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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE260975 Identification of important genes for tooth development using single cell RNA-sequence datasets of sequential developing mouse molars December 24, 2025Contributors : Yuta Chiba ; Daniel MartinSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe organ development is dictated by the genes preferentially expressed in tissue or cell types uniquely. The clarification of gene expression profile and identification of specific genes in organ provide detailed understanding of o […]
- GSE282095 Adipogenic Transcriptional Regulation Mediated by PARP7 Through NAD+ Sensing Mechanism [CUT&RUN] December 24, 2025Contributors : MiKayla S Stokes ; Yoon Jung Kim ; Sneh Koul ; Josue Zuniga ; Shu-Ping Chiu ; Tulip Nandu ; Kraus W LeeSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThe process of differentiating from a preadipocyte into a mature, fat storing, adipocyte (adipogenesis) is a complex and tightly regulated pr […]
- GSE282093 Adipogenic Transcriptional Regulation Mediated by PARP7 Through NAD+ Sensing Mechanism [ChIP-Seq] December 24, 2025Contributors : MiKayla S Stokes ; Yoon Jung Kim ; Sneh Koul ; Josue Zuniga ; Shu-Ping Chiu ; Tulip Nandu ; Kraus W LeeSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThe process of differentiating from a preadipocyte into a mature, fat storing, adipocyte (adipogenesis) is a complex and tightly regulated pr […]
- GSE288578 ScRNAseq analysis of chicken embryonic pituitary reveals cell heterogeneity and a cell type co-expressing Gh and Pomc December 24, 2025Contributors : Kuan Ling Liu ; Tom E PorterSeries Type : Expression profiling by high throughput sequencingOrganism : Gallus gallusGene expression profiles and the heterogeneity among hormone-producing pituitary cells remain poorly characterized in most vertebrates, especially in chicken embryos. Using single-cell RNA sequencing, the transcriptomes of 4,346 […]
- GSE285688 Aortic valve calcification is induced by the loss of ALDH1A1 and can be prevented by agonists of retinoic acid receptor alpha: preclinical evidence for drug repositioning December 24, 2025Contributor : Mickael RosaSeries Type : Expression profiling by arrayOrganism : Homo sapiensStudy the effect of Am80 on osteoblast differentiation
- GSE303609 Dermatomyositis is characterized by JAK1-mediated monocyte-driven vasculopathy and inflammation December 24, 2025Contributors : Grace A. Osborne ; J. Michelle KahlenbergSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDermatomyositis (DM) is a rare yet devastating autoimmune disease characterized by inflammatory and vasculopathic changes in skin and muscle. DM and systemic lupus erythematosus (lupus) skin lesions have overlapping c […]
- GSE296747 Leveraging Natural Variation and Yeast Genetics for Novel Insights on the Molecular Basis of Cytotoxicity for Parkinson's Related Protein alpha-Synuclein December 24, 2025Contributors : Julio A Molina Pineda ; Manasa Velovolu ; Tara N Stuecker ; Stephan N Witt ; Jeffrey A LewisSeries Type : Expression profiling by high throughput sequencingOrganism : Saccharomyces cerevisiaeParkinson’s disease (PD) is a progressive neurodegenerative disorder affecting more than 5 million people worldwide. A hallmark of PD is dopaminergic neur […]
- GSE314590 Ex Vivo Hypothermic Perfusion Enables 48-Hour Heart Preservation and Bench-Top Functional Recovery via Normothermic Reperfusion in a Porcine Model December 24, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Sus scrofaBackground: Ex vivo oxygenated perfusion systems is a promising approach to extend cardiac allograft preservation beyond the typical 4–6h limit allowed by static-cold-storage (SCS). Hypothermic oxygenated perfusion (HOPE) has been proven to safely preserve donor hearts, yet […]
- GSE314530 Expression data from HEK-293 cells treated with different CDK8/19 inhibitors December 24, 2025Contributors : Angga Prawira ; Yi NiSeries Type : Expression profiling by arrayOrganism : Homo sapiensHepatitis delta virus (HDV) enters hepatocytes via the receptor NTCP and requires CDK8/19 Mediator kinases to establish its infection by RNA Polymerase II. Here, we are interested in assessing the class effect of various CDK8/19 inhibitors and investigating […]
- GSE314625 WSTF deficiency reprograms regulatory networks by linking locus‑specific chromatin remodeling to altered isoform expression and misdirected signaling [mRNA-seq] December 24, 2025Contributors : Shahin Behrouz Sharif ; Jonathan H DennisSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensLoss of the chromatin remodeler WSTF (BAZ1B), a gene deleted in Williams syndrome, causes reproducible, genome-scale reprogramming of chromatin states and transcript processing that links altered chromatin composition […]
- GSE314624 WSTF deficiency reprograms regulatory networks by linking locus‑specific chromatin remodeling to altered isoform expression and misdirected signaling [CUT&Run] December 24, 2025Contributors : Shahin Behrouz Sharif ; Jonathan H DennisSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensLoss of the chromatin remodeler WSTF (BAZ1B), a gene deleted in Williams syndrome, causes reproducible, genome-scale reprogramming of chromatin states and transcript processing that links altered chromat […]
- GSE314626 Spatial genome organization is associated with nematode programmed DNA elimination December 24, 2025Contributors : James R Simmons ; Jianbin WangSeries Type : OtherOrganism : Ascaris suumProgrammed DNA elimination (PDE) is a notable exception to genome integrity, characterized by significant DNA loss during development. In many nematodes, PDE is initiated by DNA double-strand breaks (DSBs), which lead to chromosome fragmentation and subsequent DNA loss. Ho […]
- GSE314634 Reciprocal interactions between EMT and BMP signalling drive collective cell invasion. December 24, 2025Contributors : Yuri Takahashi ; Alexandra Neaverson ; Lara C Busby ; Benjamin J SteventonSeries Type : Expression profiling by high throughput sequencingOrganism : Gallus gallusDuring collective cell invasion, epithelial-to-mesenchymal transition (EMT) and morphogen signalling-mediated cell fate specification are traditionally viewed as a linear cascade: mor […]
- GSE314697 NAT10 drives head and neck squamous cell carcinoma proliferation via ac4C modification of DDIT4 mRNA December 24, 2025Contributors : Panpan Song ; Qian Xiao ; Yue Jiang ; Hui Li ; Zheng Liang ; Junguo Wang ; Xiaoyun Qian ; Xia GaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the function NAT10 in the regulation of proliferation, we established SAS cell lines in which target gene has been knocked down by siRNA.
- GSE314824 Evaluation of Metaplastic Triple-Negative Breast Cancer Extracellular Matrix Structure and Protein Composition December 24, 2025Contributors : Elizabeth C Martin ; Jorge A Belgodere ; Matthew E Burow ; Katherine L HebertSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAlterations in the tumor extracellular environment and matrix stiffness promotes tumor progression. Furthermore, correlational studies have identified enrichment of extracellular ma […]