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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE263683 Glial differentiation of mouse embryonic-stem-cell-derived neuronal precursors is a sensitive marker for assessing developmental neurotoxicity of insecticides April 21, 2025Contributor : Tomohiro ItoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMany epidemiological and animal exposure studies have suggested that exposure to environmental substances is a major risk factor for developmental neurotoxicity (DNT), such as in autism, and is related to the increasing relevance of neurodevelopme […]
- GSE295106 Single-cell gene expression of control mandibular bone marrow cells and mandibular bone marrow cells under bisphosphonate-related osteonecrosis of the jaw (BRONJ) April 21, 2025Contributors : Junyu Chen ; Yixin ShiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSingle-cell gene expression of mandibular bone marrow cells and mandibular bone marrow cells under the stimulation of BRONJ were determined by scRNAseq.
- GSE264672 EPOP Restricts PRC2.1 Targeting to Chromatin by Directly Modulating Enzyme Complex Dimerization (ChIP-Seq) April 21, 2025Contributors : Lihu Gong ; Xiuli Liu ; Xin Yang ; Ze Yu ; Siming Chen ; Chao Xing ; Xin LiuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusPolycomb repressive complex 2 (PRC2) mediates developmental gene repression as two classes of holocomplexes, PRC2.1 and PRC2.2. EPOP is an accessory subunit specific to […]
- GSE227367 Inflammation-induced epigenetic erosion drives stem cell ferroptosis during aging (CUT&Tag) April 21, 2025Contributors : Romeo Blanc ; Patrick Murphy ; Fanju MengSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusAging is a complex process associated with multiple events that lead to the decline in stem cell number and function. However, the relationship between these events and their initiation in biological sys […]
- GSE218532 Effect of the loss of Cdh1 on gene expression in mouse melanoma tumors. April 21, 2025Contributors : Jérémy H Raymond ; Véronique Delmas ; Lionel LarueSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusLoss of E-cadherin molecular consequences on gene expression was assessed by RNA-seq in NRASQ61K;Cdkn2a-/+ female and male mice.
- GSE253363 Effects of fluoro-phenyl-styrene-sulfonamide (FPSS) on transcription factor sigma B regulons in Staphylococcus aureus April 21, 2025Contributors : Sirirak Supa-amornkul ; Soraya ChaturongakulSeries Type : Expression profiling by high throughput sequencingOrganism : Staphylococcus aureus RF122Staphylococcus aureus has been shown to cause various types of tissue and systemic infections in humans and livestock with the mortality rate of 20-30%. Some isolates can be highly resistant to antib […]
- GSE248453 Gene expression profile at single cell level of synovial cells from patients with late-stage knee osteoarthritis April 21, 2025Contributors : Holly Philpott ; Garth Blackler ; Dan Klapak ; Alexander Knights ; Easton Farrell ; Benoit Fiset ; Logan Walsh ; Tristan Maerz ; Tom AppletonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensInnate immune cell are increased in the synovium in knee osteoarthritis. We used single cell RNA sequencing to analyz […]
- GSE294723 Expression data from macrophages sorted from Human Aortic Smooth Muscle Cells treated by PM2.5 April 21, 2025Contributors : Linyuan Huang ; Ruiyang Ding ; Kanglin Yan ; Junchao Duan ; Zhiwei SunSeries Type : Expression profiling by arrayOrganism : Homo sapiensTranscriptomic analysis implicated that PM2.5 could influence genes involved in the IRE1α-mediated unfolded protein responses and reduce the expression of DNAJB9, a co-chaperone formed a complex with BiP/IRE1α […]
- GSE293032 Transcriptomic comparison of hepatocytes derived from a panel of human induced pluripotent stem cells with different ethnicities April 21, 2025Contributors : Miranda R Yourick ; Xiugong GaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn the current study, we attempted to establish an in vitro model for assessing population variability in hepatotoxicity testing using a panel of hepatocytes derived from nine human induced pluripotent stem cell (iPSC) lines be […]
- GSE294781 Fungal susceptibility and early flowering in pennycress (Thlaspi arvense) are conferred by naturally occurring mutations in histone demethylase Jumonji 14 April 21, 2025Contributors : Jennette M Codjoe ; Alice Kujur ; Jammi Prasanthi Sirasani ; Anastasia Shamin ; Thomas Sauer ; Krishan Rai ; Tim Ulmasov ; Ratan Chopra ; Dilip M ShahSeries Type : Expression profiling by high throughput sequencingOrganism : Thlaspi arvensePennycress (Thlaspi arvense) is a winter oilseed domesticated recently to be incorporated as an intermedi […]
- GSE294769 Single-Cell Transcriptomic Atlas of Ovine Placenta Reveals Dynamic Cell Fate Transitions and Regulatory Networks Across Gestation April 21, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Ovis ariesThis study employed single-cell RNA sequencing (scRNA-seq) to systematically map the cellular landscape of Hu sheep placental tissues across three gestational stages (50, 80, and 120 days), uncovering dynamic cell fate transitions and regulatory mechanisms. Analysis of 51,80 […]
- GSE294842 The micro-RNA signature of hypertrophic callus-formation in bone fractures accompanied with traumatic brain injury. April 21, 2025Contributor : Andreas TrawegerSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensLong-bone-fractures occasionally heal with hypertrophic callus formation when patients suffer a concomitant traumatic brain injury. Although this phenomenon is known for decades, the causal factors are still poorly understood and no feasib […]
- GSE294846 Single-cell RNA sequencing on peripheral blood PBMCs from 4T1 mouse model treated with STING agonist deliveredy by PEG biopsy marker does not reveal peripheral T cell clonal expansion. April 21, 2025Contributors : Yuqing Zhang ; Zehua Li ; Patrick Lizotte ; Sophie KivLehan ; Kara M Soroko ; Sung-Rye Park ; Eric Minwei Liu ; Michael Y Tolstorukov ; Prafulla C Gokhale ; Cloud P Paweletz ; David A Barbie ; Thanh U BarbieSeries Type : Other ; Expression profiling by high throughput sequencingOrganism : Mus musculusTo explore whether immune escape could be s […]
- GSE294854 Single-cell RNA sequencing on TILs from 4T1 mouse model treated with STING agonist deliveredy by PEG biopsy marker shows activation of antigen presenting cells and macrophages but does not show T cell clonality. April 21, 2025Contributors : Yuqing Zhang ; Zehua Li ; Patrick Lizotte ; Sung-Rye Park ; Eric Minwei Liu ; Michael Y Tolstorukov ; Cloud P Paweletz ; David A Barbie ; Thanh U BarbieSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusTo better characterize the TME effects of ADU-S100 delivered by the PEG, we performed single cell […]
- GSE263272 Human iPS cell-derived respiratory organoids as a model for respiratory syncytial virus infection April 21, 2025Contributor : Kazuo TakayamaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRespiratory syncytial virus (RSV) is a seasonal respiratory pathogen that primarily affects young children, potentially causing severe lower respiratory tract disease. Despite the high disease burden, understanding of RSV pathophysiology remains […]