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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE310849 Repeated Disuse Atrophy in Aged Rat Skeletal Muscle (RNA-seq / Transcriptome) February 24, 2026Contributors : Adam P Sharples ; Daniel C TurnerSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusDisuse-induced muscle atrophy commonly occurs following illness, injury, or falls and becomes increasingly frequent with ageing. Whether skeletal muscle retains a “memory” of repeated disuse remains unknown. We investiga […]
- GSE271982 Histone acetylation-dependent clustering of BRD2 instructs transcription dynamics February 24, 2026Contributors : Niyazi Umut Erdogdu ; Ronald Oellers ; Asifa AkhtarSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Other ; Expression profiling by high throughput sequencingOrganism : Mus musculusBromodomain (BD) and extra-terminal domain (BET) proteins are key regulators of RNA polymerase II (Pol II)-mediated transcription an […]
- GSE320035 RNA-seq analysis of liquid-induced suspended animation (LISA) in C. elegans February 24, 2026Contributors : Junqiang Liu ; Dengke MaSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansTo elucidate the molecular landscape associated with liquid-induced suspended animation (LISA) in C. elegans, we performed transcriptomic profiling of animals subjected to high-density isosmotic liquid conditions. Wild-type […]
- GSE290339 A viral transcriptional regulator from a dsRNA virus antagonizes the innate immune response by manipulating the host co-transcription factor DHX9 [ChIP-Seq] February 24, 2026Contributors : Xueyang Pang ; Shiyu Liu ; Yixiao Zhu ; Meleana Hinchman ; Nan Qiao ; Xuejun Li ; Weiqian Dai ; Yingying Tong ; Man Xing ; Jiling Ren ; John Parker ; Yingying Guo ; Dongming ZhouSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensViral transcriptional regulators (vTRs) have emerged as potent fac […]
- GSE275174 ERV-Derived RNA-DNA Hybrids Upregulate C4b to Induce Microglial Synaptic Pruning in autism [RNA] February 24, 2026Contributors : Boxin Zhang ; Shaoxuan ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMicroglia-mediated neuroinflammation has been identified as pathogenic in autism spectrum disorders (ASD). Pathogenic factors for microglial activation remain unclear. In our study, we discovered that complement C4b is highly expre […]
- GSE310344 Repeated Disuse Atrophy in Adult Human Skeletal Muscle (RNA-seq / Transcriptome) February 24, 2026Contributors : Adam P Sharples ; Daniel C TurnerSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDisuse-induced muscle atrophy commonly occurs following illness, injury, or falls and becomes increasingly frequent with ageing. Whether skeletal muscle retains a “memory” of repeated disuse remains unknown. We investigated r […]
- GSE290346 An Epigenetetic Signature for Classifying Pancreatic Ductal Adenocarcinoma Based on their Cellular Origin February 24, 2026Contributors : Ilianna Zoi ; Patrick JacqueminSeries Type : Methylation profiling by genome tiling arrayOrganism : Mus musculusPancreatic ductal adenocarcinoma (PDAC) is among the deadliest cancers, characterized by significant heterogeneity that complicates treatment and diagnosis. While acinar and ductal cells can serve as the origins of PDAC in mice, shap […]
- GSE319822 RNA-seq analysis of mouse spinal cord after contusion injury with Syringin treatment February 24, 2026Contributors : Dejing Zhang ; Tao ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe performed RNA-seq to investigate the transcriptomic changes in mouse spinal cord at 3 days post-contusion injury, and to evaluate the effects of Syringin treatment (50 mg/kg daily for 3 days) compared to PBS control.
- GSE310939 C9orf72 Hexanucleotide Repeat RNA Drives Transcriptional Dysregulation Through Genome-wide Hybrid G-quadruplexes [ChIRP-seq] February 24, 2026Contributors : Honghe Liu ; Mingming Liu ; Jiou WangSeries Type : OtherOrganism : Homo sapiensA hexanucleotide repeat expansion in C9orf72 is the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. While repeat RNAs are implicated in disease pathogenesis, their mechanisms of actions remain incompletely understood. Here we […]
- GSE319827 Transcriptome analysis of the response of domesticated emmer wheat (Triticum turgidum subsp. dicoccum) to single vs. mixed infections with Zymosptoria tritici and Puccinia graminis February 24, 2026Contributors : Miguel A Corrales-Gutiérrez ; Luis A Sterling ; Francesca Desiderio ; Dimitar Douchkov ; Jiasui Zhan ; Salim BourrasSeries Type : Expression profiling by high throughput sequencingOrganism : Triticum turgidum subsp. dicoccumTetraploid emmer Triticum turgidum subsp. dicoccum is one of the first wheat species to be domesticated. Emmer shares man […]
- GSE319826 Conjugation of isothiocyanates with the cofactor tetrahydrobiopterin is a mechanism of glucosinolate action in insects February 24, 2026Contributor : Tam MaiSeries Type : Expression profiling by high throughput sequencingOrganism : Adalia bipunctataGlucosinolates are plant natural products that provide diverse health benefits in human diets, but are toxins and feeding deterrents for insects. While the molecular mechanisms of glucosinolate action have been well-studied in mammalian systems, t […]
- GSE319960 Plasma miR-98-5p as a diagnostic biomarker for oxaliplatin-induced neuropathic pain related to NGF and catecholamine dysregulation February 24, 2026Contributors : Yeongdon Ju ; Aelee JangSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensThis study aimed to identify differentially expressed microRNAs in plasma samples from patients with gastrointestinal cancer treated with oxaliplatin to elucidate the association between the expression levels of miRNA, nerve growt […]
- GSE320007 Oncolytic virotherapy and platinum-based chemotherapy synergize to potentiate anti-tumor immunity through targeted engagement of chemo-persistent bystander CD8+ T cells [scRNA-seq] February 24, 2026Contributors : Xiangyu Chen ; Guoshuai Cao ; Shuai YueSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe reported the CD8+ T cell exhaustion differences between chronic viral infection and tumor regarding their transcriptomic and epigenetic landscapes, immune checkpoint blockade responsiveness and underlying molecular m […]
- GSE320030 A selective and augmentable butyrate-FFAR2 signal circuitry programs the cellular identity of enteroendocrine L-cells February 24, 2026Contributors : Aanya Hirdaramani ; Chia-Wei Gheng ; Gary Frost ; Aylin HanyalogluSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusActivation of free fatty acid receptor 2 (FFAR2) on enteroendocrine L-cells mediates secretion of glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), key regulators of central appetite contr […]
- GSE310848 Repeated Disuse Atrophy in Aged Rat Skeletal Muscle (Reduced Representation Enzymatic Seq / Methylome) February 24, 2026Contributors : Adam P Sharples ; Daniel C TurnerSeries Type : Methylation profiling by high throughput sequencingOrganism : Rattus norvegicusDisuse-induced muscle atrophy commonly occurs following illness, injury, or falls and becomes increasingly frequent with ageing. Whether skeletal muscle retains a “memory” of repeated disuse remains unknown. We investig […]