Category: pubmed

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE284170 Dopamine biosynthesis in plants December 27, 2025
  Contributors : Yezhang Ding ; John Vogel ; Trent NorthenSeries Type : Expression profiling by high throughput sequencingOrganism : Brachypodium distachyonDopamine, an essential human neurotransmitter, also plays important roles in plant-microbe interactions and abiotic stress tolerance in plants. Although dopamine biosynthesis is well-characterized in humans […]
• GSE314322 Gene regulatory programs underlying diversification of facial ligaments and tendons in zebrafish December 27, 2025
  Contributors : Ryan R Roberts ; Hung-Jhen Chen ; Kuo-Chang Tseng ; J Gage CrumpSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Danio rerioThe musculoskeletal complex is held together by ligaments connecting skeletal elements and tendons bridging the musculature with […]
• GSE311048 Transcriptomic profiling of lung tissues from a rat model of acute respiratory distress syndrome and vagus nerve stimulation December 27, 2025
  Contributor : Ye GaoSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusThis dataset contains bulk RNA-sequencing profiles generated from lung tissues of Sprague–Dawley rats subjected to cecal ligation and puncture (CLP)-induced acute respiratory distress syndrome (ARDS), with or without right cervical vagus nerve stim […]
• GSE314346 β-sitosterol-mediated cardioprotection: a transcriptomic perspective December 27, 2025
  Contributor : Zhonggui ShanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusβ-sitosterol has been implicated in mitigating cardiovascular diseases, yet its role in MI remains underexplored. This study investigates the therapeutic potential and underlying mechanisms of β-sitosterol in MI using both in vivo and in vitro mo […]
• GSE314666 Discovery of myrsinane diterpenoids from Euphorbia prolifera as a new type of anti-liver fibrosis agents that inhibit PI3K-AKT signaling pathway December 27, 2025
  Contributors : Sheng Yin ; Dong Huang ; Lu Gan ; Wei Liu ; Shuqi WuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensLiver fibrosis represents an unmet clinical need. Building on the high screening hit rate of Euphorbiaceae diterpenoids in our previous anti-fibrotic campaigns, we constructed a library of 29 myrsinane dite […]
• GSE314901 Ketogenic diet dampens excitatory neurotransmission by shrinking synaptic vesicle pools December 27, 2025
  Contributors : Marion I Stunault ; Pan-Yue Deng ; Anjali Yadav ; Erica M Periandri ; Francisca N de Luna Vitorino ; Michael Thomsen ; Jasmin Sponagel ; Amelia J Barfield ; Renzelle J Ponce ; Layla Foroughi ; Benjamin A Garcia ; Gabor Egervari ; Vitaly A Klyachko ; Ghazaleh AshrafiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus […]
• GSE314956 Targeting mTORC2-Dependent AKT/FOXO1/RNF125 Signaling Exploits a Therapeutic Vulnerability in c-MET-Activated and β-catenin-Mutated Hepatocellular Carcinoma [SNU449] December 27, 2025
  Contributors : Xue Wang ; Xin ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground and Aims: Approximately 10% of human hepatocellular carcinomas (HCC) exhibit concurrent c-MET activation and β-catenin gain-of-function mutations, representing a clinically relevant HCC subtype. This study aimed to investigate t […]
• GSE314991 Sustained STING-IRF7 signaling aggravates LPS-induced endometrial inflammation via excessive neutrophil extracellular traps generation December 27, 2025
  Contributors : Min Chu ; Ding Ma ; Zhan Song ; Li Liang ; Fengjuan Xing ; Hongchu BaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe stimulator of interferon genes (STING) is a central mediator of innate immune sensing and represents a critical regulator of chronic inflammation. Upon persistent infection, excessive […]