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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE292862 Modelling mouse embryogenesis from chemically induced totipotent stem cells August 8, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe ability to faithfully initiate embryogenesis from a single, induced non-germline cell type, akin to the totipotent blastomeres, remains a significant challenge in developmental and synthetic biology. In this study, we established conditions that enabled the continuous […]
- GSE342913 In situ targeted gene expression analysis of postnatal mouse cortex of LgDel model 22q11.2 deletion sydnrome, including treatment with antioxidant August 8, 2026Contributors : Thomas M Maynard ; Shah Rukh ; Daniel W Meechan ; Zachary D Erwin ; A S LaMantiaSeries Type : OtherOrganism : Mus musculusThe antioxidant N-acetyl cysteine (NAC) restores growth and connectivity of developing upper layer cortical projection neurons and improves cognitive performance in the LgDel mouse model of 22q11.2 Deletion Syndrome. This X […]
- GSE304706 Persistent ER stress in macrophages fuels age-related inflammation and vulnerability to infection August 8, 2026Contributors : Jialiang Guan ; Tianyu Zhao ; Ying LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAging is accompanied by a state of chronic, low-grade inflammation known as inflammaging that underlies increased susceptibility to infection and many age-related pathologies. Although macrophages are central to immune r […]
- GSE274275 Effect of depletion of NSUN4 on gene expression of NCI-H226 cells [RNA-seq] August 8, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAim: To study the biological function of NSUN4 in regulating gene expression and cell proliferation.
- GSE237489 RNA-seq for iPSC-derived macrophages with/without Lipopolysaccharide (LPS) stimulation. August 8, 2026Contributors : Mo Li ; Xuan Zhou ; Baolei YuanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWiskott-Aldrich syndrome (WAS) is an immunodeficiency disorder caused by the dysfunction of the Wiskott-Aldrich syndrome protein (WASP). Although the effect of WASP on actin -polymerization is well studied, less is known about […]
- GSE274335 RNA-Seq analysis LPCAT3 knockdown effect on primary human endometrial stromal cells(HESC). August 8, 2026Contributor : Jia QiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDecidualization of human endometrial stromal cells (HESCs) is a critical process in the establishment of uterine receptivity and successful pregnancy. It involves profound cellular and molecular changes, including alterations in energy metabolism, which […]
- GSE274322 Using the Banff Human Organ Transplant (B-HOT) panel to profile the characteristics of BTM, along with the corresponding FFPE and frozen materials August 8, 2026Contributors : Ziyang Li ; Marij J Welters ; Hans J Baelde ; Jesper KersSeries Type : Expression profiling by arrayOrganism : Homo sapiensHigh correlation coefficients across the B-HOT panel (770 genes) suggested negligible effects of storage times within 24 hours on gene expression analysis.The BTM group displayed a higher proportion of immune cell gene exp […]
- GSE341616 A conserved HAND2-HAND2_OE-SMAD1/5/9 axis drives hepatic stellate cell activation and extracellular matrix overproduction in multiple fibrotic etiologies August 8, 2026Contributors : Renyong Lin ; Xiaojuan Bi ; Ning YangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe transcription factor HAND2 plays critical roles in development, but its function in hepatic stellate cells remains largely unexplored. To elucidate the transcriptional landscape modulated by HAND2, we performed RNA‑se […]
- GSE341413 Single-cell RNA-seq atlas of the intestine of Cyrtotrachelus buqueti August 8, 2026Contributors : Hanyu Wang ; Wencong Long ; Xuebing Han ; Wenli Xin ; Yaojun YangSeries Type : Expression profiling by high throughput sequencingOrganism : Cyrtotrachelus buquetiSingle-cell RNA sequencing was performed on gut tissues of Cyrtotrachelus buqueti, including larval anterior midgut, larval posterior midgut, larval hindgut, and adult hindgut, to cha […]
- GSE342447 TH-positive pulmonary nerve fiber-epithelial interaction promotes adipose thermogenesis in male mice [C22_RNA-seq] August 8, 2026Contributors : Junkun Jiang ; Bing LuanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCold exposure activates sympathetic neurons in adipose tissue to maintain thermal homeostasis. However, whether sympathetic activation in non-adipose tissues contributes to cross-organ regulation of adipose thermogenesis remains uncle […]
- GSE341948 Multi-tissue transcriptomic landscape reveals synergistic mechanisms of exercise and GLP-1 agonist in ameliorating diabetic phenotypes in db/db mice August 8, 2026Contributors : Hua Liu ; Zhenghong Kang ; Shijie Lai ; Jianting Sun ; Zhiyu Wang ; Yanzhi XuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusType 2 diabetes mellitus (T2DM) involves coordinated multi-organ metabolic dysfunction, yet the systems-level effects of combined pharmacological and exercise interventions remain u […]
- GSE342455 Transcriptomic profiling of tumor-associated macrophages following pharmacological SYK inhibition in a human breast cancer co-culture model August 8, 2026Contributors : Gonçalo Trindade ; Giacomo Domenici ; Miguel Pinto ; Viviana Correia ; Sofia Batalha ; Nádia Duarte ; Angelina S Palma ; Inês A Isidro ; Catarina BritoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTumor-associated macrophages contribute to immunosuppression in breast cancer. To investigate the transcrip […]
- GSE342462 Integrated transcriptomic and bioelectrical profiling of stem-like cellular states in a colorectal cancer using SdFFF and UHF-DEP August 8, 2026Contributors : Charlotte Jemfer ; Stephanie Durand ; Elisa Blin ; Gaelle Begaud ; Serge BattuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCancer stem-like cells (CSCs) enrichment and characterization remain an analytical challenge, as conventional marker-based approaches are often time-consuming and can alter cellula […]
- GSE342477 Characterization of an Antagonistic Antibody reactive to human and mouse TNFR2 with Anti-tumor Capacity August 8, 2026Contributor : Yang GaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAccumulating evidence indicate that tumor necrosis factor receptor type II (TNFR2) is a promising target for cancer immunotherapy, but the species-restricted reactivity of anti-human TNFR2 antibodies limits their mechanistic study in mouse tumor model […]
- GSE285471 APOE genotype modifies the gene signature of microglial and astrocytic responses to aging August 8, 2026Contributors : Wenhui Qiao ; Tadafumi C Ikezu ; Na ZhaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo determine how APOE genotypes impact the gene signature of microglia and astrocytes during aging at single cell level, we isolated brain cells from young (3 month of age) and aged (24 month of age) APOE2 and APOE3 an […]