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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE288227 Hyodeoxycholic Acid Suppresses Hepatosteatosis via GLP-1/iNKT Cell Crosstalk and PPARα Activation (Bulk RNA-seq) July 13, 2026Contributors : Eunyoung Lee ; Ryo Hatano ; Masanori Fujimoto ; Tomoaki Tanaka ; Takashi MikiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHepatosteatosis, a common liver condition, involves excessive lipid accumulation and can lead to severe complications. Its molecular mechanisms are poorly understood, highlighting t […]
- GSE272259 Effect of knockdown PAK5 on gene expression of MB231 cells July 13, 2026Contributor : Zhenhai YuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate PAK5 in tumorigenesis, we established cell lines in which target gene has been knocked down by shRNA.
- GSE288750 Hyodeoxycholic Acid Suppresses Hepatosteatosis via GLP-1/iNKT Cell Crosstalk and PPARα Activation (scRNAseq_primary hepatocytes) July 13, 2026Contributors : Eunyoung Lee ; Ryo Hatano ; Masanori Fujimoto ; Tomoaki Tanaka ; Takashi MikiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHepatosteatosis, a common liver condition, involves excessive lipid accumulation and can lead to severe complications. Its molecular mechanisms are poorly understood, highlighting t […]
- GSE288229 Hyodeoxycholic Acid Suppresses Hepatosteatosis via GLP-1/iNKT Cell Crosstalk and PPARα Activation (scRNAseq_CD4+ lymphocytes) July 13, 2026Contributors : Eunyoung Lee ; Ryo Hatano ; Hayato Yoshikawa ; Yukihiro Endo ; Ryo Koyama-Nasu ; Atsushi Onodera ; Motoko Y. Kimura ; Takashi MikiSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusHepatosteatosis, a common liver condition, involves excessive lipid accumulation and can lead to severe complications. I […]
- GSE302041 Single-cell transcriptomics revealing LRFC specification dynamics July 13, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaA conserved GA–ROS–GASA1 regulatory module specifies and commits plant lateral root founder cells by orchestrating nuclear migration, asymmetric division, and ROS homeostasis.
- GSE292209 Reassessment of the roles of coronin proteins as actin effectors and in signalling July 13, 2026Contributors : Tohnyui Ndinyanka Fabrice ; Urszula Brykczynska Kunzmann ; Jean PietersSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCoronin proteins are present in all known non-plant eukaryotes, and are involved in key biological processes including cytoskeletal dynamics and the regulation of cell population sizes in […]
- GSE337028 The Small Non-coding RNA MicC is a Critical Regulator of the Stress Resistance and Virulence of Extraintestinal Pathogenic Escherichia coli July 13, 2026Contributors : O'Connor Matthews ; Brittany Fleming ; Kevin Nelson ; Alejandra Mendez ; Alan Stenquist ; Sam Bonkowsky ; Richard Kulesus ; William Brazelton ; Matthew Blango ; Matthew A MulveySeries Type : Expression profiling by high throughput sequencingOrganism : Escherichia coliSmall non-coding RNA (sRNA) molecules can modulate diverse bacterial fun […]
- GSE311113 Phage-encoded sRNA counteracts xenogeneic silencing in pathogenic E. coli July 13, 2026Contributors : Pranita Poudyal ; Daniel G Mediati ; Jai J TreeSeries Type : Expression profiling by high throughput sequencingOrganism : Escherichia coli O157:H7 str. SakaiHorizontal gene transfer introduces foreign DNA that can disrupt cellular processes and is therefore subject to xenogeneic silencing by nucleoid-associated proteins such as H-NS and Hha. I […]
- GSE337536 Decitabine induces innate immune gene expression in rare melanoma models July 13, 2026Contributor : Kasey CoutsSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRare melanoma subtypes, including mucosal melanoma, can exhibit reduced tumor-intrinsic innate immune and interferon-associated gene expression, which may contribute to immune evasion and limited responses to immune checkpoint inhibitors. We invest […]
- GSE337809 CYP3A4-mediated metabolic variability drives resistance and systemic toxicities under targeted therapies for non–small cell lung cancer July 13, 2026Contributors : Pragya Kumar ; Julia Pelesko ; Malgorzata T Weh ; Menkara C Henry ; Bina Desai ; Ramu Kakumanu ; Min Liu ; Natalia Siqueira ; Robert Vander Velde ; Viktoriya Marusyk ; Jyllica Aurelio ; Eric B Haura ; Jhanelle Gray ; Bruna Pellini ; David G Basanta ; Andriy MarusykSeries Type : Expression profiling by high throughput sequencingOrganism : Mus m […]
- GSE337949 Fertility Gene Introns Harbor Transposable Elements that Shape Y-Loop Architecture July 13, 2026Contributors : E.K. Beard ; Jeffrey P Gamer ; Amelie Raz ; Mayu InabaSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterTransposable elements (TEs) are powerful drivers of genome evolution, yet how they persist under selection and become incorporated into host regulatory networks remains poorly understood. In th […]
- GSE338025 Multiome analysis of PDxOs (HCI-003, HCI-005, HCI-011) treated with a CDK4/6 inhibitor for 3 weeks July 13, 2026Contributor : Varley KatherineSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing ; OtherOrganism : Homo sapiensThis study uses single-nucleus multiome profiling, as well as bulk methylation profiling, to characterize the transcriptional, chromatin accessibility, and DNA methylat […]
- GSE338135 NRAS knockdown reverses monocytic cell state and resensitizes resistant FLT3-AML cells to gilteritinib July 13, 2026Contributors : Sunil K Joshi ; Hadi Maazi ; Janét Pittsenbarger ; Belinda B Garana ; Andy Kaempf ; Ariane Huang ; Marina A Gritsenko ; Chelsea Hutchinson ; Karl K Weitz ; Rosalie K Chu ; Sara J Gosline ; Paul D Piehowski ; Ann-Kathrin Eisfeld ; Martin Carrol ; Alexander E Perl ; Karin D Rodland ; Bill H Chang ; Alexey Revenko ; Jeffrey W Tyner ; Brian J Druk […]