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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE169273 Epigenetic Signatures of Brain Aging by Single Nucleus Methylation Sequencing [DHC-18mo-m-002] December 22, 2025Contributors : Wei Tian ; Anna Bartlett ; Jordan Altshul ; Rosa Gomez Castanon ; Joseph R Nery ; Jacinta D Lucero ; Julia K Osteen ; Huaming Chen ; M M Behrens ; Joseph R EckerSeries Type : Methylation profiling by high throughput sequencingOrganism : Mus musculusIllustrating aging effects on the epigenomic features of brain is critical to understand brain f […]
- GSE286198 E2F1 methylation by SETD6 disrupts BRD4-E2F1 binding and modulates gene regulation in prostate cancer cells December 22, 2025Contributors : Gizem T Ulu ; Margarita Kublanovsky ; Michal Feldman ; Sara Weirich ; Dan Levy ; Albert JeltschSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe SETD6 protein lysine methyltransferase has a role in the regulation of various cellular processes including cancer initiation and progression. It methylates se […]
- GSE263659 NAC controls nascent chain fate through tunnel sensing and chaperone action[RNA] December 22, 2025Contributors : Natalia Barbosa ; Jae H Lee ; Fabian Morales-Polanco ; Martin Gamerdinger ; Elke Deuerling ; Judith FrydmanSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansThe nascent polypeptide-associated complex (NAC) is a conserved ribosome-bound factor with essential yet incompletely understood roles in pro […]
- GSE180572 Studies on genomic imprinting in preimplantation embryos of non-human primates [CUT&RUN] December 22, 2025Contributors : Lianyong Qiao ; Jixiang Zhang ; Haifeng Wan ; Yali Xie ; Hu NieSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Macaca mulattaGenomic imprinting resulted by asymmetric epigenome of parents is a conserved phenomenon restricting biased expression of genes on two alleles. Disorder of imprinting can cause se […]
- GSE272129 Combined epigenetic therapy with FACT and BET inhibitors remodels chromatin and disrupts oncogenic transcription in Diffuse Midline Glioma [ATAC-seq] December 22, 2025Contributors : Holly Holliday ; Nisitha Jayatilleke ; Chelsea Mayoh ; Samuel E RossSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensAberrant epigenetic regulation is a hallmark of Diffuse Midline Glioma (DMG), an incurable pediatric brain tumor. The H3K27M driver histone mutation leads to transcriptional dy […]
- GSE269823 cFGF23 alleviates kidney inflammatory gene signatures induced by sustained FGF23 signaling December 22, 2025Contributors : Ganesh Pathare ; Giuseppe Ronzitti ; Claire BardetSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRNA-seq was performed on the kidneys of Hyp-Duk mice (a model for lifelong elevated FGF23 levels) and Hyp-Duk mice harboring adeno-associated virus expressing cFGF23 (AAV-cFGF23). The kidneys of Hyp-Duk mice […]
- GSE314174 Crosstalk between the Ino80 complex and TOR signaling drives fungal adaptation to hypoxia through chromatin remodeling December 22, 2025Contributors : Adnane Sellam ; Antony T. Vincent ; Faiza Tebbji ; Manjari Shrivastava ; Morgane DubéSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Candida albicansIn the present study, we undertook a genetic screen of the GRACE (Gene Replacement and Conditional Exp […]
- GSE281521 SMAD nucleocytoplasmic shuttling relies on nucleoporin RanBP2 and VIM-AS1 long non-coding RNA during TGF-β signaling December 22, 2025Contributors : Dorival M Rodrigues-Junior ; Mohamad M Ali ; Carl-Henrik Heldin ; Aristidis MoustakasSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensActivation of the transforming growth factor β (TGF-β) signaling leads to established hallmarks of cancer such as the epithelial-to-mesenchymal transition (EMT), initiating […]
- GSE314298 NKG2A+ NK Cell Cytotoxicity of Epstein-Barr Virus Infected B Cells is Mediated Through the NKG2D and NKp30 Activating Receptors December 22, 2025Contributors : Josselyn K Pena ; Joshua S Badshah ; Sheri M KramsSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEpstein–Barr virus (EBV) is a ubiquitous gamma-herpesvirus that persists as a chronic, asymptomatic infection in over 90% of the adult human population. EBV infections are mainly asymptomatic and subside due […]
- GSE314200 Transcriptomics of PLAG1 VC and KD in K562 imatinib resistant cell using RNA-sequencing. December 22, 2025Contributors : Shashi Kumari ; Dr. Rukmini Govekar ; Dr. Rahul Mojidra ; Dr. Mythreyi NarasimhanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCML-CP Patients showing resistance to Imatinib, due to Bcr-Abl mechanisms of resistance are treated with 2nd and 3rd generation TKIs but some non-responders shown Bcr-Abl indepe […]
- GSE314458 Differential retinoic acid responses across testicular development in vitro December 22, 2025Contributors : Brad C Hansen ; Sarah A Hatem ; Lucas A Huang ; John K Amory ; Elaine M Faustman ; Edward J KellySeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusSpermatogonial differentiation is controlled by distinct spatial and temporal activities of metabolizing enzymes and signaling molecule formation. In vitro […]
- GSE314569 Impacts on the Placenta-Brain Axis in Pregnant Mice Devoid of Gut Microbiota December 22, 2025Contributors : Rosalind T Herrington ; Zhen Lyu ; Ragavi Raman ; Sarah E Seda ; Claire Snyder ; Nathan J Bivens ; Zhentian Lei ; Tanhaul Islam ; Lloyd W Sumner ; Trupti Joshi ; Cheryl S RosenfeldSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGut microbiota play an important role in regulating individual health. It is a […]
- GSE314665 TrAEL-seq captures DNA replication December 22, 2025Series Type : OtherOrganism : Homo sapiens ; Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE285256 Characterizing the expression, binding and function properties of Methyl-CpG-binding Domain (MBDs) genes in tomato [DAP-Seq] December 22, 2025Contributor : Zhaobo LangSeries Type : OtherOrganism : Solanum lycopersicumGenomic DNA methylation is an epigenetic mark, which plays important roles in plant growth and development, and gene stability. In Arabidopsis thaliana, studies have demonstrated that the methyl-CpG-binding domain (MBD) proteins AtMBD5, AtMBD6 and AtMBD7 can specifically bind methylat […]
- GSE314162 Hybrid capture RNA-seq defines temporal gene expression in Rickettsia December 22, 2025Contributors : Allison T Scott ; Vincent L Butty ; Stuart S Levine ; Rebecca L LamasonSeries Type : Expression profiling by high throughput sequencingOrganism : Rickettsia parkeri str. PortsmouthPathogenic Rickettsia species are obligate intracellular bacteria that must reside in a mammalian host or arthropod vector cell to survive. Although these bacteria t […]