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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE306607 RNA sequencing of HeLa cells with scramble control and CNOT11 knockdown August 6, 2026Contributors : Saori Nishijima ; Toru Suzuki ; Tadashi YamamotoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHeLa cells were transfected with scramble siRNA or siRNA targeting the CCR4-NOT subunit CNOT11. After 72 hours, total RNA was extracted and subjected to polyA-selected RNA sequencing.
- GSE304808 Functional anaylsis of IRF9 in the chicken innate antiviral immune response August 6, 2026Contributors : Grace Schmidt ; Tae Hyun KimSeries Type : Expression profiling by high throughput sequencingOrganism : Gallus gallusThe chicken immune system is distinct from many mammalian models due to its reduced immune gene repertoire yet retained ability to mount a highly effective immune response. In mammals, interferon regulatory factor 9 (IRF9) is a k […]
- GSE312014 Deficiency of pnkp in zebrafish causes microcephaly, seizures and developmental delay through mitochondrial dysfunction August 6, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Danio rerioVariants in the polynucleotide kinase-phosphatase (PNKP) gene leads to a severe neurological disease characterized by microcephaly, intractable seizures, and developmental delay (MCSZ). Despite its clinical impact, the underlying pathological mechanisms remain unclear. In t […]
- GSE308846 Reprogramming lineage features promotes epithelial behavior in carcinoma cells [ATAC-seq] August 6, 2026Contributor : Terada LanceSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensCancer cells distort epigenetic control of gene expression, allowing for a remarkable degree of plasticity and loss of cell type identity. At the same time, expression of identity-discordant lineage determinants can significantly shi […]
- GSE225153 Increasing TET expression and 5-hydroxymethylcytosine formation by a carbocyclic 5-aza-2’-deoxy-cytidine antimetabolite [RNA-seq] August 6, 2026Contributors : Maike Däther ; Elsa Peev ; Annika Fröhlich ; Binje Vick ; Sogol Fatourechi ; Gilles Gasparoni ; Matthias Heiss ; Corinna C Pleintinger ; Emmanuel A Bisong ; Hans Hurmitz ; Davide Guglielminotti ; Yasmin V Gärtner ; Tina Aumer ; Kartsen Spiekermann ; Jörn Walter ; Irmela Jeremias ; Franziska R Traube ; Thomas CarellSeries Type : Expression prof […]
- GSE316081 SLF2 and SMC5 dysfunction drives HSC aging and predisposes to MDS, defining a new inherited bone marrow failure syndrome [RNA-seq] August 6, 2026Contributors : Sho Shibata ; Kazuhisa Chonabayashi ; Yasuko Matsumura ; Yoshinori YoshidaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPathogenic variants in SLF2 and SMC5 cause a developmental disorder known as Atelis Syndrome, characterized by microcephaly, short stature, and hematological abnormalities, most notabl […]
- GSE342329 Transcriptomic profiling of small intestine from irinotecan-treated wild-type and Gsdme-deficient mice August 6, 2026Contributors : Tadayoshi Karasawa ; Hidetoshi Aizawa ; Masafumi TakahashiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIrinotecan (CPT-11) is a topoisomerase I inhibitor that is widely used for solid tumors, including colorectal and pancreatic cancers. Although irinotecan exerts potent antitumor effects, it also cause […]
- GSE283811 Epithelial BMP signaling regulates gastric tissue responses upon H. pylori infection August 6, 2026Contributors : Giulia Beccaceci ; Sigal Michael ; Mollenkopf Hans ; Berger HilmarSeries Type : Expression profiling by arrayOrganism : Mus musculusIn the gastric mucosa, BMP signaling is known to regulate the differentiation of progenitor epithelial cells into differentiated pit secretory mucous cells thanks to BMP ligands production in stromal cells located […]
- GSE342565 Chromatin accessibility profiling of high endothelial cells (HECs) from mouse peripheral lymph node and Peyer's patch by ATAC-seq August 6, 2026Contributors : Yuhan Bi ; Junliang Pan ; Eugene Butcher ; Kevin Brulois ; Menglan XiangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusHigh endothelial venules (HEVs) are specialized blood vessels that mediate lymphocyte entry into secondary lymphoid organs. We performed ATAC-seq on high endothelial cells […]
- GSE342498 Developmental Synchrony of Retinal Waves, Apoptosis, and Angiogenesis in Postnatal Retina August 6, 2026Contributors : Michael A Savage ; Cori Bertram ; Jean de Montigny ; Courtney A Thorne ; Rachel Queen ; Majlinda Lako ; Gerrit Hilgen ; Evelyne SernagorSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPostnatal mouse retinal development is a multi-faceted process involving the coordinated interaction of spontaneous neural […]
- GSE342584 Tumor-targeted IL-10 combined with IL-2 amplifies anti-tumor immunity August 6, 2026Contributors : Zhichen Sun ; Yifei Hu ; Tao Wang ; Jian QiaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTumor-targeting cytokines have emerged as a promising strategy for cancer immunotherapy, although their mechanisms of action often remain complex. In this study, we developed a novel approach by combining tumor-ta […]
- GSE342612 Transcriptomic and H3K27ac chromatin responses of human microglia to acute PFOS exposure and recovery August 6, 2026Contributors : Cheng Yating ; Weng Yi-LanSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensPer- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants associated with adverse neurological effects, but their impact on microglial gen […]
- GSE342614 A configurable AP-1 network governs cell-state heterogeneity and adaptive plasticity in melanoma cells August 6, 2026Contributors : Magda Bujnowska ; Yonatan N Degefu ; Mohammad Fallahi-SichaniSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiensAP-1 transcription factors have been implicated in cellular plasticity, differentiation-state heterogeneity, and phenotype switchi […]
- GSE304289 Caspase-3 Control of RNA Splicing and Mitochondrial Dynamics in Microglia during Parkinson’s Disease August 6, 2026Contributors : Rafael Medina-Guzman ; Bazhena Bahatyrevich-Kharitonik ; Marie-Kim St-Pierre ; Sara Marquéz-Perez ; Elena Gavilán ; Alicia Flores-Cortes ; Cristóbal Coronel-Guisado ; Rodrigo García-Valiente ; Sandro Argüelles ; Edel Kavanagh ; Yiyi Yang ; Tomas Deierborg ; Cristina González-Aguilera ; José L Venero ; Bertrand Joseph ; Miguel à BurguillosSerie […]
- GSE342322 APE1-Mediated Transcriptional Reprogramming in Esophageal Adenocarcinoma Cells under Acidic Bile Reflux Stress August 6, 2026Contributors : Heng Lu ; Lei Chen ; Dunfa Peng ; Wael El-RifaiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEsophageal adenocarcinoma (EAC) arises in the setting of Barrett's esophagus, an intestinal metaplastic precursor lesion that can develop in patients with chronic Gastroesophageal reflux disease (GERD). Thi […]