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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE264545 Next Generation Sequencing of Retinal Pigment Epithelial (RPE) cells differentiated from induced pluripotent stem cells (iPSCs). April 15, 2025Contributor : Rajarshi PalSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe have previously reported on RPE differentiation protocol that mimic the morphological, molecular, and functional characteristics of RPEs (GSE140545). In the present study, we developed an improved protocol that generates clinical grade hiPSC-RP […]
- GSE272623 Cutaneous T cells promote distinct transcriptional programs in human skin structural cells associated with inflammatory disease April 15, 2025Contributors : Peter A Morawski ; Hannah A DeBerg ; Mitch Fahning ; James Schlenker ; William Schmitt ; Iris K Gratz ; Jeffrey S Carlin ; Daniel J CampbellSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensT cells coordinate with structural cells in the skin to promote appropriate inflammatory responses and subsequent rest […]
- GSE270717 The m6A demethylase FTO controls activation-induced cell death in effector CD8+ T cells by modulating Fas expression April 15, 2025Contributors : Lina Sun ; Tianzhe Zhang ; Yanhong Su ; Baojun ZhangSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusFunctional CD8+ T cell immune response is critical for immune surveillance and host defense against infection and tumor. Epigenetic mechanisms associated with RNA modification in controlling CD8+ T […]
- GSE294553 Placental mitochondrial calcium uniporter modulates offspring susceptibility to obesity in a sex-dependent manner April 15, 2025Contributors : Juan Abrahante Llorens ; Megan Beetch ; Seokwon Jo ; Emilyn AlejandroSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMitochondria regulate bioenergetics, metabolism, and calcium storage, but their role in the placenta and how they may shape offspring metabolic health remains unclear despite associations w […]
- GSE283187 Synaptic vesicle endocytosis deficits underlie GBA-linked cognitive dysfunction in Parkinson’s disease and Dementia with Lewy bodies April 15, 2025Contributors : David Bäckström ; Vidyadhara Devarunda Jaganath ; Risha Chakraborty ; Jiapeng Ruan ; Jae-Min Park ; Pramod K Mistry ; Sreeganga S ChandraSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGBA mutations are major risk factors for Parkinson’s disease (PD) and Dementia with Lewy Bodies (DLB), two common α-synuc […]
- GSE263306 Imbalanced TGF-beta signalling and autophagy drive erythroid priming of hematopoietic stem cells in Beta-thalassemia April 15, 2025Contributors : Giuliana Ferrari ; Maria R Lidonnici ; Giulia Chianella ; Ivan Merelli ; Matteo BarcellaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe evaluated how the disease impacts the gene expression within hematopoietic stem cells and progenitors
- GSE237176 Synthetic deconvolution reveals combinatorial properties in transcriptional regulation by auxin April 15, 2025Contributors : Emmanuel Thevenon ; Jérémy Lucas ; Renaud Dumas ; François ParcySeries Type : OtherOrganism : Arabidopsis thalianaAuxin orchestrates multiple transcriptional programs throughout plant development. In flowering plants, responses to auxin relies on a large multigenic family of transcription factors, the auxin response factors (ARF). While ARF co […]
- GSE294226 Recurrent de novo variants in the spliceosomal factor CRNKL1 cause severe microcephaly and pontocerebellar hypoplasia with seizures April 15, 2025Contributors : Louise Bicknell ; Sankalita Ray DasSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioSplicing is a complex process, required to create the transcriptomic diversity needed for specialised functions in higher eukaryotes. The spliceosome contains more than 100 proteins and RNA molecules which coordinate this dy […]
- GSE292773 Knockdown of xenotropic and polytropic retrovirus receptor 1 in thyroid cancer cells April 15, 2025Contributor : Shih-Ping ChengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensXenotropic and polytropic retrovirus receptor 1 (XPR1), initially identified as a receptor for murine leukemia viruses, has been shown to function as a phosphate exporter, maintaining inorganic phosphate homeostasis in cells. Recently, XPR1 was […]
- GSE294335 Anatomical and Molecular Characterization of the Zebrafish Meninges April 15, 2025Contributors : Marina Venero Galanternik ; Daniel Castranova ; Ryan D Gober ; Tuyet Nguyen ; Madeleine I Kenton ; Brant WeinsteinSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioThe meninges are a set of connective tissue layers that surround the central nervous system, protecting the brain from mechanical shock, supporti […]
- GSE294227 Recurrent de novo variants in the spliceosomal factor CRNKL1 cause severe microcephaly and pontocerebellar hypoplasia with seizures [HeLa] April 15, 2025Contributors : Louise Bicknell ; Sankalita Ray DasSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSplicing is a complex process, required to create the transcriptomic diversity needed for specialised functions in higher eukaryotes. The spliceosome contains more than 100 proteins and RNA molecules which coordinate this d […]
- GSE294367 Long-range massively parallel reporter assay reveals rules of distal enhancer-promoter interactions April 15, 2025Contributors : Yawei Wu ; Jie Li ; Emma L Bartley-Dier ; Cassidy Pitts ; Barak A CohenSeries Type : OtherOrganism : Homo sapiensLong-range activation is an essential property of enhancers, yet the features determining long-range enhancer activities have not been systematically investigated due to a lack of high-throughput methods to measure long-range enhanc […]
- GSE294486 Ribociclib Derivative RB-BC Induces Apoptosis in Breast Cancer through p53 Pathway Activation April 15, 2025Contributors : Boyu Zhang ; Jing JISeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBreast cancer persists as the most prevalent malignancy and principal contributor to cancer-associated mortality among women worldwide, exhibiting marked disease heterogeneity and therapeutic resistance. Consequently, the development of n […]
- GSE294544 Research on the effect of PRMT5 on the genomic binding sites of ΔNp63α and its impact on the global transcriptomic regulation in the human tongue squamous cell carcinoma cell line UM1. April 15, 2025Contributors : Shijie Fan ; Yucheng Qi ; Chenghua LiSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiensBy performing PRMT5 knockdown in the human tongue squamous cell carcinoma cell line UM1, we analyzed the effects of this treatment on the global gene tran […]
- GSE264167 Auxin affects gene editing efficiency through regulating chromatin accessibility April 15, 2025Series Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Nicotiana tabacumATAC-seq of tobacco callus cells cultured by different NAA concentrations during in vitro tissue culture illustrates the landscape of chromatin openness across the entire genome，which provides a novel direction and theoretical basis for improving gene ed […]