Healthcare updates

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE310310 Transcriptomic profiling of endothelial cells with altered cholesterol May 10, 2026
  Contributor : Nicolas SantanderSeries Type : Expression profiling by high throughput sequencingOrganism : Gallus gallus ; Mus musculusCholesterol has been associated with the regulation of angiogenesis in endothelial cells of the central nervous system, but the mechanisms responsible for this regulation have not been explored at the genome level. Here, we pe […]
• GSE302088 Inhibition of Acetyl-CoA-carboxylase induces endoplasmic reticulum stress and has synergistic effects with anti-cancer therapies May 10, 2026
  Contributors : Shan Naing Lin ; Dai Jiawei ; Wang Yueyue ; Pusztai LajosSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: Acetyle-CoA-carboxylase-1 (ACC1) is overexpressed in many cancer types relative to normal tissues and catalyzes the rate limiting step of de novo fatty acid synthesis. In this study, we ide […]
• GSE327921 Targeting PDE2A of macrophages attenuates sorafenib-induced cardiotoxicity May 10, 2026
  Contributors : Sijia Li ; Shuangli Zhu ; Kai Fu ; Can Pan ; Yuelu Lan ; Xueping Wang ; Xin Su ; Zhangqi Cao ; Fang Wang ; Liwu FuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground: Sorafenib, a multi-kinase inhibitor widely used in hepatocellular carcinoma, is associated with clinically relevant cardiotoxicity, […]
• GSE312966 Network-based analysis reveals potential microRNA regulation of oncogenic pathways in SOX10-depleted uveal melanoma May 10, 2026
  Contributors : Xin Lai ; Chunyan Luan ; Anja Wessely ; Markus Heppt ; Julio VeraSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensSOX10 is essential for melanocyte development and maintenance and plays a critical role in uveal melanoma (UM) initiation and progression. While SOX10's transcriptional regulation of p […]
• GSE292595 YAPTAZ and neuroblastoma cell plasticity [scRNA-Seq] May 10, 2026
  Contributors : Cécile Thirant ; Isabelle Janoueix-LeroseySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSpontaneous and reversible plasticity between two tumor cell states, noradrenergic and mesenchymal, has been described in neuroblastoma cell lines. Here, we show that YAP, TAZ, and their target genes are marked by su […]
• GSE330204 H3K36me3 enrichemnt on the genome of Komagataella phaffii GS115 May 10, 2026
  Series Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Komagataella phaffii GS115The goal of the study was to examine the the histone modification mark H3K36me3 occupancy in the ORF regions of K. phaffii.
• GSE329834 Genetic interaction analysis of PIH1 deletion strains (GIM screen) May 10, 2026
  Contributor : Cosmin SaveanuSeries Type : Genome variation profiling by arrayOrganism : Saccharomyces cerevisiae ; Saccharomyces cerevisiae S288CA S. cerevisiae strain with deletion of the PIH1 gene was combined with two collections of yeast mutants: one in which non-essential genes were deleted and one in which an long 3' UTR extension has been added t […]
• GSE292598 YAPTAZ and neuroblastoma cell plasticity [RNA-Seq] May 10, 2026
  Contributors : Cécile Thirant ; Isabelle Janoueix-LeroseySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSpontaneous and reversible plasticity between two tumor cell states, noradrenergic and mesenchymal, has been described in neuroblastoma cell lines. Here, we show that YAP, TAZ, and their target genes are marked by su […]
• GSE329959 Diversity and evolution of chromatin regulatory states across eukaryotes [ChIP-Seq] May 10, 2026
  Contributors : Arnau Sebe-Pedros ; Cristina Navarrete ; Sean A MontgomerySeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Acanthamoeba castellanii ; Arabidopsis thaliana ; Bigelowiella natans ; Creolimax fragrantissima ; Dictyostelium discoideum ; Guillardia theta ; Naegleria gruberi ; Nematostella vectensis ; Physcomi […]
• GSE329952 Diversity and evolution of chromatin regulatory states across eukaryotes May 10, 2026
  Contributors : Arnau Sebe-Pedros ; Cristina Navarrete ; Sean A MontgomerySeries Type : Expression profiling by high throughput sequencingOrganism : Acanthamoeba castellanii ; Arabidopsis thaliana ; Bigelowiella natans ; Creolimax fragrantissima ; Dictyostelium discoideum ; Guillardia theta ; Naegleria gruberi ; Nematostella vectensis ; Physcomitrium patens ; […]
• GSE329979 Spatiotemporal Role of GLI2 in Driving SHH-Medulloblastoma Tumorigenesis May 10, 2026
  Contributors : Samuel Rivero-Hinojosa ; Najiba MuradSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMedulloblastoma (MB) is a malignant cerebellar tumor primarily affecting children. SHH MB with GLI2 amplification is associated with a particularly poor prognosis. Although GLI2 amplification is clinically recognized, its […]
• GSE330007 Transcriptomic Analysis Reveals Molecular Signatures Distinguishing Vocal Fold Leukoplakia from Benign Lesions: Synergistic Dysregulation of Chronic Inflammation, Immune Dysfunction, and Epithelial Barrier Disruption May 10, 2026
  Contributors : Zhixian Xiao ; Li Zhou ; Xiaocui Long ; Li Tian ; Xing LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensObjective: Vocal cord leukoplakia (VCL) represents a precancerous laryngeal lesion with a risk of malignant transformation. By employing transcriptomic analysis, this research sought to ascertain the k […]
• GSE330111 Postnatal conversion of methylcytosine to hydroxymethylcytosine reconfigures the human neuronal epigenome May 10, 2026
  Contributors : Xu Heng ; Chien Jo-Fan ; Kozlenkov Alexey ; Vadukapuram Ramu ; Li Junhao ; Wei Yu ; Dwork Andrew J. ; Liu Chunyu ; Dracheva Stella ; Mukamek Eran A.Series Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensHealthy brain development requires a coordinated process of postnatal cellular maturation throughout the firs […]
• GSE298095 Inducible fusion with the CHASERR long noncoding RNA transcript upregulates haploinsufficient CHD2 expression May 10, 2026
  Contributor : Igor UlitskySeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusLong noncoding RNAs are now realized to function in various biological processes via multiple, and as of yet not fully understood, modes of action. CHASERR is a long […]
• GSE329625 A deep cellular atlas of the human ventral substantia nigra in Parkinson's identifies a genetic and molecular overlap with insulin resistance May 10, 2026
  Contributors : Viola Volpato ; David Menassa ; Preethi Sheshadri ; Stefania Giussani ; Michal Rokicki ; Lucia Cardo ; Marirena Bafaloukou ; Ann-Kathryn Schalkamp ; Agata Zaremba ; Jimena Monzón-Sandoval ; Ngoc-Nga Vinh ; Joanne Morgan ; Michele Hu ; Scott Miners ; Richard Wade-Martins ; Cynthia Sandor ; Laura Parkkinen ; Caleb WebberSeries Type : Expression […]