Category: pubmed

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE262411 Single-cell transcriptomics reveals the effects of high-fat diet on hypothalamic(ARC) and hindbrain(DVC) glucose sensing August 24, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
• GSE344787 Decoding Immune Cell Subset Crosstalk in Biomaterial-Mediated Bone Regeneration: A Sequential Two-Stage Neutrophil-Macrophage Circuit August 24, 2026
  Contributors : Weiye Wang ; Yang Shi ; Zhijian XieSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusThis study uses single-cell RNA sequencing to profile the early immune cell landscape during biomaterial-mediated bone regeneration in a rat calvarial defect model treated with a Janus microsphere delivery system. We i […]
• GSE298137 Deficiency of SATB1 in naive CD4+ T cells alters the 3D chromatin structure and promotes T cell aging [ATAC-seq 2] August 24, 2026
  Contributors : Bao Wang ; Qian BianSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusT cell aging significantly increases the incidence of infections, tumors, and autoimmune diseases in elderly individuals. However, the regulatory factors and molecular mechanisms that influence T cell aging remain unclear. W […]
• GSE294939 Decoding Plasticity Regulators and Transition Trajectories in Glioblastoma with Single-cell Multiomics [RNA-seq] August 24, 2026
  Contributors : Laura Rueda-Gensini ; Manu Saraswat ; Elisa Heinzelmann ; Moritz MallSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGlioblastoma (GB) is incurable and resistant to therapy despite genomic stability under treatment, implicating non-genetic cellular plasticity as a central driver of progression. Whether su […]
• GSE305321 Self-organizing human dual neural organoids model sensory ganglion-spinal cord co-development and region-specific disease defects [scRNA_hPCO_D6-D9-D16-D22] August 24, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe have employed a single cell sequencing approach using 10x Genomics scRNA-seq to study hPCOs.
• GSE303597 Spatial partitioning of NSD2 deposits H3K36me2 as an active histone mark to promote repetitive sequence expression [TT-Seq] August 24, 2026
  Series Type : OtherOrganism : Mus musculusHistone H3 lysine 36 dimethylation (H3K36me2) plays a key role in transcriptional elongation and chromatin organization, yet how its deposition is spatially controlled across the genome remains unclear. Here, we identify TOP1 as a critical recruiter of the H3K36me2 methyltransferase NSD2 to gene bodies. Disruption of […]
• GSE344362 Gene expression profiling of Venetoclax-treated HL-60 cells August 24, 2026
  Contributors : Yu Hang ; Zhu Xiang ; Li Wanying ; Zhu Haiyan ; Cai Bo ; Liu Yu ; Zeng Yang ; Gao ChunjiSeries Type : Expression profiling by arrayOrganism : Homo sapiensVenetoclax is a selective BCL-2 inhibitor with antileukemic activity. To investigate the transcriptional alterations induced by Venetoclax in human acute myeloid leukemia cells, HL-60 cells w […]
• GSE307674 A point mutation in the nuclear speckle protein and splicing factor SRRM2 is associated with amyotrophic lateral sclerosis and causes dysregulation of synapse-associated genes August 24, 2026
  Contributors : Qingui Shi ; Haissi CuiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMultisystem proteinopathy (MSP) is a pleiotropic degenerative disorder which affects the nervous system, muscles, and bones. The identification of risk factors and their molecular contribution to MSP expands our understanding of diseas […]
• GSE344364 A single-cell and spatial transcriptomic atlas provides insights into the genetic regulation of secondary growth and specialized metabolism in the carrot taproot [Spatial Transcriptomics] August 24, 2026
  Contributors : Xiaoyu Han ; Ye Chen ; Xinyue Zhan ; Song Yang ; Pinli Hu ; Siqi Liang ; Bao Nie ; Xing Liu ; Feiyun Zhuang ; Haojing Shao ; Cheng Li ; Li WangSeries Type : OtherOrganism : Daucus carotaCarrot (Daucus carota) is an economically important vegetable, accumulating a wealth of bioactive secondary metabolites (SMs), and is a promising model species […]
• GSE344363 A single-cell and spatial transcriptomic atlas provides insights into the genetic regulation of secondary growth and specialized metabolism in the carrot taproot [scRNA-seq] August 24, 2026
  Contributors : Xiaoyu Han ; Ye Chen ; Song Yang ; Xinyue Zhan ; Pinli Hu ; Siqi Liang ; Bao Nie ; Xing Liu ; Feiyun Zhuang ; Haojing Shao ; Cheng Li ; Li WangSeries Type : Expression profiling by high throughput sequencingOrganism : Daucus carotaCarrot (Daucus carota) is an economically important vegetable, accumulating a wealth of bioactive secondary metabo […]
• GSE344487 Paneth cell-derived Notch ligands DLL1 and DLL4 are crucial for intestinal crypt base stem cells August 24, 2026
  Contributors : Michaela Quintero ; Theresa M Keeley ; Justin Colacino ; Nan Gao ; Peter J Dempsey ; Linda C SamuelsonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNotch signaling is essential for maintaining intestinal stem cell activity and directing epithelial cell fate. Paneth cells have been proposed to be niche c […]
• GSE344583 ATRX Deficiency Drives Aberrant Type I Interferon Signalling Through cGAS-Dependent Transcriptional Dysregulation [Quantseq_Anifrolumab] August 24, 2026
  Contributors : Marie-Therese A El-Daher ; Graeme Grimes ; Yanick J CrowSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe X-linked α-thalassaemia intellectual disability syndrome (ATRX) protein is a chromatin remodeller involved in transcriptional regulation and genome stability. While the importance of ATRX in develop […]
• GSE344586 Metabolic and transcriptomic profiles of glioblastoma invasion revealed by comparisons between patients and corresponding orthotopic xenografts in mice August 24, 2026
  Contributors : Pierre Bady ; Cristina Cudalbu ; Marta Lai ; Lijing Xin ; Olga Gusyatiner ; Marie-France Hamou ; Mario Lepore ; Jean-Philippe Brouland ; Roy T Daniel ; Andreas F Hottinger ; Monika E HegiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusThe invasive behavior of glioblastoma, the most aggressi […]
• GSE314199 Transcriptional profile of Influenza H3-specific memory B cells following LAIV vaccination [LAIV.bulkRNAseq] August 24, 2026
  Contributors : Christopher D Scharer ; Anoma Nellore ; Alexander Rosenberg ; Christopher FucileSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensLive attenuated influenza vaccination (LAIV) is the only FDA approved mucosal vaccine. Here, we determined the transcriptional profile of circulating memory B cell subsets that a […]
• GSE344351 Ciclosonide reduces lipid droplet burden in APOE4 astrocytes August 24, 2026
  Contributors : Antonio Vázquez-Cobá ; Sarah A Zünd ; Marina Ruelas ; Jasmine Phénix ; Lisa M MunterSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPrior studies have shown that ApoE ε4 astrocytes display a higher LD count than ApoE ε3 astrocytes. We examined the effects of pharmacological agents on lipid droplets (LDs) […]