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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE280706 RNA-seq timecourse for Nudt21 KO and Nudt21 Hypomorph esophageal basal cells November 21, 2025Contributors : Nikolaos Tsopoulidis ; Konrad HochedlingerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMost mammalian genes contain multiple polyadenylation signals, yielding mRNA-isoforms with different 3’UTR ends via alternative polyadenylation (APA). While APA can profoundly impact protein levels, its physiological […]
- GSE282471 Genomic and transcriptomic analysis of Japanese melanoma reveals candidate biomarkers for immune checkpoint inhibitor responders. November 21, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground Immune checkpoint inhibitor (ICI) has greatly improved the prognosis of advanced melanoma. Whereas the efficacy in Japanese patients has been found to be lower than Caucasian, the genomic and transcriptomic features associated with response to ICI of Japanese me […]
- GSE281094 ATAC-seq and RNA-seq analysis of Eriocheir sinensis muscle in inter-molt stage November 21, 2025Contributors : Jingjing Li ; Jinsheng Sun ; Tong HaoSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Eriocheir sinensisThe chromatin accessibility and gene expression of muscle in E. sinensis in inter-molt (C) stage were sequenced by Assay of Transposase Accessible C […]
- GSE289648 Maternal acute SARS-CoV-2 infection impairs preimplantation embryo development and reprograms early offspring hematopoietic system November 21, 2025Contributors : Meiling Zhang ; Di Liu ; Songmao Li ; Jiansheng Liu ; Fanghao Guo ; Haibin Zhu ; Li Zhang ; Di Sun ; Yu Yan ; Yanquan Li ; Rui Qiao ; Haixia Ding ; Qing Zhang ; Mengxi Guo ; Yongjian Ma ; Zhiwei Liu ; Wen Li ; Yuxuan ZhengSeries Type : Expression profiling by high throughput sequencing ; Other ; Methylation profiling by high throughput sequenc […]
- GSE282643 Establishment of U2OS osteosarcoma cell line with GREM1 knockdown II November 21, 2025Contributor : Yuchen HanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo explore the downstream regulatory pathway of GREM1, we established a U2OS osteosarcoma cell line with GREM1 knockdown
- GSE310786 Staphylococcal Enterotoxin A Shapes Monocyte Transcription and Macrophage Polarization: Implications for Immune Responses in Infection and Inflammation November 21, 2025Contributors : Claudia Arasa ; Khaleda Rahman Qasi ; David Brodin ; Manuel Mata Forsberg ; Eva Sverremark-EkströmSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensStaphylococcal enterotoxins (SE) crosslink the MHC-II on antigen-presenting cells (APC) with the T-cell receptor, inducing a polyclonal T-cell response. Althoug […]
- GSE295626 The deubiquitinase OTUD1 orchestrates cisplatin chemosensitivity of non-small cell lung cancer through destabilizing RAD23B/XPC November 21, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensLung cancer, especially the subgroup non-small cell lung cancer (NSCLC), continues to be one of the most commonly diagnosed cancers and the leading cause of cancer-related deaths worldwide. Cisplatin has long been a cornerstone of chemotherapy and has improved the prognosi […]
- GSE309522 Eosinophils enhance granuloma-mediated control of persistent Salmonella infection November 21, 2025Contributors : Daniel S Butler ; Blanda Di Luccia ; Jose G Vilches-Moure ; Denise M MonackSeries Type : OtherOrganism : Mus musculusSalmonella enterica can persist asymptomatically within tissues for extended periods. This is achieved through intricate host-pathogen interactions in immune cell aggregates called granulomas, wherein Salmonella establish favora […]
- GSE303648 Rb1 deficiency induces synthetic lethality with ATR and PKMYT1 co-inhibition in breast cancer November 21, 2025Contributors : Xiao-Ting Jiang ; Mei-Kuang Chen ; Jiwang Lee ; Xiayu Rao ; Jing Wang ; Khandan KeyomarsiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTargeting cell cycle checkpoints has emerged as a promising strategy in cancer therapy, yet single-agent inhibitors often fail due to compensatory mechanisms. Here, we d […]
- GSE310020 TGFα is Required for Hair Follicle Function During Aging and its Loss Leads to Progressive Alopecia November 21, 2025Contributor : Alexander G MarnerosSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGene expression changes in the epidermis of mice lacking Tgfa
- GSE309904 Acute Kidney Injury Following Fatty Liver Ischemia-Reperfusion Injury November 21, 2025Contributors : Wenjun Zhang ; Zachary Rokop ; Chandan K Sen ; Chandrashekhar Kubal ; Hongyu GaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo understand the roles of ferroptosis in subsequent acute kidney injury (AKI) following hepatic ischemia-reperfusion injury (hIRI) in steatosis livers. The hIRI was induced in m […]
- GSE310190 Postnatal maternal care impacts hypothalamic Esrrg gene expression, co-expression profiles, and the DNA methylome in prenatal bisphenol-exposed rats [3' Tag-seq] November 21, 2025Contributors : Samantha C Lauby ; Dennis C Wylie ; Hannah E Lapp ; Melissa Salazar ; Amy E Margolis ; Frances A ChampagneSeries Type : OtherOrganism : Rattus norvegicusBackground: Environmental exposures co-occurring during early life have a profound influence on neurodevelopment. Our previous work in rats suggests that postnatal maternal care modulates the […]
- GSE310191 Postnatal maternal care impacts hypothalamic Esrrg gene expression, co-expression profiles, and the DNA methylome in prenatal bisphenol-exposed rats [BiSulfite-seq] November 21, 2025Contributors : Samantha C Lauby ; Dennis C Wylie ; Hannah E Lapp ; Melissa Salazar ; Amy E Margolis ; Frances A ChampagneSeries Type : Methylation profiling by high throughput sequencingOrganism : Rattus norvegicusBackground: Environmental exposures co-occurring during early life have a profound influence on neurodevelopment. Our previous work in rats sugges […]
- GSE310290 Early life microbiota skew long-term gene expression and epigenome of bone marrow hematopoietic precursors November 21, 2025Contributors : Ahmed K Kabil ; Alissa Cait ; Wilder Scott ; Michael R Hughes ; Kelly M McNagnySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAsthma is the most prevalent chronic childhood disease in developed nations, yet its etiology remains incompletely understood. Emerging evidence suggest a crucial role for the gut […]
- GSE223627 GPR25 promotes the formation of lung and liver tissue-resident memory CD8+ T cells November 21, 2025Contributors : Sungjun Park ; Han Feng ; Francisco E Castañeda-Castro ; Job Rocha Hernandez ; Benjamin Schmiedel ; Christian H Ottensmeier ; Pandurangan VijayanandSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTissue-resident memory (TRM) CD8+ T cells are key players that orchestrate protective anti-viral and anti-tumo […]