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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE301517 Chromatin topology dynamics of dexamethasone-treated trabecular meshwork identifies 78 causal genes for intraocular pressure and primary open angle glaucoma [RNA-seq] April 10, 2026Contributors : Nivedita Singh ; Zachary Batz ; Jayshree Advani ; Milton A English ; Rupalatha Maddala ; Ponugoti Vasantha Rao ; Anand SwaroopSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe physiology of trabecular meshwork (TM) controls aqueous humor outflow resistance and thereby intraocular pressure (IOP), a major […]
- GSE300087 Macropinocytosis inhibition attenuates pro-fibrotic responses in lung fibroblasts and pulmonary fibrosis April 10, 2026Contributors : Konstantin Tsoyi ; Ivan O Rosas ; Coarfa Cristian ; Ruiz Maria Elisa ; Waich AlanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe conducted a single cell RNA sequencing experiment to determine the effect of a macropinocytosis inhibitor (5-(N-ethyl-N-isopropyl)-Amiloride, EIPA) in Precision Cut Lung Slic […]
- GSE302740 Dehydration promotes intracellular lipid synthesis and lipid accumulation April 10, 2026Contributors : Jason Watts ; Juan Arroyo Ornelas ; Ma Wan ; Don DelkerSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusNFAT5 is transcription factor that regulates gene expression in response to hypertonic stress. Here we profile NFAT5 occupancy before and hour following hypertonic stress in mouse inner med […]
- GSE302540 TRAPPC4 resists ferroptosis and promotes head and neck squamous cell carcinoma progression by regulating GPX4 protein stability via TRIM55 April 10, 2026Contributors : Zhao Ding ; Yanxun Han ; Xiaojun ZhaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensFerroptosis resistance continues to be a major challenge in the treatment of head and neck squamous cell carcinoma (HNSCC), yet the molecular mechanisms driving this resistance remain inadequately understood. Here, we cond […]
- GSE288724 Network analysis of normal colon organoids exposed to metformin reveals likely regulatory role for colorectal cancer genome-wide association study candidate genes April 10, 2026Contributors : Matthew Devall ; Graham Casey ; Li LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHere we aimed to define the effects of a three-day, 24-hour repeated dose exposure of metformin (90um) of colon epithelial cell gene expression through RNA-seq and network analysis (WGCNA) of 10 colon organoid lines deriv […]
- GSE243728 Cross-platform Hi-C meta-analysis identifies functional insulators that actively block enhancer-promoter interactions April 10, 2026Contributors : Wanying Xu ; Jian Cui ; Shanshan Zhang ; Leina Lu ; Xiaoxiao Liu ; Yan Li ; Fulai JinSeries Type : Other ; Genome binding/occupancy profiling by high throughput sequencing ; Third-party reanalysisOrganism : Mus musculusInsulator protein CTCF controls genome architecture through forming thousands of cohesin-dependent structural loops. However, […]
- GSE327108 Tet governs transcriptional programs required for intestinal stem cell development and homeostasis April 10, 2026Contributors : Niccole Auld ; Ye-Jin Park ; Yanyan Qi ; Hongjie LiSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterFor two decades, Drosophila intestinal stem cells (ISCs) have served as a premier model for studying somatic stem cell biology. Yet, the intrinsic mechanisms driving divergent developmental trajec […]
- GSE293833 The impact of SOGA1 deficiency on gene expression in ovarian cancer cells April 10, 2026Contributor : Min LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSOGA1 is an autophagy-related factor that significantly influences cancer progression.Here, we identified the critical role of SOGA1 in the diagnosis and prognosis of ovarian cancer through bioinformatics analysis.Further functional experiments demonstr […]
- GSE327455 DYRK1A enhances antitumor immunity in type 1 conventional dendritic cells via mTORC1 activation [tumor-infiltrating type 1 conventional dendritic cells] April 10, 2026Contributors : Hongjiao Wang ; Songlin He ; Pan Zhu ; Zuliang JieSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusType 1 conventional dendritic cells (cDC1s) play an integral role in mediating immune responses and maintaining homeostasis, yet the molecular mechanisms underlying their functions remain poorly understood. I […]
- GSE327265 Single-cell RNA sequencing of ancestral and evolved Saccharomyces cerevisiae across 20 environmental conditions April 10, 2026Contributors : Annisa Dea ; Yongqing Lan ; Valeryia Aksianiuk ; David Pincus ; Arjun S RamanSeries Type : Expression profiling by high throughput sequencingOrganism : Saccharomyces cerevisiaeWe performed single-cell RNA sequencing (scRNA-seq) of Saccharomyces cerevisiae cells across 20 environmental conditions using a lab w303 strain (ancestral) and an evolv […]
- GSE327598 Cyclin-dependent kinase-9 and oxidative phosphorylation inhibition overcome ibrutinib resistance in mantle cell lymphoma April 10, 2026Contributors : Carly Roleder ; Xiaofan Zhao ; Vi Lam ; Edward C Dominguez ; Canping Chen ; Sonia Rodgriguez-Rodriguez ; Lili Wang ; Tycel Phillips ; Sonia Rodgriguez-Rodriguez ; Zheng Xia ; Alexey V DanilovSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensResistance to Bruton tyrosine kinase inhibitors (BTKi) is inevitabl […]
- GSE327614 Early cell autonomous and niche-mediated alveolar epithelial response to influenza infection in primary lung organoids April 10, 2026Contributors : Amber Elitz ; William J ZachariasSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusInfluenza A virus (IAV) infection is a significant cause of morbidity and mortality for patients worldwide. Alveolar type 2 (AT2) cells are the […]
- GSE327644 Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells April 10, 2026Contributors : Hyuncheol Jung ; Pascal Devant ; Carter Ching ; Mineto Ota ; Emma Dann ; Ronghui Zhu ; Chandrima Modak ; Ana Vasquez-Ibarra ; Jennifer Hamilton ; Zachary Steinhart ; Wayne Ngo ; Luis Sandoval ; Jae Hyung Jung ; Jenny Lee ; Da Xu ; Meirui An ; Esha Urs ; Peixin Amy Chen ; Vincent Allain ; Takuya Tada ; Brian Shy ; Jonathan Pritchard ; James K N […]
- GSE295693 Small RNA sequencing of extracellular vesicles extracted from adipose tissue of healthy weight or obese human subjects April 10, 2026Contributor : Jin WangSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensWe identified EVs as novel regulatory factors that mediate adipose tissue–brain communication and are crucial for the central control of whole-body energy homeostasis. Our findings reveal that AT-EVs and their cargo microRNAs (miRNAs) are crucial […]
- GSE327095 C1q and immunoglobulins mediate activity-dependent synapse loss in the adult brain. April 10, 2026Contributors : Gerard Crowley ; Minjung Kim ; Nathanael O’Neill ; Emir Turkes ; Fateme Ghasemi ; Luca Giudice ; Sebastiaan De Schepper ; Benjy J. Y. Tan ; Benito Maffei ; Laís S. S. Ferreira ; Julie Rebejac ; Javier Rueda-Carrasco ; Margarita Toneva ; John Christian Fajardo ; Judy Z. Ge ; Zhengyue Grace Yang ; Paula Korhonen ; Phillip Muckett ; Damaris Benne […]