Healthcare updates

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE249710 LXR agonism enhances T cell activation upon crosspresentation by LXR-DKO BMDCs. December 30, 2025
  Contributor : Benjamin N OstendorfSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHere, we analyze transcriptional profiles of OT-I CD8+ T cells co-cultured with LXR-/- bone marrow-derived dendritic cells pulsed with the SIINFEKL peptide in the absence or presence of the synthetic LXR agonist RGX-104.
• GSE278123 DNA methylation profiling of Nlrp5 +/+, and -/- and germinal vesical murine oocytes December 30, 2025
  Contributor : Leah Nic AodhaSeries Type : Methylation profiling by high throughput sequencingOrganism : Mus musculusNlrp5 encodes a core component of the subcortical maternal complex (SCMC) a cytoplasmic protein structure unique to the mammalian oocyte and cleavage-stage embryo. NLRP5 mutations have been identified in patients presenting with early embryo ar […]
• GSE269328 Glucagon receptor agonism and treatment withdrawal effect on liver transcriptomes of diet-induced obese mice December 30, 2025
  Contributors : Shelly R Nason ; William C Roell ; Kirk M Habegger ; Scot J MatkovichSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGlucagon is historically viewed as the main counter-regulatory hormone to insulin in glucose homeostasis. Although chronic glucagon receptor (GCGR) agonism induces hyperglycemia and glucose […]
• GSE285531 Transcriptional regulation of temporal dynamics in human neurogenesis and neuronal maturation [ATAC-seq] December 30, 2025
  Series Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensHuman pluripotent stem cells (hPSCs) provide a valuable platform for studies of human neuronal differentiation, but the mechanisms regulating the timing of this process remain poorly understood. This study compares two differentiation systems with distinct ti […]
• GSE281305 Generation of multi-omic datasets using high-throughput molecular profiling of DNA methylation human data December 30, 2025
  Contributors : Amblard Elise ; Chuffart Florent ; Kermezli Yasmina ; Armenoult Lucile ; Baures Aurelia ; Cassard Audrey ; Ayadi Mira ; Cros Jerome ; Blum Yuna ; Richard MagaliSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensTumor heterogeneity significantly affects cancer progression and therapeutic response, yet quantifying i […]
• GSE294729 Spatial transcriptomics reveal lineage complexity of gastric incomplete intestinal metaplasia and its association with gastric cancers [ATAC-Seq] December 30, 2025
  Series Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThis research underscores the unique molecular phenotype and lineage complexity of Inc IM, emphasizing its significance as a precancerous lesion in gastric tissues. Our findings lay the groundwork for future investigations into the epigenetic and transcriptio […]
• GSE290187 Transcriptional profiling of bulk liver tissue from male and female PPARa knockout mice and mice expressing a human PPARa transgene following treatment with PFOA or vehicle drinking water in conjunction with an American diet December 30, 2025
  Contributors : Greylin Nielsen ; Eric Reed ; T Webster ; W J Heiger-Bernays ; B Lara ; D H Sherr ; T Hyötyläinen ; J J SchlezingerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPer- and polyfluoroalkyl substances (PFAS) are a family of persistent chemicals that have been released pervasively in the environment leading […]
• GSE315111 Chromatin accessibility and transcriptome in human neuronal model exposed to Parkinson's environmental toxins [RNA-Seq] December 30, 2025
  Contributors : Jingchao Hong ; Juanjuan HuangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensParkinson's disease is a complex neurodegenerative disorder where environmental factors play a predominant role in sporadic cases. While environmental toxins are implicated in PD pathogenesis via epigenetic pathways, the sp […]
• GSE315059 The cytokine receptor Fn14 is a molecular brake on neuronal activity that mediates circadian function in vivo December 30, 2025
  Contributors : Austin Ferro ; Dominic J Vita ; Trevor Fallon ; Anosha Arshad ; Leah Boyd ; Tess Stanley ; Qianyu Lin ; Adrian Berisha ; Uma Vrudhula ; Adrian M Gomez ; Irene Sanchez-Martin ; Jeremy C Borniger ; Lucas CheadleSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo survive, organisms must adapt to a staggering […]
• GSE315114 Gene expression data of distal colon mucosa from young and old human December 30, 2025
  Contributors : Tingyi Sun ; Deshan ZhouSeries Type : Expression profiling by arrayOrganism : Homo sapiensThe disruption of the mucosal barrier of the digestive tract is a common pathological change in the elderly, which often causes inflammatory bowel disease among old people. Given that RNA molecules are dysregulated in numerous diseases, we performed high‑ […]
• GSE315113 Chromatin accessibility and transcriptome in human neuronal model exposed to Parkinson's environmental toxins [ATAC-Seq] December 30, 2025
  Contributors : Jingchao Hong ; Juanjuan HuangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensParkinson's disease is a complex neurodegenerative disorder where environmental factors play a predominant role in sporadic cases. While environmental toxins are implicated in PD pathogenesis via epigenetic pa […]
• GSE315116 Gene expression changes in UBE2I-knockdown primary human endometrial stromal cells (hESCs) compared to control cells December 30, 2025
  Contributor : Ji-Long LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo portray the molecular mechanism for UBE2I function in hESCs, cell treated with siUBE2I and siNC were subjected to RNA-seq analysis.
• GSE315117 Gene expression changes in Ube2i-deleted mouse uterus on postnatal day 21 (PND21). December 30, 2025
  Contributor : Ji-Long LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe specifically deleted Ube2i in the female reproductive tract using the Pgr-Cre driver. To portray the molecular mechanism for Ube2i function in uterus, uterine tissues were collected from Ube2i f/f and Ube2i d/d mice on PND21 and subjected to RNA […]
• GSE315134 A circadian rheostat drives proton electrochemical gradients to optimize cell-type specific growth in Arabidopsis December 30, 2025
  Contributors : Paloma Mas ; Lu XiongSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaPlant growth relies on the activity of key transcription factors. Here, we uncover a mechanism for organ-specific growth driven by opposing electrochemical signals that propagate in a cell-type-specific manner. Using a geneticall […]
• GSE226493 Fezf2 promotes differentiation of Aire-expressing and mimetic epithelial populations regulating thymic homeostasis December 30, 2025
  Contributors : Xian Liu ; Joe Germino ; Yi Wang ; Jared Balolong ; Hong Sun ; Irina Proekt ; Vasilis Ntranos ; Mark S Anderson ; James M Gardner ; Corey N MillerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusFezf2 has been implicated in shaping tissue-restricted antigen (TRA) expression and as an “Aire-like” factor in […]