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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE291239 Glial-specific and inducible full body C3 deficiency does not affect amyloid pathology in the AppNL−G−F mouse model of Alzheimer’s disease June 3, 2026Contributors : Pieter Dujardin ; Clint De Nolf ; Roosmarijn VandenbrouckeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackgroundAlzheimer's disease (AD) is intricately linked with neuroinflammation, with the complement system, particularly C3, emerging as a critical player. However, research has been hampered by […]
- GSE282301 Histone H3 epigenetic modifications ChIPseq [men] June 3, 2026Contributors : Maria I Bokarewa ; Karin M Andersson ; Malin C Erlandsson ; Chandrasekaran VenkataragavanSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensChIPseq analysis of histone H3 epigenetic modification - K27me3 - chromatin binding in activated CD4+ T cells
- GSE301365 Single-cell analysis of human iPSC-derived midbrain organoids generated with triphasic Wnt modulation combined with a dynamic bioreactor June 3, 2026Contributors : Hariam Raji ; Maria Jose Perez J. ; Michela DeleidiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHuman midbrain organoids (hMOs) derived from induced pluripotent stem cells offer a promising platform to model Parkinson’s disease (PD), but current systems often fall short in generating mature, regionally […]
- GSE297635 A WAT-to-BAT communication facilitates sustained activation of BAT thermogenesis during cold exposure [CUT&Tag] June 3, 2026Contributors : Jieyuan Xue ; Xuyun ZhaoSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusBAT activation for thermogenesis is a physiological mechanism that maintains body temperature during cold exposure. However, how BAT is dynamically activated and preserve its sustained activation in cold is not completel […]
- GSE309864 Modulating MyoD1 dosage activates alternate cell fate beyond myogenic differentiation [ATAC-seq] June 3, 2026Contributors : Oscar N Whitney ; Gina M Dailey ; Joseph K McKenna ; Xavier Darzacq ; Robert TjianSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThe study investigates how MyoD1 dosage controls myogenic cell fate, employing bulk RNA-seq, ATAC-seq, and CUT&RUN. We determined genome-wide transcriptional, […]
- GSE306288 Spatial transcriptomic profiling of the human aortic valve reveals cellular sex differences near sites of calcification June 3, 2026Contributors : Talia Baddour ; Van K Ninh ; Rayyan M Gorashi ; Rene Peña ; Kevin R King ; Brian A AguadoSeries Type : Other ; Expression profiling by high throughput sequencingOrganism : Homo sapiensSex differences in aortic valve stenosis (AVS) progression have been documented clinically, but the underlying cellular mechanisms that drive sex-dependent calci […]
- GSE334083 Arginine methylationof BAF155 regualtes interactions with RNA processing machinery [ATAC-seq] June 3, 2026Contributor : Jesse RaabSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensPost-translational modifications (PTMs) of chromatin remodelers are abundant but functionally understudied. Here we investigate the role of asymmetric dimethylation of arginine 1064 (BAF155me2a) on the SWI/SNF core subunit BAF155, a ma […]
- GSE213428 Role of TAp63 in myogenesis June 3, 2026Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE334085 Arginine methylation of BAF155 regulates interactions with RNA processing machinery [TT-seq] June 3, 2026Contributor : Jesse RaabSeries Type : OtherOrganism : Homo sapiensPost-translational modifications (PTMs) of chromatin remodelers are abundant but functionally understudied. Here we investigate the role of asymmetric dimethylation of arginine 1064 (BAF155me2a) on the SWI/SNF core subunit BAF155, a mark deposited by CARM1/PRMT4 that has been linked to tumor p […]
- GSE334084 Arginine methylationof BAF155 regualtes interactions with RNA processing machinery [CUT&RUN] June 3, 2026Contributor : Jesse RaabSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensPost-translational modifications (PTMs) of chromatin remodelers are abundant but functionally understudied. Here we investigate the role of asymmetric dimethylation of arginine 1064 (BAF155me2a) on the SWI/SNF core subunit BAF155, a ma […]
- GSE334086 Arginine methylationof BAF155 regualtes interactions with RNA processing machinery [RNA-seq] June 3, 2026Contributor : Jesse RaabSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPost-translational modifications (PTMs) of chromatin remodelers are abundant but functionally understudied. Here we investigate the role of asymmetric dimethylation of arginine 1064 (BAF155me2a) on the SWI/SNF core subunit BAF155, a mark deposited b […]
- GSE334097 Identification of genomic features that uniquely impact estrogen receptor alpha binding and its effects on gene expression in endometrial cancer [ChIP-seq] June 3, 2026Contributors : Alexandra Richey ; Noel Kitchen ; Craig Rush ; Jason GertzSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensEstrogen receptor alpha (ER) is an established oncogenic transcription factor in breast and endometrial cancer; however, more is known about the mechanisms controlling ER behavior in bre […]
- GSE334100 Identification of genomic features that uniquely impact estrogen receptor alpha binding and its effects on gene expression in endometrial cancer [RNA-seq] June 3, 2026Contributors : Alexandra Richey ; Noel Kitchen ; Jason GertzSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEstrogen receptor alpha (ER) is an established oncogenic transcription factor in breast and endometrial cancer; however, more is known about the mechanisms controlling ER behavior in breast cancer, and therapies t […]
- GSE272732 Egr2 inhibition of PDGFRα in oligodendrocytes is necessary for resocialization normalizing cooperation defects in early socially isolated mice June 3, 2026Contributors : Sijia Chen ; Shixin Ding ; Min Cao ; Shuying Zhang ; Yue Li ; Yuxi Jin ; Yimiao Wang ; Ze Wang ; Yu Wu ; Junying Gao ; Yanli Zhang ; Ming XiaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSocial neglect is a major contributing factor to social behavior impairment during adolescence, thus it is crucial f […]
- GSE334029 EpiFat Coverage: integrative multiomics analysis and machine learning modelling for heart disease June 3, 2026Contributors : Andrei Alexandru Mircea ; Stephen Schwenderer ; Eric Rytkin ; Tatiana Efimova ; Zoltan Kutalik ; Keith Crandall ; Kedar Aras ; Igor EfimovSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: Epicardial adipose tissue (EAT) has emerged as a key factor in the pathogenesis of cardiovascular diseases, […]