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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE255449 Function and mechanism of PAPOLA-mediated poly(A) lengthening in leukemia [RNA-Seq] December 14, 2025Contributors : Siyao Guo ; Shuibin LinSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe polyadenylation of mRNA is pivotal for mRNA stability and efficient mRNA translation. The length of poly(A) tail is dynamically changed under various physiological conditions; however, the functions and mechanisms of aberrant poly( […]
- GSE250385 Spatial transcriptomics reveals functional compartmentalization of the lung tissue of OP patient December 14, 2025Contributors : Ying Tang ; Cuilin Chu ; Siyuan Bu ; Qin Sun ; Airan Liu ; Lingyan Huang ; Hongmei WangSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensTo characterize the spatial characteristics of the lung tissue of OP patient, we collected lung samples for Visium CytAssist from one patient with OP
- GSE255667 Function and mechanism of PAPOLA-mediated poly(A) lengthening in leukemia [FLAM-Seq] December 14, 2025Contributors : Siyao Guo ; Shuibin LinSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe polyadenylation of mRNA is pivotal for mRNA stability and efficient mRNA translation. The length of poly(A) tail is dynamically changed under various physiological conditions; however, the functions and mechanisms of aberrant poly( […]
- GSE255603 Function and mechanism of PAPOLA-mediated poly(A) lengthening in leukemia [RIP-Seq] December 14, 2025Contributors : Siyao Guo ; Shuibin LinSeries Type : OtherOrganism : Homo sapiensThe polyadenylation of mRNA is pivotal for mRNA stability and efficient mRNA translation. The length of poly(A) tail is dynamically changed under various physiological conditions; however, the functions and mechanisms of aberrant poly(A) length control in cancers remain poorly un […]
- GSE294315 Function and mechanism of PAPOLA-mediated poly(A) lengthening in leukemia (mouse) December 14, 2025Contributors : Siyao Guo ; Shuibin LinSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe polyadenylation of mRNA is pivotal for mRNA stability and efficient mRNA translation. The length of poly(A) tail is dynamically changed under various physiological conditions; however, the functions and mechanisms of aberrant poly( […]
- GSE255668 Function and mechanism of PAPOLA-mediated poly(A) lengthening in leukemia December 14, 2025Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE308896 Cancer cells transfer invasive properties through microRNAs contained in collagen-tracks December 14, 2025Contributors : Frederic Saltel ; Lucile Rouyer ; Léa Normand ; Elodie Richard ; Nathalie Allain ; Julie Giraud ; Sylvaine Di-Tommaso ; Anne-Aurélie Raymond ; Cyril Dourthe ; Jean-William Dupuy ; Kévin Moreau ; Richard Iggo ; Nathalie Dugot-Senant ; Gaetan MacGrogan ; Anthony Bouter ; Sisareuth Tan ; Alexandre Favereaux ; Violaine Moreau ; Reini F. Luco ; Man […]
- GSE301626 NGLY1-dependent conversion of N-glycosylated N to D is essential for transcription of proteasome genes December 14, 2025Contributors : Yasumasa Nishito ; Yukiko YoshidaSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo investigate the sequence editing-specific effects on Nrf1 functions, we utilized glycan-less Nrf1 mutants, 9NA and 9ND, in which all nine of the putative N-glycosylation sites (N-X-S/T; asparagine (N) serine (S), threonine (T), and X is any am […]
- GSE312734 study on the role and mechanism of SOCS6 in keratinocytes December 14, 2025Contributors : Fugang Xiao ; Jinrong ZengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAtopic dermatitis is a severe skin disorder. Keratinocytes, as the epidermal barrier cells, are an important component in maintaining the skin barrier function. The role of SOCS6 in keratinocytes is still unclear. In this dataset, w […]
- GSE312054 Fat mass and obesity-associated (FTO)/SOCS6-m⁶A axis epigenetic modification links obesity to atopic dermatitis by regulating keratinocyte function December 14, 2025Contributors : Fugang Xiao ; Jinrong ZengSeries Type : Expression profiling by arrayOrganism : Homo sapiensAtopic dermatitis is one of the severe skin diseases. Keratinocytes, as the epidermal barrier cells, are an important component for maintaining the skin barrier function. In this dataset, we have included the m⁶A methylation RNA data obtained from norma […]
- GSE313132 Inflammation-induced lncRNA SNHG1 Orchestrates Spermatogonium Development in Non-obstructive Azoospermia via IL-17A Signaling Pathway December 14, 2025Contributors : Yongtong Zhu ; Maocai Li ; Xiaomin Zhan ; Li Liu ; Cairong Chen ; Yao Zhou ; Pei He ; Rui HuaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNon-obstructive azoospermia (NOA) is a critical subtype of male infertility associated with inflammation. However, the molecular mechanisms underlying this phenomeno […]
- GSE313194 Enterocloster citroniae and related gut microbiome species modulate Vibrio cholerae biofilm formation through the production of bioactive small molecules December 14, 2025Contributor : Antunes L CaetanoSeries Type : Expression profiling by high throughput sequencingOrganism : Vibrio cholerae C6706Cholera is a deadly diarrheal disease that affects millions of people globally. Although V. cholerae, the causative agent of the disease, has been extensively studied in isolation, it was relatively recently that scientists started i […]
- GSE313231 RNA-seq data of liver tissues from Alb-WT Bicd2fl/fl and Alb-Cre Bicd2fl/fl mice subjected to S-100 induced AIH model December 14, 2025Contributors : Wenyu Tian ; Weixuan Wang ; Dan LvSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRNA-seq was performed on liver tissues from Alb-WT Bicd2fl/fl and Alb-Cre Bicd2fl/fl mice subjected to S-100 induced AIH model. The study aims to characterize gene expression changes associated with hepatic inflammatory resp […]
- GSE313240 scRNA-seq data of hepatic immune cells isolated from Alb-WT Bicd2fl/fl and Alb-Cre Bicd2fl/fl mice subjected to S-100 induced AIH model December 14, 2025Contributors : Wenyu Tian ; Weixuan Wang ; Dan LvSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo determine the changes in liver immune cells upon hepatic Bicd2 deficiency, we performed scRNA-seq to analyze the hepatic immune microenvironment in Alb-WT Bicd2fl/fl and Alb-Cre Bicd2fl/fl mice subjected to S-100 induced […]
- GSE313266 LEFKOTHEA modulates gene expression at the transcriptional and post-transcriptional levels during early light response December 14, 2025Contributors : Anastasios Alatzas ; Despina Samakovli ; Loukia Roka ; Konstantinos Panagiotopoulos ; Gerasimos Daras ; Dimitra Milioni ; Stamatis Rigas ; Kosmas Haralampidis ; Polydefkis HatzopoulosSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaLight is the source of energy for photosynthetic organisms such as […]