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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE283495 Intestinal epithelial cell diversity and function in respect to age, anatomical localization, and microbial exposure - the global transcriptome December 23, 2024Contributors : Johannes Schöneich ; Aline Dupont ; Matthias A Schmitz ; Isabel Richter ; Stefan Schlößer ; Mathias W HornefSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe small intestinal epithelium is composed of several defined epithelial cell lineages, which in turn exhibit marked transcriptional and functional d […]
- GSE283143 Intestinal epithelial cell diversity and function in respect to age, anatomical localization, and microbial exposure - the proximal to distal transcriptome December 23, 2024Contributors : Johannes Schöneich ; Aline Dupont ; Mathias W HornefSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe small intestinal epithelium is composed of several defined epithelial cell lineages, which in turn exhibit marked transcriptional and functional diversity along the crypt-villus and proximal-to-distal l […]
- GSE285166 Bisulfite sequencing of methylation changes in the D4Z4 region caused by HSV-1 December 23, 2024Contributors : Ming Gao ; Junjie ZhangSeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensBisulfite-seq analysis of U2OS cells infected with HSV-1
- GSE283522 Development and validation of a spatially informed assay that resolves biomarker discordance and predicts treatment response in breast cancer. December 23, 2024Contributors : Evan D Paul ; Barbora Huraiová ; Natália Valková ; Natália Matyašovská ; Daniela Gábrišová ; Soňa Gubová ; Helena Ignačáková ; Tomáš Ondris ; Michal Gala ; Silvia Bendíková ; Jarmila Bíla ; Katarína Buranovská ; Diana Drobná ; Zuzana Krchňáková ; Maryna Kryvokhyzha ; Daniel Lovíšek ; Viktoriia Mamoilyk ; Veronika Mančíková ; Nina Vojtaššáková […]
- GSE263679 Integrated stress response associated with dark microglia contributes to neurodegeneration [TRAP-seq] December 23, 2024Contributors : Anna Flury ; Leen Aljayousi ; Siaresh Aziz ; Hye-Jin Park ; Mohammadparsa Khakpour ; Colby Sandberg ; Fernando G Ibanez ; Olivia Braniff ; Pragney Deme ; Jackson D McGrath ; Thi Ngo ; Jack Mechler ; Denice M Ramirez ; Dvir Avnon-Klein ; John W Murray ; Jia Liu ; Norman J Haughey ; Sebastian Werneburg ; Marie-Eve Tremblay ; Pinar AyataSeries Ty […]
- GSE221666 The evaluation of exosomal miRNA biomarkers for cachexia December 23, 2024Contributors : Xunliang Jiang ; Rui ZhangSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensIn order to screen miRNAs related to cachexia, we collected plasma from patients with gastric cancer cachexia or without cachexia, and extracted exosomes from plasma.Then, we analyzed the gene expression profile of 3 gastric can […]
- GSE284602 High efficient chromatin conformation capture with post-enrichment (HiChew) in single cells December 23, 2024Contributors : Zhichao Chen ; Yeming Xie ; Chen Tan ; Fengying Ruan ; Chen Zhang ; Chong TangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensWe present HiChew (High efficient chromatin conformation capture with post-enrichment), a novel method for analyzing three-dimensional chromatin organization in singl […]
- GSE267559 The acute stress response is mediated by prefrontal 5α-reductase 2 in males via allopregnanolone synthesis December 23, 2024Contributors : Philip Moos ; Marco BortolatoSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusAcute stress triggers rapid brain responses, including increased allopregnanolone (AP) synthesis via 5α-reductase (5αR). However, the involvement of this enzyme in stress response remains elusive. Here, we investigated the r […]
- GSE284707 GWAS identifies a OsPIF4 gene underlying iWUE under fluctuating light and drought combined stress in rice December 23, 2024Contributors : Mingnan Qu ; Suyang Fang ; Jemaa EssemineSeries Type : Expression profiling by high throughput sequencingOrganism : Oryza sativaFluctuating light (FL) usually occur concomitantly with drought stress (DS); this combined (FL-DS) condition influences intrinsic water use efficiency (iWUE) pattern during FL and DS response. However, the molecular m […]
- GSE284633 Cancer SLC3A2-mediated lysine uptake restricts T cell immunity against hepatocellular carcinoma December 23, 2024Contributors : Chenghao Huang ; Yating Chang ; Yipeng RaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusOur research demonstrates that in hepatocellular carcinoma (HCC), tumor cells outcompete T cells for lysine (Lys) by overexpressing the SLC3A2 transporter, thereby reducing Lys availability within the […]
- GSE284740 TFEB controls expression of human syncytins during cell-cell fusion [ChIP-Seq] December 23, 2024Contributors : Meagan N Esbin ; Liza Dahal ; Joseph McKenna ; Xavier Darzacq ; Robert TjianSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensDuring human development, a subset of differentiating fetal cells form a temporary organ, the placenta, which invades the uterine wall to support nutrient, oxygen, and […]
- GSE284986 Serine mistranslation induces the integrated stress response through the P1 stalk December 23, 2024Contributors : Zhang Hong ; Ling JiqiangSeries Type : Expression profiling by high throughput sequencingOrganism : Saccharomyces cerevisiaeAminoacyl-tRNA synthetases (aaRSs) are essential enzymes that support robust and accurate protein synthesis. A rapidly expanding number of studies show that mutations in aaRSs lead to multiple human diseases, including ne […]
- GSE284995 Aquaporin 5 deficiency suppresses fatty acid oxidation and delays liver regeneration through the transcription factor PPAR. December 23, 2024Contributors : Bin LI ; Shixu Liu ; Wenshuo Han ; Peirong Song ; Hetong Sun ; Xin Cao ; Guohu Di ; Peng ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAfter 70% partial hepatectomy (PHx), the metabolic pathways leading to hepatocyte lipid droplet accumulation during liver regeneration remain unclear. Aquaporin 5 (A […]
- GSE283142 Intestinal epithelial cell diversity and function in respect to age, anatomical localization, and microbial exposure - the crypt/villus transcriptome December 23, 2024Contributors : Johannes Schöneich ; Aline Dupont ; Matthias A Schmitz ; Isabel Richter ; Antoine-Emmanuel Saliba ; Mathias W HornefSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe small intestinal epithelium is composed of several defined epithelial cell lineages, which in turn exhibit marked transcriptional and func […]
- GSE284576 Identification of the H+-K+-ATPase ATP4A as hypoxia-regulated target for acute kidney injury prevention December 23, 2024Contributors : In H Bang ; Yafen Liang ; Boyun Kim ; Adit A Ginde ; Agieszka K Czopik ; German Corrales ; Bentley Bobrow ; Xinxin Ma ; Majd A Shaarani ; Wei Ruan ; Jieun Kim ; Katherine Figarella ; Yanyu Wang ; Charles Green ; Holger K EltzschigSeries Type : Expression profiling by arrayOrganism : Mus musculusAcute kidney injury (AKI) is the most common dise […]