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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE308992 Transcriptional Landscape Analysis of T-bet/Runx3 in Antiviral CD8+ T Cells via Single- and Double-Knockout RNA-seq August 4, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusEffector CD8+ T cells require tight coordination of cytotoxic gene expression programs with lineage maintenance. T-bet and Runx3 are central to this process, but their combined transcriptional control mechanisms were poorly understood due to sparse transcriptional datasets […]
- GSE306256 Cell-intrinsic functions of PD-L1 activate autophagy and prevent cytokine-induced apoptosis August 4, 2026Contributors : Mihaela Stefan-Lifshitz ; Nicola Viola ; Olga Meshcheryakova ; Crystal Nieves Garcia ; Pamela Mattar ; Zhengzi Yi ; Marie Louise Aoun ; John C. McAuliffe ; Jonathan Smith ; Vikas Mehta ; Richard V. Smith ; Adam J. Gersten ; Weijia Zhang ; Rajat Singh ; Yaron TomerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus mu […]
- GSE319402 Gene expression changes induced by zinc deficiency in intestinal goblet cells August 4, 2026Contributors : Maria Maares ; Heike SprengerSeries Type : Expression profiling by arrayOrganism : Homo sapiensZn deficiency disturbs synthesis and O-glycosylation of mucins in intestinal goblet cellsZinc is an essential trace element (TE) required for numerous structural, catalytic, and regulatory protein functions. Approximately 17% of the global population […]
- GSE317143 The WRKY transcription factor FaWRKY71 modulates the response of strawberry fruits to drought stress August 4, 2026Contributors : Facundo Spadoni-Revol ; Felix J Martínez-Rivas ; Enriqueta Moyano ; Rosario Blanco-Portales ; José L Caballero ; Juan Muñoz-Blanco ; Francisco J Molina-HidalgoSeries Type : Expression profiling by high throughput sequencingOrganism : Fragaria x ananassaWe identified and functionally characterized a ripening-induced WRKY transcription factor, F […]
- GSE268389 eCLIP-seq of eIF4AIII to profile EJC-localized RNAs August 4, 2026Contributors : Kaiwen Sun ; Fengli Zhao ; Danling Zhu ; Zhe WuSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Arabidopsis thalianaVarious RNA binding proteins participate in different regulatory steps of the RNA lifecycle, affecting various aspects of gene expression. Among these RNA-binding proteins, the exon junction comp […]
- GSE326626 Vaccination with BCG reduces tau pathology and improve memory behaviors in the PS19 dementia mouse model August 4, 2026Contributors : Somnath Shee ; Wiiliam BishaiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRetrospective studies among non-muscle invasive bladder cancer (NMIBC) patients have reported significant reductions (12–78%) in Alzheimer's disease (AD) incidence among BCG recipients versus controls. To understand the unde […]
- GSE341964 Gene duplication of SNAPC1 generates transcription factors for snRNAs and sex-specific piRNAs [ChIP-Seq] August 4, 2026Contributors : Lars K Benner ; Margaret R Starostik ; Rebecca J Tay ; Ayaka Inoki ; Mindy Clark ; Suhua Feng ; Michael C Schatz ; Steven E Jacobsen ; John K KimSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Caenorhabditis elegansPiwi-interacting RNAs (piRNAs) are small non-coding RNAs essential for transposon silenci […]
- GSE294383 Transcriptome profiling analysis of heat-adapted and heat-sensitive breeder hen jejunal mucosal tissues in response to acute heat stress August 4, 2026Contributors : Yongcai Zhu ; Satoshi Kubota ; Phocharapon Pasri ; Sutisa KhempakaSeries Type : Expression profiling by high throughput sequencingOrganism : Gallus gallusHeat stress (HS) can weaken the intestinal integrity and damage the intestinal barrier function of poultry, disrupting nutrient digestion and absorption. However, the underlying molecular mec […]
- GSE341970 Exploring the m6A modification profile after METTL16 overexpression in BEAS-2B cells. August 4, 2026Contributors : Mingshun Zhang ; Tingting Xu ; Ningfei Ji ; Mao HuangSeries Type : OtherOrganism : Homo sapiensAllergic asthma is a common disease. We aimed to investigate the role of METTL16, an N6-methyladenosine (m6A) writer, in allergic asthma and epithelial homeostasis. Here we show that pulmonary METTL16 expression was decreased in patients with allergi […]
- GSE341968 TSPAN8 a plasticity marker is transcriptionally regulated through DUSP19 BRD4 crosstalk in Prostate Cancer cells August 4, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo identify upstream regulators of TSPAN8 transcription, we screened a library of 298 phosphatases using a GFP reporter under the control of the TSPAN8 promoter in PC3 cells. DUSP19 emerged as the strongest negative regulator. Unexpectedly, DUSP19-mediated regulation of TS […]
- GSE342040 Eliglustat-Induced Remodeling of Sulfo-Glycosphingolipid Metabolism and Gene Expression in hepatocellular carcinoma cells August 4, 2026Contributors : Rachele Giannecchini ; Matteo Niero ; Fabio Bozzi ; Federica Padelli ; Alessia Bertolotti ; Antonino Belfiore ; Silvia Ghislanzoni ; Luca Agnelli ; Italia BongarzoneSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDysregulation of glycosphingolipid (GSL) metabolism contributes to cancer progression by alte […]
- GSE342046 Inflammasome Hyperactivation Disrupts Construction of the Gas Exchange Surface through the NLRP3-IL-18-TNFa Axis [RNA-seq] August 4, 2026Contributors : Rongbo Li ; Xin SunSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusInflammation is a prominent feature of tissue injury, and a driver of chronic disease. However, the precise molecular mechanisms underlying the impact of inflammation remains unclear in many injury settings including in alveolar developmen […]
- GSE342074 CYP1B1-Mediated Metabolic Reprogramming Drives Immune Dysregulation in Sepsis: A Single-Cell Transcriptomic and Therapeutic Exploration August 4, 2026Contributors : Jinyan Xie ; Yinshan Wu ; Feng GuoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSepsis, a life-threatening condition characterized by dysregulated immune responses, poses significant clinical challenges due to high mortality and limited therapeutic strategies. Emerging evidence highlights immune-metabol […]
- GSE304171 Transcriptome of temporal muscle in moyamoya disease August 4, 2026Contributors : Xiankun Tu ; Jingyi ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensObjective Indirect revascularization is an effective treatment for moyamoya disease (MMD), but the surgery effect depends on the collateral vessel formation. This study aimed to explore the molecular mechanisms driving angiogenesis in […]
- GSE341961 Acoustic Cavitation-Enhanced Remodeling of Lymph Node Microenvironment Enables Deep Infiltration for Potent Cancer Vaccination August 4, 2026Contributors : Bihan Wu ; Xiaodan Xu ; Peile Jin ; Yijie Chen ; Xia Fang ; Yue Song ; Guowei Wang ; Jiajia Zhou ; Huaimin Wang ; Pintong HuangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe efficacy of peptide-based tumor vaccines is often constrained by the size-exclusion barrier of the subcapsular sinus (SCS), whi […]