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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE270169 GAPDH Controls Transcript Stability, Protein Translation and Drives Proliferation in Acute Myeloid Leukemia [GAPDH_KD_RNAseq] November 5, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDysregulation of RNA binding proteins (RBPs) is a hallmark in cancerous cells.In acute myeloid leukemia (AML) RBPs are key regulators of tumor proliferation. While classical RBPs have defined RNA binding domains, RNA recognition and function in AML by non-canonical RBPs (n […]
- GSE268442 Extracellular Vesicle Transcriptome in Ischemic Stroke Rat with Intra-arterial Transplantation of Human Neural Stem Cells (microRNA) November 5, 2025Contributors : Chuheng Chang ; Yiqing Wang ; Renzhi Wang ; Xinjie BaoSeries Type : Expression profiling by high throughput sequencing ; Non-coding RNA profiling by high throughput sequencingOrganism : Rattus norvegicusExtracellular vesicles (EVs) can cross the blood–brain barrier and enter the systemic circulation, potentially acting as peripheral biomarkers […]
- GSE274232 Low caspase 8 expression promotes neuronal progenitor mimicry and small cell lung cancer metastasis November 5, 2025Contributors : Christina Grimm ; Alicja Pacholewska ; Michal R Schweiger ; Ariadne Androulidaki ; Silvia von KarstedtSeries Type : Methylation profiling by high throughput sequencingOrganism : Mus musculusMimicry of neuronal features is emerging as malignant regulator of cancer growth and metastasis. Neuroendocrine (NE) cancers including small cell lung canc […]
- GSE272588 Multipotent progenitors with distinct clonal lineage fates, transcriptomes, and surface markers yield two hematopoietic trees November 5, 2025Contributors : Fuwei Shang ; Xi Wang ; Hans-Reimer RodewaldSeries Type : Other ; Expression profiling by high throughput sequencingOrganism : Mus musculusMultipotent progenitors (MPP) are the quantitative source of native hematopoiesis that have been thought to be replenished slowly by hematopoietic stem cells (HSC). However, recent fate mapping studies have […]
- GSE237016 APOBEC3 promotes squamous differentiation and metastases via IL1A/AP-1 signaling November 5, 2025Contributors : Andrew S Truong ; Mi Zhou ; William Y KimSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusIn urothelial carcinoma, up to 70% of mutations are caused by mutagenic activity of the APOBEC3 deaminases. To dissect the role of APOBEC3 in the progression of UC, we generated a mouse model UPPA with […]
- GSE308237 CHANGE-seq-BE enables simultaneously sensitive and unbiased in vitro profiling of Cas-dependent base editor genome-wide off-target activity V November 5, 2025Contributors : Varun Katta ; Yichao Li ; Garret Manquen ; Shengdar TsaiSeries Type : OtherOrganism : Homo sapiensTo assess genome-wide off-target activity of base editors and Cas9 nucleases identified by CHANGE-seq-BE, Digenome-seq, and CHANGE-seq, we performed hybrid capture sequencing for five therupatic loci (B2M, CBLB, CD7, CIITA, PDCD1) in human primary […]
- GSE305038 A Single Day of Reduced Activity Alters the Next Day’s Transcriptomic and Metabolic Exercise Response November 5, 2025Contributors : Kevin J Gries ; Joseph McGraw ; Emily Goetz-Sutinen ; Jessica Grimm ; Jonathan Baranowski ; Mark BerresSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRegular aerobic exercise decreases the risk of metabolic diseases, however reduced physical activity may attenuate these beneficial adaptations. This study […]
- GSE244212 Liver transcriptomic profile of 3 months old wild type and hepatocyte-specific ATF6 overexpression mice November 5, 2025Contributors : Kristian Unger ; Mathias Heikenwälder ; Xin LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHepatocellular carcinoma (HCC) is the fastest growing cause of cancer-related mortality with limited therapies. While endoplasmic reticulum (ER)-stress and the unfolded protein response (UPR) are implicated in HC […]
- GSE306588 Nucleophosmin 1 lactylation in graft kidney induces ferroptotic trigger waves that exacerbate delayed graft function [RNA-Seq] November 5, 2025Contributors : Xinyuan Li ; Xin Gou ; Tianxin Lin ; Weiyang HeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe effects of NPM1 lactylation on transcriptional profiling in HK-2 cells
- GSE306531 Nucleophosmin 1 lactylation in graft kidney induces ferroptotic trigger waves that exacerbate delayed graft function November 5, 2025Contributors : Xinyuan Li ; Xin Gou ; Tianxin Lin ; Weiyang HeSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensTo identify the genome-wide binding sites of lactylated NPM1 and understand its role in transcriptional regulation.
- GSE307740 CHANGE-seq-BE enables simultaneously sensitive and unbiased in vitro profiling of Cas-dependent base editor genome-wide off-target activity III November 5, 2025Contributors : Cicera Lazzarotto ; Elizabeth Urbina ; GaHyun Lee ; Yichao Li ; Shengdar TsaiSeries Type : OtherOrganism : Homo sapiensTo assess CHANGE-seq-BE performance, we used it to characterize ABE8e-NRCH base editor activity targeting sickle mutation (HBBS) in the HBB gene and identified additional 29 (53% more) bona fide off-targets than CIRCLE-seq. Fu […]
- GSE307892 CHANGE-seq-BE enables simultaneously sensitive and unbiased in vitro profiling of Cas-dependent base editor genome-wide off-target activity IV November 5, 2025Contributors : Varun Katta ; Yichao Li ; Garret Manquen ; Shengdar TsaiSeries Type : OtherOrganism : Homo sapiensTo assess genome-wide off-target activity of base editors and Cas9 nucleases identified by CHANGE-seq-BE, Digenome-seq, and CHANGE-seq, we performed hybrid capture sequencing for five therupatic loci (B2M, CBLB, CD7, CIITA, PDCD1) in human primary […]
- GSE308047 Identification of novel gene expression programs in thrombin-stimulated hepatic stellate cells November 5, 2025Contributors : Noah Mac ; Sia Prasad ; Gina Capece ; Ricardo Martínez-Zamudio ; Conor McClenaghan ; Lauren PooleSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTranscriptional alterations of cultured hepatic stellate cells following 4, 24, or 48h control- or thrombin-stimulation were determined using RNA Sequencing. Ill […]
- GSE250515 GLIS3 RNA-seq November 5, 2025Contributors : Alok Jaiswal ; Vladislav Pokatayev ; Daniel Graham ; Ramnik XavierSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDefine the transcriptome of fibroblasts perturbed for GLIS3 in response to fibrotic stimuli.
- GSE302398 Uncovering the Roles of PPARγ and the Immunoproteasome in ILC2 Regulation November 5, 2025Contributors : Paoline Laurent ; Franck BarratSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensILC2 cells were discovered less than 10 years ago. The activation and regulation of these cells have been extensively studied and some mechanisms have been discovered, but certain regulatory pathways have yet to be defined. PPA […]