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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE305852 Study on the mechanism of action of NUDT21 in acute T-lymphocytic leukemia [CUT&Tag] February 1, 2026Contributors : Yang Yang ; Shuiyan WuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensAlternative polyadenylation (APA) is a widespread post-transcriptional mechanism that regulates transcript stability, localization, and translation. While dysregulated APA has been implicated in multiple cancers, its role […]
- GSE259315 Royal Jelly Acid in Ulcerative Colitis Treatment: Modulating miR-210-3P/Gbp3 Pathway and Pyroptosis via miRNA Expression and NLRP3 Inflammasome (miRNA-Seq) February 1, 2026Contributors : Mingchuan Wang ; Mengyuan Wang ; Xinyi Gao ; Yang JiangSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Mus musculusThis study investigates the therapeutic effects of RJA (purity 99.42%) on DSS-induced colitis in male C57BL/6J mice. Using high-throughput miRNA sequencing, we analyzed the miRNA expression profiles […]
- GSE216193 TPX2 as key downstream target of the eIF4A controlled translational program in MYCN driven neuroblastoma February 1, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE287246 Interrupting T cell memory ameliorates exaggerated metabolic response to weight cycling February 1, 2026Contributors : Jamie N Garcia ; Matthew A Cottam ; Nathan C Winn ; Alec S Rodriguez ; Anwar F Hussein Agha ; Alyssa H HastySeries Type : Other ; Expression profiling by high throughput sequencingOrganism : Mus musculusPeople frequently go through cycles of weight gain and loss. This weight cycling has been demonstrated, in humans and animal models, to increa […]
- GSE275497 TEX cell fate and differentiation are shaped by 3D genome reorganization and chromatin architecture integrity [ATAC-seq] February 1, 2026Contributors : Hai-Hui Xue ; Weiqun Peng ; Wei Hu ; Qing Chen ; Shaoqi ZhuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusCTCF is recognized for its role in facilitating long-range chromatin interactions and 3D genome organization. In CD8+ T cells responding to chronic infection, CTCF undergoes redistribut […]
- GSE290406 Analysis of human macrophages exposed to marennine February 1, 2026Contributor : Elodie SeguraSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHuman monocyte-derived macrophages were exposed to marennine or vehicle for 8h. We found that marennine induces an inflammatory response in human macrophages.
- GSE289135 Glutamine metabolism suppresses neutrophil recruitment via epigenetic regulation to control inflammatory resolution and skin repair [CUT&Tag] February 1, 2026Contributors : Yiting Xu ; Maria Forni ; Diane King ; Qiushi Sun ; Stephen Siebel ; Van Anh Tran ; Richard Kibbey ; Kathryn Miller-Jensen ; Valerie HorsleySeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusTissue repair requires the resolution of inflammation. However, the molecular mechanisms that attenuate […]
- GSE317602 Lung gene expression in WT and estrogen receptor alpha and beta knockout mice exposed to house dust mites February 1, 2026Contributors : Carolyn D Ekpruke ; Patricia SilveyraSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSex differences in asthma severity suggest that estrogen signaling plays a key regulatory role in airway inflammation and remodeling, yet the specific contribution of estrogen receptors (ERα and ERβ) remains poorly define […]
- GSE317599 Neddylation inhibition extends lifespan and preserves cardiac function during aging via mitophagy February 1, 2026Contributors : Barta Hayley ; Chen Kangxuan ; Gorr Matthew ; Xia Menghang ; Zhang Li ; Chaudhuri Samhita ; Jin Jiacheng ; Xu Xianyao ; Xin Gang ; Hund Thomas ; Wold Loren ; Finkel Toren ; Sun NuoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAge-related cardiac dysfunction is closely linked to impaired mitophagy and mi […]
- GSE317721 The Potential Core Role of the FN1-Hippo Signaling Axis in the Pathological Mechanism of Autism spectrum disorder February 1, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAutism Spectrum Disorder (ASD) lacks reliable biomarkers and targeted therapies. This study integrated serum transcriptomics and proteomics from 13 ASD and 13 typically developing (TD) children to elucidate core molecular mechanisms. Differential expression analysis identi […]
- GSE317661 CSN3 promotes gastric cancer invasion and is associated with immune infiltration via activating NOD/TLR pathways February 1, 2026Contributors : Gang Wang ; Dalai Xu ; Lei Qiu ; Feng Lu ; Yongchang MiaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe found that CSN3 is highly expressed in gastric cancer and is associated with advanced tumor stage, lymph node metastasis, and poor prognosis. Functional assays showed that CSN3 promotes proliferatio […]
- GSE317753 Genome-wide identification and tissue-specific profiling of microRNAs in lentil (Lens culinaris Medik.) February 1, 2026Contributors : Melike Bakir ; Saffet Teber ; Ozge Doganay ; Hamdi Ozaktan ; Tolga Can ; Abdullah Kahriman ; Eric Bishop von WettbergSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Lens culinarisMicroRNAs (miRNAs) are key post-transcriptional regulators that influence plant development, metabolism, and stress adaptation. Despite […]
- GSE317792 Transcriptomic analysis of Platycodin D (PD)-improved idiopathic pulmonary fibrosis (IPF) mice February 1, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study focuses on the role of PD, a natural compound derived from traditional Chinese medicine, in the prevention and treatment of IPF, a disease in which pulmonary fibroblast-to-myofibroblast transdifferentiation is a key pathogenic driver. By employing both in vivo a […]
- GSE317801 The impact of rearing environment on C. elegans: Phenotypic, transcriptomic and intergenerational responses to 3D enriched habitats February 1, 2026Contributors : Aurélie Guisnet ; Maxime Rivest ; Michael HendricksSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansEnvironmental context profoundly influences organismal biology, yet laboratory studies often rely on simplified conditions that may not fully capture natural phenotypic repertoire. This exploratory […]
- GSE305440 Study on the mechanism of action of NUDT21 in acute T-lymphocytic leukemia [PAS-seq] February 1, 2026Contributors : Yang Yang ; Shuiyan WuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAlternative polyadenylation (APA) is a widespread post-transcriptional mechanism that regulates transcript stability, localization, and translation. While dysregulated APA has been implicated in multiple cancers, its role in T-cell acut […]