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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE292754 Fibroblasts Are the Primary Contributors to a Disrupted Micro-Environment in End-Stage Pediatric Hypertrophic Cardiomyopathy April 15, 2026Contributors : Yi Zhao ; Xiao Li ; Hanna Tadros ; Diwakar Turaga ; James MartinSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHypertrophic cardiomyopathy (HCM) is a relatively rare but debilitating diagnosis in the pediatric population, and patients with end-stage HCM require heart transplantation. Here, we have examin […]
- GSE297630 Expression data of control or anti-PD-1 antibody tolerant LLC cells April 15, 2026Contributor : M SumiiSeries Type : Expression profiling by arrayOrganism : Mus musculusEven after anti-PD-1 antibody is administrated to subcutaneous model mouse using LLC cells, there are a few cells which survive, and these tolerant cells are considered to be the source of later recurrence.We used microarray analysis to explore the mechanism behind the tol […]
- GSE294771 A cellular anatomy of normal adult human female urethra April 15, 2026Contributors : Douglas W Strand ; John T LafinSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensA cellular atlas of healthy human female urethra could provide a better mechanistic understanding of voiding dysfunction and infection. Single cell RNA sequencing was performed on young adult human female urethra with in situ v […]
- GSE304937 A continuous temporal atlas of mouse nasal morphogenesis in single-cell resolution [scRNA-seq] April 15, 2026Contributors : Huan Chen ; Baomei CaiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe nasal organ serves as the primary gateway for respiratory pathogens, and a critical site for olfaction and immune defense, yet, its embryonic development remains poorly characterized at cellular and molecular levels.To systematicall […]
- GSE301374 Inhibition of H3K79me2 by DOT1L inhibitor EPZ5676 promotes mouse embryonic lung branching morphogenesis via increasing epithelium proliferation April 15, 2026Contributors : Huan Chen ; Yunjing DuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHistone modifications play a crucial role in regulating pulmonary branching morphogenesis, yet their specific contributions remain incompletely understood. Here, we demonstrate that H3K79me2 is broadly distributed throughout the airway […]
- GSE252138 RNA-seq of three groups mice in hippocampus. April 15, 2026Contributor : Hongbo ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe sought to examine whether urolithin A could alleviate the cognitive impairments of chronic alcoholic mice. RNA-sequencing (RNA-seq) on mice hippocampus were performed in order to identify the key biological processes and pathways regulated by u […]
- GSE306298 Cohesin-mediated loop extrusion and enhancer-associated factors additively contribute to Sox2 looping with its distal enhancer [4C-Seq] April 15, 2026Contributors : Moreno Martinovic ; Koen D Flach ; Hans Teunissen ; Elzo de WitSeries Type : OtherOrganism : Mus musculusSox2 expression is regulated by a distal enhancer cluster known as the Sox2 Control Region (SCR). Although Sox2 and the SCR exhibit strong interactions in chromosome conformation capture experiments, acute depletion of cohesin only mildly a […]
- GSE327640 Targeting UBE2F induces a resilience program enhancing CD8 T cell immunity [Bulk RNA-seq] April 15, 2026Contributor : Xiaonan MaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCD8 memory T cells (TMEM) and exhausted T cells (TEX) are essential for host defense against infection and cancer, yet their therapeutic potential is often limited by insufficient persistence and sustained functional capacity. Strategies to enhance […]
- GSE327625 Pristimerin enhances erastin-induced ferroptosis in AML cells via the ATF3/SLC7A11 axis April 15, 2026Contributor : Shan ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAcute myeloid leukemia (AML) is a highly aggressive hematologic malignancy predominantly seen in adults, with chemotherapy remaining the primary modality for its clinical management. Nevertheless, the efficacy of chemotherapy is often compromised by […]
- GSE327731 A community machine learning challenge to predict the effects of gene perturbations on T cell differentiation for cancer immunotherapy April 15, 2026Contributors : Jiaqi Zhang ; Marc A Schwartz ; Mohammed Mutaher ; Oluwatomisin Olajide ; Yuri Pritkyin ; Orr Ashenbrg ; Nir Hacohen ; Caroline UhlerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPerturbations of genes with functional importance in T cells could be used to change the distribution of CD8 T cell states to […]
- GSE327705 Mast cells selectively deliver extracellular vesicle-encapsulated mRNA to colorectal cancer cells April 15, 2026Contributors : Heather O'Hagan ; Rosie LanzlothSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMast cells (MCs), a type of granulocytic immune cell, exert contrasting effects on tumorigenesis. The anti- or pro-tumorigenic activity of MCs depends on the cancer type, tumor microenvironment, as well as MC localization […]
- GSE327968 Gene expression profiling of GLP1R-IL17A axis in obesity driven PTPN11-mutant leukemia April 15, 2026Contributors : Santhosh Kumar Pasupuleti ; Reuben KapurSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusObesity-associated metabolic inflammation contributes to the progression of PTPN11-mutant myeloid leukemia through activation of the IL-17A–mediated inflammatory axis and suppression of GLP-1R signaling. In this study, […]
- GSE328023 Single-cell CITE-seq profiling of human bone marrow B cells with IgD and IgM antibody-derived tags April 15, 2026Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensWe performed single-cell RNA sequencing with cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq) on human bone marrow samples to characterize B cell populations. Cells were profiled using the 10x Genomics Chromium platform with simultaneous me […]
- GSE328024 A multi-omic dataset of cellular and microRNA profiles in human breast milk across a spectrum of gestational ages April 15, 2026Contributors : Ling Ma ; Zhengming Zhan ; Kang Zhang ; Xia Hong ; Yangke Li ; Yanyan Huo ; Daqian Zhu ; Lian Jiang ; Fan Yang ; Yanjun Zhao ; Wenxian Wang ; Jiaojiao Song ; Junmei Zhou ; Jinjin ChenSeries Type : Non-coding RNA profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiensBreast milk compos […]
- GSE286360 Angiopoietin-2 aggravates Alzheimer’s disease by promoting BBB breakdown and neuroinflammation. April 15, 2026Contributors : Eunhyeong Lee ; Seoyeon Kim ; Minah Kim ; Joon-Yong AnSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDisruption of the blood-brain barrier (BBB) and increased vascular leakage contribute to neuroinflammation in Alzheimer’s disease (AD), driving disease pathogenesis and progression. However, the mechanism […]