Healthcare updates

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE337663 Therapy-persistent leukemia is selectively vulnerable to SLC23A1 restoration via targeting KHSRP (AML patient samples) July 10, 2026
  Contributors : Qingyu Luo ; Andrew A LaneSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAcute myeloid leukemia (AML) remains highly prone to relapse driven by therapy-persistent residual cells. To discover specific vulnerabilities in this population, we performed genome-wide CRISPR interference screens in AML cells tre […]
• GSE269556 Targeting the oncohistone-ASCL1 axis disrupts plasticity and suppresses pediatric gliomas [CUT&TAG] July 10, 2026
  Contributors : Alan Jiao ; Yang ShiSeries Type : OtherOrganism : Homo sapiensPhenotypic plasticity, a hallmark of cancer facilitated by epigenomic reprogramming, represents a significant challenge but also therapeutic opportunity for cancer treatment. How plasticity is regulated in diffuse midline gliomas (DMGs), incurable pediatric brain tumors characterize […]
• GSE269554 Targeting the oncohistone-ASCL1 axis disrupts plasticity and suppresses pediatric gliomas [CUTAC] July 10, 2026
  Contributors : Jiao Alan ; Shi YangSeries Type : OtherOrganism : Homo sapiensPhenotypic plasticity, a hallmark of cancer facilitated by epigenomic reprogramming, represents a significant challenge but also therapeutic opportunity for cancer treatment. How plasticity is regulated in diffuse midline gliomas (DMGs), incurable pediatric brain tumors characterize […]
• GSE301941 Fenofibrate-mediated inhibition of tumor proliferation and progression by modulating the PTPN14/MARK/Hippo signaling axis July 10, 2026
  Contributors : Yang Liu ; Xuedi Cao ; Tengrui Zhang ; Jianling Yang ; Xiaotong Yu ; Zixuan Zhen ; Yinjia Li ; Yang Ye ; Xin Zhou ; Kewu Zeng ; Lixiang XueSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPTPN14 is a non-receptor tyrosine phosphatase that functions as a tumor suppressor through negative regulation of the H […]
• GSE281077 Seed endophytic bacterium induces a priming-like drought transcriptomic state in an invasive plant prior to stress exposure July 10, 2026
  Contributors : Seorin Jeong ; Tae-Min Kim ; Byungwook Choi ; Yousuk Kim ; Eunsuk KimSeries Type : Expression profiling by high throughput sequencingOrganism : Lactuca serriolaSeedborne endophytes may facilitate plant establishment by modifying host responses to environmental stress, but the mechanisms underlying these effects remain poorly understood. This m […]
• GSE302255 Drosha in mesangial cells regulates Glomerular Capillary Tufts Formation Through Drosha/Ribosome/Gata3 Axis July 10, 2026
  Contributors : Zixuan Fan ; Lang Qin ; Jiajia Qin ; Tingxuan Xu ; Wenjun Xiao ; Jin Tang ; Yonghui He ; Xin Li ; Weiqian Chen ; Chuwen Lin ; Xuan JiangSeries Type : Expression profiling by high throughput sequencing ; Non-coding RNA profiling by high throughput sequencingOrganism : Mus musculusCAKUT (congenital anomalies of the kidney and the urinary tract) […]
• GSE302233 The effect of nitrogen on wheat during drought and recovery after rehydration. July 10, 2026
  Contributor : Junyi MuSeries Type : Expression profiling by high throughput sequencingOrganism : Triticum aestivumFor transcriptomic analysis under drought, re-watering (RW), and re-watering with nitrate (RWN) conditions, wheat seedlings were germinated and transplanted into soil tanks once the first leaf emerged from the coleoptile, then irrigated with 2 L […]
• GSE335335 miRNA profiling data supporting “IL-4/C1q activated astrocyte-derived extracellular vesicles promote stroke infarct recovery by recruiting peripheral leukocytes” July 10, 2026
  Contributors : Shangjing Xin ; Lucy Zhang ; Nhi V Phan ; Mengying An ; Ligen Shi ; S. Thomas Carmichael ; Tatiana SeguraSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Rattus norvegicusThis study aims to engineer an injectable biomaterial platform to promote brain repair post-stroke. We used extracellular vesicles derived from […]
• GSE334362 Generation of spermatogonia from human and non-human primate pluripotent stem cells July 10, 2026
  Contributors : Eoin C Whelan ; Mingyue Guo ; Ryo Yokomizo ; Yasunari Seita ; Young Sun Hwang ; Yuichiro Shirafuta ; N A Leu ; Keren Cheng ; Franziska Ahrend ; Astrid D Haase ; Kotaro SasakiSeries Type : Non-coding RNA profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiensFailures in germline develo […]
• GSE335511 Single cell sequencing data supporting "IL-4/C1q activated astrocyte-derived extracellular vesicles promote stroke infarct recovery by recruiting peripheral leukocytes" July 10, 2026
  Contributors : Shangjing Xin ; Lucy Zhang ; Nhi V Phan ; Mengying An ; Ligen Shi ; S. Thomas Carmichael ; Tatiana SeguraSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study aims to engineer an injectable biomaterial platform to promote brain repair post-stroke. We used extracellular vesicles derived from reactive […]
• GSE335480 Single-cell tracking reveals tumor-reactive T cell plasticity during melanoma TIL therapy July 10, 2026
  Contributors : Michael T Sandholzer ; Clara Serger ; Alessia G Liner ; Sarp Uzun ; David Koenig ; Helen Thut ; Reto Ritschard ; Jonas D Fuerst ; Andreas Zingg ; Natalia Rodrigues Mantuano ; Benjamin Kasenda ; Katharina Glatz ; Elisabeth A Kappos ; Matthias Matter ; Andreas Holbro ; Frank Stenner ; Jakob Passweg ; Nina Khanna ; Lukas Jeker ; Mascha Binder ; A […]
• GSE336966 N6-methyladenosine circRNA Epitranscriptomic Microarray analysis in peripheral blood of patients with β-thalassemia intermedia and major_10 samples July 10, 2026
  Contributors : Hailong Huang ; Meihuan ChenSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensβ-thalassemia is a group of bone marrow disorders characterized by defects in erythropoiesis. Circular RNAs (circRNAs) are functionally significant and hold tremendous potential as diagnostic biomarkers and therapeutic targets in numerous human di […]
• GSE337003 Long-read sequencing reveals transposable element-derived chimeric transcripts at zygotic genome activation in mammalian embryos July 10, 2026
  Contributors : Saki Kawakami ; Koichi Kitao ; Shuntaro Ikeda ; Shinnosuke HondaSeries Type : Expression profiling by high throughput sequencingOrganism : Bos taurus ; Mus musculusWe performed long-read RNA-seq using mouse late 2-cell and bovine 8-16 cell embryos for constructing transposable element (TE)-driven chimeric mRNA library.
• GSE337641 Single-cell transcriptomic analysis of Wfdc2-deficient mouse lungs and response to amiloride treatment July 10, 2026
  Contributor : HeonYung GeeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study investigated the transcriptomic consequences of WFDC2 deficiency in mouse lungs and the response to ENaC inhibition. WFDC2 deficiency caused respiratory distress associated with epithelial defects, immune activation, and hyperactivation […]
• GSE302407 Regulation of Splicing by mec-8 July 10, 2026
  Contributors : Xiaoyu Liang ; Adam Norris ; Zachery WolfeSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansMEC-8 splicing factor affects alternative splicing of many genes in neurons and other tissues of C. elegans. MEC-8 consists of two RRMs, and this experiment set out to test whether RRM1 and RRM2 are both re […]