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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE266894 Epigenetic scars in regulatory T cells are retained after successful treatment of chronic hepatitis C with direct-acting antivirals [ATAC-Seq] September 19, 2025Contributors : So-Young Kim ; June-Young Koh ; Dong Lee ; Jun Park ; Won Kim ; Eui-Cheol ShinSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensDuring chronic HCV infection, several immune components are altered both quantitatively and qualitatively. The recent introduction of DAAs led to a high cure rate of […]
- GSE234597 Synovial Th17 transdifferentiation into exTh17 sustains chronic IL-17-independent inflammatory arthritis September 19, 2025Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE277585 The Ashkenazi-centric G334R variant of TP53 is severely impaired for transactivation but retains tumor suppressor function in a mouse model [RNA-seq] September 19, 2025Contributors : David C Stieg ; Katilyn Casey ; Bhanu C Karisetty ; Julia I Leu ; Fiona Larkin ; Peter Vogel ; Jozef Madzo ; Maureen MurphySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMutations in the TP53 tumor suppressor gene are the most abundant genetic occurrences in cancer. Some of these mutations lead to loss o […]
- GSE277548 Targeting the PDGFRa-SHP2 Signaling Enhances Therapeutic Effect of Radiotherapy on Treating IDH1 Mutant Glioma September 19, 2025Contributors : Xiaozhou Yu ; Xiao Song ; Deanna Tiek ; Runxin Wu ; Maya Walker ; Craig Horbinski ; Bo Hu ; Shi-Yuan ChengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: Isocitrate dehydrogenase mutant (IDH-mut) glioma represents a distinct subtype of adult glioma. Although IDH-mut glioma displays slightly be […]
- GSE302271 Plasmacytoid dendritic cells are dispensable or detrimental in murine systemic or respiratory viral infections [RNA-Seq 2] September 19, 2025Contributors : Clemence Ngo ; Khalissa Rahmani ; Michael Valente ; Marc Dalod ; Elena TomaselloSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPlasmacytoid dendritic cells (pDCs) are major producers of type I/III interferons. Since these cytokines are crucial for antiviral defense, it is assumed to be also the case for […]
- GSE295639 Effects of a Probiotic Formulation Based on SF68, Phytosterols, and 6S-5-Methyltetrahydrofolic Acid on Body Composition, Biochemical Parameters, Gut Microbiota, and Gastrointestinal and General Symptoms of Overweight/Obese Subjects: The PrObesity Study September 19, 2025Contributors : Giuditta Pagliai ; Simone Baldi ; Marta T Asensi ; Ilaria Giangrandi ; Sofia Lotti ; Alessia Bertelli ; Francesco Cei ; Sara Bertorello ; Gianluca Bartolucci ; Serena Borghi ; Amedeo Amedei ; Matteo Becatti ; Claudia Fiorillo ; Anna M Gori ; Rossella Marcucci ; Barbara Colombini ; Francesco SofiSeries Type : OtherOrganism : Homo sapiensObesity […]
- GSE308130 Oncogenic MAPK signalling induces epithelial cell state change and therapeutic resistance in vivo III September 19, 2025Contributors : Mark White ; Megan Mills ; Laura Millett ; Kathryn Gilroy ; Owen SansomSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe colorectal epithelium is a rapidly renewing tissue, with a remarkable capacity to regenerate following injury. In colorectal cancer (CRC), this regenerative capacity can be co-opted t […]
- GSE308490 Genetic landscape of non-UV-induced cutaneous squamous cell carcinomas September 19, 2025Contributors : Carmen Al Youssef ; Mansour Alkobtawi ; Bénédicte Oulès ; Selim Aractingi ; Dany NassarSeries Type : OtherOrganism : Homo sapiensSkin squamous cell carcinoma (cSCC) is the second most common skin cancer and is most often caused by cumulative UV exposure. However, cSCC may also arise independently of UV exposure, on sites of sustained skin dama […]
- GSE308136 A regulator of amino acid catabolism controls Acinetobacter baumannii gut colonization September 19, 2025Contributor : Lauren D PalmerSeries Type : Expression profiling by high throughput sequencingOrganism : Acinetobacter baumanniiAsymptomatic gut colonization increases the risk of clinical infection and transmission by the multidrug-resistant pathogen Acinetobacter baumannii. Ornithine utilization was shown to be critical for A. baumannii competition with the […]
- GSE308133 Oncogenic MAPK signalling induces epithelial cell state change and therapeutic resistance in vivo IV September 19, 2025Contributors : Mark White ; Megan Mills ; Laura Millett ; Kathryn Gilroy ; Owen SansomSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe colorectal epithelium is a rapidly renewing tissue, with a remarkable capacity to regenerate following injury. In colorectal cancer (CRC), this regenerative capacity can be co-opted t […]
- GSE308366 RRBS-seq of single-cell clones of four cell Lines reveals highly-conserved methylated sites in DNA [RNA-Seq] September 19, 2025Contributors : Yicen Ding ; Fei Zhang ; Mengju He ; Yani KangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDNA methylation is one of the most studied epigenetics, and its effects on embryonic development, cell differentiation, cell development, aging, apoptosis, carcinogenesis, and genomic stability are all im-portant […]
- GSE308367 RRBS-seq of single-cell clones of four cell Lines reveals highly-conserved methylated sites in DNA September 19, 2025Contributors : Yicen Ding ; Fei Zhang ; Mengju He ; Yani KangSeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensDNA methylation is one of the most studied epigenetics, and its effects on embryonic development, cell differentiation, cell development, aging, apoptosis, carcinogenesis, and genomic stability are all im-portan […]
- GSE308489 Host cell Z-RNAs activate ZBP1 during virus infections. September 19, 2025Series Type : OtherOrganism : Homo sapiens ; Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE234595 Synovial Th17 transdifferentiation into exTh17 sustains chronic IL-17-independent inflammatory arthritis (Bulk RNA-Seq) September 19, 2025Contributors : M Zoccheddu ; M N Svensson ; P Dutta ; M Ro ; Y Wang ; H Kim ; Z Mikulski ; K Dobaczewska ; F Ingegnoli ; A Denn ; R Caporali ; P S Randelli ; D McBride ; N J Shah ; W Zhipin ; J Moore ; K J Won ; F Ay ; N BottiniSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRheumatoid arthritis (RA) is the most common […]
- GSE308127 Transcriptome profiling of porcine valvular interstitial cells undergoing mesenchymal-to-endothelial transition under osteogenic induction September 19, 2025Contributors : Binglin Li ; Dan zhuSeries Type : Expression profiling by high throughput sequencingOrganism : Sus scrofaCalcific aortic valve disease (CAVD) is a progressive disorder characterized by fibrosis, calcification, and endothelial dysfunction. Valvular interstitial cells (VICs) are the predominant cell type within the aortic valve and play key role […]