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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE286966 Deep learning identifies Pbx1 as a network hub of hematopoietic stem cell aging [scRNA-seq] August 3, 2026Contributors : Hiroshi Kobayashi ; Yusuke Shiozawa ; Seishi Ogawa ; Keiyo TakuboSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHematopoietic stem cells (HSCs) constitute a well-structured hematopoietic system that undergoes an age-related bias toward myeloid/platelet differentiation. The mechanism by which this aging h […]
- GSE341872 Transcriptonal profiling of 5 dpf pdcd7/cx20 pd1215 zebrafish mutants and WT siblings August 3, 2026Contributors : Daniel Levic ; Michel Bagnat ; Carina BlockSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioFor this experiment, we sought to characterize gene expression changes and intron splicing events in 5 dpf pdcd7/cx20 pd1215 mutants relative to WT siblings.
- GSE301174 Efficacy,safety and biodistribution of intranasally delivered adenoviral COVID-19 vaccines in hamsters August 3, 2026Contributors : Nihay Laham-Karam ; Emma Koivunlehto ; Petri Mäkinen ; Erika Gurzeler ; Einar Niskanen ; Rikku Fagerlund ; Tobias Freitag ; Erkko Ylösmäki ; Joaquim Segales ; Kari Alitalo ; Kalle Saksela ; Seppo Ylä-Herttuala ; Aino Sormunen ; Ahmed Tawfik ; Tiia Suomalainen ; Hassan Ugurulu ; Jimi Virkkala ; Jordi Rodon ; Guillermo Cantero ; Nuria Roca ; Tui […]
- GSE295306 Autonomous circadian bladder capacity rhythm independent of the central clock August 3, 2026Contributors : Shuhei Suzuki ; Hiromitsu Negoro ; Haruna Nonaka ; Ichiro Chihara ; Yoshiyuki Nagumo ; Shigeki Shimba ; Kenichi Kimura ; Hiromi Yanagisawa ; Hiroyuki NishiyamaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study investigates the autonomous regulatory function of the bladder for its capacity circadia […]
- GSE304611 Tissue-specific transcriptomic insights into peel thickness in muscadine (Muscadinia rotundifolia) August 3, 2026Contributors : Alana Brinley ; Shirin Shahkoomahally ; Fahong Yu ; Islam El-Sharkawy ; Ali Sarkhosh ; Tie LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Vitis rotundifoliaMuscadine grape (Muscadinia rotundifolia) is a native fruit crop valued for its natural stress tolerance and disease resistance, yet its characteristically th […]
- GSE304334 DNA methylation profiling of Arabidopsis BR-regulated ces-D and ces-qM mutants August 3, 2026Contributors : Veronica E Ramirez ; Robert S Piecyk ; Rashmi R Hazarika ; Brigitte Poppenberger ; Frank JohannesSeries Type : Methylation profiling by high throughput sequencingOrganism : Arabidopsis thalianaWhen organisms encounter pathogens, they rapidly activate complex defense programs to ensure survival. While these immune responses are vital, they ofte […]
- GSE341740 GAS6 drives chemoresistance and immune escape in ovarian cancer August 3, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHigh-grade serous ovarian cancer (HGSOC) has poor prognosis owing to widespread platinum resistance and unsatisfactory efficacy of chemo-immunotherapy, so novel mechanisms of therapeutic failure are urgently required. The GAS6/AXL axis supports tumor survival and immunosup […]
- GSE307502 OCIAD2 promotes epithelial to mesenchymal transition during mesendoderm specification of human pluripotent stem cells August 3, 2026Contributors : Kajal Kamat ; Maneesha InamdarSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe mitochondrial protein OCIAD2 is misexpressed in several cancers and neurodegenerative diseases. However, insights into its physiological role, particularly in the context of stem cell differentiation, remain unexplored. Our […]
- GSE341810 Transcriptomic responses of Acinetobacter baumannii ATCC19606 efflux pump mutants under chloramphenicol stress August 3, 2026Contributors : Wuen Ee Foong ; Xinxin Xiang ; Wenjun He ; Xuan Yan ; Jiabin Huang ; Klaas M. Pos ; Heng-Keat TamSeries Type : Expression profiling by high throughput sequencingOrganism : Acinetobacter baumanniiEfflux pumps play a key role in antibiotic resistance in Acinetobacter baumannii. Here, we investigated the transcriptomic responses of A. baumannii A […]
- GSE341769 RNA sequencing analysis of THP-1 cells treated with chlorquinaldol August 3, 2026Contributors : Runfa Chen ; Miaomiao Cai ; Yuting Dai ; Boyuan Shen ; Yinghong He ; Wen Zhang ; Zhijie Cui ; Jing Yang ; Zhengfan Jiang ; Xiang ZhouSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBased on our findings that chlorquinaldol can exert a potent antiviral effect both in vivo and in vitro, to explore the molec […]
- GSE341811 Pleckstrin-2 Promotes Cutaneous Squamous Cell Carcinoma by Recruiting Profilin-1 to the Membrane to Destabilize Cytosolic PTEN August 3, 2026Contributors : Guanfei Zhang ; Meng Liu ; Lanlan Cui ; Zongguan Huang ; Mo Zhang ; Fengyun Sun ; Zhenzhen Lu ; Changwei Hu ; Xiaofei Zhao ; Yiming Hu ; Ying Li ; Shujun Han ; Yan Zheng ; Yongping ShaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCutaneous squamous cell carcinoma (cSCC) is a prevalent skin malignancy d […]
- GSE341837 Integrating Transcriptomics, Mendelian Randomization, Machine Learning, and Experimental Validation to Identify Feature Genes in Sepsis with Thyroid Dysfunction_discovery cohort August 3, 2026Contributor : Li YeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSepsis is frequently associated with thyroid dysfunction. However, the underlying molecular mechanisms and effective biomarkers for sepsis with thyroid dysfunction remain unclear.
- GSE341840 Integrating Transcriptomics, Mendelian Randomization, Machine Learning, and Experimental Validation to Identify Feature Genes in Sepsis with Thyroid Dysfunction_validation cohort August 3, 2026Contributor : Li YeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSepsis is frequently associated with thyroid dysfunction. However, the underlying molecular mechanisms and effective biomarkers for sepsis with thyroid dysfunction remain unclear.
- GSE315204 Cell-type-specific transcriptional responses to clozapine and risperidone in mouse frontal cortex August 3, 2026Contributors : L Prohens ; N Rodríguez ; S MasSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTreatment-resistant schizophrenia (TRS) represents a major clinical challenge, with clozapine being the only antipsychotic with proven efficacy. To investigate the cellular mechanisms underlying clozapine’s unique therapeutic p […]
- GSE339493 Interleukin-33 activated group 2 innate lymphoid cells drive type 2 immune dysfunction in endometriosis August 3, 2026Contributors : Katherine B Zutautas ; Danielle J Sisnett ; Dan H Vo ; Alexandra Wodz ; Katja J Jarick ; Christoph S Klose ; Olga Bougie ; Bruce A Lessey ; Chandrakant TayadeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusImmune dysfunction is a key contributor to endometriosis (EM) pathophysiology, with a type 2-skewed […]