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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE269231 Mitochondrial reorganization is rate-limiting for direct cardiac reprogramming March 12, 2025Contributors : Brian Spurlock ; Yifang Xie ; Yiran Song ; James Hua ; Haley Vaseghi ; Meenakshi Nishtala ; Rustem Salmenov ; Jiandong Liu ; Li QianSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDirect cardiac reprogramming of cardiac fibroblasts (CFs) into induced cardiomyocytes (iCMs) has emerged as a promising potent […]
- GSE266133 A cardiac fibroblast-enriched micropeptide regulates inflammation March 12, 2025Contributors : Youchen Yan ; Tingting Zhang ; Xin He ; Tailai Du ; Zhan-Peng HuangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusKnockdown of IAMP resulted in significant alterations in the transcriptome. Upon cross-analysis of the transcriptomic changes induced by the two siRNAs, we identified 190 genes that were comm […]
- GSE291626 Delta family protocadhins contribute to protoglomerular targeting of olfactory sensory neuron axons in the olfactory bulb March 12, 2025Contributors : Daniel T Barnes ; Jonathan A RaperSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioTo understand how neural circuits are assembled, it is essential to identify and characterize the axonal guidance cues and receptors that determine the axonal trajectories and connections between neurons. We performed single- […]
- GSE272842 Life-long microbiome rejuvenation improves intestinal metabolism and inflammaging in mice [scRNA-seq] March 12, 2025Contributors : Felix Sommer ; Joana P Bernardes ; Lena Best ; Nina Sommer ; Jacob Hamm ; Berith Messner ; Víctor A López-Agudelo ; Antonella Fazio ; Georgios Marionos ; Samer Kadibaldan ; Go Ito ; Maren Falk-Paulsen ; Christoph Kaleta ; Philip RosenstielSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAlterations in comp […]
- GSE244654 Genome-wide transcriptome differences associated with perceived discrimination in an urban, community-dwelling middle-aged cohort March 12, 2025Contributors : Natasha L Pacheco ; Nicole Noren Hooten ; Sharon F Wu ; Maame Mensah-Bonsu ; Yongqing Zhang ; Kumaraswamy Chitrala ; Supriyo De ; Nicolle A Mode ; Ngozi Ezike ; Danielle Beatty-Moody ; Alan B Zonderman ; Michele K EvansSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDiscrimination is a type of social adve […]
- GSE228503 SARS-CoV-2 proteins inhibit mitochondrial HIGD1A to induce complement-mediated endothelial cell injury March 12, 2025Contributors : Shuxun Liu ; Xuetao CaoSeries Type : OtherOrganism : Homo sapiensPurpose: The purpose is to systemically identify the genes regulating CD59 expressed on endothelial cells by Crispr/cas9-gRNA library screening Methods: We profiled gRNA sequnecing of endothelial cells with significant CD59 changes and those cells without significant CD59 changes […]
- GSE291416 ChIP-seq profiling of estrogen receptor binding in MCF-7 cells exposed to 5α-DTT, Flutamide, Estradiol, and Bisphenol B March 12, 2025Contributors : BuHyun Youn ; HyeSook Youn ; Soomin Yum ; Haksoo LeeSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensEndocrine-disrupting chemicals (EDCs) can modulate estrogen receptor (ER) signaling by altering its transcriptional activity. To investigate these effects, we performed chromatin immunoprecipi […]
- GSE253734 The miR-29-IFN-γ-JAK-STAT axis attenuates CD8+ T cell overactivation and differentiation in ulcerative colitis, and delivery of mimics in LMSH-CS hydrogel reduces colitis in mice March 12, 2025Contributors : Huiyuan Guo ; Yingying Lin ; Yuqi Wang ; Yuning ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the mechanism of miR-29ab in regulation of Tcells , we established miR-29ab1-/- mice and applied dss inflammation model
- GSE291450 Activation of the ERRα Transcriptional Pathway Alleviates Anthracycline-induced Cardiotoxicity by Improving Mitochondrial Metabolism March 12, 2025Contributors : Xiaoping Wang ; Guanjing Wang ; Yan Wei ; Weili Li ; Ziyi Yin ; Yun Chen ; Qi Qiu ; Wei Wang ; Yong WangSeries Type : Expression profiling by high throughput sequencingOrganism : Sus scrofaAnthracycline-induced metabolic remodeling and mitochondrial damage are critical early events that contribute to cardiac dysfunction. However, the gene regu […]
- GSE291421 Gene expression data in total mRNA from human SKMEL28 melanoma cell line transduced with shCont, shp16, shATR March 12, 2025Contributors : Katherine M Aird ; Naveen K TanguduSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensp16/CDKN2A is a critical cell cycle regulator and tumor suppressor that is lost in ~50% of all human cancers. Recent studies have identified roles of p16 outside of the cell cycle, including in ATR and mTORC1 activation. […]
- GSE291457 Decoding muscle-resident Schwann cell dynamics during neuromuscular junction remodeling [spinal crush] March 12, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis investigation leverages single-cell RNA sequencing (scRNA-Seq) to delineate the contributions of muscle-resident Schwann cells to neuromuscular junction (NMJ) remodeling in models of healthy, partially denervated, and completely denervated muscles. The study identifie […]
- GSE291553 Transcriptomic Analysis of CAD Cell Differentiation March 12, 2025Contributors : Omar A Quintero-Carmona ; Dora Posfai ; Carlos A Cevallos ; Anna L White ; Brooke A Fazio ; Lillian S Wendt ; Jasmine W Feng ; April L Horton ; John M WarrickSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCAD cells were derived from Cath.a cells, a mouse central nervous system catecholaminergic cell line […]
- GSE291618 Using DNA Affinity Purification sequencing (DAP-seq) to identify in vitro binding sites of transcription factors potentially involved in aromatic degradation March 12, 2025Contributors : Myers S Kevin ; Linz M Alexandra ; Baumgart A Leo ; Zhang Yu ; Blaby Ian ; Mewalal Ritesh ; Ng Vivian ; Noguera R Daniel ; Donohue J TimothySeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Novosphingobium aromaticivoransThe genome-wide binding sites of 44 transcription factors from the aromatic metaboliz […]
- GSE263490 (RNA-seq-SHSY5Y) Hao-Fountain syndrome protein USP7 mediates neuronal differentiation via BCOR-ncPRC1.1 March 12, 2025Contributors : Joyce W van der Meer ; Axelle Larue ; Jan A van der Knaap ; Gillian E Chalkley ; Ayestha Sijm ; Leila Beikmohammadi ; Aniek van der Vaart ; Karel Bezstarosti ; Dick W Dekkers ; Wouter S Doff ; P. J van de Wetering-Tieleman ; K Lanko ; T S Barakat ; Tim Allertz ; A J van Haren ; Jeroen A Demmers ; Yaser Atlasi ; C P VerrijzerSeries Type : Expre […]
- GSE291406 Impaired T cell and neoantigen retention in time serial analysis of metastatic non-small cell lung cancer in patients unresponsive to TIL cell therapy March 12, 2025Contributors : Ben Creelan ; Chao Wang ; Sean Yoder ; Chaomei ZhangSeries Type : OtherOrganism : Homo sapiensCell therapy with tumor-infiltrating lymphocytes (TIL) has yielded durable responses for multiple cancer types, but the causes of therapeutic resistance remain largely unknown. Here multi-dimensional analysis was performed on time serial tumor and blo […]