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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE248613 Antagonistic stem cell fate under stress governs decisions between hair graying and melanoma [array] July 7, 2025Contributors : Emi K Nishimura ; Yasuaki MohriSeries Type : Expression profiling by arrayOrganism : Mus musculusThe exposome, an individual’s lifelong environmental exposure, profoundly impacts health. Somatic tissues undergo functional decline with age, exhibiting characteristic ageing phenotypes including hair graying and cancer. However, the specific geno […]
- GSE265839 Neutrophil modulation by IL-1β-induced fibroblasts July 7, 2025Contributors : Ming Zhao ; Qianjin Lu ; Sujie JiaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNeutrophils are key contributors to the pathogenesis of SLE. Using single-cell sequencing data from SLE skin lesions, we identified a subcluster of CXCL1+ fibroblasts primarily induced by IL-1β. To better understand the effe […]
- GSE249074 Antagonistic stem cell fate under stress governs decisions between hair graying and melanoma [RNA-Seq] July 7, 2025Contributors : Emi K Nishimura ; Yasuaki MohriSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe exposome, an individual’s lifelong environmental exposure, profoundly impacts health. Somatic tissues undergo functional decline with age, exhibiting characteristic ageing phenotypes including hair graying and cancer. Howev […]
- GSE301760 Pentoxifylline and Norcantharidin Synergistically Suppress Melanoma Growth in Mice: A Multi-Modal In Vivo and In Silico Study July 7, 2025Contributors : Israel Lara-Vega ; Minerva Najera-Martinez ; Armando Vega-LopezSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground: Melanoma is a highly aggressive skin cancer with limited therapeutic re-sponse. Targeting intracellular signaling pathways and promoting tumor cell differen-tiation are promising ther […]
- GSE270148 Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumors. July 7, 2025Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusMonocyte–derived macrophages (mo-macs) often drive immunosuppression in the tumor microenvironment (TME) and tumor-enhanced myelopoiesis in the bone marrow (BM) fuels these populations. Here, […]
- GSE243960 The mitotic STAG3–cohesin complex shapes male germline nucleome [Hi-C] July 7, 2025Contributors : Masahiro Nagano ; Bo Hu ; Kosuke Ogata ; Fumiya Umemura ; Yukiko Ishikura ; Yoshiaki Nosaka ; Hiromichi Sasada ; Hanbo Wang ; Daichi Kondo ; Yoshitaka Kato ; Ken Mizuta ; Yukihiro Yabuta ; Hiroshi Ohta ; Francisca N de Luna Vitorino ; Hiroshi Arima ; Jacek Majewski ; Benjamin A Garcia ; Yasushi Ishihama ; Mitinori SaitouSeries Type : OtherOrga […]
- GSE179959 Mesenchymal Stem Cell Transplantation Attenuates Venous Stenosis of Hemodialysis Vascular Access Arteriovenous Fistula July 7, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculus ; Sus scrofaThis SuperSeries is composed of the SubSeries listed below.
- GSE301589 CD4 T cells July 7, 2025Series Type : Expression profiling by high throughput sequencing ; Methylation profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE301581 Methylome description of CD4 T cells during chronic viral infection with either deletion of Dnmt3a, Tet2 or both Dnmt3a and Tet2. July 7, 2025Contributors : Brian Dalley ; Chris Stubben ; Timothy Parnell ; Bryce Fuchs ; J. Scott HaleSeries Type : Methylation profiling by high throughput sequencingOrganism : Mus musculusThe purose of this experiment was to determine how the loss of Tet2 and Dnmt3a altered the methylation program of CD4 Th1 and Tfh cells during chronic viral infection.
- GSE301643 Unanchored K63-linked polyubiquitin chains: a novel second messenger involved in G protein-coupled receptors early signaling events July 7, 2025Contributors : Priscilla Doyon ; Mohamad-Ali El-Mortada ; Jiunn Roy ; Firas El-Mortada ; Simon-Pierre Gravel ; Marc J ServantSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGPCR rapidly transduced extracellular cues via their ability to activate effector proteins leading to the production of a variety of well-characteri […]
- GSE301608 Transcriptomic stress responses in Vaccinium spp. F1 hybrids: Implications for temperature-resilient cranberry breeding using a crop wild relative July 7, 2025Contributors : Audrey Dickinson ; Jackson Kubal ; Nicholas Allsing ; Emily Murray ; Todd P Michael ; James J PolashockSeries Type : Expression profiling by high throughput sequencingOrganism : Vaccinium macrocarpon ; Vaccinium oxycoccosCranberry (Vaccinium macrocarpon) is an important North American fruit crop with vulnerability to temperature extremes and a […]
- GSE301657 Severe Attenuation of Circadian Clock Output in the Heart following Sustained Augmentation of Cardiomyocyte Protein O-GlcNAcylation July 7, 2025Contributors : Gobinath Shanmugam ; Samuel F Chang ; Helen E Collins ; Chae-Myeong Ha ; Selma Kane ; Luke Potter ; Lily Xie ; Luyun Zou ; Jianhua Zhang ; John C Chatham ; Adam R Wende ; Martin E YoungSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground. Changes in circadian-related behaviors (e.g., the timing of f […]
- GSE301684 Chronic social defeat stress induces meningeal neutrophilia via type I interferon signaling in males July 7, 2025Contributors : Stacey L Kigar ; Mary-Ellen Lynall ; Allison E DePuyt ; Robert Atkinson ; Virginia H Sun ; Joshua D Samuels ; Nicole E Eassa ; Chelsie N Poffenberger ; Michael L Lehmann ; Samuel J Listwak ; Ferenc Livak ; Abdel G Elkahloun ; Menna R Clatworthy ; Edward T Bullmore ; Miles HerkenhamSeries Type : Expression profiling by high throughput sequencin […]
- GSE301698 Clonal Expansion and Diversification of Germinal Center and Memory B Cell Responses to Booster Immunization in Primates July 7, 2025Contributors : Lachlan P Deimel ; Yoshiaki Nishimura ; Gabriela S Silva Santos ; Viren A Baharani ; Brianna Hernandez ; Thiago Y Oliveira ; Andrew J MacLean ; Marie Canis ; Sadman Shawraz ; Anna Gazumyan ; Harald Hartweger ; Paul D Bieniasz ; Theodora Hatziioannou ; Malcolm A Martin ; Michel C NussenzweigSeries Type : Expression profiling by high throughput […]
- GSE246415 Comparative CRISPRi screens reveal a human stem cell dependence on mRNA translation-coupled quality control [sgRNA] July 7, 2025Contributors : Geraldine Rodschinka ; Sergio Forcelloni ; Andrew Behrens ; Sascha Wani ; Danny D NedialkovaSeries Type : OtherOrganism : Homo sapiensThe translation of mRNA into proteins in multicellular organisms needs to be carefully tuned to changing proteome demands in development and differentiation, and defects in translation often have a disproportion […]