Healthcare updates

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE318201 Immunological responses and clinical outcomes in dogs with osteosarcoma receiving standard therapy and a Listeria vaccine expressing HER2 January 31, 2026
  Contributors : Nicola J Mason ; Laura Selmic ; Audrey Ruple ; Cheryl A London ; Lisa Barber ; Kristen Weishaar ; James A Perry ; Jennifer Mahoney ; Brian Flesner ; Jeffrey N Bryan ; Jennifer L Willcox ; Jenna H Burton ; David M Vail ; William C Kisseberth ; Cheryl E Balkman ; Angela L McClearyWheeler ; Katie M Curran ; Haley Leeper ; John Paul Woods ; Anthon […]
• GSE305420 RHOV is a Detachment-Responsive Rho GTPase Necessary for Early Metastatic Reprogramming in Ovarian Cancer January 31, 2026
  Contributors : Nadine Hempel ; Amal T ElhawSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTranscoelomic dissemination is the predominant route of ovarian cancer metastasis and a major driver of patient mortality. In our pursuit to identify novel tumor cell adaptations necessary for metastatic spread, we identified a co […]
• GSE254752 Reciprocal Activating Interactions between Neurons and Metaplastic Acinar Cells Promote Cancer Initiation and Progression in Pancreas January 31, 2026
  Contributors : Fang Wei ; Qi Zou ; Jie He ; Keping XieSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNerves are a critical component of tumor microenvironment. This study investigated the interactions between acinar-to-ductal metaplasia (ADM) and neural infiltration and their consequential impacts on the initiation and […]
• GSE171764 Gene expression analysis in Dengue virus infection January 31, 2026
  Contributors : S Gowri Sankar ; A Alwin Prem AnandSeries Type : Expression profiling by arrayOrganism : Homo sapiensDifferential gene expression in dengue severity from serum samples
• GSE285931 Two thymidylate synthase inhibitory drugs induce markedly different genomic uracil patterns, mutagenic processes and cellular response in HCT116 colon cancer cells [re-analysis of GSE126822] January 31, 2026
  Contributors : Eszter Holub ; Gábor Papp ; Hajnalka L Pálinkás ; Milda B Szajkó ; Richard Izrael ; Beáta G Vértessy ; Angéla BékésiSeries Type : OtherOrganism : Homo sapiensThe presence of genomic uracil and its respective repair play key roles in colorectal, gastric, and other solid tumor therapies targeting thymidylate biosynthesis. Previously, we establis […]
• GSE278468 Single cell mRNA sequencing of Peyer's patch LysoDCs and cDC2s and blood CD45+CD115hi cells January 31, 2026
  Contributors : Cécilia Luciani ; Margaux Lagier ; Camille Wagner ; Alexandre Bonomo ; Rose Hardy ; Hugues LelouardSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe investigated the genetic relatedness between CD115hi blood cell subsets, LysoDCs and Peyer's patch cDC2s, a close but ontogenically unrelated phagocyte […]
• GSE317716 Influence of gut microbiota on oral drug absorption and metabolism January 31, 2026
  Contributors : Purna C Kashyap ; Krishna R Kalari ; Karunya K KandimallaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGut microbiota are known to influence oral drug disposition, yet the specific host pathways they affect remain poorly characterized. This study provides a transcriptome-wide characterization of how phy […]
• GSE288409 The 3D genomics of lampbrush chromosomes highlights the role of active transcription in chromatin organization [scHi-C] January 31, 2026
  Contributors : Timofey Lagunov ; Maria Gridina ; Artem Nurislamov ; Tatiana Kulikova ; Antonina Maslova ; Viktor Konstantinov ; Andrey Popov ; Alla Krasikova ; Veniamin FishmanSeries Type : OtherOrganism : Gallus gallusLampbrush chromosomes are giant meiotic bivalents in growing oocyte nuclei that have served as a classic model system for studying chromatin […]
• GSE317918 A Longitudinal, Multi-omic Atlas Reveals the Emergence of a Spatially Organized Immunosuppressive Ecosystem in Resistant Melanoma [SNV] January 31, 2026
  Contributor : Gao ZhangSeries Type : Genome variation profiling by arrayOrganism : Homo sapiensThis study employed the NanoString nCounter platform to perform targeted, quantitative molecular profiling of longitudinally collected FFPE tumor samples to elucidate molecular mechanisms underlying resistance to anti–PD-1 therapy. nCounter® Vantage 3D™ Single Nucl […]
• GSE317912 A Longitudinal, Multi-omic Atlas Reveals the Emergence of a Spatially Organized Immunosuppressive Ecosystem in Resistant Melanoma January 31, 2026
  Contributor : Gao ZhangSeries Type : Protein profiling by protein arrayOrganism : Homo sapiensThe goal of this study is to explore the mechanisms of resistance in melanoma under various immunotherapy treatments, particularly focusing on anti-PD-1 therapy, through the analysis of RPPA data. The study includes 38 tumor samples from two melanoma patients, with […]
• GSE317936 A Longitudinal, Multi-omic Atlas Reveals the Emergence of a Spatially Organized Immunosuppressive Ecosystem in Resistant Melanoma [nCounter protein] January 31, 2026
  Contributor : Gao ZhangSeries Type : Protein profiling by protein arrayOrganism : Homo sapiensThis study employed the NanoString nCounter platform to perform targeted, quantitative molecular profiling of longitudinally collected FFPE tumor samples to elucidate molecular mechanisms underlying resistance to anti–PD-1 therapy. nCounter® Vantage 3D™ Single Nucle […]
• GSE317937 A Longitudinal, Multi-omic Atlas Reveals the Emergence of a Spatially Organized Immunosuppressive Ecosystem in Resistant Melanoma [nCounter RNA] January 31, 2026
  Contributor : Gao ZhangSeries Type : Expression profiling by arrayOrganism : Homo sapiensThis study employed the NanoString nCounter platform to perform targeted, quantitative molecular profiling of longitudinally collected FFPE tumor samples to elucidate molecular mechanisms underlying resistance to anti–PD-1 therapy. nCounter® Vantage 3D™ Single Nucleotide […]
• GSE318153 Tumor cytokine profiles in a radioresistant TC-1 mouse model treated with IL-7 and radiotherapy January 31, 2026
  Contributors : Jung Yoon Ho ; Jin-Gwan Jeon ; Mi-Ryung Han ; Sung Jong Lee ; Soo Young Hur ; Youn Jin ChoiSeries Type : Protein profiling by protein arrayOrganism : Mus musculusCytokine and chemokine expression profiles were generated to characterize treatment- and radioresistance-associated differences in the tumor microenvironment of a TC-1 mouse model. Us […]
• GSE302731 Micro-bulk RNA-seq of trilaminar omphalopleure of Monodelphis domestica to investigate placental cytokine signaling January 31, 2026
  Contributors : Daniel J Stadtmauer ; Gunter P WagnerSeries Type : Expression profiling by high throughput sequencingOrganism : Monodelphis domesticaThe brief placental attachment of the gray short-tailed opossum Monodelphis domestica spans only the final two days of the 14-day pregnancy. During this time the fetus grows rapidly and a pronounced spike in infl […]
• GSE317695 Identification progenitor Keratinocyte Subpopulations in HaCaT via high throughput sequencing January 31, 2026
  Contributor : Garrido EfraínSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEpidermal progenitor cells rely on tightly regulated transcriptional and epigenetic programs to preserve cellular plasticity and prevent premature differentiation; however, these regulatory mechanisms remain incompletely characterized. In this s […]