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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE273809 Profiling of Androgen Receptor in prostate cancer cells in response to androgen deprivation and the onset of the neuroendocrine phenotype October 13, 2025Contributors : Rocco Cipolla ; Marina Pinskaya ; Marc Gabriel ; Antonin MorillonSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensAndrogen deprivation therapy (ADT), also called chemical castration, is one of the prevailing treatments of local and metastatic prostate cancer enabling inhibition of the Androge […]
- GSE215466 Alteration of the N6-methyladenosine methylation landscape in a mouse model of polycystic ovary syndrome October 13, 2025Contributors : Bin Jiang ; Waixing LiSeries Type : Non-coding RNA profiling by array ; OtherOrganism : Homo sapiens ; Mus musculusTo explore the N6-methyladenosine (m6A) methylation abnormality of mRNAs and its potential roles in the mouse model of polycystic ovary syndrome (PCOS)
- GSE307900 Comparative analysis of isoproterenol and lipopolysaccharide mediated cytoprotective responses in the heart October 13, 2025Contributors : Kenji Rowel Q Lim ; Douglas L MannSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study aimed to compare the mechanisms by which isoproterenol and lipopolysaccharide induce cytoprotection in the heart. We performed bulk RNA sequencing to compare the transcriptomic effects of isoproterenol and lipopol […]
- GSE236006 The effect of STING antagonist SN-011 on the gene expression changes in the mouse brain after ischemic stroke October 13, 2025Contributors : Haiyang Hu ; Munire Maimaiti ; Chen WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMounting evidence indicates that the cGAS-STING pathway represents the major DNA sensing pathway to invoke immune and inflammatory responses in neuroinflammatory disorders. Here, we examined the effect of STING antagon […]
- GSE216820 Histone H3K4me3 epigenetic modification ChIPseq October 13, 2025Contributors : Maria I Bokarewa ; Karin M Andersson ; Malin C Erlandsson ; Nina Oparina ; Chandrasekaran VenkataragavanSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensChIPseq analysis of histone H3 epigenetic modifications - K4me3 - chromatin binding in activated CD4+ T cells
- GSE248693 Interpretable Inflammation Landscape of Circulating Immune cells (ILCIC_cirrhosis) October 13, 2025Contributors : Laura Jiménez-Gracia ; Davide Maspero ; Sergio Aguilar-Fernández ; Francesco Craighero ; Juan C Nieto ; Holger HeynSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensInflammation is a biological phenomenon beneficial for homeostasis, but unfavorable if dysregulated. Although major progress has been made in c […]
- GSE244056 Revealing heterogeneity and damage response in the adult human utricle October 13, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE303047 MODY PDX1P33T: A Mouse Model Reveals Phenotypic Divergence from Human Disease October 13, 2025Contributors : Aliona Harten ; Maximilian R Schmidtke ; Florian Giesert ; David A Skerrett-Byrne ; Raffaele Teperino ; Gerhard K Przemeck ; Martin Hrabě de AngelisSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIntroduction: Maturity-onset Diabetes of the Young (MODY) is a rare form of diabetes and arises from mutations […]
- GSE301555 Transcriptomic Profiling of siCHRNA5 and siTP53 Perturbations in ER-Positive MCF7 Breast Cancer Cells October 13, 2025Contributors : Ozlen Konu ; Ayse G KeskusSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEstrogen receptor (ER)-positive MCF7 breast cancer cells were treated with siRNAs targeting CHRNA5, TP53, or both in combination to investigate TP53-dependent and independent transcriptional responses to CHRNA5 knockdown. Previous s […]
- GSE304938 Loss of Brg1 and Pten in pancreatic ductal cells forms intraductal tubulopapillary neoplasm via the YAP/TAZ pathway October 13, 2025Contributors : Kei Iimori ; Akihisa FukudaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground & Aims Intraductal tubulopapillary neoplasm (ITPN) is a rare, high-grade tumour of the pancreatic duct, characterised by distinct molecular features including frequent alterations in the components of switch/sucrose […]
- GSE303568 Prospective isolation of mouse and human hematopoietic stem cells using PLXDC2 October 13, 2025Contributors : Yosuke Tanaka ; Yasushi KubotaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNumerous strategies exist to isolate hematopoietic stem cells (HSCs) using complex combinations of markers and flow cytometry. However, robust identification of HSCs using imaging techniques is substantially more challenging whi […]
- GSE304962 Multi-omics analyses reveal DjTcf4 critical for proper timing of differentiation in planarian regeneration October 13, 2025Contributors : Hao Wang ; Mengmeng Lu ; Lei Huang ; Xiaopeng Zou ; Hongfei Liu ; Ya Gao ; Yanming Wang ; Yunchao KanSeries Type : OtherOrganism : Dugesia japonicaThe blastema is key to forming complete tissues in regenerating Dugesia japonica (D. japonica). However, the dynamic changes in cellular compositions and transcription landscapes in blastema during […]
- GSE306257 A Global View of Cell Type Homology and Transcriptomic Divergence in the Mammalian Brain October 13, 2025Contributors : Matthew Schmitz ; Alex PollenSeries Type : Expression profiling by high throughput sequencingOrganism : Macaca mulattaThis study is a high-level comparison of the embryonic brains of Homo sapiens, Macaca mulatta, and Mus musculus using scRNA-seq. This submission includes the novel Macaca mulatta scRNA-seq generated for this study between PCD40 […]
- GSE306906 Fosl1 is a transcriptional effector of BRAFV600E-driven intestinal tumorigenesis October 13, 2025Contributors : Zakia Alam ; Rebecca Nightingale ; Analia Lesmana ; Cheng Liu ; Laura J Jenkins ; Mark F Richardson ; Larry J Croft ; Ian Y Luk ; Camilla M Reehorst ; Fiona Chionh ; Natalia Vukelic ; Faiza Basheer ; Eugene Tulchinsky ; Joshua Badshah ; Troy Dumenil ; Latifa Bakiri ; Erwin F Wagner ; Niall C Tebutt ; Vicki Whitehall ; John M Mariadason ; Amard […]
- GSE267403 RNA-mediated mechanisms of regulation of the Androgen Receptor activity in response to androgen deprivation October 13, 2025Contributors : Rocco Cipolla ; Marina Pinskaya ; Marc Gabriel ; Antonin MorillonSeries Type : OtherOrganism : Homo sapiensAndrogen deprivation therapy (ADT), also called chemical castration, is one of the prevailing treatments of local and metastatic prostate cancer enabling inhibition of the Androgen Receptor (AR) pathway and tumor regression. However, the […]