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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE266176 Tranposable Element Control by TRIM28 Safeguards PGC Sex Determination Program [RNA-Seq] April 29, 2025Contributors : Jonathan DiRusso ; Lingyu Zhan ; Tao Yu ; Amander ClarkSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTransposable elements are increasingly appreciated as regulatory elements in early mammalian development, especially in cells which exhibit pluripotency. Mammalian primordial germ cells (PGCs) must exit […]
- GSE266173 Tranposable Element Control by TRIM28 Safeguards PGC Sex Determination Program [ChIP-Seq] April 29, 2025Contributors : Jonathan DiRusso ; Lingyu Zhan ; Amander ClarkSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusTransposable elements are increasingly appreciated as regulatory elements in early mammalian development, especially in cells which exhibit pluripotency. Mammalian primordial germ cells (PGCs) must […]
- GSE268643 rAAV-miniBEND: A Targeted Vector for Brain Endothelial Cell Gene Delivery and Cerebrovascular Malformation Modeling II April 29, 2025Contributors : Jun-Liszt Li ; Zhanying Bi ; Xing-jun Chen ; Tianyue Ming ; Woo-ping GeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn-depth analysis of the molecular mechanisms underlying the initiation and development of bAVM was conducted through single-nucleus RNA sequencing of cells from bAVM lesions in Braf-CAfl […]
- GSE266178 Tranposable Element Control by TRIM28 Safeguards PGC Sex Determination Program April 29, 2025Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE295548 Tumorigenic p53S Balances Aging and Tumorigenesis via Regulating DREAM/MMB and its Downstream Telomere DNA Replication Pathways April 29, 2025Contributors : Qianqian Wang ; Jun Yang ; Haili Li ; Quan Zheng ; Kailong Hou ; Liangxia Jiang ; Bin Guo ; Shuting Jia ; Xiaoming Wu ; Juhua Dan ; Ying LuoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe Werner Syndrome (WS) is characterized with both premature aging and tumorigenic phenotypes. We introduced a tumori […]
- GSE274973 Mouse liver assembloids model periportal architecture and biliary fibrosis [scRNA-seq] April 29, 2025Contributors : Meritxell Huch ; Anna M Dowbaj ; Armin Niksic ; Cedric LandererSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusModelling liver disease requires in vitro systems that replicate disease progression1,2. Current tissue-derived organoids fail to reproduce the complex cellular composition and tissue architectur […]
- GSE278571 Neuron-targeted caveolin-1 enhances the neuroprotective, neuronal and synaptic plasticity transcriptome and improves cognitive function in symptomatic Alzheimer’s Disease models April 29, 2025Contributors : Dongsheng Wang ; Andrei V Chernov ; Ryan Lam ; Hongxia Wang ; Wenxi Li ; Xiaojing Li ; Tiffany Duong ; Shanshan Wang ; Brian P HeadSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPrevious work demonstrated that hippocampal delivery of AAV9-synapsin-promoted Cav-1 (SynCav1) to presymptomatic PSAPP mice all […]
- GSE253945 Tissue RNAsSeq of germ-free IL10KO versus WT mice in the presence or absence of human gut microbes April 29, 2025Contributors : Ki-Wook Kim ; Teruyuki Sano ; Nicolas Chevrier ; Michihiro Takahama ; Madison PlasterSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIL10 plays a crucial role in regulating immune responses. Although IL10 deficiency induces spontaneous gut inflammation in a commensal-dependent manner, the importance of IL […]
- GSE295339 Overexpression of PTHrP in beta cells reveals key effects on endoplasmic reticulum stress April 29, 2025Contributors : Ibiagbani M Max-Harry ; Noriko Kantake ; Kathryn L Corbin ; Thomas R Rosol ; Craig S NunemakerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAdministration of parathyroid hormone-related protein (PTHrP) has been shown to increase insulin content and secretion in mice. PTHrP also increases beta-cell mass […]
- GSE295171 LINC01963 Promotes Pancreatic Cancer Proliferation via METTL3/IGF2BP2 Axis-Mediated m6A Modification of c-Myc April 29, 2025Contributors : Qixian Liu ; Huanwen Wu ; Zhiyong LiangSeries Type : OtherOrganism : Homo sapiensC-Myc overexpression is an important molecular hallmark of pancreatic ductal adenocarcinoma (PDAC), but directly targeting c-Myc is extremely challenging. Identifying key upstream factors involved in c-Myc overexpression provides promising indirect targets for c-M […]
- GSE295361 Gene expression differences in primary Human Ectocervix and Endocervix Chips April 29, 2025Contributors : Anna Stejskalova ; Karina Calderon ; David B Chou ; Aakanksha Gulati ; Jessica F Feitor ; Zohreh Izadifar ; Ola Gutzeit ; Yasmine Bouchibti ; Siyu Chen ; Roberto Plebani ; Justin Cotton ; Jasmine G Hughes ; Thomas Ferrante ; Bogdan Budnik ; Girija Goyal ; Abidemi Junaid ; Carlito B Lebrilla ; Donald E IngberSeries Type : Expression profiling b […]
- GSE295522 Pexophagy-driven redox imbalance promotes virus-induced ferroptosis April 29, 2025Contributors : Yingjie Sun ; Yang Qu ; Chan DingSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPeroxisomes are critical organelles that maintain cellular redox homeostasis. Many viruses induce oxidative stress and degrade peroxisomes, but the mechanisms and consequences remain unclear. In this study, we systematically […]
- GSE295523 Gastric epithelial cells infected with Helicobacter pylori for 24 hours April 29, 2025Contributors : Minglin Zhang ; Fen WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHelicobacter pylori (H. pylori) infects nearly half of the global population. H. pylori infection is associated with various gastric diseases and is a recognized causative factor for gastric cancer. The mechanisms underlying the persi […]
- GSE266172 Tranposable Element Control by TRIM28 Safeguards PGC Sex Determination Program [ATAC-Seq] April 29, 2025Contributors : Jonathan DiRusso ; Amander ClarkSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusTransposable elements are increasingly appreciated as regulatory elements in early mammalian development, especially in cells which exhibit pluripotency. Mammalian primordial germ cells (PGCs) must exit latent pl […]
- GSE277888 Constitutive expression of IκBζ promotes tumor growth and immunotherapy resistance in melanoma [mouse RNA-seq] April 29, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground: IκBζ, a rather unknown co-regulator of NF-κB, is mostly inducibly expressed and can either activate or repress a specific subset of NF-κB target genes. While its role as a transcriptional regulator of various cytokines and chemokines in immune cells has been re […]