Quick Links : Search PubMed , Finding Full Text , PubMed Advanced Search , Clinical Queries , Single Citation Matcher , FAQs & User Guide , Explore MeSH Database , Explore PubMed Journals
Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE292284 Depletion of lamin-associated polypeptide 2 alpha leads to chromatin reorganization and redistribution of A-type lamins to open genomic regions [ATAC-seq] July 30, 2026Contributors : Daria Filipczak ; Fatih Sarigol ; Daniel Malzl ; Roland Foisner ; Nana NaetarSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusBackground: Lamins are major regulators of the spatial and functional organization of chromatin. Lamins at the nuclear periphery form the lamina that anchors heterochr […]
- GSE302818 SPEN is an androgen receptor dependent tumor suppressor and mediates hormonal therapy resistance in prostate cancer July 30, 2026Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE295644 Single-cell transcriptomic profiling of splenic cells under chronic anemia in mice July 30, 2026Contributors : Chong Yang ; Rui Yokomori ; Toshio SudaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSingle cell RNA-seq analysis for spleen tissue isolated from mice subjected to chronic phenohydrazine (PHZ) and bleeding (BLD) treatment respectively.
- GSE313652 RNA-seq of bronchoalveolar lavage cells from wild-type mice reconstituted with wild-type or Cry1/2 double-knockout bone marrow. July 30, 2026Contributors : Tingting Mills ; Chorong Han ; Ji Ye Lim ; Sun Young Kim ; Nobuya Koike ; Zheng Chen ; Seung-hee YooSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusChronic obstructive pulmonary disease (COPD) is a progressive inflammatory lung disease characterized by alveolar destruction and impaired tissue repair. Alth […]
- GSE304566 Combinatorial targeting of the miR-379/miR-410 cluster normalizes glucose and lipid homeostasis in male models of diabetes and obesity July 30, 2026Contributors : Manuel Gil-Lozano ; Estefania Simoes ; Moya Wu ; Tobias Wiedemann ; Yun Kwon ; Revathi Sekar ; Pauline Morigny ; Maria Troullinaki ; Juliane Merl-Pham ; Michael Buettner ; Anette Feuchtinger ; Celine Jouffe ; Adriano Maida ; Daniela Hass ; Daniel Samaga ; Juliano Machado ; Maude Giroud ; Katarina Klepac ; Carolyn L Cummins ; Marcos Rios-Garcia […]
- GSE316614 Targeting mutation-agnostic disease pathways ameliorates ciliopathy-related mesenchymal drift in RPE July 30, 2026Contributors : Dominik Reichert ; David McGaughey ; Kapil BhartiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCiliopathies are a family of disorders involving mutations in over 150 genes affecting the primary cilium, with retinal degeneration as a prominent feature driven by concomitant developmental and maturation de […]
- GSE315090 RNA-seq of PAPRi-resistant BRCA2-deficient cancer cells July 30, 2026Contributors : Qi-En Wang ; Na LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBulk RNA-seq of PARPi-resistant cells derived from ovarian cancer cell line PEO1, its parental cell PEO1, and PEO4 cells
- GSE338508 Faf2 is required for neural differentiation in embryonic neural progenitor cells July 30, 2026Contributors : Anneke D Kakebeen ; Leon Dunphy ; Heather K Hazen ; Lee A NiswanderSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNeural progenitor cell differentiation is a complex process requiring the proper integration of instructive and permissive factors. Instructive cues including signaling molecules and transcri […]
- GSE338165 Single-cell analysis identifies monocyte signatures of disease activity and clinical subtypes in Behçet’s disease July 30, 2026Contributors : Carmona Elio ; Deniz Rabia ; Cemal Bes ; Direskeneli Haner ; Gül Ahmet ; Sawalha H AmrSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis study used single-cell RNA sequencing of PBMCs from 34 Behçet’s disease patients and 12 healthy controls to characterize immune dysregulation across disease activity s […]
- GSE338670 Pandion PT-101 single-cell RNA-seq of CD122+ non-myeloid cells following IL-2 mutein treatment July 30, 2026Contributors : Kristina Harris ; Dan Campbell ; Laura Cooney ; Alice LongSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis study uses samples from the Pandion Phase 1a IL-2 mutein (PT-101) trial to investigate the mechanism of action of IL-2 mutein therapy. IL-2 mutein is engineered for increased affinity for CD25 an […]
- GSE338655 Bulk RNAseq of sorted Treg cells from a single ascending dose clinical trial in healthy adults of IL-2 mutein MK-6194 (formerly known as PT-101) July 30, 2026Contributors : Harris Kristina ; Campbell Dan ; Cooney Laura ; Long Alice ; Fanning MitchSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe objectives are to use cryopreserved PBMC samples from the Phase 1a single ascending dose trial of IL-2 mutein (MK-6194/PT-101) in healthy adults to define the transcriptional respo […]
- GSE339040 Brachyury expression levels predict lineage potential and axis-forming ability of in vitro derived neuromesodermal progenitors July 30, 2026Contributor : A Binagui-CasasSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNeuromesodermal progenitors (NMPs) produce the spinal cord and musculoskeleton in the elongating anterior-posterior axis. In vivo, NMPs possess dual potency, coinciding with regions coexpressing SOX2 and Brachyury (TBXT). In vitro, SOX2/TBXT co […]
- GSE339599 Truncating RELA variants drive autoinflammation and autoimmunity by impairing the negative feedback control of NF-k July 30, 2026Contributors : Johanna Klughammer ; Min A Lee-KirschSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe NF-κB signaling pathway coordinates inflammation, cell survival, and proliferation, while restraining excessive cell death to maintain immune homeostasis. Truncating mutations in RELA, encoding the NF-κB subunit p65, […]
- GSE341178 Cholesterol maintains the degradative capacity of lysosomes during clearance and recycling of dysfunctional mitochondria July 30, 2026Contributors : Haoning Yang ; Koji Matsuhisa ; Meng Wei ; Wataru Nishi ; Dylan Hong Zheng Koh ; Aik Yong Sim ; Isabelle Bonne ; Yasunori SahekiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEfficient clearance and recycling of dysfunctional mitochondria through the robust catabolic activity of lysosomes is essential fo […]
- GSE341489 Hidden outcomes of CRISPR/Cas9 genome editing revealed by targeted sequencing in isogenic human iPSC clones [RNA-seq] July 30, 2026Contributors : Tubalova Maria ; Koksharova Galina ; Costa Silvia ; Krepischi Ana ; Fishman Veniamin ; Gridina MariaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCRISPR/Cas9 editing can create complex on-target alterations that escape conventional PCR genotyping. We characterized ten edited human induced pluripotent st […]