Healthcare updates

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE235016 RNA-seq revealed the anti-pyroptotic effect of suramin by suppressing NLRP3/caspase-1/GSDMD pathway in LPS-induced MH-S alveolar macrophages June 6, 2026
  Contributors : Yuhui Zhu ; Haidong ZhouSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground:Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), acting as one common sepsis-associated organ injury, induces uncontrolled and self-amplifies pulmonary inflammation. Given the lack of clinically effective […]
• GSE272962 Co-transcriptional RNA processing boosts zygotic genes and restrains noncoding transcription June 6, 2026
  Contributors : Jingzhao Xu ; Xiaohua ShenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTranscription decodes protein-coding genes and interprets regulatory information embedded in the genome by generating RNA. In eukaryotes, gene transcription is coupled with RNA processing via the carboxyl terminal domain (CTD) of RN […]
• GSE269233 The roles of Nudt15 in leukemic and hematopoietic stem cells June 6, 2026
  Contributor : Zhonghui ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNUDT15 encodes nucleotide triphosphate diphosphatase that is responsible for metabolizing purine analog drugs, and its genetic mutation results in severe side effects from thiopurine therapy. However, the functions of Nudt15 in leukemic stem cel […]
• GSE299240 Ectothermic vertebrates evolved gut-associated germinal center-like structures June 6, 2026
  Contributors : Weiguang Kong ; Peng YangSeries Type : Expression profiling by high throughput sequencingOrganism : Cyprinus carpioGerminal centers (GCs), specialized microanatomical structures that emerged in endothermic vertebrates, serve as critical hubs for immune surveillance and lymphocyte activation. The constant exposure to foodborne pathogens drives […]
• GSE288939 Multimodal characterization of the effects of stimulation on the human brain ex vivo and in vivo. June 6, 2026
  Contributors : Haley D Moore ; Stefano Berto ; Ashwinikumar Kulkarni ; Mantre Dehnad ; Anne Freelin ; Bryan Granger ; Suganya Subramanian ; Bradley C Lega ; Genevieve KonopkaSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiensThe underlying mechanisms of the […]
• GSE300535 Generation of Tetraploid Organs in Mice [E18.5] June 6, 2026
  Contributors : Shu Wei ; Guowei Zou ; Yanyan Zhang ; Shuaipeng Li ; Mei Hu ; Juan Du ; Jiawen Liu ; Lin Ran ; Chikai Zhou ; Jiangwei LinSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTetraploidy is rare in mammals but common in plants and fish, a phenomenon that offers evolutionary benefits. In mammals, tetraploid cell […]
• GSE299359 Cardiomyocyte-Specific Smad7 protects the pressure-overloaded heart, inhibiting the TbR1/Smad2/3 cascade June 6, 2026
  Contributors : Claudio Humeres ; Izabela Tuleta ; Arti V Shinde ; Anis Hanna ; Aadya Deepak ; Nikolaos G FrangogiannisSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCardiomyocytes are the major effectors of cardiac remodeling under pressure overload, undergoing hypertrophy and contractile dysfunction in response to sus […]
• GSE326120 Single-cell RNA sequencing (scRNA-seq) of murine hematopoietic stem and progenitor cells (HSPCs) and mesenchymal stromal cells (MSCs) under cardiac stress induced by transverse aortic constriction. June 6, 2026
  Contributors : Manabe Ichiro ; Nakayama Yukiteru ; Goto KohsakuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe performed scRNA-seq using the 10x Genomics platform to investigate how cardiac stress influences the transcriptional profiles of murine HSPCs and MSCs. HSPCs and MSCs were isolated from bone marrow of contro […]
• GSE325469 Common mycelial network modulates neighbour-primed plant defences against foliar pathogens by co-opting distinct inter-plant metabolic and biotic stress responses. June 6, 2026
  Contributors : Zigmunds Orlovskis ; Ilva Nakurte ; Ēriks Voroņins ; Annija Kotova ; Daniels Pugačevskis ; Dawood Shah ; Annija Andersone ; Kārlis Blūms ; Ivars Silamiķelis ; Soon-Jae LeeSeries Type : Expression profiling by high throughput sequencingOrganism : Medicago truncatulaInter-plant communication is key for the successful thriving of plant communitie […]
• GSE326308 Bulk RNA sequencing of murine mesenchymal stromal cells (MSCs) under cardiac stress induced by transverse aortic constriction. June 6, 2026
  Contributors : Manabe Ichiro ; Nakayama Yukiteru ; Goto KohsakuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe performed bulk RNA-seq to investigate how cardiac stress influences the transcriptional profiles of murine MSCs. MSCs were isolated from bone marrow of control (sham-operated) and mice subjected to transvers […]
• GSE326121 Single-cell RNA sequencing (scRNA-seq) of murine mesenchymal stromal cells (MSCs) under cardiac stress induced by transverse aortic constriction. June 6, 2026
  Contributors : Manabe Ichiro ; Nakayama Yukiteru ; Goto KohsakuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe performed scRNA-seq using the 10x Genomics platform to investigate how cardiac stress influences the transcriptional profiles of female murine MSCs. MSCs were isolated from bone marrow of control (sham-opera […]
• GSE333495 SETDB1 regulates gene expression in mouse brown adipose tissue and primary brown adipocytes June 6, 2026
  Contributor : Qiang ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSETDB1 is a histone methyltransferase that catalyzes H3K9me3 and plays critical roles in transcriptional repression. To investigate its function in brown adipose tissue (BAT), we performed RNA-seq across three complementary models: (1) BAT tissue fr […]
• GSE333910 Transcriptomic profiling of C2C12 myotubes treated with D-galactose and red ginseng-derived interventions June 6, 2026
  Contributors : Byeong-Don Min ; Aeyung Kim ; Seokwon Kim ; No soo Kim ; Sang-Min ParkSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study investigated transcriptomic alterations in differentiated C2C12 myotubes following treatment with D-galactose and red ginseng-derived interventions. Fully differentiated C2C12 m […]
• GSE333980 Knockouts of sulfur metabolism genes induce chronic inflammation and immune dysregulation in Drosophila melanogaster June 6, 2026
  Contributors : O.G Zatsepina ; V.A Shilova ; M.B. Evgen’ev ; A.P Rezvykh ; D.G GarbuzSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterIn this study, we examined a unique collection of Drosophila melanogaster strains with knockouts of three key genes involved in H₂S synthesis and metabolism, with the aim of elu […]
• GSE333984 OsELP3/ELP4, rice Elongator factor complex subunits, epigenetically regulates rice blast resistance June 6, 2026
  Contributors : Yanfei Wu ; Zhenshneg Qiao ; Yuquan Fu ; Zixiang Li ; Zhichao Wang ; Xuezhu Du ; Feng ShengSeries Type : Expression profiling by high throughput sequencingOrganism : Oryza sativaRice blast, caused by Magnaporthe oryzae (M.oryzae), is one of the three most devastating rice diseases, significantly reducing both yield and grain quality. The Elong […]