Healthcare updates

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE271162 Chemoproteomic profiling by a bioorthogonal probe reveals cell growth inhibition by histone H4 dopaminylation July 6, 2025
  Contributors : Yinfeng Zhang ; Yaqi Yang ; Wenyan Wu ; Wenting SongSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDopaminylation, the covalent attachment of dopamine to the side chain of glutamine (Gln, Q) in proteins, has been identified as a class of posttranslational modification. Due to the limited number of substr […]
• GSE250198 Loss of NR2F6 reduces tissue-resident macrophages and protects from Salmonella typhimurium infection July 6, 2025
  Contributors : Woelk Johannes ; Pfeifhofer-Obermair Christa ; Benz Julia ; Brigo Natascha ; Bamberger Milena ; Kleiter Alexeja ; Hermann Martin ; Weiss Günther ; Hermann-Kleiter NataschaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNuclear receptors regulate key functions of mononuclear phagocytes and are critical com […]
• GSE273100 Study of the impact of the lncRNA HSCHARME knock-out on human cardiomyocites [RNA-seq] July 6, 2025
  Contributors : Monica Ballarino ; Giulia Buonaiuto ; Alessandro PalmaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe identified the human HSCHARME lncRNA and performed its functional inactivation in cardiomyocytes (CM) to study its impact on CM maturation and pathology-associated pathways.
• GSE272714 Fibroblast-derived CSF1 is essential for intestinal macrophage maintenance July 6, 2025
  Contributors : Daichi Nonaka ; Soichiro Yoshida ; Miyuki Watanabe ; Eriko Sumiya ; Shinichiro SawaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTissue-resident macrophages are considered to be maintained through the interaction with the local microenvironment. However, precise mechansims which regulate the gut macroph […]
• GSE274869 Unveiling age-associated immune priming properties of astrocytes for trigerring microglial Aβ clearance in an APOE isoform-dependent manner [hMG_RNA-seq] July 6, 2025
  Contributors : Jinsoo Seo ; Se-In Lee ; Fan GaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAlzheimer's disease (AD)-associated allele, apolipoprotein E4 (APOE4), exhibits pathological characteristics in an age-dependent manner despite its presence from birth. The molecular and cellular changes leading to diseas […]
• GSE274868 Unveiling age-associated immune priming properties of astrocytes for trigerring microglial Aβ clearance in an APOE isoform-dependent manner [Ast_RNA-seq] July 6, 2025
  Contributors : Jinsoo Seo ; Se-In Lee ; Fan GaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAlzheimer's disease (AD)-associated allele, apolipoprotein E4 (APOE4), exhibits pathological characteristics in an age-dependent manner despite its presence from birth. The molecular and cellular changes leading to diseas […]
• GSE279286 Phenotypic screen in vivo identifies sclerostin as a regulator for the development of nonalcoholic steatohepatitis in mice July 6, 2025
  Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusEmploying the piggyBac (PB) transposon insertion as a tool, we established a collection of >5000 mouse strains for phenotypic screen in vivo. A pipeline was established in order to identify mutations which contribute to the development of lipid metabolism disorder and l […]
• GSE301450 Lpar5 Regulates CD8 T Cell Survival and NK Receptor Expression During the Early Response to LCMV Clone 13 July 6, 2025
  Contributors : Marc A D'Antonio ; Brian C Ware ; James E DiLisio ; Mary J Michaels ; Jacqueline A Turner ; Lauren M Habenicht ; Bennett J Davenport ; Thomas E Morrison ; Roberta Pelanda ; Laurent Gapin ; Raul M TorresSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPersistent antigen exposure during chronic viral in […]
• GSE301381 Regional differences in neonatal enterocytes July 6, 2025
  Contributors : Carina L Block ; Michel Bagnat ; Cagla Eroglu ; Kristina SakersSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe report bulk scRNAseq data obtained from 2 P6 mice. Input was isolated epithelium cells of the small intestine in a 2cm segment of the jejunum and 2 cm segment in the ileum of the same mouse, 1 […]
• GSE301379 Reactivation of mammalian regeneration by turning on an evolutionarily disabled genetic switch [scRNA-seq] July 6, 2025
  Contributors : Weifeng Lin ; Xiaohui Jia ; Wei WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculus ; Oryctolagus cuniculusMammals display prominent diversity in the ability to regenerate damaged ear pinna, but the genetic changes underlying the failure of regeneration remain elusive. We performed comparative single-cel […]
• GSE301421 The kinase PLK1 promote melanoma progression in the BRAFV600E/PTEN-deficient mouse July 6, 2025
  Contributors : Mao Fengyi ; Liu XiaoqiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the role of PLK1 in melanoma progression, we introduced the overexpression of PLK1 to the BRAFV600E/PTEN-deficeint melanoma mouse model. After tumor induction, we harvested the tumors and performed the RNA-seq to analyze […]
• GSE301435 A parabrachial hub for the prioritization of survival behavior during pain July 6, 2025
  Contributors : Nitsan Goldstein ; Amadeus Maes ; Heather N Allen ; Tyler S Nelson ; Kayla A Kruger ; Nicholas K Smith ; Albert T Yeung ; Morgan Kindel ; Jamie R Carty ; Lavinia Boccia ; Niklas Blank ; Emily Lo ; Rachael E Villari ; Ella Cho ; Erin L Marble ; Michelle Awh ; Yasmina Dumiaty ; Melissa J Chee ; Rajesh Khanna ; Christoph Thaiss ; Bradley K Taylor […]
• GSE301448 Epigenetic Reactivation of CNS Endothelial Developmental Programs Triggers Adult Brain Angiogenesis, Promotes Post-Stroke Revascularization and Neuroregeneration [RNAseq-Stroke] July 6, 2025
  Contributors : Peeyush Kumar ; Sithra ThomasSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe identified the role of brain endothelial cell Hdac2 and Ezh2 mediated epigenetic mechanism in maintaining blood brain barrier in adult mice. Also, we we studied the impact of reactivation of brain endothelial cell Wnt/β-cateni […]
• GSE230580 The Epigenetic Regulator PHF16 Redresses Homeostasis During Intestinal Injury Repair [RNA-seq] July 6, 2025
  Contributors : Ik Soo Kim ; Sung H Baek ; Jun-Yeong AhnSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe intestinal stem cells (ISCs) are highly vulnerable to DNA damage, being in a constant state of proliferation1. Reserve crypt stem cells restore homeostatic intestinal epithelium following damage-induced ablation of […]
• GSE274870 Unveiling age-associated immune priming properties of astrocytes for trigerring microglial Aβ clearance in an APOE isoform-dependent manner [ATAC-seq] July 6, 2025
  Contributors : Jinsoo Seo ; Se-In Lee ; Fan GaoSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensAlzheimer's disease (AD)-associated allele, apolipoprotein E4 (APOE4), exhibits pathological characteristics in an age-dependent manner despite its presence from birth. The molecular and cellular changes lea […]