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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE277285 Pa01c cells treated with ERK and MK2 inhibitors December 13, 2025Contributors : Kian H Lim ; Iftikhar A KhawarSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe trested Pa01c cells with DMSO and, BVD-523 and ATI-450 alone or in combination for 48 hours
- GSE221083 Integrative proteomics and transcriptomics identify novel fibrosis-related biomarkers of patients with post-HBV hepatitis cirrhosis December 13, 2025Contributors : Yutong Dong ; Yuwei Liu ; Xiaomei Wang ; Junqi NiuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: Hepatitis B virus (HBV) infection is an important public health burden. Chronic HBV infection always leads to chronic hepatitis, liver fibrosis and increases the incidence of liver cancer. However […]
- GSE294833 Electro-assisted cell printing directs in vitro gastrulation and epiblast-like morphogenesis from human pluripotent stem cells II December 13, 2025Contributor : Yixue LuoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis study develop a versatile techonology to largely generate biomimetic epiblast-like tissues based on human induced pluripotent stem cells (hiPSCs) and well-defined biomatrix. Single hiPSCs are wrapped in laminin-alginate (L-A) hydrogel with optim […]
- GSE294329 Single‑cell RNA sequencing unveils fibroblast heterogeneity in proliferative vitreoretinopathy membranes December 13, 2025Contributors : Fengjuan Gao ; Yuqiao Ju ; Lili Zhang ; Ting Zhang ; Qing Chang ; Shunxiang Gao ; Xin Huang ; Yuan Zong ; Gezhi XuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensProliferative vitreoretinopathy (PVR) is a vision-threatening fibrotic disorder characterized by pathological membrane formation, yet its cellul […]
- GSE308115 Liver Transcriptomics Reveals UB-NPs Regulate Lipid Metabolism and Inflammation Genes December 13, 2025Contributors : Chang Liu ; Shangnian Liu ; Chao He ; Tingting Han ; Yajuan Zhao ; Yanjuan Li ; Yijun Lin ; Zimeng Niu ; Dengqun Liao ; Caixia Chen ; Xianen LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study utilized RNA-Seq to investigate hepatic gene expression changes in obese mice following intervention wit […]
- GSE297610 KMT2C deficiency promotes meningioma progression through H3K27ac-mediated HIPPO Pathway Inactivation December 13, 2025Contributors : Liuchao Zhang ; Jing JiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensKMT2C is a frequently mutated gene in meningiomas, however, its functional role in meningioma pathogenesis remains poorly understood. Here we demonstrate that KMT2C expression is reduced in high-grade meningiomas and that its deficienc […]
- GSE313055 This study compares the differential gene expression patterns of oncogenes and tumor suppressor genes fold changes derived from prostate cancer cell lines of both racial etnicities,a health disparities study. December 13, 2025Contributors : Hirendra Banerjee ; Saunadia Deloatch ; Jamie Noble ; Narendra Banerjee ; Karrington Perry ; Erik Armstrong ; Zahidur Abedin ; Soumya Banerjee ; Ahmed El-Hashash ; Anasua BanerjeeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCell culture, RNA isolation, RNA sequencing using next gen
- GSE312948 Transcriptomic Profiling of Splenic Red Pulp Macrophages in Response to Dietary Iron Deficiency December 13, 2025Contributors : Pratik Kumar Mandal ; Patryk Slusarczyk ; Komal Chouhan ; Raghunandan Mahadeva ; Gabriela Zurawska ; Marta Niklewicz ; Matylda Macias ; Aleksandra Szybińska ; Aneta Jończy ; Zhaoyuan Liu ; Florent Ginhoux ; Małgorzata Lenartowicz ; Wojciech Pokrzywa ; Elizabeta Nemeth ; Katarzyna Mleczko-SaneckaSeries Type : Expression profiling by high throug […]
- GSE313067 Single-cell heterogeneity in interferon induction potential is heritable and governed by variation in cell state II December 13, 2025Contributors : Elizabeth A Thayer ; Gabriela Shipman ; Joel Rivera-Cardona ; Tarun Mahajan ; QiWen Teo ; Sebastian Paez ; Joseph Lederer ; Jie Chen ; Nicholas C Wu ; Sergei Maslov ; Christopher B BrookeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensType I and III interferons (IFNs) are among the first lines of defense […]
- GSE313066 Single-cell heterogeneity in interferon induction potential is heritable and governed by variation in cell state I December 13, 2025Contributors : Elizabeth A Thayer ; Gabriela Shipman ; Joel Rivera-Cardona ; Tarun Mahajan ; QiWen Teo ; Sebastian Paez ; Joseph Lederer ; Jie Chen ; Nicholas C Wu ; Sergei Maslov ; Christopher B BrookeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensType I and III interferons (IFNs) are among the first lines of defense […]
- GSE313068 Single-cell heterogeneity in interferon induction potential is heritable and governed by variation in cell state III December 13, 2025Contributors : Elizabeth A Thayer ; Gabriela Shipman ; Joel Rivera-Cardona ; Tarun Mahajan ; QiWen Teo ; Sebastian Paez ; Joseph Lederer ; Jie Chen ; Nicholas C Wu ; Sergei Maslov ; Christopher B BrookeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensType I and III interferons (IFNs) are among the first lines of defense […]
- GSE313071 Single-cell heterogeneity in interferon induction potential is heritable and governed by variation in cell state IV December 13, 2025Contributors : Elizabeth A Thayer ; Gabriela Shipman ; Joel Rivera-Cardona ; Tarun Mahajan ; QiWen Teo ; Sebastian Paez ; Joseph Lederer ; Jie Chen ; Nicholas C Wu ; Sergei Maslov ; Christopher B BrookeSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensType I and III interferons (IFNs) are among the first lin […]
- GSE313101 FOLFIRINOX Plus Nivolumab Promotes Irregular Intra-Tumoral Lymphoid Aggregates in Borderline Resectable Pancreatic Adenocarcinoma: A Phase 1 Trial December 13, 2025Contributors : Jason M Link ; Zev Wainberg ; Timothy DonahueSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCombination therapies of chemotherapy and immune checkpoint inhibitors (ICIs) have failed to improve survival in pancreatic ductal adenocarcinoma (PDAC), except in rare MSI-H cases, despite their success in other […]
- GSE313107 AMPK agonism optimizes the in vivo activation and anti-leukemia efficacy of chimeric antigen receptor T cells December 13, 2025Contributors : Erica L Braverman ; Craig Byersdorfer ; Poholek Amanda ; Yang AaronSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBACKGROUND: Chimeric antigen receptor (CAR) T cells have achieved remarkable clinical success. However, up to 50% of CAR T cell-treated leukemia patients relapse and long-term survivor data i […]
- GSE313178 Targeting the cGAS–STING Pathway Mitigates Huntington Disease Pathogenesis in a Knock-In Mouse Model December 13, 2025Contributors : Sunayana Dagar ; Anuradha Kesharwani ; Isabella Zuniga ; Marianne Charlene Monet ; Ganesh Halade ; Gunjan Upadhyay ; Uri Nimrod Ramírez Jarquín ; Violeta Gisselle Lopez-Huerta ; Emaad Mirza ; Ning Quan ; Srinivasa SubramaniamSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCyclic GMP–AMP synthase (cGAS) an […]