Healthcare updates

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE329938 Comprehensive profiling of ALK fusion lung adenocarcinomas identifies mutant p53 driven DNA replication and repair deregulation in targeted therapy resistance [RNA-Seq] May 12, 2026
  Contributors : Esther Redin ; Yingqian A Zhan ; Charles M RudinSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAcquired resistance to ALK tyrosine kinase inhibitors (TKIs) remains a major barrier in ALK-fusion lung adenocarcinoma (LUAD), with up to 50% of resistant tumors lacking known resistance drivers. Here, we perfo […]
• GSE329891 Engulfment by brain macrophages in a short-lived vertebrate May 12, 2026
  Contributor : Rahul NagvekarSeries Type : Expression profiling by high throughput sequencingOrganism : Nothobranchius furzeriEngulfment by macrophages is critical for waste clearance in the vertebrate brain. Understanding clearance mechanisms may open new therapeutic possibilities to counter brain aging and neurodegenerative diseases. However, few in vivo mo […]
• GSE289872 Eosinophils promote a second wave of postnatal smooth muscle cell differentiation in intestinal villi May 12, 2026
  Contributors : Jeremiah Bernier-Latmani ; Tania Wyss ; Tatiana V PetrovaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIntestinal villus smooth muscle cells (SMCs) play a critical structural and functional role in the gut, notably facilitating dietary fat transport via villus-associated lymphatic lacteals. In the early […]
• GSE330325 Epic Methylation analysis on Glycogen Storage Disorder type 1a and Healthy Controls fibroblasts May 12, 2026
  Contributors : Uri Sprecher ; Noam MוuchtarSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensAn analysis of differences in the genomic methylation pattern between GSD1a and HC samples using the Illumina EPIC V2 array as shown in the Disease-associated programming of cell memory in glycogen storage disorder type 1a manuscript. T […]
• GSE307171 HCMV Immediate Early Proteins Promote Lytic Infection and Reactivation in Monocytes May 12, 2026
  Contributors : Kitsberg Yaarit ; Nachshon Aharon ; Michal Schwartz ; Noam Stern-GinossarSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHuman cytomegalovirus (HCMV) is a prevalent pathogen of the herpesvirus family, infecting most of the human population worldwide. Like all herpesviruses, HCMV can establish a latent inf […]
• GSE297180 Magnetic Field Suppresses Non-Small Cell Lung Cancer via RSRP1-Mediated Secretory Signaling Axis May 12, 2026
  Contributors : jie sun ; yingying tong ; yu jia ; xu jia ; mei zhang ; guanghua yangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMagnetic field therapy holds promise for tumor treatment, yet its underlying mechanisms remain controversial. The traditional ROS theory fails to fully explain the observed magnetic field-i […]
• GSE330223 Convergence of cytokine dysregulation and antibody deficiency in common variable immunodeficiency with inflammatory complications May 12, 2026
  Contributors : Miranda L Abyazi ; Kayla A Bell ; Gavin Gyimesi ; Turner Baker ; Minji Byun ; Huaibin M Ko ; Charlotte Cunningham-Rundles ; Feng Feng ; Paul J MaglioneSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: Noninfectious complications are the greatest cause of morbidity and mortality in common variabl […]
• GSE316165 ZNF384-Driven WTAP Transactivation Promotes H. pylori-Induced Gastric Carcinogenesis via m6A-Mediated Stabilization of PFKP and Glycolytic Flux May 12, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHGC-27 GC cells were stimulated with Helicobacter pylori. RNA-seq was performed to identify diffferentially-expressed gene in Hp-infected gastric cancers.
• GSE330243 GATA4 loss promotes mutant Kras-driven pancreatic ductal adenocarcinoma in the absence of canonical precursor lesions [bulk RNA-Seq] May 12, 2026
  Contributors : Madriles Francesc ; P. de Andrés Mónica ; Chesnokov Mikhail ; Martinez de Villarreal Jaime ; Real Francisco X.Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGATA6 and GATA4 play key roles in pancreatic development and are essential to maintain the classical transcriptional program in pancreatic ductal ad […]
• GSE330233 CHD8 haploinsufficiency impairs ventral progenitor proliferation and inhibitory neuronal maturation in human ventral forebrain organoids May 12, 2026
  Contributors : Tomoya Iwasaki ; Atsuki Kawamura ; Masaaki NishiyamaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe performed bulk RNA-seq analysis of human ventral forebrain organoids to investigate transcriptomic changes associated with CHD8 heterozygous knockout. Sequencing data were generated from CHD8 heterozygou […]
• GSE330245 GATA4 loss promotes mutant Kras-driven pancreatic ductal adenocarcinoma in the absence of canonical precursor lesions [Epithelial RNA-seq] May 12, 2026
  Contributors : Francesc Madriles ; Mónica P. de Andrés ; Mikhail Chesnokov ; Jaime Martinez de Villarreal ; Francisco X. RealSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGATA6 and GATA4 play key roles in pancreatic development and are essential to maintain the classical transcriptional program in pancreatic ductal ad […]
• GSE330249 GATA4 loss promotes mutant Kras-driven pancreatic ductal adenocarcinoma in the absence of canonical precursor lesions [ChIP-Seq] May 12, 2026
  Contributors : Francesc Madriles ; Mónica P. de Andrés ; Mikhail Chesnokov ; Jaime Martinez de Villarreal ; Francisco X. RealSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusGATA6 and GATA4 play key roles in pancreatic development and are essential to maintain the classical transcriptional program in pancre […]
• GSE330256 Tumor-derived miR200a inhibits metastasis via Wnt5a/IL-6/B7-H4 axis in ovarian cancer [RNA-seq] May 12, 2026
  Contributors : He Fei ; Lina Yang ; Fengyin JiangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGene expression analysis in human Ovarian Cancer cells(HEY) treated with gain of function of miR200a.
• GSE328568 VdGGCT, a GGCT_like super family protein, is required for mycelial growth, conidiation and pathogenicity of Verticillium dahliae May 12, 2026
  Contributors : Huimin Li ; Ping Ma ; Qinggang GuoSeries Type : Expression profiling by high throughput sequencingOrganism : Verticillium dahliaeGiven the scarcity of known virulence factors in V. dahliae, which causes severe agricultural losses globally, identification of novel virulence genes is imperative for developing small-molecule inhibitor-based strat […]
• GSE330201 PEDV Discontinuous Transcription Generates A Novel Subgenomic RNA to Enhance Immune Evasion and Viral Fitness May 12, 2026
  Contributor : Dehua LuoSeries Type : OtherOrganism : Porcine epidemic diarrhea virusDuring viral evolution, RNA viruses accumulate advantageous mutations that enhance replicative, adaptability, and evasion of host immune responses. While most studies have focused on amino acid substitutions that alter protein function, functional RNA-level mutations remain l […]