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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE278822 liver isolated single cell RNAseq v1 October 31, 2025Contributors : Maytal Gefen ; Shanny Layani ; Emma Klahr ; Zohar Shemuelian ; Johannes Brandi ; Thomas Jacobs ; Christiane Steeg ; Lorenz Adlung ; Christoph Kilian ; Merav Ordan ; Oren Gordon ; Nathalie Abudi ; Rinat Abramovitch ; Yuval Nevo ; Sharona Elgavish ; Hadar Benyamini ; Jonathan Monin ; Elina Zorde Khvalevsky ; Nofar Rosenberg ; Aurelia Markezana ; […]
- GSE201566 Differential autophagy responses in macrophages in chronic inflammatory gastrointestinal disorders October 31, 2025Contributors : Sonakshi Udinia ; Mrinmoy DasSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground & Aims: Macrophages are critical to maintain intestinal homeostasis and contribute to localized inflammation, once dysregulated. How their responses across chronic gut pathologies like idiopathic inflammation or in […]
- GSE280046 Transcriptome sequencing of THP1 cells infected with Brucella October 31, 2025Contributor : Qiu RunhuiSeries Type : Expression profiling by array ; Non-coding RNA profiling by arrayOrganism : Homo sapiensBrucella was infected at 1 MOI and cell samples were collected twelve hours later.
- GSE246890 Putative indicators of thyroid hormone system disruption - a transcriptional footprint of developmental hypothyroidism in hippocampus October 31, 2025Contributors : Louise Ramhøj ; Bertrand Evrard ; Frédéric ChalmelSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusThyroid hormone (TH) system disrupting compounds can impair brain development by perturbing TH action during critical life stages. Human exposure to TH system disrupting chemicals is therefore of great c […]
- GSE244622 Single-cell transcriptome sequencing provides insight into multiple chemotherapy resistance in a patient with refractory DLBCL: a case report October 31, 2025Contributors : Zhao Kewei ; Zhang LilingSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRelapsed and refractory diffuse large B-cell lymphoma (DLBCL) is associated with poor prognosis. As such, a comprehensive analysis of intratumoral components, intratumoral heterogeneity, and the immune microenvironment is essential t […]
- GSE270115 SGSS05-NS3 as a potent SETD8 inhibitor that activates p53 pathway in Neuroblastoma October 31, 2025Contributors : Veronica Veschi ; Carol J Thiele ; Chunhua Yan ; Ying HuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPurpose: The intergration of genetic and chemical screens identified SETD8 as a new druggable target in neuroblastoma tumor. The goal of this study is to evaluate the transcriptome profiling (RNA-seq) o […]
- GSE260601 A disrupted compartment boundary underlies abnormal cardiac patterning and congenital heart defects October 31, 2025Contributors : Benoit G Bruneau ; Irfan S Kathiriya ; Kavitha S RaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusFailure of septation of the interventricular septum (IVS) is the most common congenital heart defect (CHD), but mechanisms for patterning the IVS are largely unknown. We show that a Tbx5+/Mef2cAHF+ progenit […]
- GSE307622 Western Diet-induced Visceral Adipose Tissue Inflammation Promotes Alzheimer's Disease Pathology via Microglial Activation in a Mouse Model October 31, 2025Contributors : Soyoung Kwak ; Hae Won Kim ; Ji Sun Lim ; Jeong-Ho Hong ; Mi-Hee Yu ; Mee-Na Park ; Junho KangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIntroduction: Western diet (WD)-induced visceral adipose tissue (VAT) inflammation is characterized by adipocyte hypertrophy, hypoxia, and apoptosis. Epididymal whi […]
- GSE307469 Bulk RNA sequencing for gene expression profiling of iPSC-derived liver sinusoidal endothelial cells treated with Antithymocyte globulin compared with normal rabbit IgG October 31, 2025Contributors : Shuntaro Kawamura ; Yosuke Yoneyama ; Norikazu Saiki ; Takanori TakebeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAntithymocyte globulin (ATG) is a widely used immunosuppressive agent, yet its off-target vascular effects remain a clinical challenge in part due to a lack of relevant human models. To el […]
- GSE308226 RBMXL3 binds a wide range of RNA molecules in human TCam-2 cells (eCLIP data) October 31, 2025Contributors : Natalia Rozwadowska ; Agata Barszcz ; Erik DassiSeries Type : OtherOrganism : Homo sapiensRBMXL3 is a primate-specific gene localized on the X chromosome, which expression is detectable mainly in the male gonad. So far, very little is known about RBMXL3 protein function and its molecular network but recent reports mention the RBMXL3 gene in th […]
- GSE308045 The Peptide Genomic Therapy Increases Antibacterial Immunity and Survival in Sepsis by Reprograming the Gene Orthologs of Human Immunodeficiencies in the Spleen and Lungs October 31, 2025Contributors : Huan Qiao ; Jozef Zienkiewicz ; Yan Liu ; Jacek HawigerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSepsis is a life-threatening complication of infections afflicting 49 million patients worldwide with 11 million sepsis-related deaths. In the USA, this growing public health problem concerns 1.7 million […]
- GSE308336 PFOA impairs host immune response in viral infection October 31, 2025Contributors : Wang Hui ; Liang Yuejin ; Firose KhanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe performed scRNAseq on spleen cells pooled from 4 mice per group using the 10x Genomics scRNA-seq Flex assay, following the protocol outlined by the Chromium Fixed RNA Profiling Reagent Kit. Single cell sequencing of sp […]
- GSE308620 Effects of TCDCA-FXR on obesity-induced endothelial dysfunction and hypertension October 31, 2025Contributors : Wencheng Zhang ; Hanlin LuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRegarding the role of TCDCA in alleviating obesity-induced ED, we sought to identify the key targets that could directly clarify the biological effects of TCDCA. We carried out RNA-seq of human umbilical vein endothelial cells (HUVE […]
- GSE308621 Effects of TCDCA-FXR on obesity-induced endothelial dysfunction and hypertension II October 31, 2025Contributors : Wencheng Zhang ; Hanlin LuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRegarding the role of TCDCA in alleviating obesity-induced ED, we sought to identify the key targets that could directly clarify the biological effects of TCDCA. We carried out RNA-seq of human umbilical vein endothelial cells (HUVE […]
- GSE278554 Early transcriptional responses post-recanalization in a mouse model of middle cerebral artery occlusion October 31, 2025Contributors : Truong An Bui ; Glen C Jickling ; Ian R WinshipSeries Type : Expression profiling by arrayOrganism : Mus musculusIschemic stroke is a leading cause of death and disability worldwide. Recanalization therapies for acute ischemic stroke, which include mechanical thrombectomy and rt-PA delivery, are limited as while the operations are successful, […]