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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE290865 NAC promotes co-translational protein folding at the ribosomal tunnel exit March 23, 2026Contributors : Jaime Santos ; Manuel Günnigmann ; Radoslaw J Gora ; Marija Iljina ; Masa Predin ; Ilgin Eser Kotan ; Pratiman De ; Dhawal Choudhary ; Juwon Jang ; Frank Tippmann ; Nenad Ban ; Sander Tans ; Shu-ou Shan ; Günter Kramer ; Bernd BukauSeries Type : OtherOrganism : Homo sapiensThe nascent polypeptide-associated complex (NAC) is crucial for protein […]
- GSE273962 Constitutive activation of canonical Wnt signaling in hem progenitors suppresses the fate of hem-derived Cajal-Retzius cells March 23, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCajal-Retzius cells (CR cells) are the earliest born neurons in the cerebral cortex, and have been implicated in neuronal migration and development of cortical circuitry. One of the sources of CR cells is the cortical hem, which is rich in morphogens of the canonical WNT s […]
- GSE295612 APOE4 expression causes distinct effects on meningeal immunity, brain lipid composition, and cognition in male and female mice March 23, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis experiment was designed to understand the distinct effects of sex and APOE genotype on the transcriptome of meningeal dural vascular and resident immune cells. After transcardiac perfusion with a buffered saline solution containing heparin and actinomycin D, meningeal […]
- GSE293605 Typical plasticisers DEHP, DBP treatment of human liver-like organs March 23, 2026Contributors : Yaru Tian ; Lijuan You ; Xiaoning Ji ; Jing Yang ; Zhisen Zhuang ; Hui YangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPhthalates are widely used as industrial plasticisers in the manufacture of plastics, resins, rubbers, paints, emulsifiers, medical devices, personal care products, and so on. Diethyl […]
- GSE302932 Transcriptomic profiling of chlorogenic acid and taurine treatment in human skin cells provides insights into cellular senescence mechanisms March 23, 2026Contributors : Beomsu Kim ; Joong-Gon Shin ; In-Shik Hong ; Yeeun Ahn ; Jung Yeon Seo ; Jae Young Shin ; Sooyeon Lee ; Seung-Hyun Jun ; Eui Taek Jeong ; Hyunbin Cho ; Miso Park ; Dansay Kim ; Nae Gyu Kang ; Yunkwan Kim ; Hong-Hee WonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensChlorogenic acid (CGA) and taurine are w […]
- GSE297073 Human pluripotent stem cell-derived atrioventricular node-like pacemaker cells exhibit biological conduction bridge properties [hpsc_scRNAseq] March 23, 2026Contributors : Michelle Lohbihler ; Amos A Lim ; Stéphane Massé ; Maggie Kwan ; Omar Mourad ; Olya Mastikhina ; Brandon M Murareanu ; Malak Elbatarny ; Renu Sarao ; Beiping Qiang ; Wahiba Dhahri ; Matthew L Chang ; Alice L Xu ; Amine Mazine ; Shahryar Khattak ; Sara S Nunes ; Kumaraswamy Nanthakumar ; Michael A Laflamme ; Stephanie ProtzeSeries Type : Expres […]
- GSE324761 A chemical inducer of ribophagy limits the toxicity of ALS-related arginine-rich peptides March 23, 2026Contributors : Bartlomiej Porebski ; Vanesa Lafarga ; Oscar Férnandez-CapetilloSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens9ORF72 intronic repeat expansions are the most frequent mutation found in Amyotrophic Lateral Sclerosis (ALS), producing toxic arginine-rich dipeptides (DPR) that disrupt RNA metabolism and trig […]
- GSE262305 Bortezomib increases immunotherapy efficacy through enhancement of STING and IFN-γ signaling in lung adenocarcinoma March 23, 2026Contributors : Yu Xi ; Kelin Meng ; Taiyan Yu ; Congjian WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBTZ has been reported to block cell proliferation and promote apoptosis of NSCLC cells. However, the clinical trails of BTZ alnoe or BTZ combinated with other chemotherapy have failed. Here, we reported that BTZ […]
- GSE325213 Transcriptomic analysis of fetal sheep liver across gestation (Gestational days 100, 124, and 144) March 23, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Ovis ariesThe fetal liver plays a central role in metabolic and immune adaptation during development. We performed bulk RNA sequencing of ovine fetal liver at gestational days 100, 124, and 144 to characterize transcriptional changes associated with hepatic maturation.
- GSE325187 Senescent Endothelial Cells in Cerebral Microcirculation Are Key Drivers of Age-Related Blood-Brain Barrier Disruption, Microvascular Rarefaction, and Neurovascular Coupling Impairment in Mice March 23, 2026Contributors : Anna Csiszar ; Zoltan Ungvari ; Roland Patai ; Tripti Gautam ; Tae-Gyu Oh ; Jenny R Gipson ; Makayla L FosterSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWith advancing age, neurovascular dysfunction manifests as impaired neurovascular coupling (NVC), microvascular rarefaction, and blood-brain barrier […]
- GSE325225 CD69 regulates the tissue dynamics of epigenetically imprinted memory CD4+ T cells [scATAC-seq] March 23, 2026Contributors : Rui Hirasawa ; Chiaki Iwamura ; Masahiro Kiuchi ; Hiroyuki Yagyu ; Takahisa Hishiya ; Norie Hamaguchi ; Atsushi Sasaki ; Kohei Kakinuma ; Kanae Ohishi ; Akane Kurosugi ; Masahiro Nemoto ; Kota Kokubo ; Takuto Hiramoto ; Tomohisa Iinuma ; Syuji Yonekura ; Atsushi Onodera ; Motoko Y Kimura ; Shinichiro Motohashi ; Damon J Tumes ; Toyoyuki Hanaza […]
- GSE325226 CD69 regulates the tissue dynamics of epigenetically imprinted memory CD4+ T cells [scRNA-seq] March 23, 2026Contributors : Rui Hirasawa ; Chiaki Iwamura ; Masahiro Kiuchi ; Hiroyuki Yagyu ; Takahisa Hishiya ; Norie Hamaguchi ; Atsushi Sasaki ; Kohei Kakinuma ; Kanae Ohishi ; Akane Kurosugi ; Masahiro Nemoto ; Kota Kokubo ; Takuto Hiramoto ; Tomohisa Iinuma ; Syuji Yonekura ; Atsushi Onodera ; Motoko Y Kimura ; Shinichiro Motohashi ; Damon J Tumes ; Toyoyuki Hanaza […]
- GSE325227 CD69 regulates the tissue dynamics of epigenetically imprinted memory CD4+ T cells [RNA-seq_ATAC-seq] March 23, 2026Contributors : Rui Hirasawa ; Chiaki Iwamura ; Masahiro Kiuchi ; Hiroyuki Yagyu ; Takahisa Hishiya ; Norie Hamaguchi ; Atsushi Sasaki ; Kohei Kakinuma ; Kanae Ohishi ; Akane Kurosugi ; Masahiro Nemoto ; Kota Kokubo ; Takuto Hiramoto ; Tomohisa Iinuma ; Syuji Yonekura ; Atsushi Onodera ; Motoko Y Kimura ; Shinichiro Motohashi ; Damon J Tumes ; Toyoyuki Hanaza […]
- GSE268413 Retrospective analysis reveals the early origin and development of pulmonary perivascular cells [scRNA-seq] March 23, 2026Contributors : Beatrice F Tan ; Isabel Sreeram ; Ruben G Boers ; Joachim B Boers ; Robbert RottierSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusEmerging evidence suggests pericytes play a significant role in various lung diseases. However, characterizing pericytes remains challenging, impeding our understanding of the […]
- GSE320403 The role of retinoic acid receptor signaling in liver cells during Alcohol-associated liver disease resolution by spatial transcriptomics analysis March 23, 2026Contributors : Irina Tikhanovich ; Michael SchonfeldSeries Type : OtherOrganism : Mus musculusAbstinence is beneficial for patients with alcohol-associated liver disease (ALD), but disease resolution after alcohol cessation occurs slowly and only in a subset of patients. Mechanisms of fibrosis resolution in ALD are not yet fully understood. Previous work hig […]