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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE291095 mRNA sequencing on esophageal cells of Krt5-CreERT2:R26SmoM2/EYFP (K5:Smo) mice, untreated and treated with ibuprofen February 3, 2026Contributors : Benjamin Beck ; Louison Descampe ; Benjamin Dassy ; Alizée Vercauteren DrubbelSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn our study, we used mRNA sequencing to investigate the effect of ibuprofen on the transcriptome of esophageal epithelial cells of K5:Smo mice.
- GSE291090 Single cell mRNA sequencing on esophageal cells of Krt5-CreERT2:R26SmoM2/EYFP (K5:Smo) mice untreated and treated with ibuprofen February 3, 2026Contributors : Benjamin Beck ; Louison DescampeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn our study, we used single-cell RNA sequencing to investigate the effect of ibuprofen on cell-mediated communication between esophageal epithelial cells and their microenvironment in K5:Smo mice.
- GSE246186 H3K115 marks fragile nucleosomes at regulatory sites [ChIP-seq] February 3, 2026Series Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusAcetylation of lysine residues in the tail domain of histone H3 at active regulatory elements are well characterised, but the less studied acetylations of histone globular domain lysines also hold regulatory potential based on their potential impact on nucleo […]
- GSE294082 Glucocorticoids suppress early lung inflammation and impair control of SARS-CoV-2 in non-human primates. February 3, 2026Contributors : Christine E. Nelson ; Keith D. Kauffman ; Shunsuke Sakai ; Taylor Newbolt ; Jay Bucchnan ; Taylor W. Foreman ; April M. Walker ; Felipe Gomez ; Joel D. Fleegle ; Richard Herbet ; Tom Hill ; Justin Lack ; Sevilay Turan ; Reed Johnson ; Laura E. Via ; Daniel L. BarberSeries Type : Expression profiling by high throughput sequencingOrganism : Maca […]
- GSE288245 Long-term post-ovariectomy mouse model recapitulates hypothalamic transcriptomic changes observed during the menopausal transition in women February 3, 2026Contributors : Jordana C Bloom ; Victor M NavarroSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMenopause significantly impacts women's health, yet hypothalamic changes during this transitionremain poorly understood. We analyzed gene expression in human hypothalamic samples acrossmenopausal transition, revealing s […]
- GSE282076 Occupancy-based Mechanism Is the Chief Mode of ROS1 Function in Preventing DNA Hypermethylation February 3, 2026Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Methylation profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Arabidopsis thaliana ; Brassica napusThis SuperSeries is composed of the SubSeries listed below.
- GSE317638 Effect of RXRα agonist bexarotene on gene expression in hepatocytes of hepatic RXRα knockout mice February 3, 2026Contributor : Hang ZengSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRetinoid X receptor alpha (RXRα) is a ligand-activated nuclear receptor involved in the regulation of retinoid metabolism. RXRα activation by agonist bexarotene can significantly induce hepatomegaly and promote liver regeneration after 70% partial he […]
- GSE288651 Transcriptomic analysis of human uterine leiomyoma February 3, 2026Contributor : Yue FengSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusLeiomyoma are single gene driving neoplasm and currently 5-6 associated genes identified
- GSE317742 Characterization of dendritic cells migrated from the tumor site to the thymus [RNA-Seq] February 3, 2026Contributors : Yangsong Wang ; Ryo Koyama-Nasu ; Yukihiro Endo ; Ichita Hasegawa ; Atsushi Onodera ; Mingyu Chen ; Kiyoshi Hirahara ; Shinichiro Motohashi ; Toshinori Nakayama ; Motoko Y KimuraSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study was designed to investigate the specificity of dendritic cells migrat […]
- GSE317739 Human epicardial organoids from pluripotent stem cells resemble fetal stage with potential cardiomyocyte-transdifferentiation February 3, 2026Contributors : XINLE ZOU ; FANWEN WANG ; HUILING ZHENG ; TIANCI KONGSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEpicardium, the most outer mesothelium, exerts crucial functions in fetal heart development and adult heart regeneration. Here we use a three-step manipulation of WNT signalling entwined with BMP and RA si […]
- GSE317744 Thymic CD11c+ cells [scRNA-seq] February 3, 2026Contributors : Yangsong Wang ; Ryo Koyama-Nasu ; Yukihiro Endo ; Ichita Hasegawa ; Atsushi Onodera ; Mingyu Chen ; Kiyoshi Hirahara ; Shinichiro Motohashi ; Toshinori Nakayama ; Motoko Y KimuraSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study investigates the dynamics of thymic dendritic cells (DCs) under tumor […]
- GSE317933 Toosendanin Suppresses Acute Myeloid Leukemia by Targeting DDX5/c-Myc Axis to inhibit Protein Synthesis February 3, 2026Contributors : Xianchao He ; Jing Luo ; Hongru Chen ; Yu Hou ; Dan Liu ; Yuanyuan LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe treatment of acute myeloid leukemia (AML) continues to be challenged by relapse and resistance, necessitating the development of novel therapeutic strategies. Toosendanin (TSN), a natu […]
- GSE318002 Cellular diversity of the developing chick trigeminal ganglion at single-cell resolution February 3, 2026Contributors : Arvind Arul Nambi Rajan ; Erica J HutchinsSeries Type : Expression profiling by high throughput sequencingOrganism : Gallus gallusBackground: The trigeminal ganglion (TG) is a structure of the peripheral nervous system, composed of neuronal and non-neuronal cell types, that integrates sensory input from the face and jaw. The developing TG is d […]
- GSE289429 The tumour suppressor STAG2 cooperates with DREAM to maintain quiescence in the urothelium [Hi-C] February 3, 2026Contributors : Maria Ramal ; Jaime Martínez de Villarreal ; Francisco X RealSeries Type : OtherOrganism : Mus musculusThe maintenance of quiescence is essential for tissue homeostasis. STAG2 is one of the few genes mutated in the normal urothelium of organ donors, with mutant cells undergoing positive selection 1. STAG2 is also a major tumour suppressor gene […]
- GSE317633 Elicitation of HIV broadly neutralizing antibodies from CRISPR-Cas reprogrammed B cells in non-human primates February 3, 2026Contributors : Mary Tenuta ; Morgan Bravo ; Jason WeinfurterSeries Type : Expression profiling by high throughput sequencingOrganism : Macaca mulattaHIV broadly neutralizing antibodies (bnAbs) are promising reagents for prevention and therapy of disease; however, their elicitation is constrained by genetic limitations of the human B cell antigen-receptor (BC […]