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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE293263 Comparative single cell genomics of facial signaling centers of avian and murine embryos [HH22_scATAC-seq] March 24, 2026Contributors : Stella Kyomen ; Louk SetonSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Gallus gallusMorphogens are crucial in craniofacial development, directing cellular processes that shape facial features in vertebrates. In this study, we used single-cell RNA and ATAC sequencing to investigate the genomic regulat […]
- GSE297161 Selective Sensitivity of Ph-like B-ALL to BRG1 Inhibition Identifies a Therapeutic Vulnerability March 24, 2026Contributors : V. S. S. Abhinav Ayyadevara ; Shikha Gaur ; Ashley Paik ; Ria Perencsik ; Monika Toma ; Gerald Wertheim ; Huimin Geng ; Tomasz Skorski ; Srividya Swaminathan ; Christian Hurtz ; Shreya PatilSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDespite therapeutic advances, high-risk subtypes of B-cell acute lym […]
- GSE294010 Cord-derived iNKT cells are enriched with human NKT10 and exert the immunosuppressive function through the interaction with NRP1 [scMultiomics-seq] March 24, 2026Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensInvariant Natural Killer T (iNKT) cells are a unique subset of T lymphocytes that recognize glycolipid antigens presented by the non-polymorphic MHC class I-like molecule CD1d through a semi-invariant T cell antigen receptor. In mice, this receptor consists of the […]
- GSE303283 eIF4E2 Deficiency Drive Cisplatin Resistance in NSCLC March 24, 2026Contributors : Xianrong Lin ; Rui Zhang ; Wenjun Tao ; Jun ZhangSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensCisplatin resistance remains a major obstacle in treating non-small cell lung cancer (NSCLC). Mechanistic insights into the translational control of cisplatin resistance remain sparse. This study ident […]
- GSE301446 Elimination of senescent cells with senolytic host-directed therapy reduces tuberculosis progression in mice. March 24, 2026Contributors : Somnath Shee ; Wiiliam BishaiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBy eliciting lung necrosis, which enhances aerosol transmission, Mycobacterium tuberculosis (Mtb) sustains its long-term survival as a human pathogen. In studying the necrotic granuloma lesions unique tocharacteristic of Mtb-infe […]
- GSE279022 RNA N6-Methyladenosine (m6A) regulates cell cycle progression in Diffuse Midline Glioma (DMG) and confers sensitivity to FTO inhibition March 24, 2026Contributor : Samuel E RossSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe epitranscriptome has not previously been evaluated in DMG. Given the pivotal role of m6A in normal OPC biology, investigating its dysregulation in DMG could uncover new therapeutic options and improve our understanding of the disease's u […]
- GSE266430 Analysis of cellular and exosomal RNAs in AC16 cells regulated by hypertrophic cardiomyocyte March 24, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCardiovascular diseases (CVDs) and cancer are among the most serious life-threatening diseases with very high morbidity and mortality rates. An increasing number of clinical studies have shown that cardiovascular disease is strongly associated with an increased risk of can […]
- GSE325515 H2AC19 acts as a novel regulator of angiogenesis to promote the progression of lung adenocarcinoma March 24, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: Angiogenesis is a significant character of lung adenocarcinoma (LUAD) and is an important reason leading to high mortality rates of LUAD patients. Identification of potential therapeutic targets for regulating angiogenesis has clinical importance for the treatm […]
- GSE325488 Accelerated cerebromicrovascular senescence contributes to cognitive decline in a mouse model of paclitaxel (Taxol)-induced chemobrain March 24, 2026Contributors : Anna Csiszar ; Zoltan Ungvari ; Roland Patai ; Tripti Gautam ; Tamas KissSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusChemotherapy-induced cognitive impairment ("chemobrain") is a frequent side-effect in cancer survivors treated with paclitaxel (PTX). The mechanisms responsible for PTX-induce […]
- GSE325678 Impact of ATEVs on transcriptional profile of pancreatic tumor tissues derived from a poorly immunogenic pancreatic cancer cell clone March 24, 2026Contributor : Mengying HuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAntigen processing and presentation (APP) is essential for adaptive immunosurveillance. We uncover a mechanism whereby activated T cell-derived extracellular vesicles (ATEVs) drive a positive feedback loop that enhances antigen presentation and imm […]
- GSE325587 Spatial transcriptomics identifies IL-32 as a lipid droplet-associated cytokine linked to tubular injury in human diabetic kidney disease March 24, 2026Contributors : Kieran Meadows ; Hyunjae Chung ; Son Vo ; Aysa Imanzadeh ; Heewon Seo ; Sisay G Belay ; Asha Swamy ; Wulin Teo ; Kevin Chapman ; Graciela Andonegui ; Hallgrimur Benediktsson ; Peter K Stys ; Thang Pham ; Daniel A Muruve ; Justin ChunSeries Type : OtherOrganism : Homo sapiensDiabetic kidney disease (DKD) is a severe complication of diabetes mel […]
- GSE325703 PAX3-SIX2 muscle stem cell heterogeneity drives muscle-specific repair dynamics diversification March 24, 2026Contributors : Virginia Zoglio ; Sarah Chebouti ; Fayez Issa ; Théo Massard ; Benjamin Polin ; Sylvie Manin ; Pascal Maire ; Dawon Choi ; Indigo T.C. Chan ; Tom H Cheung ; Joana Esteves de Lima ; Frederic RelaixSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSkeletal muscle regeneration relies on muscle-specific stem ce […]
- GSE325716 The MEK/MYC/p21 Axis Drives Senescence Bypass and BCL-xL Dependence in Vincristine-Resistant Rhabdomyosarcoma March 24, 2026Contributors : Yadong Wang ; Andrea D Largent ; Dorothy Lee ; Paulomi Modi ; Long Wang ; Anshu Bandhlish ; Myron Ignatius ; Eleanor Y ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma, with outcomes for relapsed or metastatic disease remaining poo […]
- GSE325739 The microbiome protects against septic hyperinflammation and bacterial proliferation in a zebrafish model of blood infection with E.coli and mycobacteria March 24, 2026Contributors : Herman P Spaink ; Li Liu ; Bjørn E Koch ; Elke H KrekelsSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioThe microbiome is an important immune regulator, but the mechanisms by which commensal microbes shape systemic host defense during bloodstream infection remain poorly defined and commonly used pre-clinic […]
- GSE292458 Elimination of senescent cells with senolytic host- directed therapy reduces tuberculosis progression in mice March 24, 2026Contributors : Somnath Shee ; Wiiliam BishaiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBy eliciting lung necrosis, which enhances aerosol transmission, Mycobacterium tuberculosis (Mtb) sustains its long-term survival as a human pathogen. In studying the necrotic granuloma lesions unique tocharacteristic of Mtb-infe […]