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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE140522 Single cell RNA-sequencing shows generation of highly proliferative and robust effector CD8 T cell populations in the tumor. November 1, 2025Contributors : Troy D Randall ; Tyler R McCaw ; Alexander F Rosenberg ; Mingyong LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo determine how Entinostat (ENT) treatment affected tumor-infiltrating CD8 T cells, we treated TS/A tumor-bearing mice with vehicle or ENT daily beginning at day 7 and performed single cel […]
- GSE280965 chrna3 modulates alcohol response in zebrafish November 1, 2025Contributors : Joshua Raine ; Caroline Kibat ; Ajay S MathuruSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioAlcohol use disorders (AUDs) are complex phenomena governed by genetics, neurophysiology, environment, and societal structures. New methods to understand the underlying neurogenetics are valuable for designing per […]
- GSE239732 MCF7 cells were cultured in pH6.6 medium for 6/12/24h November 1, 2025Contributors : Hanchu Xiong ; Liu YangSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensAcidosis has been found to have multiple effects on tumor cells and immune cells among the tumor microenvironment. Ferroptosis is a nonapoptotic and iron-dependent form of cell death characterized by the accumulation of lipid perox […]
- GSE217791 Shroom3 Affects Neuroepithelial Morphogenesis through Regulating Cytoskeletal Proteins in Cynomolgus Monkey’s Organoids November 1, 2025Contributor : Peng LiSeries Type : Expression profiling by high throughput sequencingOrganism : Macaca fascicularisThe loss of SHROOM3 plays an important role at the neuroepithelial stage, demonstrating the indispensability of SHROOM3 and indicating the great potential of organoids in understanding the mechanism of neural tube defects (NTDs).
- GSE247983 Remodeling of 3D Gene Architecture in Myocardium from Embryonic Development to Early Aging [snRNA-Seq] November 1, 2025Contributors : Yuwei Gou ; Qianzi TangSeries Type : Expression profiling by high throughput sequencingOrganism : Sus scrofaHeart-related diseases are increasingly attacking the younger population, and getting more prevalent as the population ages. Better understanding of heart development and aging could help decipher the mechanism of associated heart diseas […]
- GSE247255 scRNA-seq for E16.5 intestinal epithelial cells grown in conventional organoid cultures or as engineered tissues November 1, 2025Contributors : Martti Maimets ; Cecilia Lövkvist ; Astrid M Baattrup ; Stine L Hansen ; Kim B JensenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAs part of our characterization of cellular complexity within our in vitro cultures, we performed scRNA-seq experiments analysing mouse E16.5 intestinal epithelial cells cul […]
- GSE308362 Fat sensory cues in early life program central response to food and obesity November 1, 2025Contributors : Laura Casanueva Reimon ; Ayden Gouveia ; André Carvalho ; Joscha Schmehr ; Mouna El Mehdi ; Rolando Moreira-Soto ; Carlos Ardanaz ; Janice Bulk ; Lionel Rigoux ; Paul Klemm ; Anna Lena Cremer ; Frederik Dethloff ; Yvonne Hinze ; Heiko Backes ; Patrick Giavalisco ; Sophie SteculorumSeries Type : Expression profiling by high throughput sequencin […]
- GSE275486 Single cell-RNA Sequencing Shows Exercise Protects db/db Mouse Pancreatic Injuries by Regulating Endothelial Cells Homeostasis November 1, 2025Contributors : Wenya Weng ; Manjuan Li ; Mengmeng Peng ; Zixuan Wang ; Guoyong Fan ; Shicui Jiang ; Chi Zhang ; Xuemian LuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe prevalence and mortality rates of type 2 diabetes mellitus (T2DM) continue to increase, imposing a significant burden on individuals and nations wo […]
- GSE308584 Position-Specific Methylation of Benzo[a]pyrene Drives AHR-Dependent Fin Duplication in Zebrafish November 1, 2025Contributors : Mackenzie L Morshead ; Lisa Truong ; Robyn L TanguaySeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioPolycyclic aromatic hydrocarbons (PAHs) are an environmental contaminant class characterized by fused aromatic rings. PAHs are released through the incomplete combustion of organic materials as well as petro […]
- GSE308471 transcriptomic differences between ACMs stimulated with a high LCAC C16 concentration and control November 1, 2025Contributors : Rui Lin ; Yuan WangSeries Type : Expression profiling by high throughput sequencingOrganism : RattusAbout 20% of acute myocardial infarction (AMI) patients with multivessel disease experience adverse outcomes after complete revascularization. We aim to investigate the underlying metabolic mechanism of ischemia-reperfusion injury responsible fo […]
- GSE308638 The conserved Prp40 WW domains facilitate non-canonical intron splicing via bridging 5'-splice-site and branch-site interaction November 1, 2025Contributors : Luh Tung ; Chung-Shu Yeh ; Hsin-Hung Lin ; Hsin-Yue Tsai ; Shang-Lin Chang ; Hsuan-Kai Wang ; Amy Larson ; Fu-Lung Yeh ; Chia-Ling Hsu ; Jeffery A Pleiss ; Cheng-Fu Kao ; Wei-Hau Chang ; Tien-Hsien ChangSeries Type : Expression profiling by high throughput sequencingOrganism : Saccharomyces cerevisiaePrecise regulation of molecular interaction […]
- GSE308892 Variant-specific interaction of kinectin 1 with the multi–tRNA synthetase complex regulates ER sheet organization November 1, 2025Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensKinectin 1 (KTN1) is an integral endoplasmic reticulum (ER) sheet protein that functions in ER organization and translation elongation. Alternative splicing introduces sequence diversity into the cytoplasmic region of KTN1, but the functional relevance of these var […]
- GSE309058 An isodecoder‑resolved map of mouse tRNAs, tRNA‑derived small RNAs, and RNA modification signatures across 19 tissues November 1, 2025Contributors : Aidan C Manning ; Todd M Lowe ; Patricia P ChanSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Mus musculusTransfer RNAs (tRNAs) and their derived small RNAs (tDRs) vary across mammalian tissues, but the . We applied Ordered Two-Template Relay sequencing (OTTR-seq) to profile small RNAs in 19 tissues from adult m […]
- GSE280917 Loss of METTL3 potentiates transposable element expression and drives inflammation-induced cell plasticity in the mammary epithelium [ChIP-seq] November 1, 2025Series Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensSustained proliferation and aberrant cellular plasticity are the hallmarks of breast premalignancy, yet the mechanisms driving this process remain unclear. Using CRISPR knockout screens, we systematically characterized the regulators of cellular fitness in th […]
- GSE306909 Enhancer Remodeling-Driven Mevalonate Pathway Confers Resistance to KRAS Inhibitor in Colorectal Cancer November 1, 2025Contributors : Yaoyu Guo ; J TanSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiensThis study investigates the resistance mechanisms to pan-KRAS inhibitors in colorectal cancer (CRC). We established a panel of patient-derived organoids (PDOs) and cell lines […]