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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE255689 Core immunometabolic reprogramming of Mycobacterium tuberculosis-infected mouse lungs and stage-specific effects by glutamine supplementation February 10, 2026Contributors : Qingkui Jiang ; Ryan J Dikdan ; Yunping Qiu ; Irwin J Kurland ; Karl Drlica ; Selvakumar Subbian ; Sanjay Tyagi ; Lanbo ShiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAn emerging field of immunometabolism in tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis, offers an oppor […]
- GSE285109 Non-necroptotic MLKL function damages mitochondria and promotes hematopoietic stem cell aging [ATAC-seq] February 10, 2026Contributors : Yuta Yamada ; Masayuki YamashitaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusHematopoietic stem cells (HSCs) survive many types of cellular stress but often lose their regenerative and lymphopoietic capacities as a result. Such functional decline also occurs with age, and dysfunctional HS […]
- GSE276656 Gene expression + ATAC multiome profiling of mPFC engram cells after OSK partial reprogramming February 10, 2026Contributors : Cesar Sierra ; Gabriel Berdugo-Vega ; Johannes GräffSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusCounteracting cognitive decline is an important goal in regenerative medicine. Recently, partial cellular reprogramming has emerged as a pr […]
- GSE285111 Non-necroptotic MLKL function damages mitochondria and promotes hematopoietic stem cell aging February 10, 2026Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE285110 Non-necroptotic MLKL function damages mitochondria and promotes hematopoietic stem cell aging [RNA-seq] February 10, 2026Contributors : Yuta Yamada ; Masayuki YamashitaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHematopoietic stem cells (HSCs) survive many types of cellular stress but often lose their regenerative and lymphopoietic capacities as a result. Such functional decline also occurs with age, and dysfunctional HSCs with impair […]
- GSE289238 In vivo co-cultures of colitis-associated cancer epithelial organoids alone or with matched proximal colon fibroblasts or with matched colitis-associated cancer fibroblasts February 10, 2026Contributors : Emina H Huang ; Oliver Wessely ; R A Schweickart ; Reece K DeHaan ; Sarvestani SamanehSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe pathogenosis of colitis-associated cancer is unclear. These studies use single nuclear RNA-sequencing on human samples to understand the dominant contributions of cell […]
- GSE289177 Single nuclei transcriptomics of Cryptocercus cockroach February 10, 2026Contributors : Catherine Gatt ; Esra Kaymak ; Thomas Bourguignon ; Fabio ZaniniSeries Type : Expression profiling by high throughput sequencingOrganism : Cryptocercus punctulatusCryptocercus punctulatus was dissociated into single nuclei and prepared with 10X Genomics 3’ scRNA-Seq libraries.
- GSE289456 R-loop-induced DNA replication defects drive neuropathy in Koolen-de Vries syndrome February 10, 2026Contributors : Jeroen van den Berg ; Jolanthe Lingeman ; Haico van AttikumSeries Type : OtherOrganism : Homo sapiensKoolen-de Vries syndrome (KdVS) is a neurodevelopmental disorder caused by KANSL1 haploinsufficiency. KANSL1 encodes a scaffold protein of the non-specific lethal (NSL) complex, which regulates transcription of constitutively expressed genes vi […]
- GSE289287 Trop-2 governs anti-metastatic desmosomal integrity February 10, 2026Contributors : Ondrej Vacek ; Terézia Kurucová ; Boris Tichý ; Karel SoučekSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTrop-2 and DSG2 are proteins critical for the formation of intercellular contacts in healthy epithelial tissue. In cancer cells, their roles have been reported to vary, acting as either tumor suppre […]
- GSE317098 Comparative analysis of the transcriptomic response to cisplatin in drug-sensitive and drug-resistant testicular germ cell tumors. February 10, 2026Contributors : Mehwish W Khan ; Michael J SpinellaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTesticular germ cell tumors (TGCTs) are uniquely curable with cisplatin-based therapies even when widely metastatic, however cisplatin resistance does occur resulting in very poor prognosis. The mechanisms to explain TGCT h […]
- GSE289489 Uncovering the isoform-resolution kinetic landscape of nonsense-mediated mRNA decay with EZbakR February 10, 2026Contributors : Justin W Mabin ; Isaac W Vock ; Matthew D Simon ; Robert HoggSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGene expression is a product of RNA synthesis and degradation kinetics, which can vary among transcript isoforms of the same gene. Some isoforms contain premature termination codons (PTCs) and are […]
- GSE318428 Integrated Transcriptomic and Metabolomic Analyses Reveal Distinct Energy Metabolic Signatures and Functional Properties of RPE Cells under Two Culture Conditions February 10, 2026Contributors : Fan Zhang ; Chenlu WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRetinal pigment epithelium (RPE) degeneration is a major cause of vision loss in multiple retinal diseases, including age-related macular degeneration, Bietti crystalline dystrophy and Stargardt disease. Induced pluripotent stem cell ( […]
- GSE318608 Ribo-ITP coupled ribosome profiling identifies non-canonical translational events in low input samples February 10, 2026Contributors : Ghatpande Vighnesh ; Paul Uma ; Howard Mackenzie ; Cenik CanSeries Type : OtherOrganism : Mus musculusIn the last decade, an unexpectedly large number of translated regions (translons) have been discovered using ribosome profiling and proteomics. Translons can regulate mRNA translation and encode micropeptides that contribute to multiprotein c […]
- GSE318644 The regulatory landscape of optic fissure closure in the vertebrate eye February 10, 2026Contributors : Brian Ho Ching Chan ; Mariya Moosajee ; Holly Hardy ; James Prendergast ; Joe RaingerSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Gallus gallusThe process of optic fissure closure (OFC) is a critical tissue fusion event in eye development. Failure of OFC results in coloboma, a persistent gap in the e […]
- GSE318651 P21+TREM2+-Senescent Macrophages Fuel Inflammaging and Metabolic Dysfunction-Associated Steatotic Liver Disease [RNAseq_sgCMPK2] February 10, 2026Contributors : Anthony J Covarrubias ; Ivan A Salladay-Perez ; Cristian PonceSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCellular senescence drives chronic sterile inflammation during aging via the senescence-associated secretory phenotype (SASP); however, the cell types responsible for this pathology remain poorly […]