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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE230033 CAR-T cells shape the immunological potential of the tumor microenvironment September 17, 2025Contributors : Julia Frede ; Julia Poller ; Kayleen Shi ; Hannah Stuart ; Noori Sotudeh ; Claire Havig ; Klothilda Lim ; Caroline R Wiggers ; Eugene Y Cho ; Tushara Vijaykumar ; Johannes M Waldschmidt ; Monica S Nair ; Praveen Anand ; Valeriya Dimitrova ; Anna Montanaro ; Nikhil C Munshi ; Kenneth C Anderson ; Nathan Martin ; Shari M Kaiser ; Marc-Steffen Ra […]
- GSE212153 Requirements for Establishment and Epigenetic Inheritance of Mammalian Heterochromatin [ChIP-Seq] September 17, 2025Contributors : Antonis Tatarakis ; Harleen Saini ; Danesh MoazedSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusHeterochromatic domains of DNA account for a large fraction of mammalian genomes and have critical roles in silencing of transposons and genes but the mechanisms that establish and maintain these […]
- GSE269513 Allele-specific genomics decodes gene targets and mechanisms of the non-coding genome September 17, 2025Contributors : Tim Hasenbein ; Daniel AndergassenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusA substantial proportion of disease variants reside in non-coding RNAs (ncRNAs), which serve as important regulatory elements. However, most ncRNA targets remain unknown, hindering our understanding of complex diseases. We f […]
- GSE243467 MiR-19b-1 drives gestational hypoxia-Induced pulmonary hypertension through NADPH oxidases September 17, 2025Contributors : Yishi Qin ; Katharina Hochkogler ; Laura Zelarayan-Behrend ; Federico Bleckwedel ; Gabriela Salinas ; Andreas Petry ; Agnes GörlachSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGestational hypoxia can lead to intrauterine growth restriction and programming of cardiovascular diseases in adulthood via dif […]
- GSE277322 An epigenetic repressor TRIM66 dictates monogenic olfactory receptor expression, neural activity, and olfactory behavior September 17, 2025Contributors : Hongqiang Bao ; Yalei Kong ; Qian LiSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing ; OtherOrganism : Mus musculusOlfactory receptor gene choice is an extremely intricate example of monogenic and monoallelic expression, where one out of over 1,000 receptor gene […]
- GSE272302 C. elegans display antipathy behavior towards food after contemporaneous integration of nutritional needs and dietary lipid availability. [neuronal] September 17, 2025Contributors : Nicole L Stuhr ; Carmen M Ramos ; Chris D Turner ; Alexander A Soukas ; Sean P CurranSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansOrganisms utilize sophisticated neurocircuitry to select optimal food sources within their environment. Methylobacterium is a lifespan-promoting bacterial diet for […]
- GSE299737 Single-cell transcriptome analysis deciphers stem cell-like epithelial cells as metastatic phenotype and immune characteristics of tumor deposition positive in Colorectal Cancer September 17, 2025Contributors : Shuang Xie ; Xi'e Hu ; Gang Wang ; Zuyin Wu ; Ning Liang ; Qian Huang ; Yunhu Bai ; Jixin Zhang ; Chunxu Zhang ; Xiaolong Wei ; Qingrui Hou ; Guoqiang Bao ; Qian Wang ; Nan Wang ; Xianli HeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: Intratumoral heterogeneity (ITH) limits the accurate […]
- GSE279218 Profiling linkage-specific ubiquitin chain functions reveals a key role of K29-linked ubiquitylation in epigenome integrity September 17, 2025Contributors : Javier Arroyo-Gómez ; Nazaret Reverón-GómezSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensLinkage-specific ubiquitin (Ub) chains dictate the functional outcome of many critical Ub-dependent signaling processes. However, the functions and targets of several poly-Ub topologies remain poorly u […]
- GSE307564 The Gain-of-Function TREM2-T96K Mutation Increases Risk for Alzheimer’s Disease by Impairing Microglial Function September 17, 2025Contributors : Pilat Dominika ; Le Hoang ; Prokopenko Dmitry ; Lin Chih-Chung Jerry ; Eimer A William ; Quinti Luisa ; Gavrilles P Evan ; Garcia N Sheyla ; Heitman N Sara ; Alzheimer’s Disease Neuroimaging Initiative ADNI ; McGinty Danielle ; Centibas Murat ; Sadreyev I Ruslan ; Tanzi E Rudolph ; Griciuc AnaSeries Type : Expression profiling by high throughp […]
- GSE303091 The SMC Hinge is a Selective Gate for Obstacle Bypass September 17, 2025Contributors : Hon Wing Liu ; Florian Roisné-Hamelin ; Michael Taschner ; James Collier ; Madhusudhan Srinivasan ; Stephan GruberSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Bacillus subtilisDNA loop-extruding SMC complexes play vital roles in genome maintenance and DNA immunity. However, the ability of these ring- […]
- GSE307686 The Gain-of-Function TREM2-T96K Mutation Increases Risk for Alzheimer’s Disease by Impairing Microglial Function [scRNA-Seq] September 17, 2025Contributors : Pilat Dominika ; Le Hoang ; Prokopenko Dmitry ; Lin Chih-Chung Jerry ; Eimer A William ; Quinti Luisa ; Gavrilles P Evan ; Garcia N Sheyla ; Heitman N Sara ; McGinty Danielle ; Centibas Murat ; Sadreyev I Ruslan ; Tanzi E Rudolph ; Griciuc AnaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe aim of this […]
- GSE307887 The α/β hydrolase DWARF14-Like 2 regulates growth and development in Arabidopsis thaliana September 17, 2025Contributors : Xiaofan Nie ; Liangliang Li ; Chenbo Zhu ; Kaixin Yang ; Jiahe Fu ; Wenbo Jia ; Wei Xie ; Weiqiang LiSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaTo understand the role of DLK2 in regulating plant growth and development, we performed the comparative transcriptome profiling WT and DLK2-OE1 seedl […]
- GSE307943 Solithromycin mitigates Prevotella intermedia–induced exacerbation of MRSA ventilator-associated pneumonia by modulating hyperinflammatory responses and enhancing alveolar macrophage function September 17, 2025Contributors : Naoki Iwanaga ; Koki FukushimaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSolithromycin protects by activating alveolar macrophages and promoting TNF-related responses, suggesting a novel immunomodulatory role for solithromycin in host defense against exacerbation of MRSA-VAP by P. int. sup.
- GSE307958 PRDM16 Regulates Prostate Cancer Cell Dormancy and Prevents Bone Metastatic Outgrowth September 17, 2025Contributor : Mostafa M NasrSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusUnderstanding dormancy in prostate cancer (PCa) is challenging due to model availability. Here, using murine and human PCa cell lines, we generated a stress-induced model of dormancy in vitro and demonstrated that the phenotype co […]
- GSE296331 Creeping fat-derived mechanosensitive fibroblasts drive intestinal fibrosis in Crohn’s disease strictures [Xenium] September 17, 2025Contributors : Khristian E Bauer-Rowe ; Benjamin PhamSeries Type : OtherOrganism : Homo sapiensA significant complication of Crohn’s disease (CD) is intestinal fibrosis, which narrows the bowel lumen to cause a stricture. Creeping fat (CF) is the wrapping of mesenteric adipose tissue (MAT) around inflamed and fibrotic bowel, but its role in stricture progres […]