Gene Expression Omnibus Announcements -Study Releases

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE229216 DNA methylation constrains nucleosome retention in sperm and H3K4 methylation deposition in early mouse embryos [ATATA] October 21, 2024
  Contributors : Grigorios Fanourgakis ; Antoine PetersSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusDNA methylation serves a stable gene regulatory function in mature somatic cells. In the germ line and during early embryogenesis, however, DNA methylation undergoes global erasure and re-establishment to s […]
• GSE230871 A marker chromosome in psychosis identifies glycine decarboxylase (GLDC) as a novel negative regulator of excitatory synaptic activity in the hippocampus October 21, 2024
  Contributors : Maltesh Kambali ; Yan Li ; Petr Unichenko ; Jessica Feria ; Rachita Yadav ; Jing Liu ; Patrick McGuiness ; Johanna G Cobb ; Muxiao Wang ; Rajasekar Nagarajan ; Jinrui Lyu ; Vanessa Vongsouthi ; Colin J Jackson ; Elif Engin ; Joseph T Coyle ; Michael E Talkowski ; Gregg E Homanics ; Vadim Y Bolshakov ; Christian Henneberger ; Uwe RudolphSeries […]
• GSE229239 DNA methylation constrains nucleosome retention in sperm and H3K4 methylation deposition in early mouse embryos [RRBS] October 21, 2024
  Contributors : Grigorios Fanourgakis ; Laura G Toneu ; Antoine PetersSeries Type : Methylation profiling by high throughput sequencingOrganism : Mus musculusDNA methylation serves a stable gene regulatory function in mature somatic cells. In the germ line and during early embryogenesis, however, DNA methylation undergoes global erasure and re-establishment t […]
• GSE243035 Ageing-associated long non-coding RNA extends lifespan and reduces translation in non-dividing cells [aal1_ChIRP-RNAseq] October 21, 2024
  Contributor : Shajahan AnverSeries Type : OtherOrganism : Schizosaccharomyces pombeGenomes pervasively produce long non-coding RNAs (lncRNAs) of largely unknown functions. Some of these lncRNAs have been implicated in roles related to ageing and associated diseases. Here we characterize aal1 (ageing-associated lncRNA 1) which is induced in non-dividing, agei […]
• GSE240785 RNAseq of SMAD2/3DKO and Smad4KO in pluripotent mESC and EBs October 21, 2024
  Contributors : Bingnan Zhao ; Jintong Shi ; Yanhua Du ; Qiong WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo dissected the roles of SMAD2/3 and SMAD4 in mouse embryonic stem cells (mESC), knockouts of SMAD2/3 (SMAD2 and SMAD3 double knockout, S2/3DKO) and SMAD4 (SMAD4 knockout, S4KO) were used to conduct RNAseq […]
• GSE263987 Single-Cell Transcriptomics Reveals the Molecular Basis of Human iPS Cell Differentiation into Ectodermal Ocular Lineages October 21, 2024
  Contributors : Laura Howard ; Yuki Ishikawa ; Tomohiko Katayama ; Sung-Joon Park ; Matthew J Hill ; Derek J Blake ; Kohji Nishida ; Ryuhei Hayashi ; Andrew J QuantockSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe generation of a self-formed, ectodermal, autonomous multi-zone (SEAM) from human induced pluripotent st […]
• GSE245963 Biomarker discovery in paired mid luteal endometrial biopsies October 21, 2024
  Contributors : Joanne Muter ; Pavle J Vrljicak ; Sascha Ott ; Jan J BrosensSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCell state determination is apparent within the endometrium during the mid-luteal window of implantation. Using previously identified biomarkers of cell states (SCARA5 and DIO2) we performed bulk RN […]
• GSE279586 Identification of chromatin states in mouse testicular germ cells using CUT&Tag October 21, 2024
  Contributors : Weihua Wang ; Junqiao Xing ; Xiqi ZhangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusHere we describe successful implementation of CUT&Tag sequencing technology for profiling of protein-DNA interactions in mouse testicular germ cells. By performing CUT&Tag sequencing using antibodi […]
• GSE279577 Transcriptomic Landscape of Hyperthyroidism in Mice Overexpressing Thyroid Stimulating Hormone October 21, 2024
  Contributor : Ichiro YamauchiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusActivation of thyroid stimulating hormone receptor (TSHR) fundamentally leads to hyperthyroidism. To elucidate TSHR signaling, we conducted transcriptome analyses for hyperthyroid mice that we generated by overexpressing TSH. TSH overexpression […]
• GSE279610 Cell-cycle deregulation in diffuse large B-cell lymphoma promotes critical dependence on the cyclin-G associated kinase October 21, 2024
  Contributors : Olivia B Lightfuss ; Preet Kumar ; Lingxiao Li ; Toral Shastri ; Austin D Newsam ; Paola Manara ; Abdessamad Y Alaoui ; Diego H Parets ; Pierre Younes ; Dhanvantri Chahar ; Artavazd Arumov ; Caroline A Coughlin ; Indigo P Williams ; Ola Landgren ; Stephan Schürer ; Vance Lemmon ; Francesco Maura ; Daniel Bilbao ; Yangbo Feng ; Hassan Al-Ali ; […]
• GSE279599 SS-31 Ameliorates DSS-Induced Colitis Through Mitochondrial Protection, Gene Regulation and Gut Microbiota Modulation October 21, 2024
  Contributors : Keqi Yu ; Lu Ye ; Shengtao Liao ; Chuanfei Li ; Ke Zhan ; Zhechuan Mei ; Lin LvSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study investigated the efficacy of SS-31 in alleviating DSS-induced colitis in mice and clarified its potential mechanism through transcriptome sequencing. DSS was used to in […]
• GSE279637 Senescent lung fibroblasts in idiopathic pulmonary fibrosis facilitate non-small cell lung cancer progression by secreting exosomal MMP1 October 21, 2024
  Contributors : Tao Ren ; Qiong Y LeiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensLung cancer is a fatal complication of idiopathic pulmonary fibrosis (IPF) with a poor prognosis. Current treatments are insufficient in improving the prognosis of lung cancer patients with comorbid idiopathic pulmonary fibrosis (IPF-LC) […]
• GSE279704 Bruton’s tyrosine kinase inhibitor leads to bidirectional transcript regulation of Nurr1: A new key to Parkinson’s disease October 21, 2024
  Contributors : Soo Youn Lee ; Yu-Rim Lee ; Jeung Hee AnSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusParkinson’s disease (PD) is a progressive neurological movement diseases with few therapeutic targets identified to date. The primary treatment for PD is levodopa, but it is only effective in the initial stage and indu […]
• GSE279796 Setdb1 regulates proper differentiation of adult intestinal stem cells via restraining permissive chromatin structure and transcriptional variability October 21, 2024
  Contributors : Dimitris Botskaris ; Ioannis Deligiannis ; Ioanna Peraki ; Haroula Kontaki ; Marianna Stagaki ; Matthieu Lavigne ; Celia Martinez-Jimenez ; Iannis TalianidisSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThe histone methylase Setdb1 plays […]
• GSE186579 Profiling of PRC1 and PRC2 occupancy reveals the preponderant role of PRC1 in regulating the limb development program October 21, 2024
  Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.