Healthcare updates

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE255228 Mapping the zebrafish chromatin accessibility landscape by UUATAC-seq July 14, 2025
  Contributors : Guoji Guo ; Xiaoping Han ; Hanyu Wu ; Xueyi Wang ; Daiyuan LiuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Danio rerioThe current understanding of regulatory sequences in the vertebrate genome is still incomplete. By introducing an adapter switching strategy, we developed an ultra-throughput ultra-se […]
• GSE270072 Dual mitotic bookmarking by GAF condensates and H3K27ac orchestrates differential propagation of cell fate memory in neural development [CUT&Tag] July 14, 2025
  Contributors : Rulan Zhang ; Jie Liu ; Zimo Zhang ; Zili Chen ; Tanpeng Wang ; Yuying Shen ; Zejun Lan ; Jingyi Chu ; Haoxuan Tang ; Xiyue Zhang ; Yan SongSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Drosophila melanogasterIn brain development, neural stem cells (NSCs) undergo asymmetric cell divisions to replicate […]
• GSE264229 Mapping the male mouse chromatin accessibility landscape by UUATAC-seq July 14, 2025
  Contributors : Guoji Guo ; Xiaoping Han ; Hanyu Wu ; Xueyi Wang ; Daiyuan LiuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThe current understanding of regulatory sequences in the vertebrate genome is still incomplete. By introducing an adapter switching strategy, we developed an ultra-throughput ultra-s […]
• GSE282423 Imaging-based drug screening combined with moleuclar profiling identifies signatures and drivers of therapy resistance in pediatric AML [RNA-seq] July 14, 2025
  Contributors : Ben Haladik ; Margarita Maurer-Granofszky ; Peter Zoescher ; Raul Jimenez-Heredia ; Alexandra Frohne ; Anna Segarra-Roca ; Chloe Casey ; Felix Kartnig ; Sarah Giuliani ; Christina Rashkova ; Peter Repiscak ; Michael N Dworzak ; Giulio Superti-Furga ; Kaan BoztugSeries Type : Expression profiling by high throughput sequencing ; Genome binding/o […]
• GSE274757 Chromatin retained MUSHER lncRNA integrates ABA and DOG1 signalling pathways to enhance Arabidopsis seeds dormancy. July 14, 2025
  Contributors : Sebastian P Sacharowski ; Lien Brzezniak ; Michal Krzyszton ; Szymon SwiezewskiSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Arabidopsis thalianaMany plant lncRNAs regulate gene expression by binding to chromatin, but how they are retained at the target loci is unclear. We identify a new, chromatin-localize […]
• GSE302214 scRNAseq and TCRseq of tumor infiltrating CD8 T cells from samples July 14, 2025
  Contributor : Feixiang WangSeries Type : Other ; Expression profiling by high throughput sequencingOrganism : Homo sapiensThe goal of this study is to investigate the role of ageing on tumor infiltrating CD8 T cellsAgeing is a major risk factor for various cancers, and patients aged 65 years or older represent up to 60% of newly diagnosed cancer patients. Ag […]
• GSE284189 Mapping the chromatin accessibility landscape by UUATAC-seq July 14, 2025
  Contributors : Guoji Guo ; Xiaoping Han ; Hanyu Wu ; Xueyi Wang ; Daiyuan LiuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Ambystoma mexicanum ; Danio rerio ; Eublepharis macularius ; Gallus gallus ; Mus musculusThis SuperSeries is composed of the SubSeries listed below.
• GSE301387 Convergent DNA Methylation Abnormalities at Bivalent Chromatin in Human Growth Disorders July 14, 2025
  Series Type : Methylation profiling by genome tiling array ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
• GSE301386 Convergent DNA Methylation Abnormalities at Bivalent Chromatin in Human Growth Disorders [CUT&RUN] July 14, 2025
  Contributors : Marie Strauss ; Minji ByunSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensOvergrowth with Intellectual Disability (OGID) is characterized by generalized overgrowth, including a head circumference and/or height ≥ 2 standard deviations (s.d.) above the mean, accompanied by mild to moderate int […]
• GSE302155 Protein arginine methyltransferase 7 regulates the cell cycle and promotes the progression of prostate cancer July 14, 2025
  Contributors : Hongyuan Wan ; Hangshen Zhou ; Jiandong Gui ; Dongjie Yang ; Lijie Zhu ; Ninghan Feng ; Yuanyuan MiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: Prostate cancer (PCa) is the second most common cancer in males worldwide. Arginine methyltransferase 7 (PRMT7) expression is associated with tumor […]
• GSE301528 Comprehensive evaluation of bone marrow microenvironment in patients with autoimmune hemolytic anemia: from trephine biopsy to single cell RNA sequencing. July 14, 2025
  Contributors : Bruno Fattizzo ; Matteo Claudio Da Vià ; Francesca Lazzaroni ; Alfredo Marchetti ; Alessio Marella ; Akihiro Maeda ; Antonio Giovanni Solimando ; Loredana Pettine ; Francesco Passamonti ; Niccolò Bolli ; Wilma BarcelliniSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHere we investigated bone marrow (BM) […]
• GSE302163 Repurposing Zafirlukast Confers Renal Protection in Ischemia-Reperfusion Injury via Suppressing Macrophage METosis [RNA-Seq] July 14, 2025
  Contributors : Xiaochun Ye ; Meiyun Wen ; Yumei Huang ; Ruofang Zheng ; Ping Wang ; Ran Chen ; Longwei ZhaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTacrolimus is widely used to prevent post-transplant acute kidney injury (AKI) but causes severe toxicities (e.g., nephrotoxicity, hyperglycemia). We repurposed zafir […]
• GSE302166 Human brain organoids: a new model to study Cryptococcus neoformans neurotropism July 14, 2025
  Contributors : Alfred Harding ; Lee Gehrke ; Jatin Vyas ; Hannah Brown HardingSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWith the rise in immunocompromised individuals and patients with immune-related comorbidities such as COVID-19, the rate of fungal infections is growing. This increase, along with the current pla […]
• GSE302167 MYDGF Governs Endothelial Homeostasis in Hypertension July 14, 2025
  Contributors : Xiaohan Liu ; Min Liu ; Huiying JinSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMyeloid-derived growth factor (MYDGF) demonstrates well-established cardioprotective properties. However, its endothelial-specific functions and potential therapeutic applications in hypertension remain largely unexplored. […]
• GSE251954 Mapping the chicken chromatin accessibility landscape by UUATAC-seq July 14, 2025
  Contributors : Guoji Guo ; Xiaoping Han ; Hanyu Wu ; Xueyi Wang ; Daiyuan LiuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Gallus gallusThe current understanding of regulatory sequences in the vertebrate genome is still incomplete. By introducing an adapter switching strategy, we developed an ultra-throughput ultra- […]