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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE208406 RNAseq analysis of Synph-293 cells July 18, 2025Contributors : Do H Kwon ; Gwang LeeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe report the gene expression profile in Synph-293 cells, which are stably FLAG-tagged synphilin-1 overexpressing HEK293 cells.
- GSE238086 Dual roles of dermal adipogenesis in initiating and resolving neutrophilic skin inflammation July 18, 2025Contributors : Ling-juan Zhang ; Rundong Wu ; Tian XiaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDermal white adipose tissue (dWAT) is highly plastic and pivotal in host defense; however, its role in controlling neutrophil function remains unstudied. Here we found that Imiquimod-induced psoriatic skin inflammation […]
- GSE208530 Gene expression profiles of Leigh syndrome mouse samples and Ndufs4 knockout human iPSCs before and after Pioglitazone treatment July 18, 2025Contributors : Peikai Chen ; Xiaoxian Zhang ; Qizhou Lian ; Ling ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusLeigh syndrome is a progressive neurodegenerative disease caused by knockout (KO) of the Ndufs4 gene, leading to mitochondrial oxidative stress, inflammation and aberrant mitochondrial dyna […]
- GSE272614 PD-L1/PD-1 checkpoint pathway regulates astrocyte morphogenesis and myelination during mouse brain development July 18, 2025Contributors : Yanyan Wang ; Shukui Zhang ; Tianyu Zhang ; Jianwei JiaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo gain futher insight into how astrocyte-derived PD1 regulates astrocyte morphogenesis and myelination, RNA-seq was used to analyze the genome-wide changes resulting from isolated astrocyte of P5 astro […]
- GSE254396 Single-cell and bulk RNA sequencing of mouse atherosclerosis disease stage course [TRAP-seq] July 18, 2025Contributors : Henri Niskanen ; Tiit Örd ; Aarthi Ravindran ; Retu Haikonen ; Minna U KaikkonenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAtherosclerotic coronary artery disease (CAD) development encompasses changes in immune cell activation across different tissues, including vascular and metabolic tissues. Howeve […]
- GSE279556 Pathogenic DICER1 RNase IIIb Hotspot Mutation Induces 3p-miRNA Gain-of-Function via Argonaute Strand Switch [miR-seq] July 18, 2025Contributors : Malagobadan Sharan ; Gu ShuoSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusDicer is an essential enzyme in microRNA biogenesis. Mutations in the DICER1 gene are linked to various cancers, notably through the DICER1 syndrome. To investigate the impact of the pathogenic hotspot mutations […]
- GSE278105 Z138-SNP_array_data July 18, 2025Contributors : Renée Beekman ; Silvia Bea ; Cristina LopezSeries Type : SNP genotyping by SNP arrayOrganism : Homo sapiensThe Z138 cell line is a mantle cell lymphoma cell line carrying the t(11;14) translocation. SNP array data analysis combined with chromosome sorting data allowed to identify heterozygous SNPs on the wildtype and translocated chromosome 11 […]
- GSE302337 Failing heart-specific cardiac fibroblasts induce heart failure via c-Myc Expansion [snRNA-seq] July 18, 2025Contributors : Manami Katoh ; Jin Komuro ; Shinsuke Yuasa ; Masaki IedaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHeart failure (HF) is a major global problem with increasing numbers of patients and deaths in many countries. Existing studies on HF have focused primarily on cardiomyocytes, with few studies targeting […]
- GSE300469 Nuclear RPSA triggers R-loop accumulation to induce cell death against RNA viral infection [DRIP-seq] July 18, 2025Series Type : OtherOrganism : Homo sapiensWhile RNA viruses evade host immune responses by perturbing transcriptional and translational machinery, the host organism counteracts viral invasion through activation of regulated cell death pathways. However, the precise molecular mechanisms underlying host-initiated cell death activation in response to viral infe […]
- GSE302518 The muscle-specific MEF2D⍺2 isoform promotes muscle ketolysis and running capacity in mice July 18, 2025Contributors : Kumar Sushil ; Ji Xuan ; Iqbal Hina ; Xiangnan Guan ; Mis Brittany ; Dave Devanshi ; Kumar Suresh ; Besler Jacob ; Dash Ranjan ; Xia Zheng ; Singh Ravi K.Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusKetone bodies are an alternate fuel source generated by the liver in response to low carbohydrate availa […]
- GSE302408 Hyperactive PDGFRβ signaling induces cataractogenesis via TGFβ and STAT5-IGF1 July 18, 2025Contributors : Jesse J Reardon ; Yixuan Ma ; Nathaniel S Grabinski ; Yalini Ramamoorthy ; Rebecca L Packard ; Johnathon G Schiebel ; Heather L Chandler ; Gina M SizemoreSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIntroduction: Cataracts are the world’s leading cause of reversible blindness. Although cataract formati […]
- GSE302523 Differential Expression of Long Non-Coding RNA in Postmenopausal Fibroids July 18, 2025Contributors : Tsai-Der Chuang ; Shawn Rysling ; Nhu Ton ; Daniel Baghdasarian ; Omid KhorramSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis study aimed to characterize the differential expression profile of long non-coding RNA transcripts in postmenopausal leiomyomas compared to their paired myometrium
- GSE302587 Pou2f3⁺ Cells Contain Multilineage Potential Progenitors as Revealed by scRNA-seq Analysis July 18, 2025Contributors : Mi Lin ; Qiyue Chen ; Guangtan Lin ; Ping Li ; Jianxian Lin ; Jianwen QueSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo further study the lineage potential of Pou2f3⁺ cells, we performed single-cell RNA sequencing (scRNA-seq) of lineage-labeled cells isolated from the gastric tissues of Pou2f3-CreERT; […]
- GSE302588 CXCL5 inhibition suppresses gastric mixed neuroendocrine-non-neuroendocrine neoplasms arising from transformed Pou2f3+ epithelium July 18, 2025Contributors : Mi Lin ; Qiyue Chen ; Guangtan Lin ; Ping Li ; Jianxian Lin ; Jianwen QueSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo explore the possibility that tumor development relies on a shared oncogenic facilitator rather than on specific SOX2 or SOX9 expression patterns, we performed bulk RNA sequencing of […]
- GSE302883 scRNAseq data of primary Sjögren's syndrome July 18, 2025Contributor : Jun HuangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensLabial gland tissues were obtained from three individuals diagnosed with pSS and three healthy donors. All participants were recruited from the Rheumatology and Immunology Department of Kunshan First People's Hospital during 2022.