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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE273775 Enhanced CLIP-Seq (eCLIP-Seq) of FLAG-tagged wild-type and mutant MYC in U2OS-MYC-KO-MYC-Tet-On cells May 8, 2025Contributors : Sihan Li ; Zehua Wang ; Da YangSeries Type : OtherOrganism : Transcription factor (TF) MYC binds to thousands of gene regulatory elements in the genome such as promoters and enhancers and exerts an amplification effect on the expression of most genes, regardless of the E-box motif existence. In this study, we discovered that MYC is an RNA-bind […]
- GSE224484 A gatekeeper mechanism of the noradrenergic neural control of tear secretion via the NA-Adra1a-Ucp2 pathway May 8, 2025Contributors : Qun Wang ; Qingjun Zhou ; Lixin XieSeries Type : Expression profiling by high throughput sequencingOrganism : Tears are mainly secreted from the lacrimal gland under precise controls by autonomic neural response to external sensory and psychogenic emotional stimulation. Dynamic volume and compositional changes of tears may lead to development […]
- GSE179932 RAF conformational autoinhibition and 14-3-3 proteins promote paradoxical activation May 8, 2025Contributors : Gaurav Mendiratta ; Kodye Abbott ; Yao-Cheng Li ; Jingting Yu ; Jianfeng Huang ; Maxim N Shokhirev ; Thomas McFall ; Geoffrey Wahl ; Edward C StitesSeries Type : Expression profiling by high throughput sequencingOrganism : RAF kinase inhibitors can, in some conditions, increase RAF kinase signaling. This process, which is commonly referred to […]
- GSE252698 RNA-binding activity plays an important role in MYC function May 8, 2025Series Type : Genome binding/occupancy profiling by high throughput sequencing ; OtherOrganism : This SuperSeries is composed of the SubSeries listed below.
- GSE252694 RNA-dependent CUT&RUN (rCUT&RUN) of MYC and TBP in MCF-7 cells May 8, 2025Contributors : Sihan Li ; Zehua Wang ; Da YangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : MYC binds to thousands of gene regulatory elements in the genome such as promoters and enhancers and exerts an amplification effect on the expression of most genes, regardless of the E-box motif existence. In this study, we d […]
- GSE268605 ATAC-seq analysis of kidney cortex following KLF6 induction May 8, 2025Contributors : Sian E Piret ; Maanasa Hanubal ; Merin Davis ; Jiakang Wang ; Samaneh DiMartino ; Nehaben A Gujarati ; Tej Bahadur ; Asha Rath ; Robert Bronstein ; Yiqing Guo ; Sandeep K MallipattuSeries Type : Expression profiling by high throughput sequencingOrganism : The goal of this study was to identify chromatin changes mediated by KLF6 induction 24 ho […]
- GSE256313 Widespread impact of nucleosome remodelers on transcription at cis-regulatory elements [RNA-seq] May 8, 2025Contributors : Benjamin J Patty ; Rinku Dhungana ; Sarah J HainerSeries Type : Expression profiling by high throughput sequencingOrganism : Nucleosome remodeling complexes and other regulatory factors work in concert to build a chromatin environment that directs the expression of a distinct set of genes in each cell using cis-regulatory elements (CREs) such […]
- GSE296155 Loss of the USP22 deubiquitylase confers resistance to chemotherapy in small cell lung cancer [RNA-seq] May 8, 2025Contributor : Scott BestSeries Type : Expression profiling by high throughput sequencingOrganism : Small cell lung cancer (SCLC) responds exceptionally well to cytotoxic chemotherapy. However, relapse with the emergence of chemoresistant disease is rapid and accompanied by poor treatment outcomes. To understand the genetic basis of chemoresistance in SCLC, w […]
- GSE293267 Modeling diabetic alpha cell dysfunction using stem cell-derived alpha cells May 8, 2025Series Type : Expression profiling by high throughput sequencingOrganism : This SuperSeries is composed of the SubSeries listed below.
- GSE296261 Loss of the USP22 deubiquitylase confers resistance to chemotherapy in small cell lung cancer May 8, 2025Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : This SuperSeries is composed of the SubSeries listed below.
- GSE296258 Loss of the USP22 deubiquitylase confers resistance to chemotherapy in small cell lung cancer [CUT&Tag] May 8, 2025Contributor : Scott BestSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Small cell lung cancer (SCLC) responds exceptionally well to cytotoxic chemotherapy. However, relapse with the emergence of chemoresistant disease is rapid and accompanied by poor treatment outcomes. To understand the genetic basis of chemoresista […]
- GSE296395 Comparative Study on the Effects of Silicon Nanoparticles and Cellulose Nanocrystals on Drought Tolerance in Tall Fescue (Festuca arundinacea Schreb.) May 8, 2025Contributors : Li Meng ; Hu Sile ; Bai Xulong ; Ren Jie ; Tian Kanliang ; Zhang Huili ; Zhang Zhilong ; Nguyen VanquySeries Type : Expression profiling by high throughput sequencingOrganism : Tall fescue (Festuca arundinacea Schreb.) is a commonly used herbaceous species for slope ecological restoration in China. However, water scarcity often constrains its […]
- GSE296574 Reduction of neuronal activity mediated by blood-vessel regression in the adult brain May 8, 2025Contributors : Xiaofei Gao ; Xing-jun Chen ; Meng Ye ; Jun-Liszt Li ; Tianyue Ming ; Nannan Lu ; Woo-ping GeSeries Type : Expression profiling by high throughput sequencingOrganism : To explore the role of brain vascular TAK1 and its functional mechanism , we performed RNA-seq between Cdh5-CreER::Tak1fl/fl mice and their littermate control mice at the age of […]
- GSE296624 Monocyte Single-Cell Multimodal Profiling in Cardiovascular Disease Risk States May 8, 2025Contributors : Alexander Bashore ; Chenyi XueSeries Type : Expression profiling by high throughput sequencingOrganism : Monocytes are a critical innate immune system cell type that serves homeostatic and immunoregulatory functions. They have been identified historically by the cell surface expression of CD14 and CD16. However, recent single-cell studies have […]
- GSE271432 Loss of the Endothelial Glycocalyx Component EMCN Leads to Glomerular Impairment May 8, 2025Contributors : Zhengping Hu ; Issahy Cano ; Fengyang Lei ; Jie Liu ; Ramon Bossardi Ramos ; Harper Gordon ; Eleftherios I Paschalis ; Magali Saint-Geniez ; Yin Ng ; Patricia A D’AmoreSeries Type : Expression profiling by high throughput sequencingOrganism : Endomucin (EMCN), an endothelial-specific glycocalyx component, was found to be highly expressed by th […]