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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE303036 Eye-conic' spatial transcriptomics of keratoconus corneas April 3, 2026Contributors : Alicja Wysocka ; Katarzyna Jaskiewicz-Rajewicz ; Jakub Wozniak ; Malgorzata Rydzanicz ; Rafal Ploski ; Monika Udziela ; Jacek Szaflik ; Marzena GajeckaSeries Type : OtherOrganism : Homo sapiensThe cornea is a transparent, avascular eye tissue composed of five layers: epithelium, Bowman's layer, stroma, Descemet's membrane, and endoth […]
- GSE296612 The impact of KLF2-KLF3 regulated cellular localization on exhausted T cell differentiation [scMultiome-seq] April 3, 2026Contributors : Jian Shen ; Arjun Kharel ; Kexin GaiSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Mus musculusDuring chronic viral infection, CD8 T cells lose effector function and acquire an exhausted phenotype, a process accompanied by changes in migratory behavi […]
- GSE326932 Genotoxicity profiling reveals distinct platform- and cell type–specific effects in therapeutic gene editing for genetic hyperinflammation April 3, 2026Contributors : Lei Lei ; Masako M. Kaufmann ; Jessica Lao ; Gudrun Thoulass ; Sandra Ammann ; Hui Xiao ; Manuel Rhiel ; Viviane Dettmer-Monaco ; Julian Grünewald ; Geoffroy Andrieux ; Jamal Alzubi ; Bret R. Miller ; Kristoffer Weißert ; Linda Gräßel ; Christoph Schell ; Anna Lena Illert ; J. Keith Joung ; Melanie Boerries ; Tatjana I. Cornu ; Stephan Ehl ; M […]
- GSE304478 Copper control of the suppressive capacity in regulatory T cells [RNA-Seq] April 3, 2026Contributors : Yage Zhang ; Fan Shi ; Haoyu Tang ; Fudi Wang ; Songmin Ying ; Qian WuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusFine-tuning nutrient flow and energy production is required to sustain the functionality and survival of Tregs, yet key factors and pathways remain to be identified. Here, we show that, mi […]
- GSE286253 Tissue-specific mRNA m6A reprogramming unveils vitamin-driven post-transcriptional regulation in mice April 3, 2026Contributors : Xiaoyun Wang ; Jia Li ; Anrui LiuSeries Type : OtherOrganism : Mus musculusVitamins are critical regulators of cellular processes, yet their influence on mRNA modifications, particularly N6-methyladenosine (m6A), remains poorly understood. This study investigates the effects of various vitamins (VB2, VB6, and VB12) on the mRNA m6A epitranscrip […]
- GSE272640 Modular small RNA drives the emergence of virulence traits and environmental trade-offs in Vibrio cholerae April 3, 2026Contributors : Deepak Balasubramanian ; Salvador Almagro-MorenoSeries Type : Expression profiling by high throughput sequencingOrganism : Vibrio cholerae O1 biovar El TorThe sole gain of laterally acquired virulence genes does not fully explain the transition of environmental strains into human pathogens. To date, the specific molecular drivers and fitness t […]
- GSE326424 Aldosterone-induced gene expression changes in the brain [Multiomic] April 3, 2026Contributors : Miriam C McDonough ; Ahmet Kuralay ; Trevor C Butler ; Silvia Gasparini ; Madelin R Schwager ; Christopher L Jacobs ; Anton Gulko ; Alysia B Meyers ; Linus T Tsai ; Joel C Geerling ; Jon M ReschSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus muscu […]
- GSE293763 Impaired BCAA metabolism exacerbates vascular calcification by decreasing histone H3K23 propionylation April 3, 2026Contributors : Jianyun Yan ; Liyun FengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn this study,we report the protective effect of BCKDHA on vascular calcification in chronic kidney disease (CKD). To explore the underlying mechanism of BCKDHA's protective effect on vascular calcification, we performed high-thr […]
- GSE326453 Biomass Combustion Produces Hormone-like Pollutants: An Ignored Source April 3, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBiomass burning, including household fuels and wildfires, affects billions globally, yet the unique health-related chemical components of PM2.5 emitted from these sources remain poorly understood. Here, we demonstrate that combustion of biomass—yak dung and pine—generates […]
- GSE326425 Aldosterone-induced gene expression changes in the brain [scRNA-Seq] April 3, 2026Contributors : Miriam C McDonough ; Ahmet Kuralay ; Trevor C Butler ; Silvia Gasparini ; Madelin R Schwager ; Christopher L Jacobs ; Anton Gulko ; Alysia B Meyers ; Linus T Tsai ; Joel C Geerling ; Jon M ReschSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo uncover how aldosterone regulates gene expression in HSD2 neu […]
- GSE326616 Aldosterone-induced gene expression changes in the brain April 3, 2026Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE326622 Mechanotransduction unifies healthy non-diabetic wound healing over time by promoting a Cd14+/C1qa+ fibroblast subpopulation April 3, 2026Contributors : Kellen Chen ; Geoffrey Gurtner ; Abdelrahman Alsharif ; Katharina BerrymanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDiabetes is a major growing public health concern, but the impact on cellular impairments in chronic wounds remains incompletely understood. Fibroblasts, key players in all phases of w […]
- GSE326913 Developmentally-inspired budding morphogenesis by optogenetic receptor tyrosine kinase signaling April 3, 2026Contributors : Alex Hughes ; Louis Prahl ; Ronald Canlla ; Sandra ShefterSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe mammalian kidney relies on a branched network of collecting ducts for fluid transport and homeostasis. Replicating this network in vitro would parallelize function in synthetic replacement kidneys […]
- GSE296572 Transcriptomic analysis of therapy-naïve and alectinib-treated H3122 xenograft tumors from NSG and humanized HGF-NSG mice April 3, 2026Contributors : Bina Desai ; Andriy Marusyk ; Sandhya PrabhakaranSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo uncover the identity of the HGF-independent stromal-mediated resistance mechanism(s), we performed transcriptomic analyses of treatment-naïve and alectinib-treated H3122 xenograft tumors from NSG and humani […]
- GSE326416 Inherent Specificity and Variation Sensitivity as Quantitative Metrics for RBP Binding April 3, 2026Contributors : Joseph M Luna ; Soon Yi ; Sashi Singh ; Rohan Krishna ; Vidusha KothwelaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensInteractions between RNAs and RNA binding proteins (RBPs) regulate gene expression in eukaryotic cells. RNA-RBP affinity measurements in vitro reveal diverse binding preferences, yet app […]