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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE181259 Idelalisib and pneumococcal infection induce distinct transcriptional responses in mouse precision-cut lung slices December 20, 2025Contributors : Liu Guanghui ; Kinga Balogh Sivars ; Jerome Bouquet ; Taylor Cohen ; Catherine Betts ; Susan Busch ; Johanna SagemarkSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIdelalisib has excellent activity in management of chronic lymphocytic leukemia and follicular lymphoma while inducing serious microbial pneu […]
- GSE128467 Plpp1 protects MaSC (mammary stem cell) from malignant proliferation December 20, 2025Contributors : Li Zhuo ; Wei YongSeries Type : Expression profiling by arrayOrganism : Mus musculusMammary stem cell enriched subpopulations P4 (CD24+CD29hi) and luminal progenitor subpopulation P5 (CD24+CD29lo) were sorted from mammary gland from adult wild type C57BL6 mice and Plpp1 KO mice. The trascriptome profiles are determined and compared. In additio […]
- GSE235598 Systemically inducing trained immunity overcomes solid tumors’ immunosuppressive microenvironment December 20, 2025Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE235364 Systemically inducing trained immunity overcomes solid tumors’ immunosuppressive microenvironment. [scMULTIome] December 20, 2025Contributors : Lisa Willemsen ; Bram Priem ; Menno de Winther ; Willem MulderSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusscATACseq on the bone marrow of mice with and without a B16F10 tumor.
- GSE284982 Deoxynivalenol(DON) and related compounds target protein processing to induce immunotoxic effects in human T cells and macrophages [M2] December 20, 2025Contributors : Ying yang ; Xiaohong wang ; Lijuan You ; Qiannan zhang ; Xudong Jia ; Hui YangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDeoxynivalenol (DON) is a fungal toxin mainly produced by Fusarium graminearum and Fusarium graminearum, and is present in cereal crops such as wheat, barley, oats, rye, and corn. […]
- GSE284604 Zinc Finger and BTB Domain Containing 32 (Zbtb32) transcription factor promotes CD8+ T cell differentiation and function in cancer [RNA-Seq] December 20, 2025Contributors : Birui Pan ; Xiaohong Zhao ; Ruifeng Li ; Chen DongSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn the tumor microenvironment (TME), “exhausted” CD8+ T cells are classified into progenitor (Tpex) and terminally exhausted (Ttex) populations. Tpex cells could be reinvigorated during immune checkpoint bloc […]
- GSE303377 Colorectal Cancer cohort from the Geneva Cancer Registry December 20, 2025Contributors : Simone Benhamou ; Evelyne Fournier ; Giacomo Puppa ; Thomas McKee ; Frederic Ris ; Laura Rubbia-Brandt ; Valeria Viassolo ; Thomas Zilli ; Inti Zlobec ; Pierre Olivier Chappuis ; Elisabetta Rapiti ; Petros TsantoulisSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe Geneva Cancer Registry database collec […]
- GSE284987 Deoxynivalenol(DON) and related compounds target protein processing to induce immunotoxic effects in human T cells and macrophages [Zebrafish] December 20, 2025Contributors : Ying Yang ; Xiaohong Wang ; Lijuan You ; Qiannan Zhang ; Xudong Jia ; Hui YangSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioDeoxynivalenol (DON) is a fungal toxin mainly produced by Fusarium graminearum and Fusarium graminearum, and is present in cereal crops such as wheat, barley, oats, rye, and corn. I […]
- GSE309759 Glucose metabolism regulates human cortical cell diversification and maturation December 20, 2025Contributors : Taylor R Pennington ; Alexandria S M Morales ; Ammar Mehdi ; Sophia Cerna ; Gradi Bamfonga ; Alicia M Saarinen ; Fabiha Firoz ; Tran Ngyuen ; Sierra Wilferd ; Christopher Plaisier ; Benjamin Bartelle ; Haiwei Gu ; Clifford Folmes ; Madeline G AndrewsSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDefining […]
- GSE308294 Paracrine stimulation of brown adipose tissue vascularization by adipocyte O-GlcNAc signaling December 20, 2025Contributors : Luwen Li ; Liwei Dong ; Yaping Shan ; Jintang Xie ; Ting Song ; Sai Zhang ; Yun Kong ; Shiqi Zhang ; Chengwei Gu ; Die Hu ; Weijia Wang ; Yunfan YangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBrown adipose tissue (BAT) is extensively vascularized, which is essential for its physiological activities. […]
- GSE310779 Investigating epigenetic biomarkers of age, sex, and disease in captive South African cheetahs (Acinonyx jubatus jubatus) December 20, 2025Contributors : Ysrael Michelle ; Moore Caroline ; Kubiski StevenSeries Type : Methylation profiling by genome tiling arrayOrganism : Acinonyx jubatus ; Homo sapiens ; Mus musculus ; Rattus norvegicusEpigenetic modifications, particularly DNA methylation, are strongly associated with chronological age across mammalian species. This study developed cheetah-spe […]
- GSE312223 Microarray data for normal human melanocytes, untreated A375 melanoma cells, and A375 cells treated with Timosaponin AIII December 20, 2025Contributor : Bei ZhaoSeries Type : Expression profiling by arrayOrganism : Homo sapiensMelanoma is an aggressive skin cancer with limited treatment options, particularly in advanced stages. Novel therapeutic agents with defined molecular mechanisms are urgently needed. Timosaponin AIII, a naturally occurring steroidal saponin from Anemarrhena asphodeloides, […]
- GSE313541 Gene expression profiles in injured renal tubules in rat model of colistin-induced nephrotoxicity December 20, 2025Contributor : Kohei MatsushitaSeries Type : Expression profiling by arrayOrganism : Rattus norvegicusThe aim of this study is to investigate the gene expression profiles of injured renal tubules in colistin-induced nephrotoxicity.
- GSE313751 Human tolerogenic dendritic cell subtypes exert divergent effects on induction of cytotoxic CD4+ T cells December 20, 2025Contributors : Gabrielle Barran ; Najib Naamane ; Abdul Mannan Baru ; Amy E Anderson ; Jane Falconer ; Catharien M HilkensSeries Type : Expression profiling by arrayOrganism : Homo sapiensTolerogenic dendritic cells (tolDC) are currently in clinical trials for the treatment of autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. The metho […]
- GSE302999 Chronic NK cell activation results in a dysfunctional, tissue resident-like state mediated by KLF2 deficiency December 20, 2025Contributor : Jacob A MyersSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAdoptive transfer of NK cells can induce complete remissions in 30-50% of patients with refractory acute myeloid leukemia and lymphoma. While blood chimerism occurs, attaining functional homing to the site of tumor without exhaustion has been elu […]