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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE273079 Castration Increases Aggressiveness of Prostatic Luminal Progenitor Cells in Prostate Cancer Through FosL1/AP-1-Mediated Transcriptional Reprogramming December 5, 2025Contributor : Florian RambowSeries Type : Expression profiling by high throughput sequencingOrganism : In this study, we show that the castration-tolerance potential of prostatic LSCmed (Lin-/Sca-1+/CD49fmed) cells is not intrinsic but rather results from transcriptomic reprogramming that further enhances their aggressiveness. Using scRNAseq specifically app […]
- GSE312440 Corticosterone drives behavioral inflexibility via plasticity-related gene expression in the dorsal striatum December 5, 2025Contributors : Michael D Murphy ; Keegan S Krick ; Shuo Zhang ; Elizabeth A HellerSeries Type : Expression profiling by high throughput sequencingOrganism : Behavioral flexibility allows organisms to modify actions based on new information, such as shifts in reward value or availability, and is promoted by the dorsomedial striatum (DMS). In contrast, behavio […]
- GSE276389 Targeted PDGFRα+ fibroblast ablation exacerbates pathologic features of asthma in house dust mite-induced allergenic asthma model December 5, 2025Contributors : Juwon Park ; Michelle D Tallquist ; Ha E Shin ; Sanyeowool An ; Jack HecklSeries Type : Expression profiling by arrayOrganism : This study demonstrates the consequence of PDGFRα+ fibroblast ablation in adult lung homeostasis in both steady-state and asthmatic conditions. Our study highlight that the essential roles of PDGFRα+ fibroblast in mai […]
- GSE240524 TET1-mediated DNA hydroxymethylation controlling ferroptosis resistance in cancer [RNA-seq] December 5, 2025Contributors : Lingling Yang ; Jun Lu ; Xi JiangSeries Type : Expression profiling by high throughput sequencingOrganism : Ferroptosis, a non-apoptotic programmed cell death marked by iron-dependent lipid peroxidation, is closely associated with cancer. Despite of intensive investigation about the molecular pathways underlying ferroptosis, the mechanism that […]
- GSE220177 Effect of TPTN on gene expression in doxorubicin-induced dilated cardiomyopathy December 5, 2025Contributors : Haiyan Chen ; Houyuan Hu ; Jianxiang ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : To investigate the intrinsic mechanism of TPTN in treating DOX-induced dilated cardiomyopathy, we established DOX-induced dilated cardiomyopathy model mice and TPTN treated mice, using healthy mice as the normal control. We then […]
- GSE249365 Spatiotemporally controlled function of SMARCA5 distinguishes pancreatic malignancy from tissue regeneration [RNA-Seq] December 5, 2025Contributors : Yong Li ; Jing Han ; Charles J David ; Mo ChenSeries Type : Expression profiling by high throughput sequencingOrganism : De-differentiation or trans-differentiation is a common response to injury in many tissues, and the processes predispose cells to cancer. Acute pancreatitis-induced acinar-to-ductal metaplasia (ADM) is similar to pancreatic […]
- GSE240526 TET1-mediated DNA hydroxymethylation controlling ferroptosis resistance in cancer [ChIP-seq] December 5, 2025Contributors : Lingling Yang ; Jun Lu ; Xi JiangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Ferroptosis, a non-apoptotic programmed cell death marked by iron-dependent lipid peroxidation, is closely associated with cancer. Despite of intensive investigation about the molecular pathways underlying ferroptosis, the […]
- GSE296930 Stromal Fibroblast Mutant Trp53 Promotes Mammary Tumor Development via Enhanced Secretion of Paracrine Factors December 5, 2025Contributors : Bin Liu ; Yun ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mutations in the tumor suppressor gene TP53 have been identified in breast cancer-associated fibroblasts and are associated with poor patient prognosis. However, the functional impact of fibroblastic mutant p53 on breast cancer development remains unc […]
- GSE283773 Exosomal Prognostic Score (EXPS)-based Prognostic Model in Pancreatic Tumours: Construction and Validation December 5, 2025Contributors : Tianyin Ma ; Yufeng YuanSeries Type : Expression profiling by high throughput sequencingOrganism : Pancreatic adenocarcinoma (PAAD) is a highly lethal malignancy with limited therapeutic options and poor prognosis. Extracellular vesicles (EVs), essential mediators of intercellular communication, are emerging as non-invasive biomarkers for diag […]
- GSE311389 Modeling Mowat-Wilson Syndrome with patient iPSCs reveals transcriptional and phenotypic defects in neural progenitors December 5, 2025Contributors : Ilaria Musante ; Giulia Gorrieri ; Serena Tamburro ; Giovanni Fiorito ; Federico Zara ; Emilia Ricci ; Paolo ScudieriSeries Type : Expression profiling by high throughput sequencingOrganism : Zinc finger E-box-binding homeobox 2 (ZEB2) is a key transcription factor involved in multiple aspects of nervous system development, including neuronal […]
- GSE301308 Tuneable hydrogel-based micropillar arrays for myelination studies. December 5, 2025Contributors : Claire Vinel ; Soufian Lasli ; Emad MoeendarbarySeries Type : Expression profiling by high throughput sequencingOrganism : Oligodendrocytes (OLs) play a critical role in central nervous system (CNS) function by myelinating axons and enabling rapid signal conduction. To model the key biomechanical parameters that regulate myelination, we develo […]
- GSE312039 Differential transcriptional effects of mycobacterial nucleomodulins MgdE and MmpE in THP-1 macrophages December 5, 2025Contributors : Chen Liu ; Baojie Duan ; Qiang Jiang ; Yifan Wang ; Yingyu Chen ; Changmin Hu ; Lei Zhang ; Aizhen GuoSeries Type : Expression profiling by high throughput sequencingOrganism : This study uses RNA-seq to quantitatively compare the gene expression profiles of THP-1 macrophages infected with the wild-type (WT), mgdE-deleted (ΔmgdE), and mmpE-del […]
- GSE312212 Evaluation of clonality in lentigo maligna December 5, 2025Contributors : Mark Shackleton ; Pacman Szeto ; Peinan Zhao ; Sophie LimSeries Type : Genome variation profiling by high throughput sequencingOrganism : Lentigo maligna (LM), a type of in situ melanoma, has a high rate of local recurrence following curative-intent surgical resection. Although recurrences might represent inadequately excised incident LMs, app […]
- GSE312234 Programmatic design and editing of cis-regulatory elements December 5, 2025Contributors : Jacob Schreiber ; Franziska K Lorbeer ; Monika Heinzl ; Franziska Reiter ; Baptiste Rafanel ; Yang Young Lu ; Alexander Stark ; William Stafford NobleSeries Type : OtherOrganism : The development of modern genome editing and DNA synthesis has enabled researchers to edit DNA sequences with high precision but has left unsolved the problem of des […]
- GSE249367 Spatiotemporally controlled function of SMARCA5 distinguishes pancreatic malignancy from tissue regeneration December 5, 2025Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : This SuperSeries is composed of the SubSeries listed below.