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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE237958 ZBTB48 is a pioneer factor regulating B-cell-specific CIITA expression [RNA-seq] December 26, 2024Contributors : Grishma Rane ; Vartika Khanchnadani ; Dennis KappeiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCIITA is the master regulator of MHC II gene expression and hence the adaptive immune response. CIITA expression itself is tightly regulated by three cell type-specific promoters, pI, pIII, and by pIV. Here, […]
- GSE259370 Analysis of a pair of HCA-7 derived cells with low expressing (CC) or high expressing (CC-CR) levels of miR-100 and miR-125b and RNA collected from Ago2 RNA immunoprecipitation (RNAseq_human_AGO2_IP.8635) December 26, 2024Contributors : James G Patton ; Hannah M NelsonSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensWe report the results of RNA-Seq from a pair of HCA-7 derived cells with low, CC, and high, CC-CR, cells as well as RNA-seq from AGO2 RNA immunoprecipitation from the two cell lines in order to identify potential targe […]
- GSE244862 Tumor suppressive role of CELF2 in skin tumorignesis December 26, 2024Contributors : Bindeshwar Sah ; Jasvinder Singh ; Yao Shen ; Liang LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the function of CELF2 in non-melanoma skin cancer, we performed immunofluorescence staining studies and found lower CELF2 expression in human squamous cell carcinoma (SCC) tumors than in a […]
- GSE259374 Analysis of an HCA-7 derived cell line (CC-CR) and cell lines generated with knockout of miR-100, miR-125b, or both miRNAs. (smallRNAseq_human_miR_KO.8556) December 26, 2024Contributors : James G Patton ; Hannah M NelsonSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensWe report the results of RNA-Seq from an HCA-7 derived cell line with high levels of miR-100 and miR-125b (CC-CR) and knockout cell lines generated from the high expressing cells. CC-CR cells had miR-100, miR-125b or both […]
- GSE259372 Analysis of a pair of HCA-7 derived cells with low expressing (CC) or high expressing (CC-CR) levels of miR-100 and miR-125b and RNA collected from Ago2 RNA immunoprecipitation December 26, 2024Series Type : Expression profiling by high throughput sequencing ; Other ; Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE192626 Comprehensive DNA methylation analysis of human neuroblastoma cells treated with blonanserin and perospirone December 26, 2024Contributors : Jianbin Du ; Yutaka Nakachi ; Ayaka Fujii ; Shinya Fujii ; Kiyoto Kasai ; Miki Bundo ; Kazuya IwamotoSeries Type : Methylation profiling by arrayOrganism : Homo sapiensThis work reveals the effect of antipsychotics on DNA methylation using the cell model. After the treatment of antipsychotics, blonanserin and perospirone, DNA methylation profi […]
- GSE268610 Inhibiting intracellular CD28 in cancer cells enhances antitumor immunity and overcomes anti-PD-1 resistance via targeting PD-L1 December 26, 2024Contributors : Zhen Yang ; Xinpeng Liu ; Xuetao CaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo determine how deficiency of Cd28 influences 4T1 cells, we performed a transcriptional analysis
- GSE283141 Multiplexed mosaic tumor models reveal natural phenotypic variations in drug response within and between populations [8 cancer cell lines] December 26, 2024Contributors : Johnny X Yu ; Jung M Suh ; Katerina D Popova ; Kristle Garcia ; Tanvi Joshi ; Bruce Culbertson ; Jessica B Spinelli ; Vishvak Subramanyam ; Kevin Lou ; Kevan Shokat ; Jonathan Weissman ; Hani GoodarziSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHeterogeneity between patients poses a significant challen […]
- GSE282907 Q11, a CYP2E1 inhibitor, exerts anti-hepatocellular carcinoma effect by inhibiting M2 macrophage polarization December 26, 2024Contributors : Cunzhen Zhang ; Yan Fang ; Hailing QiaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDespite significant advancements in cancer immunotherapy, many patients continue to respond poorly. Novel therapeutic strategies and drugs are urgently needed. Here, we found that CYP2E1 is significantly upregulated in […]
- GSE283354 Expression data from SAMP8 and SAMR1 mice brains in TFQA treatments December 26, 2024Contributor : Hongyu LinSeries Type : Expression profiling by arrayOrganism : Mus musculusTFQA treatment in SAMP8 mice showed the significant performance on improving learning and memory compared with no treatment SAMP8 mice brains. TFQA treatments in SAMP8 mice also had significant activation of neurotrophin signaling pathway, by increasing BDNF.We used mic […]
- GSE283335 Multiplexed mosaic tumor models reveal natural phenotypic variations in drug response within and between populations December 26, 2024Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE284287 Exacerbated Salmonellosis in poly(ADP-ribose) polymerase 14 deficient mice December 26, 2024Contributors : Madhukar Vedantham ; Arto PulliainenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSalmonella enterica serovar Typhimurium infection triggers a robust immune response in the host, but the molecular mechanisms regulating this response are not fully understood. Parp14 has been shown to enhance type I inter […]
- GSE285044 Aberrantly Expressed RECQL4 Helicase Supports Proliferation and Drug Resistance of Human Glioma Cells and Glioma Stem Cells December 26, 2024Contributors : Sylwia K Krol ; Agnieszka Kaczmarczyk ; Kamil Wojnicki ; Bartoisz Wojtas ; Bartlomiej Gielniewski ; Wieslawa Grajkowska ; Katarzyna Kotulska ; Cezary Szczylik ; Ryszard Czepko ; Mariusz Banach ; Wojciech Kaspera ; Wojciech Szopa ; Andrzej Marchel ; Tomasz Czernicki ; Bozena KaminskaSeries Type : Expression profiling by high throughput sequenci […]
- GSE285131 Comparative gene expression profiling of parental A375 melanoma cells and a panel of spontaneously vemurafenib-resistant derivative cell lines December 26, 2024Contributors : Jesse D Riordan ; Adam J Dupuy ; Christopher S StippSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe use of selective BRAF inhibitors (BRAFi) has produced remarkable outcomes for patients with advanced cutaneous melanoma harboring a BRAFV600E mutation. Unfortunately, the majority of patients eventually […]
- GSE237956 ZBTB48 is a pioneer factor regulating B-cell-specific CIITA expression [ChIP-seq] December 26, 2024Contributors : Grishma Rane ; Vartika Khanchnadani ; Dennis KappeiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensCIITA is the master regulator of MHC II gene expression and hence the adaptive immune response. CIITA expression itself is tightly regulated by three cell type-specific promoters, pI, pIII, and […]