Healthcare updates

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE282073 Diverse Roles of Arabidopsis ROS1 in Regulating Chromatin Accessibility and DNA Methylation [Bisulfite-Seq] February 6, 2026
  Contributors : Li Deng ; Guangfeng Zhu ; Wenying Zhong ; Lun ZhaoSeries Type : Methylation profiling by high throughput sequencingOrganism : Arabidopsis thalianaOver two decades after the discovery of ROS1 as the first eukaryotic DNA demethylase, its genome-wide binding sites and functions beyond active DNA demethylation remain unknown. Here, using advanced […]
• GSE280080 Radiotherapy synergizes with AAV-based immunotherapy to program local and systemic antitumor immunity February 6, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
• GSE288948 Macrophage Smad1 contributes to post-infarction dysfunction, suppressing angiogenic chemokine expression, and stimulating extracellular matrix remodeling February 6, 2026
  Contributors : Bijun Chen ; Shuaibo Huang ; Anis Hanna ; Silvia C Hernandez ; Nikolaos G FrangogiannisSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn healing infarcts, macrophages undergo dramatic phenotypic changes in response to cytokines and growth factors and serve as central effectors in cardiac repair and remod […]
• GSE288393 sc-RNA-seq study of dedifferentiating intestinal epithelial cells reveals oncogenic reprogramming to heterogeneous stem cell states [dataset 1] February 6, 2026
  Contributors : Kylee Zgeib ; Thompson Hui ; Atharva Inamdar ; Ansu Perekatt ; Crystal Lim ; Shima Nejati ; Binfeng Lu ; Simon Garcia ; Zahra Hashemi ; Amartya Sigh ; Dahlia Matouba ; Christina LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIntestinal tumors can arise either from mutations sustained in Lgr5⁺ stem cell […]
• GSE318538 Effect of KIFC1 knockdown on gene expression in H146 small-cell lung cancer cells February 6, 2026
  Contributors : Natsuki Nakagawa ; Hiroaki Ikushima ; Masanori KawakamiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the function of KIFC1 in small-cell lung cancer, we established the H146 cell line in which KIFC1 was knocked down using siRNA. We then performed gene expression profiling analysis using R […]
• GSE289256 Multi-omic landscape of squamous cell lung cancer February 6, 2026
  Contributors : Paul E Stewart ; Eric B Haura ; Elsa R FloresSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe identified 116 patients consented to the Total Cancer Care (TM) protocol that had donated snap frozen lung squamous cell carcinoma tumor tissues with linked molecular data as well as clinical history, tumor pat […]
• GSE318353 Single-cell transcriptomic profiling reveals the heterogeneity of miR-18a-mediated resistance to targeted therapy and immunotherapy in melanoma February 6, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn melanoma, the knockout of miR-18a not only leads to resistance to monotherapy with BRAF inhibitors but also to combined therapy with BRAF and MEK inhibitors. This resistance is achieved by promoting the expression of YAP in the Hippo pathway. Additionally, the knockout […]
• GSE255194 Tailoring a CRISPR/Cas-based Epigenome Editor for Programmable Chromatin Acylation and Decreased Cytotoxicity [CUT&RUN] February 6, 2026
  Contributors : Isaac Hilton ; Jacob GoellSeries Type : OtherOrganism : Homo sapiensPrecisely engineering histone acylation states can inform mechanistic epigenetics and catalyze new therapeutic epigenome editing opportunities. Here, we developed engineered lysine acyltransferases that enable the deposition of acetylation and longer-chain acylations in a prog […]
• GSE318384 Integrated Multi-omics Analysis Reveals Tumor-Suppressive Phenotypes and Associated Transcriptomic Remodeling upon METTL3 Overexpression in A549 Lung Cancer Cells February 6, 2026
  Contributors : Zhao Liu ; Yanwu Zhou ; Chun LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: Lung cancer (LC) remains a leading cause of cancer-related death globally. The methyltransferase METTL3, a core writer of RNA N6-methyladenosine (m6A) modification, is a key regulator in cancer. However, its systema […]
• GSE318354 Transcriptomic profiling of miR-18a CRISPR knockout melanoma identifies genes associated with therapy resistance and T cell killing February 6, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn melanoma, the knockout of miR-18a not only leads to resistance to monotherapy with BRAF inhibitors but also to combined therapy with BRAF and MEK inhibitors. This resistance is achieved by promoting the expression of YAP in the Hippo pathway. Additionally, the knockout […]
• GSE318414 Lipid metabolism dysregulation in solar lentigo: a multi-system-level analysis reveals membrane instability and energy homeostasis disruption February 6, 2026
  Contributors : Soonhyo Kwon ; Man S KimSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSolar lentigo is a common hyperpigmented skin condition caused by chronic ultraviolet exposure, primarily affecting photoaged skin. While previous investigations focused on inflammatory and melanogenic mechanisms, the comprehensive ro […]
• GSE318498 Gene expression differences between LPS, anti-CD36 Abs, or LPS plus anti-CD36 Abs treated RAW264.7 cells. February 6, 2026
  Contributors : Xin Sun ; Weixuan Wang ; Dan LvSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo comprehensively analyze the transcriptome of macrophages treated with LPS, anti-CD36 Abs, or LPS plus anti-CD36 Abs, respectively, we employed RNA sequencing (RNA-seq) assay
• GSE318501 miRNA-18a screened based on CRISPR can regulate targeted therapy resistance and T-cell killing in melanoma February 6, 2026
  Series Type : OtherOrganism : Homo sapiensIn melanoma, the knockout of miR-18a not only leads to resistance to monotherapy with BRAF inhibitors but also to combined therapy with BRAF and MEK inhibitors. This resistance is achieved by promoting the expression of YAP in the Hippo pathway. Additionally, the knockout of miR-18a results in high expression of THBS […]
• GSE279313 TGF-β controls epigenetic re-programing of IFN-antiviral trained immunity and impairs virologic control in SIV-infected rhesus macaques [bulk RNA-seq] February 6, 2026
  Contributors : Felipe ten-Caten ; Khader Ghneim ; Mirko Paiardini ; Susan P Ribeiro ; Rafick P SekalySeries Type : Expression profiling by high throughput sequencingOrganism : Macaca mulattaCurrent immunotherapeutic approaches to eliminate latently HIV-infected cells have focused on targeting the adaptive arm of the immune system using vaccines and passive t […]
• GSE318342 Snail1 Induced Suppression of Proliferation via EGR1, FOXO1, and CEPBg Creates a Vulnerability for Targeting Apoptotic and Cellular Senescence Pathways [ChIP-Seq] February 6, 2026
  Contributors : Jack Tran ; Cynthia Miranti ; Samyukta Sundaram ; Sukitrti Shivpuri ; Hunain KhawajaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThe annual ~36,000 prostate cancer (PCa) deaths represent a large clinical unmet need and a call for deeper understanding of PCa metastasis. Epithelial-mesenchy […]