wan ; Xuetong Li ; Carlos F Ibanez ; Meng XieSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAlzheimer’s disease (AD) is a progressive neurodegenerative disease that becomes a major threat to the aging population. Due to lack of effective therapy, preventive treatments ar […]
- GSE295658 In vivo CRISPRi screen reveals lncRNA portfolio crucial for cutaneous squamous cell carcinoma tumor growth [in_vivo_CRISPRi] April 28, 2025Contributors : Gyuhyeon Kim ; Zurab Siprashvili ; Xue Yang1 ; Luca Ducoli ; Paul A KhavariSeries Type : OtherOrganism : Homo sapiensCutaneous squamous cell carcinoma (cSCC) accounts for 20% of all skin cancer mortality globally, making it the second-highest subtype of skin cancer. The high prevalence of cSCC in humans highlights the need to uncover alternati […]
- GSE264115 Oral intake of high fat diet and acidic bile salts may develop carcinogenesis at the esophagogastric junction April 28, 2025Contributors : Kaname Uno ; Koichiro SudoSeries Type : Expression profiling by arrayOrganism : Mus musculusOral intake of high fat diet and acidic bile salts may promote the oxidative stress-induced Warburg effect in the tumorThe promotion of the carcinogenesis may be associated with high fat diet-related dysbiosis
- GSE201893 RBM47 Inhibits Hepatocellular Carcinoma Progression as a DNA/RNA Regulator April 28, 2025Series Type : Other ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE201818 RBM47 Inhibits Hepatocellular Carcinoma Progression as a DNA/RNA Regulator [ChIP-seq] April 28, 2025Contributors : Yingying Jiang ; Tao Guo ; Ke You ; Xi ChenSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensAfter ChIP assay, DNA sequencing was conducted to analyze the specific loci binding by RBM47 in HCCLM3 cells.
- GSE248323 The catalytic domain of SETD1B regulates H3K4me3 breadth and Myc expression in MLL-r leukemia (ChIP-seq_mus) April 28, 2025Contributors : Shintaro Izumi ; Takayuki HoshiiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusHistone H3 lysine 4 tri-methylation (H3K4me3) is abundant in MLL-rearranged (MLL-r) acute myeloid leukemia (AML) cells, but the enzymes responsible and their roles remain unclear. In this study, we perform a CRIS […]
- GSE248318 The catalytic domain of SETD1B regulates H3K4me3 breadth and Myc expression in MLL-r leukemia (CUT&Tag) April 28, 2025Contributors : Shintaro Izumi ; Takayuki HoshiiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusHistone H3 lysine 4 tri-methylation (H3K4me3) is abundant in MLL-rearranged (MLL-r) acute myeloid leukemia (AML) cells, but the enzymes responsible and their roles remain unclear. In this study, we perform a CRIS […]
- GSE294133 CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density [RNA-Seq] April 28, 2025Contributors : Alex Lish ; Courtney Benoit ; Richard Pearse ; Tracy Young-PearseSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGenetic studies implicate Clusterin (CLU) in the pathogenesis of Alzheimer’s disease (AD), yet its precise molecular impact remains unclear. Through unbiased proteomic profiling and functional […]
- GSE289565 CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density [scRNA-seq] April 28, 2025Contributors : Alex Lish ; Courtney Benoit ; Richard Pearse ; Tracy Young-PearseSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGenetic studies implicate Clusterin (CLU) in the pathogenesis of Alzheimer’s disease (AD), yet its precise molecular impact remains unclear. Through unbiased proteomic profiling and functional […]
- GSE295079 Fes-Deficient Macrophages Prime CD8+ T Cells to Stimulate Anti-tumor Immunity and Improve Immunotherapy Efficacy April 28, 2025Contributors : Brian J Laight ; Natasha Dmytryk ; Andrew Garven ; Kathrin Tyryshkin ; Peter A GreerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHomeostatic immunoregulatory mechanisms that prevent adverse effects of immune overaction can serve as barriers to successful anti-cancer immunity, representing attractive ta […]
- GSE294807 RNA-sequencing of whole lungs from mice with activating K-ras mutations and pharmacologic inhibition of STAT3 April 28, 2025Contributors : Michael J Clowers ; Seyed Javad MoghaddamSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusK-ras mutant lung adenocarcinoma (KM-LUAD) is a difficult-to-treat cancer subtype in which chronic inflammation pervades the tumor immune microenvironment (TIME). Pro-inflammatory pathways dampen the response to treat […]
- GSE295450 Slowed epigenetic aging in Olympic champions compared to non-champions April 28, 2025Contributors : Zsolt Radák ; Iván Fejes ; Csaba KerepesiSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensThe lifestyle patterns of top athletes are highly disciplined, featuring strict exercise regimens, nutrition plans, and mental preparation, often beginning at a young age. Recently, it was shown that physically active indiv […]
- GSE295649 In vivo CRISPRi screen reveals lncRNA portfolio crucial for cutaneous squamous cell carcinoma tumor growth [RNASeq_knockdown] April 28, 2025Contributors : Gyuhyeon Kim ; Luca Ducoli ; Paul A KhavariSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCutaneous squamous cell carcinoma (cSCC) accounts for 20% of all skin cancer mortality globally, making it the second-highest subtype of skin cancer. The high prevalence of cSCC in humans highlights the need to unco […]
- GSE295657 In vivo CRISPRi screen reveals lncRNA portfolio crucial for cutaneous squamous cell carcinoma tumor growth [in_vitro_CRISPRi] April 28, 2025Contributors : Gyuhyeon Kim ; Luca Ducoli ; Paul A KhavariSeries Type : OtherOrganism : Homo sapiensCutaneous squamous cell carcinoma (cSCC) accounts for 20% of all skin cancer mortality globally, making it the second-highest subtype of skin cancer. The high prevalence of cSCC in humans highlights the need to uncover alternative actors and mechanisms influen […]
- GSE248326 The catalytic domain of SETD1B regulates H3K4me3 breadth and Myc expression in MLL-r leukemia April 28, 2025Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusThis SuperSeries is composed of the SubSeries listed below.