Healthcare updates

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE325583 Mest transcript elongation to Mestxl sustains, but does not initiate, maternal allele bias of the convergent gene Copg2 in neural differentiation (Cut&Run) August 26, 2026
  Contributors : Sophie Périllous ; Céline Gonthier-Guéret ; Philippe Arnaud ; Franck CourtSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusPrecise gene dosage control is critical for establishing cellular identity and development, especially for imprinted genes, where dosage imbalances are linked to severe p […]
• GSE270955 DNMT3L safeguards the epigenome and differentiation potential of human naive pluripotent stem cells and blastoids [RNA-Seq] August 26, 2026
  Contributors : Sherif Khodeer ; Thi-Xuan-Ai Pham ; Kobe De Ridder ; Zicong Liu ; Sigrid Verhelst ; Darren Taylor ; Adam Bendall ; Nikky Corthout ; Saurabh J Pradhan ; Ruben Almey ; San-Kit To ; Sam S van Knippenberg ; Bradley P Balaton ; Amitesh Panda ; Hilde Van de Velde ; Simon Andrews ; Nicolas Rivron ; Peter J Rugg-Gunn ; Michelle Percharde ; Maarten Dha […]
• GSE330591 DNMT3L safeguards the epigenome and differentiation potential of human naive pluripotent stem cells and blastoids [sciMET] August 26, 2026
  Contributors : Sherif Khodeer ; Thi Xuan Ai Pham ; Kobe De Ridder ; Zicong Liu ; Sigrid Verhelst ; Kaat Leroy ; Darren Taylor ; Adam Bendall ; Anna Diacofotaki ; Xinran Song ; George Young ; Nikky Corthout ; Saurabh J Pradhan ; Ruben Almey ; San Kit To ; Sam S van Knippenberg ; Bradley P Balaton ; Amitesh Panda ; Marta Wojno ; Suresh Poovathingal ; Hilde Van […]
• GSE306561 In silico Transcriptomics-based Drug Repositioning in a rat model identifies Vorinostat as a candidate to modulate neuroinflammation in Neurocysticercosis August 26, 2026
  Contributors : Omar Melo ; Oksana Huerta ; Karla Villalobos ; Nancy Chile ; Sneider A Gutierrez Guarnizo ; Hugo Naya ; Cesar M Gavidia ; Hector H Garcia ; Robert H Gilman ; Manuela VerasteguiSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusNeurocysticercosis (NCC) is a major cause of epilepsy and neurological sympto […]
• GSE305584 ZEB1-IL-6 axis promotes cancer stem cell properties in breast cancer August 26, 2026
  Contributor : Weiyue ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensZEB1 plays a pivotal role in the pathogenesis of breast cancer and therapeutic resistance by promoting cancer stem cells (CSCs). Cytokines and chemokines secreted by tumor cells are also critically involved in tumor progression. However, the relat […]
• GSE312868 Definition of a transcriptional signature of proteasome stress across cell types and its occurrence with aging August 26, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusThis SuperSeries is composed of the SubSeries listed below.
• GSE309172 Gene expression profiles of colorectal cancer (CRC) cell lines. August 26, 2026
  Contributors : Anita Sveen ; Ragnhild A LotheSeries Type : Expression profiling by arrayOrganism : Homo sapiensWe have performed gene expression profiling of CRC cell lines as part of study with drug sensitivity testing to detect exceptional treatment responses and their molecular underpinnings.
• GSE344602 Luteolin-7-O-β-D-glucuronide ameliorates psoriasis-like skin Inflammation via suppressing the AKT/mTOR and JAG1/NOTCH1 signaling pathways August 26, 2026
  Contributors : Qing Zhong ; Xiaoyu Wang ; Qingtao KongSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPsoriasis is an immune-mediated skin disease. This study evaluated the anti-psoriatic potential of Luteolin-7-O-β-D-glucuronide (LGU) in M5-stimulated HaCaT cells and IMQ-induced mouse models. LGU inhibited keratinocyte […]
• GSE344591 Moxibustion improves pain-like behavior and is associated with DNA methylation and transcriptional changes in the primary somatosensory cortex of CFA mice August 26, 2026
  Contributors : Li Zhou ; Mengying Huang ; Gege Cao ; Shuai Hou ; Haiyan YinSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMoxibustion has been widely used as an effective intervention for pain management; however, the central molecular mechanisms underlying its analgesic effects remain poorly understood. The primary so […]
• GSE344678 Single cell RNA sequencing of human Putamen August 26, 2026
  Contributors : Raleigh M. Linville ; Benjamin T. James ; Erica Engelberg-Cook ; Michael DeTure ; Kyriaki Galani ; Dennis W. Dickson ; Manolis Kellis ; Myriam HeimanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe striatum is critical for decision-making, movement, and reward processing, functions achieved through sub […]
• GSE344645 Melatonin Ameliorates NEC-Associated Brain Injury by Suppressing Microglial M1 Polarization via the AMPK-IL-1β Axis August 26, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNeonatal necrotizing enterocolitis (NEC) is a severe gastrointestinal disorder that poses a significant threat to neonatal survival. Among its numerous complications, NEC-associated brain injury is particularly detrimental, exerting profound adverse effects on long-term ne […]
• GSE344709 High Fat Diet-Induced PPARα Suppression Disrupts Mitochondrial Bioenergetics and Fuels ROS-NF-κB-driven Colorectal Tumorigenesis August 26, 2026
  Contributors : Qiushi Huang ; Libin Huang ; Rui Zhao ; You Yang ; Xiaoli Yi ; Jinlong Luo ; Yihu Mao ; Jianxia Dong ; Lie Yang ; Zongguang ZhouSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHigh-fat diet (HFD) is an established risk factor for colorectal cancer (CRC), yet the epithelial-intrinsic mechanisms that transl […]
• GSE344718 Boldine Attenuates Mechanical Allodynia and Mitigates Transcriptomic Changes in a Mouse Model of Chronic Constriction Injury August 26, 2026
  Contributors : Christopher P Cardozo ; Alexey Kozlenkov ; Carlos A ToroSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground: Neuropathic pain is a complex, chronic condition affecting 7% to 10% of the general population. Current neuropathic pain treatments fail to provide adequate relief in at least ~40% of patien […]
• GSE345045 Comparative transcriptomic and immune profiling identifies a shared molecular identity in clear cell odontogenic carcinoma and hyalinizing clear cell carcinoma [1] August 26, 2026
  Contributors : Helen X Hou ; Bidish K Patel ; Emily E Ackerman ; Tom Bisson ; Samyukta Singh ; Peter M Richieri ; A J IafrateSeries Type : OtherOrganism : Homo sapiensClear cell odontogenic carcinoma (CCOC) and hyalinizing clear cell carcinoma (HCCC) are rare head-and-neck malignancies with recurrent EWSR1::CREB family fusions that show overlapping morpholog […]
• GSE325581 Mest transcript elongation to Mestxl sustains, but does not initiate, maternal allele bias of the convergent gene Copg2 in neural differentiation (RNA-seq Dnmt3l−/+) August 26, 2026
  Contributors : Kazuhiko Nakabayashi ; Franck Court ; Philippe ArnaudSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPrecise gene dosage control is critical for establishing cellular identity and development, especially for imprinted genes, where dosage imbalances are linked to severe pathologies such as neurodevelopment […]