Healthcare updates

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE313946 Mathematical modelling reveals a ribosome level-induced survival checkpoint in drug-tolerant cancer persister cells March 15, 2026
  Contributors : Xinpu Tang ; Yi Pu ; Yuqing Wang ; Shensi ShenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusSystemic treatments for advanced cancers initially provide benefits but rarely lead to a cure due to acquired resistance. Drug-tolerant persister (DTP) cells, devoid of new mutations, can temporari […]
• GSE261616 SS-31 protects against paraquat-induced lung injury and fibrosis via inhibition of the MAPK signal pathway March 15, 2026
  Contributors : Quankuan Gu ; Peiyao Luo ; Jianpeng Wang ; Huanhuan Liu ; Xianyong Li ; Yang Chong ; Jiannan Zhang ; Yiqi Wang ; Mingbo Zhao ; Wei Yang ; Xianglin Meng ; Mingyan ZhaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAims: To explore the therapeutic effect of SS-31 on lung injury and lung fibrosis caused by […]
• GSE324546 Anti-leukemic effect of MAR-3.6.2, a novel RAN inhibitor, on AML-LSCs by targeting RAN. March 15, 2026
  Contributor : Truong NguyenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe small GTPase RAN plays a role in the biogenesis of mature miR-126, which is supplied by the bone marrow arterioles to leukemic stem cells (LSCs). MiR-126 supports the homeostasis of LSCs that initiate and maintain acute myeloid leukemia (AML) […]
• GSE292304 The m5C orchestrator NSUN7 drives SPARC/HMGB1 axis–mediated inflammation to exacerbate kidney injury [MeRIP-Seq] March 15, 2026
  Contributors : Yuhang Dong ; Xiaoming MengSeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensGrowing evidence indicates that kidney inflammation is a major contributor to the pathogenesis of various renal diseases, including acute kidney injury (AKI). Although RNA modifications have been implicated in regulating kidney in […]
• GSE292038 CITE-Seq analysis of intratumoral immune cells from YUMM1.7 melanoma treated with anti-PD-1 therapy. March 15, 2026
  Contributors : Julia Krug ; Iris C Mueller ; Nazia Afrin ; Fabian Imdahl ; Matthias Goebeler ; Emmanuel Saliba ; Clément Cochain ; Angela Riedel ; Astrid SchmiederSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusMetastatic melanoma remains a disease difficult to treat, as 50% of the patients are resistant to immu […]
• GSE308175 Uhrf1 loss alters Ctcf-mediated topological organization during early mouse embryogenesis March 15, 2026
  Contributors : Agata Kurowski ; Bohan Zhu ; Yifei Sun ; Nimisha Jain ; Ashley Chan ; Martin J. Walsh ; Sai MaSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusUHRF1 is a chromatin-binding protein essential for maintaining DNA methylation and histone modifi […]
• GSE293257 TGF-β1 Inhibits IL-1β-Induced Chemokine Expression in Human Synovial Fibroblasts March 15, 2026
  Contributors : Lei Cai ; Robert Brophy ; Tycksen Eric ; Muhammad Farooq RaiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPurpose: Fibroblast-like synoviocytes (FLSs) play a crucial role in maintaining joint homeostasis by secreting matrix components and lubricin [1, 2]. However, under inflammatory conditions, FLSs con […]
• GSE324138 A Comparative Analysis of the Methylation Status of Non-Coding RNA promoters in Fibroid and Matched Myometrium March 15, 2026
  Contributors : Tsai-Der Chuang ; Shawn Rysling ; Abigail Wiseman ; Gabriela Alfaro ; Sayna P Jahromi ; Sepideh P Jahromi ; Omid KhorramSeries Type : Non-coding RNA profiling by array ; Methylation profiling by arrayOrganism : Homo sapiensGenomic DNA from 8 paired uterine leiomyoma (fibroid) and matched myometrial tissues was analyzed using the Arraystar Huma […]
• GSE324112 Gene expression profiling of lung organoids at CSD5, CSD14, and ND14 stages. March 15, 2026
  Contributors : Syahidatulamali C Shaffi ; Badrul HishamSeries Type : Expression profiling by arrayOrganism : Mus musculusLung organoid culture in both normal and COPD-derived from cigarette smoke exposure of COPD mice model.We used microarrays to analyse the molecular mechanisms and pathways involved in regulating the regenerative potential of lung stem cell […]
• GSE324442 Comprehensive stage- and tissue-specific transcriptome of the global ecosystem service insect, marmalade hoverfly Episyrphus balteatus March 15, 2026
  Contributors : He Yuan ; Huiru Jia ; Xianyong Zhou ; Hui Li ; Kongming WuSeries Type : Expression profiling by high throughput sequencingOrganism : Episyrphus balteatusHoverflies (Diptera: Syrphidae) are globally beneficial insects that provide key ecological services, such as pollination and biological pest control. Importantly, extensive research has revea […]
• GSE324401 Evaluation of the immortalized primary human hepatocyte cell line Fa2N-4 as a model for MASLD March 15, 2026
  Contributors : Victoria E.J.M. Palasantzas ; Dicky Struik ; Trijnie Bos ; Mirjam Koster ; Jody Gelderloos-Adders ; Ellen Vos ; Krista van Dijk-Bos ; Sebo Withoff ; Jingyuan Fu ; Joanne A Hoogerland ; Johan W JonkerSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground and aims: Metabolic dysfunction-associated steat […]
• GSE324467 Targeting E-Proteins Licenses cDC1 Immunogenicity for Potent Anti-Tumor Vaccination [RNA-seq] March 15, 2026
  Contributors : Xiaoyu Zhai ; Ping Gao ; Xiaojuan Han ; Xi Wang ; Xiangwen Liu ; Chao Li ; Yuanyuan Shi ; Baidong Hou ; Xuyu Zhou ; Jianwei Wang ; Jian Song ; Fuping ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusType 1 conventional dendritic cells (cDC1s) are essential for priming anti-tumor CD8⁺ T cells, yet the […]
• GSE324468 Targeting E-Proteins Licenses cDC1 Immunogenicity for Potent Anti-Tumor Vaccination [ChIP-seq] March 15, 2026
  Contributors : Xiaoyu Zhai ; Ping Gao ; Xiaojuan Han ; Xi Wang ; Xiangwen Liu ; Chao Li ; Yuanyuan Shi ; Baidong Hou ; Xuyu Zhou ; Jianwei Wang ; Jian Song ; Fuping ZhangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusType 1 conventional dendritic cells (cDC1s) are essential for priming anti-tumor CD8⁺ T c […]
• GSE324477 Root Internalization and Temperature-Dependent Regulation of Persistence and Virulence Genes in Pseudomonas aeruginosa PAO1 on Oak Leaf Lettuce March 15, 2026
  Contributors : Tim Hoffmann ; Jennifer GrieseSeries Type : Expression profiling by high throughput sequencingOrganism : Pseudomonas aeruginosa PAO1Increasing evidence of Pseudomonas aeruginosa on fresh plant-based foods raises food safety concerns. While internalization of pathogens such as Salmonella enterica in vegetables such as lettuce is well documented […]
• GSE311942 Transcriptome profiling of human dermal fibroblasts transfected with tRF-34 mimics or negative control under UVA1 exposure March 15, 2026
  Contributors : Xiaoxi Dai ; Dan Huang ; Zhuohong Xu ; Lihao Liu ; Pianpian Hong ; Yu Hu ; Kun Chen ; Jiaan ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapienstRNA-derived fragments (tRFs) are emerging regulators of cellular senescence and stress responses. In this study, we profiled transcriptomic changes in primary h […]