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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE307702 Thimerosal Inhibits Tumor Malignant Progression Through Direct Action and Enhancing the Efficacy of PD-1-Based Immunotherapy September 16, 2025Contributors : Ping Wang ; Yan-Han Chen ; Ze-Tao Zhan ; Jun-Xiang Zeng ; Yu Chen ; Yuan Lin ; Tao Chen ; Wei-Jie ZhouSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground: Thimerosal is a mercury-containing preservative widely used in vaccines.. This study aimed to investigate its potential antitumor effects and me […]
- GSE307523 O-antigen Deficiency Sparks Metabolic Shifts That Blunt ROS-Mediated Killing by Meropenem September 16, 2025Contributors : Jiangqing Huang ; Dawei WeiSeries Type : Expression profiling by high throughput sequencingOrganism : Klebsiella pneumoniaeCarbapenem-resistant Klebsiella pneumoniae (CRKP) poses a major global health threat, particularly in healthcare-associated infections. While carbapenemase- and porin-centered mechanisms are well characterized, how subinhi […]
- GSE277309 Ablation of hematopoietic stem cell derived adipocytes reduces tumor burden in syngeneic mouse models of high-grade serous carcinoma September 16, 2025Contributors : Elizabeth R Woodruff ; Courtney A Bailey ; Francis To ; Joanne K Maltzahn ; Timothy M Sullivan ; Meher P Boorgula ; Dwight J Klemm ; Benjamin G Bitler ; Zachary L WatsonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn this study we examined the influence of hematopoietic stem cell derived adipocytes (HS […]
- GSE307948 Rate Limiting Enzymes in Nucleotide Metabolism Synchronize Nucleotide Biosynthesis and Chromatin Formation [RNA-Seq] September 16, 2025Contributors : Shashank Srivastava ; Daniel R FoltzSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensFundamental cellular processes including replication, transcription, and repair rely on both an adequate nucleotide supply and sufficient availability of new histones. Chromatin disassembly and reassembly is crucial to mai […]
- GSE286520 Glucocorticoids unleash immune-dependent melanoma control through inhibition of the GARP/TGFβ axis [scRNA-seq] September 16, 2025Contributors : Charles H Earnshaw ; Maria A Koufaki ; Richard Reeves ; Robert Sellers ; Sudhakar Sahoo ; Santiago ZelenaySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGlucocorticoids were found to trigger immune-dependent control of an orthotopic melanoma model. We used scRNAseq to better understand the changes in tum […]
- GSE278438 An siRMSD parameter of structural distortion induced by chemical modification is predictive of the off-target effect of siRNA_(1/2) September 16, 2025Contributors : Kumiko Ui-Tei ; Seongjin AnSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo investigate effects of siRNA with various 2'-ribose modifications on genome-wide off-target effect, we analyzed gene expression profile of HeLa cells transfected by their siRNAs.
- GSE307819 Transposable elements as catalysts of genome evolution in Drosophila virilis September 16, 2025Contributors : Alexander P Rezvykh ; Sergei Y FunikovSeries Type : Expression profiling by high throughput sequencing ; Other ; Non-coding RNA profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Drosophila virilisTransposable elements (TEs) drive genomic innovation, but their dynamics in non-mo […]
- GSE301547 Wild-type KRAS activation drives evasion of interferon-mediated immunity and resistance to immunotherapy in hepatocellular carcinoma September 16, 2025Contributors : Martina M LEI ; Carmen O LEUNG ; Terence K LEESeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBased on scRNA-seq analysis, we found that KRAS inhibited the expression of intrinsic interferon-mediated MHC-I and impaired extrinsic interferon-induced dendritic cell recruitment, resulting in a reduction of CD […]
- GSE307831 Human peripheral and tissue Foxp3-high regulatory T cells in patients with hepatocellular carcinoma [CITE-seq] September 16, 2025Contributors : Chien-Hao Huang ; Wei-Ting Ku ; Jayashri Mahalingam ; Cheng-Heng Wu ; Tsung-Han Wu ; Jian-He Fang ; Chung-Wei Su ; Po-Ting Lin ; Chien-Wei Peng ; Chan-Keng Yang ; Wei Teng ; Wen-Juei Jeng ; Wei-Ting Chen ; Chen-Chun Lin ; Shi-Ming Lin ; I-Shyan Sheen ; Yung-Chang Lin ; Chun-Yen LinSeries Type : Expression profiling by high throughput sequencin […]
- GSE307823 Neutrophil-enriched gene signature correlates with teplizumab therapy resistance in different stages of type 1 diabetes September 16, 2025Contributors : Gabriele Sassi ; Pierre Lemaitre ; Chantal Mathieu ; Conny GysemansSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusTeplizumab, a humanized anti-CD3 monoclonal antibody, represents a major advancement in autoimmune type 1 diabetes (T1D) treatment, capable of delaying clinical onset in stage 2 and p […]
- GSE307844 RNA-seq of THP-1 and U937 exposed to enamel matrix derivative. September 16, 2025Contributors : Panahipour Layla ; Xiaoyu Huang ; Reinhard GruberSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEnamel matrix derivatives (EMDs) treat periodontal defects and gingival recession, a process where macrophages are believed to contribute to the clinical outcome. However, the present findings are heterogeneou […]
- GSE307852 Disruption of Pre-Bötzinger Complex neuropeptidergic tonality controls fear and metabolic response September 16, 2025Contributor : Prashant RajbhandariSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusStress profoundly impacts systemic metabolism, yet the central circuits linking stress responses to peripheral metabolic regulation remain poorly defined. Here, we identify the preBötzinger complex (preBötC), a brainstem breathing rhythm g […]
- GSE307947 Rate Limiting Enzymes in Nucleotide Metabolism Synchronize Nucleotide Biosynthesis and Chromatin Formation [ATAC-Seq] September 16, 2025Contributors : Shashank Srivastava ; Daniel R FoltzSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensFundamental cellular processes including replication, transcription, and repair rely on both an adequate nucleotide supply and sufficient availability of new histones. Chromatin disassembly and reassembly is […]
- GSE307516 Gene expression profiles modulated by lipophilic sea buckthorn (Hippophae rhamnoides L.) extract in BT-549 triple-negative breast cancer cells September 16, 2025Contributors : Simona Visan ; Loredana Balacescu ; Flaviu Drigla ; Ovidiu Balacescu ; Adela PinteaSeries Type : Expression profiling by arrayOrganism : Homo sapiensConsidering that dysregulation of cholesterol levels has been established as one of the hallmarks of cancer, moreover ferroptosis, autophagy, tumor cell, immune cell stemness, and the cellular DNA […]
- GSE307813 Nanoscale photoproximity labeling of c-Myc predicts cancer specific therapeutic targets September 16, 2025Contributors : Ryan R Milione ; Feifei Tong ; Kelset L Wolfe ; Pfizer Pfizer ; Michalina Janiszewska ; Ciaran P SeathSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTranscription factors (TFs) have long been aspirational therapeutic targets for the treatment of diseases, as their dysregulation is a common mechanism for […]