Quick Links : Search PubMed , Finding Full Text , PubMed Advanced Search , Clinical Queries , Single Citation Matcher , FAQs & User Guide , Explore MeSH Database , Explore PubMed Journals
Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE230337 ATAC-Seq based chromatin accessibilty profile of GMP from mice treated with DSS, HK-EF or its excipient. January 22, 2025Contributors : Iñaki Robles-Vera ; David SanchoSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusInflammatory bowel disease induced by treatment with DSS induce destruction of gut barrier inducing massive bacterial translocation to distal tissue. Our findings suggest that gut microbiota translocation induces […]
- GSE218775 High Throughput Chromosome Conformation Capture identifies differential genome organization in virulent and avirulent strains of Mycobacterium tuberculosis January 22, 2025Contributors : Mohit Mishra ; Ajay AryaSeries Type : OtherOrganism : Mycobacterium tuberculosis H37Ra ; Mycobacterium tuberculosis H37RvIn order to understand the three-dimensional genome organization in M. tuberculosis, in this study we have used exponentially growing mycobacterial culture. We performed Hi-C on both virulent and attenuated strain of M. tube […]
- GSE254037 5G2 Mutant Mice Model Loss of a Commonly Deleted Segment of Chromosome 7q22 in Myeloid Malignancies January 22, 2025Contributors : Tamara Westover ; Jeffery M Klco ; Kevin ShannonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMonosomy 7 and del(7q) are among the most common and poorly understood genetic alterations in myelodysplastic neoplasms and acute myeloid leukemia. Chromosome band 7q22 is a minimally deleted segment in myeloid […]
- GSE253896 Variation in Bile Acid Synthesis Capacity: A Key Factor in Differentiating Lipid Deposition Patterns in Goldfish Breeds January 22, 2025Contributors : Jianqiao Wang ; Xiaojing Dong ; Xuedi DuSeries Type : Expression profiling by high throughput sequencingOrganism : Carassius auratusIn our previous study, we observed distinct lipid deposition pattern between Crane-top red goldfish (HDH) and Pearl-scale goldfish (PS), yet the regulatory mechanisms remained unclear. In this study, a comprehensi […]
- GSE277665 DOT1L and EZH2 cooperatively repress PRC2 targets to maintain the GC B cell identity in DLBCL [RNA-seq] January 22, 2025Contributors : Camiel Gobel ; Rachele Niccolai ; Joleen TraetsSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPrevious published data suggested that DOT1L indirectly represses PRC2 target genes in murine B cell model. To address whether this relationship persists in human GCB-DLBCL, by integration of transcriptomic and […]
- GSE254423 Single cell RNA sequencing of MPN patients from humans in South Korea January 22, 2025Contributors : Seung-Hyun Jung ; Sung-Eun Lee ; Sujin Yun ; Da-Eun Min ; Youngjin Shin ; Yeun-Jun Chung ; Sug H LeeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapienswe analyzed BM aspirates in reactive BMs, pre-PMFs, overt PMFs, and non-PMF MPNs by single-cell RNA sequencing (scRNA-seq), identifying cell types , including […]
- GSE281375 Cut&Tag of GMP from mice treated with DSS, HK-EF or its excipient. January 22, 2025Contributors : Iñaki Robles-Vera ; David SanchoSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusInflammatory bowel disease induced by treatment with DSS induce destruction of gut barrier inducing massive bacterial translocation to distal tissue. Our findings suggest that gut microbiota translocation induces […]
- GSE277666 DOT1L and EZH2 cooperatively repress PRC2 targets to maintain the GC B cell identity in DLBCL [ChIP-seq] January 22, 2025Contributors : Camiel Gobel ; Rachele Niccolai ; Joleen TraetsSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensTo determine whether DOT1L promotes repression of PRC2 target genes independently of EZH2, we performed H3K27me3 ChIP-seq on untreated responder Oci-Ly7 and non-responder Oci-Ly8 cell lines, and se […]
- GSE281377 Microbiota exposure following DSS-induced colitis promotes Mincle-mediated training of myeloid progenitors January 22, 2025Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Mus musculusImpairment of the intestinal barrier allows the systemic translocation of commensal bacteria, inducing a pro-inflammatory state in the host. To explore this link, we investigated innate immune responses fol […]
- GSE281376 RNAseq of GMP from mice treated with DSS, HK-EF or its excipient. January 22, 2025Contributors : Iñaki Robles-Vera ; David SanchoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusInflammatory bowel disease induced by treatment with DSS induce destruction of gut barrier inducing massive bacterial translocation to distal tissue. Our findings suggest that gut microbiota translocation induces trained immun […]
- GSE287021 Capped small RNA sequencing (csRNA-seq) for genome-wide mapping of active transcription start sites and enhancer RNAs from total RNA January 22, 2025Contributors : Mackenzie K Meyer ; Patricia Montilla-Perez ; Anna L McDonald ; Oluwadamilola J Olanrewaju ; Eva M Rickard ; Francesca Telese ; Christopher Benner ; Marina I Savenkova ; Sascha H DuttkeSeries Type : OtherOrganism : Homo sapiensProfiling ongoing transcription reveals the complete active transcriptome, including unstable enhancer RNAs, and provi […]
- GSE287345 Transcriptional analysis of murine biliary atresia identifies macrophage heterogeneity and subset-specific macrophage functions January 22, 2025Contributors : Sarah Taylor ; Deborah R WinterSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMacrophages play an important role in disease progression of pediatric cholestatic liver disease, particularly biliary atresia (BA); however, the restorative versus pathogenic role for precise macrophage subsets remains poorly […]
- GSE287356 Screen of traumatic brain injury-associated genes from lncRNA m6A-modified transcriptomes in the cerebral cortex of mice after repetitive mild traumatic brain injury January 22, 2025Series Type : OtherOrganism : Mus musculusN6-methyladenosine (m6A), a prevalent post-transcriptional modification in eukaryotic RNA, plays a significant role in regulating sensory experiences, learning, and injury in the mammalian central nervous system. However, the pattern of lncRNA m6A methylation in the mouse cortex following repetitive mild traumatic br […]
- GSE287359 Teamwork of clustered low-affinity κB sites and accessory factors regulates transcriptional strength of NF-κB RelA dimers [ChIP-seq] January 22, 2025Contributors : Shandy Shahabi ; Tapan Biswas ; Yuting Shen ; Rose Sanahmadi ; Yaya Zou ; Gourisankar GhoshSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusNon-consensus binding sites of transcription factors are often observed within the promoters and enhancers of various genes; however, their effect on tra […]
- GSE287360 Teamwork of clustered low-affinity κB sites and accessory factors regulates transcriptional strength of NF-κB RelA dimers [RNA-seq] January 22, 2025Contributors : Shandy Shahabi ; Tapan Biswas ; Yuting Shen ; Rose Sanahmadi ; Yaya Zou ; Gourisankar GhoshSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNon-consensus binding sites of transcription factors are often observed within the promoters and enhancers of various genes; however, their effect on transcriptional s […]