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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE192711 Comparison of transcriptional profiles of CD62L+ and CD62L- subsets of in vivo primed CD44hiCD4+ T cells by exposure to ovalbumin plus papain December 27, 2024Contributors : Jianguo Liu ; Linqing Du ; Shuying Yi ; Yan Lin ; Yanan Bi ; Lina Li ; Guangming Zhu ; Xiuli Jing ; Wengang Song ; Hua TangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMemory type 2 CD4+ T helper (Th2) cells play critical roles in allergic asthma, but their generation and maintenance remain poorly unde […]
- GSE241395 Expression data from the murine salivary gland (SG; submandibular gland) 8 weeks after the ovariectomy (OVX) or sham surgery (Cont) December 27, 2024Contributors : Hyung-Sik Kim ; Yoojin SeoSeries Type : Expression profiling by arrayOrganism : Mus musculusIn general, women are more susceptible to xerostomia than men. Clinical studies have indicated a noteworthy increase in the incidence of xerostomia following menopause, along with a negative correlation between saliva estrogen levels and the severity of […]
- GSE228746 Gene expression in 10 d Wild-type and Amh-cre Hdac3 KO Sertoli cells December 27, 2024Contributors : Mengrou Liu ; Lan YeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study aims to explore the transcriptional changes in Sertoli cells depleted with HDAC3. Sertoli cells were isolated from wild-type and Amh-cre Hdac3 KO mice at postnatal day 10.
- GSE253899 The effect of CXCL10 on macrophages December 27, 2024Contributor : Zhe WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo explore the effect of CXCL10 on the immune microenvironment, we induced macrophages from thp1 cell line and treated macrophages with the addition of CXCL10 and their controls.
- GSE251916 Endosomal trafficking bypassed by RAB5B-CD109 interplay promotes axonogenesis in KRAS-mutant pancreatic cancer December 27, 2024Contributors : Dingwen Zhang ; Yuming Luo ; Yan Lin ; Min YuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPerineural invasion (PNI) represents a unique biological feature causing the poor prognosis of pancreatic ductal adenocarcinoma (PDAC), especially with KRAS mutation. Extracellular vesicle (EVs)-packaged circRNAs […]
- GSE264388 H3K14ac binding by its Triple Tudor Domain globally directs SETDB1 activity December 27, 2024Contributors : Thyagarajan T Chandrasekaran ; Alexandra G Kouroukli ; Ole Ammerpohl ; Albert JeltschSeries Type : Methylation profiling by arrayOrganism : Homo sapiensSETDB1 is a major H3K9 methyltransferase. It contains a unique Triple Tudor Domain (3TD) which specifically bind the dual modification of H3K14ac in the presence of H3K9me1/2/3. In this study, […]
- GSE261764 Diurnal control of H3K27me1 deposition shapes expression of a subset of cell cycle and DNA damage response genes December 27, 2024Contributors : Jorge Fung-Uceda ; María Sol Gomez ; Laura Rodriguez Casillas ; Anna Gonzalez Gil ; Crisanto GutierrezSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaRhythmic oscillation of biological processes helps organisms to adapt their physiological responses to the most appropriate time of the day. Chromat […]
- GSE284211 Effect of porcine spermatogonia germ cells on de novo morphogenesis of testis trough xenotransplatation. December 27, 2024Contributors : Min-Gi Han ; Hyuk SongSeries Type : Expression profiling by high throughput sequencingOrganism : Sus scrofaThis study explores the role of porcine spermatogonia germ cells and testicular fibroblast in testis development and spermatogenesis through xenotransplantation. Previous research demonstrated the importance of Sertoli cells in maintainin […]
- GSE280924 Metformin Regulates Ferroptosis in Skin Cutaneous Melanoma December 27, 2024Contributors : Weiting Kang ; Da GuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo explore the effects of metformin on the proliferation and ferroptosis of skin cutaneous melanoma (SKCM) and its potential molecular mechanisms, providing a new theoretical basis and strategy for the treatment of cutaneous melanoma. RNA […]
- GSE285206 Endonuclease G promotes hepatic mitochondrial respiration by selectively increasing mitochondrial tRNAThr production December 27, 2024Contributors : Jay H Chung ; Lorant SzekvolgyiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusMitochondrial endonuclease G (EndoG) contributes to chromosomal degradation when it is released from mitochondria during apoptosis. It is presumed to also have a mitochondrial function because EndoG-deficiency cau […]
- GSE284403 Lactylated histone promotes rheumatoid arthritis progression by increasing NFATc2 expression and the production of anti-lactylated histone autoantibodies December 27, 2024Contributor : Gan WuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe elevated lactate in the joint microenvironment of patients with rheumatoid arthritis (RA) is crucial for disease progression, although the underlying mechanism remains to be elucidated. In this study, we observed significantly increased global lacty […]
- GSE285240 CGH: Rag2_and_Rsv1-h_recombinant_haplotype_analysis December 27, 2024Contributors : Robert M Stupar ; Adrian O Stec ; George L Graef ; Luis G PosadasSeries Type : Genome variation profiling by genome tiling arrayOrganism : Glycine maxSoybean lines were compared to the reference genome Williams 82 (Wm82) by CGH to catalog feature polymorphisms in a Rag2 and Rsv1-h QTL regionThe CGH comparisons reveal reveal feature polymorphis […]
- GSE285269 Spatial transcriptomics: P. aeruginosa corneal infection December 27, 2024Contributors : Hao Zhou ; Oscar Negrón ; Serena Abbondante ; Nicole Chumbler ; Eric Pearlman ; Mihaela GadjevaSeries Type : OtherOrganism : Mus musculusTo holistically unravel the complexity of pathogen-host interactions within infected tissues we leverage a dual spatial transcriptomic approach that, for the first time, simultaneously captures the expression […]
- GSE285356 PIF4 promotes stomatal movement during fluctuating light coincidant with drought stress via the SAL1-PAP signaling pathway (ChIP-Seq) December 27, 2024Contributors : Mingnan Qu ; Suyang Fang ; Jemaa Essemine ; Zhan XuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Oryza sativaFluctuating light (FL) usually occur concomitantly with drought stress (DS); this combined (FL-DS) condition influences intrinsic water use efficiency (iWUE) pattern during FL and DS response. […]
- GSE267640 Epigenomic landscape of human cumulus cells in premature ovarian insufficiency using single-base resolution methylome and hydroxymethylome. [ACE-seq] December 27, 2024Contributors : Wenhao Shi ; Dongyang Wang ; Juanzi Shi ; Chen HuangSeries Type : OtherOrganism : Homo sapiensPremature ovarian insufficiency (POI) has recently been reported to be linked with epigenetic changes. Previous studies have focused on the regulation of individual genes associated with ovarian function through single-gene epigenetic variations, howe […]