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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE311796 KRAS mutations reprogram RNA m6A modification to drive CD73-dependent immune evasion in colorectal cancer [MeRIP-seq] July 25, 2026Contributors : Seungjae Shin ; Seung-Pyo Hong ; Jong-Il Kim ; Sung-Yup ChoSeries Type : OtherOrganism : Homo sapiensKRAS mutations, present in about 40% of colorectal cancers (CRCs), are strongly associated with an immunosuppressive tumor microenvironment characterized by restricted immune infiltration and poor responses to immunotherapy. Here, we show that […]
- GSE310023 Mutation of SCARECROW-LIKE28 or CYTOKININ OXIDASE3/5 suppresses rosette branching in Arabidopsis July 25, 2026Contributors : Zhiwei Luo ; Bart Janssen ; Joanna Putterill ; Kimberley C SnowdenSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaShoot branching is an important trait that influences plant architecture and crop productivity. It is triggered by the perception of developmental and environmental cues and controlled […]
- GSE333904 KRAS mutations reprogram RNA m6A modification to drive CD73-dependent immune evasion in colorectal cancer [RNA-seq] July 25, 2026Contributors : Seungjae Shin ; Seung-Pyo Hong ; Jong-Il Kim ; Sung-Yup ChoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusKRAS mutations, present in about 40% of colorectal cancers (CRCs), are strongly associated with an immunosuppressive tumor microenvironment characterized by restricted immune infiltration and poor re […]
- GSE314060 Lymphotoxin Beta Receptor Activity in Fibroblasts Regulates Collagen Synthesis and is Crucial for Lung Fibrosis July 25, 2026Contributors : Nandita Ghosh ; Rinkesh K Gupta ; Gurupreet S Sethi ; Kai Fung ; Jeamin Jung ; Ann J Balancio ; Michael CroftSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensFibroblast-specific deletion of LTβR in mice exposed to allergen significantly reduces lung collagen deposition and inflammation, despite unchanged f […]
- GSE339169 KRAS-Mutation Driven RASA2 Promotes Pancreatic Cancer Metastasis via TGFB2-Dependent Non-Canonical Hedgehog/GLI1 Activation [CUT&Tag] July 25, 2026Contributors : Taochen He ; Qiangda Chen ; Yanfei An ; Zhihang Xu ; Zhenlai Jiang ; Jiande Han ; Yuqi XieSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensKRAS mutations are a major driver of pancreatic ductal adenocarcinoma (PDAC), promoting tumor initiation, progression, and metastasis. RASA2, a Ras GTPase […]
- GSE338460 Immune hallmarks of recurrent immune checkpoint inhibitor-mediated inflammatory arthritis July 25, 2026Contributors : Synat Keam ; Yanshuo Chu ; Sang Taek Kim ; Roza NurievaSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensImmune checkpoint inhibitor (ICI) therapy is often associated with immune-related adverse events including inflammatory arthritis (ICI-IA). However, the mechanisms underlying ICI-IA, especially i […]
- GSE339268 PBX1 knockdown RNA-seq in HUCCT1 and RBE cells July 25, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRNA-seq was performed to profile transcriptomic changes after siRNA-mediated PBX1 knockdown in HUCCT1 and RBE human cell lines. Each cell line includes siNC and siPBX1 groups with three biological replicates per group.
- GSE299520 Ankrd11 deficiency reverses the dysfunction of chronic HBV-specific T-cell [RNA-seq] July 25, 2026Contributors : Wei Xu ; Xuyu ZhouSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the transcriptomic changes in CD8 T cells upon Ankrd11 deficiency, we performed RNA-seq to analyze alterations in the transcriptome between Ankrd11-knockout and wild-type CD8 T cells.
- GSE339272 An Injectable ROS-Responsive Nanozyme Hydrogel Regulates the Uterine Microenvironment to Reverse Intrauterine Adhesions July 25, 2026Contributors : Peixian Cheng ; Xuemin Liu ; Xuetao Shi ; Yong FanSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusIntrauterine injury can induce a self-reinforcing vicious cycle involving inflammation, oxidative stress, and fibrosis, ultimately leading to intrauterine adhesions (IUA), which severely impair women’s r […]
- GSE339271 Genome-wide PBX1 binding profiling by CUT&Tag in HUCCT1 and RBE cells July 25, 2026Series Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensCUT&Tag was performed to profile PBX1 genomic binding landscapes in untreated HUCCT1 and RBE human cholangiocarcinoma cell lines. Three biological replicates were analyzed for each cell line using an anti-PBX1 antibody.
- GSE339287 Medin-Induced Pro-inflammatory and Prothrombotic Activation of Coronary Artery Endothelial Cells: A Potential Novel Mediator Linking Aging and Atherosclerosis July 25, 2026Contributors : Kaleb Morrow ; Nina Karamanova ; Randy Woltjer ; Victoria Krajbich ; Jingmin Shu ; Ming Li ; Chengyun Tang ; Alana Maerivoet ; Jillian Madine ; Yabing Chen ; Raymond Q MigrinoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: Age is the most important risk factor for coronary artery disease (CAD) […]
- GSE339291 Unleashed condensation by recurrent mutations of an epigenetic regulator promotes cancer July 25, 2026Contributors : Yansu Song ; Yi Hao ; Maria Latacz ; Marta Cykowiak ; Jiazheng Lin ; Hao JiangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThe pathological mechanisms and significance for the prevalent hotspot mutations in disordered protein regions are poorly understood. ASXL1 is an obligate co-factor f […]
- GSE339298 Transcriptomic profiling of ATP6AP1 knockdown in activated human hepatic stellate LX-2 cells July 25, 2026Contributor : Hanlin BaiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHepatic stellate cell activation is a major driver of extracellular matrix deposition during liver fibrosis. This study investigated the transcriptional changes induced by ATP6AP1 depletion in human hepatic stellate LX-2 cells. LX-2 cells were trans […]
- GSE303794 Grapevines pre-treated with biocontrol bacteria have an altered transcriptional response to Xylella fastidiosa and a reduction in Pierce’s disease severity July 25, 2026Contributors : Elizabeth Deyett ; Biagio DiSalvo ; Mélanie Massonnet ; Vanessa Ashworth ; Dario Cantu ; Steve Lindow ; Philippe E Rolshausen ; Caroline RoperSeries Type : Expression profiling by high throughput sequencingOrganism : Vitis viniferaIn a previous DNA-based microbiome study of grapevines in areas of Pierce’s Disease (PD) pressure, we determined t […]
- GSE339247 RNA-seq transcriptomic profiling reveals renoprotective mechanism of novel Psidium meroterpenoid derivatives (d)-G8 and (d)-G4 against cisplatin-induced acute kidney injury in human HK2 tubular epithelial cells July 25, 2026Contributors : Ying-Da Zang ; Hai-Jie Wu ; Xin-Yi Chen ; Zhi-Ling Ma ; Chuang-Jun Li ; Jie Ma ; Xiao-Guang Chen ; Li Sheng ; Sen Zhang ; Dong-Ming ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCisplatin is a first-line chemotherapeutic agent for multiple solid tumors, but its severe nephrotoxicity severely limits […]