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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE296299 A genome-wide functional analysis of conserved intronic regions reveals essential roles for speckle-associated detained introns [RNAseq_candidates.HAP1] June 18, 2026Contributors : Shaghayegh Farhangmehr ; Ulrich Braunschweig ; Mingkun Wu ; Syed Nabeel-Shah ; Kevin Brown ; Jason Moffat ; Benjamin J BlencoweSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThousands of human introns harbour extended regions of high evolutionarily conservation that have not been previously characterized […]
- GSE293311 Developmental Dynamics of Skeletal Muscle Can Be Recapitulated In Vitro from Pig Embryonic Stem Cells June 18, 2026Contributors : Jinsol Jeong ; Kwang-Hwan Choi ; Dong-Kyung Lee ; Chang-Kyu LeeSeries Type : Expression profiling by high throughput sequencingOrganism : Sus scrofaUnderstanding skeletal muscle development in pigs is required for fundamental developmental biology and its application in biomedical and agricultural industries. Here, we employed a directed myoge […]
- GSE302312 Synchronised regeneration of osteochondral defects via spatially patterned implants of stable and hypertrophic cartilage organoids June 18, 2026Contributors : Liuqi peng ; Isaak Decoene ; Hanna Svitina ; Ioannis PapantoniouSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRepairing deep osteochondral defects remains clinically challenging due to the intrinsic inability of articular cartilage to self-repair and the need for integrated yet distinct regeneration of […]
- GSE299763 Transcriptome analysis of KRT15 knockdown in lenvatinib-resistant papillary thyroid carcinoma cells June 18, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensLenvatinib resistance is a major clinical obstacle in the treatment of radioiodine-refractory papillary thyroid cancer (PTC), and clarifying its molecular mechanisms is crucial for developing effective therapeutic strategies. In this study, we identify Keratin 15 (KRT15) a […]
- GSE308228 NDUFS6 promotes neuroblastoma progression and represents a potential therapeutic target June 18, 2026Contributors : Enqing Zhou ; Xiaoran Du ; Deqian Chen ; Shuyang Dai ; Yong Zhan ; Yi Li ; Yifei Lu ; Lian Chen ; Kuiran Dong ; Ran Yang ; Rui DongSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensActive oxidative phosphorylation is increasingly recognized as a defining metabolic feature of high-risk neuroblastoma (NB). ND […]
- GSE304916 A transfer RNA modification drives genome-wide synonymous recoding across human commensal bacterial families June 18, 2026Contributors : Christopher D Katanski ; Chathuri Pathirage ; Jenny Chang ; Iva Veseli ; Tyler Smith ; Marcus Foo ; Yuan Wu ; Yichen Hou ; Hoang Anh V Tran ; Dominika Rudzka ; Mohammad Amin Bayat Tork ; Karen Lolans ; Amy Willis ; Weixin Tang ; A Murat Eren ; Michael Federle ; Kristin Koutmou ; Tao PanSeries Type : Expression profiling by high throughput sequ […]
- GSE333358 Integration of Transcriptional Signatures from Brain Tissue and Plasma Extracellular Vesicles of a Preclinical Tauopathy Mouse Model [brain ncRNA-Seq] June 18, 2026Series Type : Non-coding RNA profiling by high throughput sequencingOrganism : Mus musculusTauopathies, including Alzheimer’s disease, involve progressive neurodegeneration and sustained neuroinflammation. We present a multi-compartment transcriptomic atlas of 9.6-month-old PS19 tauopathy mice compared with wild-type (WT) controls (n=8/group), profiling cort […]
- GSE196383 chromatin landscape and transciptome regulated by RBBP4/p300 complex in glioblastoma June 18, 2026Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE335568 The FGF4–integrin β1 axis orchestrates diabetic wound regeneration by restoring directional collective motility. June 18, 2026Contributors : Jian Sun ; Zhifeng Huang ; Jie Zhou ; Shuodan Ding ; Zhiming ZhangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThis dataset was generated to investigate the mechanisms underlying the pro-healing effects of Fibroblast Growth Factor 4 (FGF4) on diabetic wounds. We performed RNA sequencing o […]
- GSE334417 Respiratory syncytial virus inhibits Type I Interferon signaling to maintain HLA-DM expression in CD1c + Dendritic cells June 18, 2026Contributors : Weiyee Ong ; Richard A Hopkins ; EnJun Yang ; Novita Novita ; Najwa Talib ; Bijin Au ; John E ConnollySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRespiratory Syncytial Virus (RSV) infection often elicits ineffective long-term immune responses due to inefficient immune priming, complicating disease man […]
- GSE335600 Microaerobic Copper Stress Redirects Pyruvate Metabolism and Reveals a CopL-linked Nitrogen Response in Staphylococcus aureus. June 18, 2026Contributors : Sean C Brennan ; Inderpreet Kaur ; Daniella Spencer ; Jo Purves ; Hannah R Sampson ; Julian M Ketley ; Joan A Geoghegan ; Peter W Andrew ; Kevin J Waldron ; Julie A MorrisseySeries Type : Expression profiling by high throughput sequencingOrganism : Staphylococcus aureusCopper is both an essential enzyme cofactor and an antimicrobial agent depl […]
- GSE335660 Hypoxia-preconditioned tendon stem cell-derived extracellular vesicles promote tendon regeneration by modulating macrophage heterogeneity June 18, 2026Contributors : Mingzhao Zhang ; Chenfeng HeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTendon injuries result in poor healing outcomes and functional impairment. Extracellular vesicles (EVs) derived from tendon stem cells (TSCs) have shown therapeutic potential for tendon regeneration. Because tendon tissues exist i […]
- GSE335694 Maternal Vitamin C Deficiency and Genetic Risk Factors Contribute to Congenital Malformations through Dysregulation of DNA Methylation. [CUT&Tag E8.5] June 18, 2026Contributors : Bernard van der Veer ; Kian KohSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusMaternal dietary insufficiencies can reshape the offspring epigenome during gestation, contributing to birth defects and developmental disorders. Vitamin C (VitC) is a critical co-factor for Ten-Eleven-Translocati […]
- GSE285150 Astrocyte molecular changes during basolateral amygdala-related emotional behaviors June 18, 2026Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE333357 Integration of Transcriptional Signatures from Brain Tissue and Plasma Extracellular Vesicles of a Preclinical Tauopathy Mouse Model [EV ncRNA-Seq] June 18, 2026Series Type : Non-coding RNA profiling by high throughput sequencingOrganism : Mus musculusTauopathies, including Alzheimer’s disease, involve progressive neurodegeneration and sustained neuroinflammation. We present a multi-compartment transcriptomic atlas of 9.6-month-old PS19 tauopathy mice compared with wild-type (WT) controls (n=8/group), profiling cort […]