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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE306829 Medial preoptic PNOC neurons constrain brown adipose tissue thermogenesis and energy expenditure June 2, 2026Contributors : Alexander Jais ; Dropmann LeaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe preoptic area (POA) of the hypothalamus is a key neural hub for thermoregulation, yet its role in modulating energy expenditure during caloric excess remains poorly defined. Here, we characterize prepronociceptin (PNOC)-expre […]
- GSE237963 Metabolic and Innate Immune Memory Alterations in Human Monocytes on Chiang-Mai-PM2.5 Stimulation June 2, 2026Contributors : Naunpun Sangphech ; Tanapat Palaga ; Tassanee Prueksasit ; Jomkhwan MeerakSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe rise of PM2.5 in air pollution correlates with increased disease exacerbation, especially in asthma. This study aims to examine how Chiang-Mai, Thailand PM2.5 (CM-PM2.5) affects in […]
- GSE188195 Depletion of DIS3 from human cell lines June 2, 2026Contributors : Dominika Foretek ; Marina Pinskaya ; Marc Gabriel ; Antonin MorillonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDIS3 is a 3’ to 5’ exoribonuclease responsible for degradation of multiple RNA targets. Most reports in human cells focus on its function in RNA surveillance in the nucleus. However, a small […]
- GSE290682 Nuclear class 3 PI3K co-activates fasting-specific chromatin remodeling June 2, 2026Contributors : Nathaniel F Henneman ; Genki Kawamura ; Ying Luo ; Arianna Segaloni ; Ivan Nemazanyy ; Samuel le Cam ; Calvin Steve Rodrigues ; Nicolas Kuperwasser ; Nicolas Cagnard ; Raphaël Margueron ; Dominik Lutter ; Takeaki Ozawa ; Ganna Panasyuk ; Catia O Dias ; Karim Hnia ; Jiaqi SuSeries Type : Genome binding/occupancy profiling by high throughput seq […]
- GSE279340 Lycopene Ameliorates Ionizing Radiation-Induced Intestinal Injury June 2, 2026Contributors : Xin Chen ; Rongli Xu ; Xin Xu ; Min DengSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusLycopene, a carotenoid known for its potent anti-inflammatory, antioxidant, and immune-modulating properties, is widely utilized in food, nutraceuticals, and medicine. This study aimed to explore the protective and the […]
- GSE298674 Targeting astrocytic CLC2(CLCN2) restores myelin regeneration through inhibition of SPP1/CD44 signaling pathway in leukoencephalopathy June 2, 2026Contributors : Lu Yang ; Yubao Lu ; Jia Liu ; Fan Zhu ; Ying Jiang ; Tingting Lu ; Xiufeng Zhong ; Wei Qiu ; Changyong Tang ; Fuhua PengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAccumulating myelin damage and impaired remyelination are central pathological features of leukoencephalopathies, including Multiple Scle […]
- GSE293170 Extracellular stiffness regulates site-specific lung development [AWO] June 2, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensExtracellular matrix (ECM) stiffness plays a crucial role in regulating cell fate and maturation, but its influence on lung development is limited known. Here we utilized stiffness-tunable gelatin methacryloyl (GelMA) hydrogels to investigate how ECM stiffness influences s […]
- GSE333609 Scutellarein accelerates diabetic wound healing by inhibiting P2RX1 and rescuing mitochondrial dysfunction and oxidative stress in fibroblasts June 2, 2026Contributors : Huang Yizhuo ; Shan Shengzhou ; Chang Mengling ; Yang Jun ; Liu FeiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground: Diabetic wounds are a major complication of diabetes mellitus and heal poorly due to persistent inflammation, fibroblast dysfunction, oxidative stress, mitochondrial injury, and i […]
- GSE333588 Single-cell mapping portrays the distinct expression features between chronic phase and B-lymphoblastic crisis samples from patients with CML June 2, 2026Contributors : Shuheng Yan ; Xuehong ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: Chronic myeloid leukemia (CML) is a biphasic clonal hematopoietic stem cell disorder driven by the Philadelphia chromosome (Ph)-encoded BCR::ABL1 oncogene. The blast phase (BP) in CML progressed from indolent chronic ph […]
- GSE333749 Glia underlies brain wide activation and sleep behavior during sickness through adrenergic-glutamatergic axis June 2, 2026Contributors : Sara B Noya ; Jianing Yang ; Amita Sehgal ; Zhifeng Yue ; Andrew NguyenSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterSickness induces coordinated changes in physiology and behavior, including increased sleep, and despite specific circuits responsible for some of them have been recently descri […]
- GSE333737 MERFISH spatial transcriptomic profiling of extracellular matrix and vascular-associated populations in the adult human pancreas June 2, 2026Contributors : Luisa K Meneses ; Zev J Gartner ; Julie B SneddonSeries Type : OtherOrganism : Homo sapiens ; synthetic constructThe extracellular matrix (ECM) and basement membrane (BM) are critical structural and signaling components of the human pancreatic endocrine niche. To define the cellular sources and spatial organization of vascular ECM programs in […]
- GSE333956 Identification of genomic features that uniquely impact estrogen receptor alpha binding and its effects on gene expression in endometrial cancer [ATAC-seq] June 2, 2026Contributors : Alexandra Richey ; Noel Kitchen ; Jason GertzSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensEstrogen receptor alpha (ER) is an established oncogenic transcription factor in breast and endometrial cancer; however, more is known about the mechanisms controlling ER behavior in breast cancer, a […]
- GSE334023 Specification of the interstitial cell lineage in the fetal mouse ovary requires balanced Notch signaling June 2, 2026Contributors : Yu-Ying Chen ; Saniya Rattan ; Chang Liu ; Xin Xu ; Humphrey YaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe ovary contains two major somatic lineages, granulosa cells and interstitial cells, that arise from progenitors within the coelomic epithelium. However, how these two lineages diverge during […]
- GSE334031 A strain-specific role for the UDP-glucose 4-epimerase Uge3 in Aspergillus fumigatus virulence June 2, 2026Contributors : Nicole E Kordana ; Charles Puerner ; Angus Johnson ; Jane T Jones ; Caitlin H Kowalski ; Katherine G Quinn ; Ko-wei Liu ; François Le Mauff ; Robert A CramerSeries Type : Expression profiling by high throughput sequencingOrganism : Aspergillus fumigatusExpression of a fungal-specific sub-telomeric gene, hrmA, in Aspergillus fumigatus is import […]
- GSE306610 Spaceflight multi-omics reveals vulnerabilities of human germ cell development June 2, 2026Contributors : Ying Li ; Hui Gao ; Jie Xiong ; Nan Wang ; Yongchun Yuan ; Linjun Wang ; Jinzhong Xu ; Wenze Huang ; Gikin Tan ; Xiaojuan He ; Qiangfeng Zhang ; Tao Zhang ; Kehkooi KeeSeries Type : Other ; Expression profiling by high throughput sequencingOrganism : Homo sapiensExposure to microgravity, cosmic radiation, and other spaceflight conditions induc […]