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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE256350 AAV vectors trigger DNA damage responses and STING-dependent inflammation in human CNS cells March 13, 2025Contributors : Yulia Dzhashiashvili ; Emily Fabyanic ; Xin HuangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAdeno-associated viral (AAV) vector-based gene therapy is gaining foothold as a treatment option for a variety of genetic neurodegenerative diseases. Nonetheless, dose-dependent toxicities and severe adverse e […]
- GSE269024 Expression data from lung cancer cell lines March 13, 2025Contributors : Hirofumi Watanabe ; Yusuke InoueSeries Type : Expression profiling by arrayOrganism : Homo sapiensMicroarrays were performed to detail the differential gene expression about co-expression patterns of the transcription factors that exert detrimental effects in small cell lung cancer cell lines.
- GSE261718 Mechanistic Studies of the Regulation of Cardiomyocytes Spatial Distributions by Heterogeneous Erbb2 Expression [scRNA-Seq] March 13, 2025Contributors : Jin-xiu Liang ; Jia Li ; Tao Cheng ; Pei-dong HanSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioPurpose: To explore the endogenous expression pattern of Erbb2.Methods: Approximately 1000 hearts dissected from 72 hpf Tg(myl7:mCherry) embryos were digested in 0.25% trypsin-EDTA solution for single-cell RNA […]
- GSE271294 Single cell atlas of the Drosophila embryonic salivary gland reveals key morphogenetic control steps March 13, 2025Contributors : Annabel May ; Katja RöperSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterIn order to investiage the morphogenetic control of early tube development in the Drosophila melanogaster embryo we performed single-cell-RNAseq-analysis of FACS-isolated early salivary gland placodal cells (stage 10-12), […]
- GSE270142 Islet-antigen reactive B cells display a unique phenotype and BCR repertoire in individuals at-risk for and diagnosed with type 1 diabetes March 13, 2025Contributors : Catherine A Nicholas ; Fatima A Tensun ; Spencer A Evans ; Kevin P Toole ; Hali Broncucia ; Jay R Hesselberth ; Peter A Gottlieb ; Kristen L Wells ; Mia J SmithSeries Type : OtherOrganism : Homo sapiensAutoreactive B cells play an important but ill-defined role in autoimmune type 1 diabetes (T1D). To better understand their contribution to dis […]
- GSE242033 SETD3 regulates endoderm differentiation of mouse embryonic stem cells through its effect on the canonical Wnt signaling pathway activity March 13, 2025Contributors : Emre Balbasi ; Ceren Alganatay ; Nurcan Tuncbag ; Dersu Sezginmert ; Nihal Terzi CizmeciogluSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWith self-renewal and pluripotency features, embryonic stem cells (ESCs) provide an invaluable tool to investigate early cell fate decisions. Pluripotency exit and li […]
- GSE274643 Hyperleukocytosis in a neuroblastoma patient after treatment with natural killer T cells expressing a GD2-specific chimeric antigen receptor and IL15 March 13, 2025Contributors : Gengwen Tian ; Amy N Courtney ; Hangjin Yu ; Saleh Bhar ; Xin Xu ; Gabriel Barragan ; Claudia Martinez Amador ; Nisha Ghatwai ; Deborah Schady ; Antonino Montalbano ; David de la Cerda ; Donald Williams Parsons ; Erica J Di Pierro ; Andras Heczey ; Leonid S MetelitsaSeries Type : Expression profiling by high throughput sequencingOrganism : Hom […]
- GSE288170 Alzheimer's disease risk ABCA7 p.A696S variant disturbs the microglial response to amyloid pathology in mice March 13, 2025Contributors : Xiaoye Ma ; Yingxue Ren ; Takahisa KanekiyoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe adenosine triphosphate–binding cassette transporter A7 (ABCA7) gene is ranked as one of the top susceptibility loci for Alzheimer’s disease (AD). While ABCA7 mediates lipid transport across cellular membranes, A […]
- GSE287230 An atypical atherogenic chemokine that promotes advanced athero¬sclerosis and hepatic lipogenesis March 13, 2025Contributors : Omar El Bounkari ; Simon EbertSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAtherosclerosis is the underlying cause of myocardial infarction and ischemic stroke. It is a lipid-triggered inflammatory condition of arterial vessels driven by cytokines and chemokines. Chemokines that affect both vascular an […]
- GSE291355 Implication of bone marrow adipose tissue in bone homeostasis during osteoarthritis March 13, 2025Contributors : Natalia ZAPATA-LINARES ; Maria E. CALLEJA-CERVANTES ; Juan R. RODRIGUEZ-MADOZ ; Stéphanie LUCAS ; Xavier HOUARDSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensObjective: To explore the role of bone marrow adipocytes (BMAds) in osteoarthritis (OA). Methods: Male and female C57BL/6 mice (n=4/group) underwen […]
- GSE288532 S. elongatus PCC 7942 Circadian Control Bioproduction Transcriptomics March 13, 2025Contributors : Pavlo Bohutskyi ; Zachary D Johnson ; Lindsey N AndersonSeries Type : Expression profiling by high throughput sequencingOrganism : Synechococcus elongatusThe industrial feasibility of photosynthetic bioproduction using cyanobacterial platforms remains challenging due to insufficient yields, particularly due to competition between product forma […]
- GSE291506 Neuronal chromatin remodeling factors in the mammalian nervous system [RNA-seq] March 13, 2025Contributors : Kaitlin Montanera ; Alyssa Ialongo ; Ssu-Yu Yeh ; Ho Sung RheeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusChromatin remodeling factors play important roles in accessibility formation of regulatory DNA. The mechanism by which chromatin remodeling factors regulate regulatory DNA regions that activate ex […]
- GSE291510 Neuronal chromatin remodeling factors in the mammalian nervous system [ATAC-seq] March 13, 2025Contributors : Montanera Kaitlin ; Ialongo Alyssa ; Yeh Ssu-Yu ; Rhee Ho SungSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusChromatin remodeling factors play important roles in accessibility formation of regulatory DNA. The mechanism by which chromatin remodeling factors regulate regulatory DNA regions th […]
- GSE291762 Clinically translatable mitochondrial gene therapy in muscle using tandem zinc finger nuclease architecture March 13, 2025Contributors : Pavel Nash ; Lindsey Van HauteSeries Type : OtherOrganism : Mus musculusWe studied the use of tandem zinc finger nucelase arrangements delivered by AAV in a mouse model of mitochondrial genetic disease.
- GSE248132 LARP6 promotes carcinogenic features of triple negative breast cancer cell line by directly modulating alternative splicing of associated genes March 13, 2025Series Type : Other ; Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.