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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE200242 Genome-wide maps of nuclear lamina interactions in AML12 cells upon MATR3 KD [DamID-Seq] March 14, 2025Contributors : Bo Wen ; Yuwen Zhang ; Xuan CaoSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusWe performed DamID-seq assay in WT and MATR3-depleted AML12 cells to investigate the Lamina-associated-domains (LADs) affected by loss of MATR3.
- GSE261235 Expansion of endogenous T cells in CSF of pediatric and young adult CNS tumor patients undergoing locoregional delivery of IL13R⍺2-targeting CAR T cells: an interim analysis March 14, 2025Contributors : Leo D Wang ; Angela M Taravella Oill ; Suzette Blanchard ; Melody Wu ; Jonathan C Hibbard ; Colt Egelston ; Sean Sepulveda ; Lance Peter ; Julie Kilpatrick ; Margarita Muñoz ; Tracey Stiller ; Noah Shulkin ; Jamie Wagner ; Ally M Dolatabadi ; Monica Nisis ; Jennifer K Shepphird ; Gabriela Sanchez ; Chetan R Lingaraju ; Mishika Manchanda ; Hein […]
- GSE230859 Gene expression profile of adult ventricular myocytes (AVM) from mouse model B3AR-Tg and WT littermates 9 weeks post TAC surgery March 14, 2025Contributors : Jean-Luc Balligand ; Lauriane Michel ; Jérôme AmbroiseSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCardiac β3-adrenergic receptors (β3AR) are upregulated in diseased hearts and mediate antithetic effects to those of β1AR and β2AR. β3AR agonists were recently shown to protect from myocardial remodeling […]
- GSE261647 Coordinated transcription factor and chromatin dynamics enable innate immune memory in single macrophages March 14, 2025Contributors : Andrew G Wang ; Minjun Son ; Aleksandr Gorin ; Emma Kenna ; Abinash Padhi ; Bijentimala Keisham ; Alexander Hoffmann ; Savas TaySeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusCells of the innate immune system need to interpret dynamic microenvironments and rapidly respond to sequential sign […]
- GSE261571 Biosynthesis of oxyresveratrol in mulberry (Morus alba L.) is mediated by a group of p-coumaroyl-CoA 2'-hydroxylases acting upstream of stilbene synthases March 14, 2025Contributors : Antonio Santiago ; Tomás MatusSeries Type : Expression profiling by high throughput sequencingOrganism : Morus albaMulberry (Morus alba L.) is considered a millenary medicinal plant and a food source for silkworms. Different M. alba extracts offer a variety of biological and pharmacological properties that are largely attributed to stilbenoids […]
- GSE264326 Metastatic medulloblastoma remodels the local leptomeningeal microenvironment to promote further metastatic colonization and growth March 14, 2025Contributor : Michael D TaylorSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMedulloblastoma metastasis often occurs in the leptomeningeal spaces; however, the biology of the metastatic tumour cells and the local leptomeningeal niche are poorly characterized. We performed single-cell RNA sequencing to analyze the lepto […]
- GSE262868 Inhibition of MBTPS1 reprograms cold into inflamed tumors and potentiates anti-PD-1 immunotherapy March 14, 2025Contributors : Yi-Yu Wang ; Zhe Fu ; Jin-Fei LinSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDespite notable advancements in cancer immunotherapy, the overall response rate among cancer patients remains low. Therefore, exploring strategies combining immunotherapy with adjuvant approaches to augment adaptive immune re […]
- GSE291467 GRHL and PGR control WNT4 expression in the mammary gland via 3D looping of conserved and species-specific enhancers [4C-Seq] March 14, 2025Contributors : Yorick van de Grift ; Renée van AmerongenSeries Type : OtherOrganism : Mus musculusThis dataset belongs to a study in which we functionally dissect the cis-acting enhancer network and spatiotemporal transcriptional mechanisms that regulate WNT4 expression in the mouse mammary gland and the human breast. As part of these efforts, we performed 4 […]
- GSE291413 GRHL and PGR control WNT4 expression in the mammary gland via 3D looping of conserved and species-specific enhancers [ATAC-Seq] March 14, 2025Contributors : Katrin E Wiese ; Nika Heijmans ; Renée van AmerongenSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThis dataset belongs to a study in which we functionally dissect the cis-acting enhancer network and spatiotemporal transcriptional mechanisms that regulate WNT4 expression in the mouse mammar […]
- GSE291628 Shaking culture attenuates circadian rhythms in induced pluripotent stem cells during osteogenic differentiation through the YAP-TEAD axis March 14, 2025Contributors : Yunyu Fu ; Hiroko Okawa ; Hiroshi EgusaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCircadian rhythms synchronize cellular activities with the Earth’s 24-hour cycle, primarily regulated by clock genes that influence metabolism, physiology, and osteogenesis. While genetic regulation of circadian rhythms […]
- GSE291583 IQGAP3 bridges matrix stiffness with cancer stem cell maintenance and radioresistance by stabilizing SOX2 II March 14, 2025Contributors : Po Zhang ; Xujia Wu ; Donghai Wang ; Jeremy RichSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDrivers of therapeutic resistance in cancer include evolution of tumor cell heterogeneity and the tumor microenvironment (TME). Here, we found that increased matrix stiffness promotes radioresistance in gliobla […]
- GSE291659 A TFEB-TGFβ axis systemically regulates diapause, stem cell resilience and protects against senescence. March 14, 2025Contributor : Jennifer MakSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansDiapause is a long-lived state of resilience that allows organisms to outlast adversity. C. elegans can endure months in a fasting-induced adult reproductive diapause (ARD) and, upon refeeding, regenerate and reproduce. Here, we find tha […]
- GSE291835 Radiation and anti-PD-L1 synergize by stimulating a stem-like T cell population in the tumor-draining lymph node [TCR-Seq] March 14, 2025Contributors : Buchwald Zach ; Shen Yang ; Connolly ErinSeries Type : OtherOrganism : Mus musculusRadiotherapy (RT) and anti-PD-L1 synergize to enhance local and distant (abscopal) tumor control. However, clinical results in humans have been variable. With the goal of improving clinical outcomes, we investigated the underlying synergistic mechanism focusing […]
- GSE291836 Radiation and anti-PD-L1 synergize by stimulating a stem-like T cell population in the tumor-draining lymph node March 14, 2025Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE198784 Single cell RNA sequencing of human normal and failing heart March 14, 2025Contributors : Si Zhang ; Ting-Ting Tang ; Xiang Cheng ; Nian-Guo DongSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapienswe performed single cell RNA sequencing (scRNA-seq) in human normal and failing hearts. Heart tissues from 3 ICM and 2 DCM patients, as well as heart tissues from 3 donors were used for scRNA/TCR-seq. […]