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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE304648 Single cell RNA-Seq of meninges immune landscape in GBM August 26, 2026Contributors : Michael Killian ; Francisco J QuintanaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe meninges play a critical role in the immunosurveillance of the central nervous system, but the contribution of the dura to the immune response to glioblastoma (GBM) remains elusive. Using single cell sequencing and T […]
- GSE308725 MLL3 and MLL4 maintain hematopoietic stem cell multipotency and license hematopoiesis by actively opposing a B-cell default state August 26, 2026Contributor : Jeffrey MageeSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusFLAG-MLL3 ChIPmentation in 32D cells to understand MLL3 chromatin localization
- GSE306561 In silico Transcriptomics-based Drug Repositioning in a rat model identifies Vorinostat as a candidate to modulate neuroinflammation in Neurocysticercosis August 26, 2026Contributors : Omar Melo ; Oksana Huerta ; Karla Villalobos ; Nancy Chile ; Sneider A Gutierrez Guarnizo ; Hugo Naya ; Cesar M Gavidia ; Hector H Garcia ; Robert H Gilman ; Manuela VerasteguiSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusNeurocysticercosis (NCC) is a major cause of epilepsy and neurological sympto […]
- GSE317302 Repurposing Resmetirom suppresses MASH-associated hepatocellular carcinoma, with mechanistic implications of MDK/LRP1-mediated metabolic reprogramming and immunosuppression [scRNA-Seq] August 26, 2026Contributors : Xin V Zhang ; Tina Suoangbaji ; Wai-Hung D Ho ; Oi-Lin I NgSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground: The molecular mechanism of metabolic dysfunction-associated steatohepatitis (MASH)-associated hepatocellular carcinoma (HCC) remains poorly understood, and effective treatments are lackin […]
- GSE312791 Single cell atlas of the human retinal pigment epithelium and the choroid August 26, 2026Contributors : Rui Chen ; Jin Li ; Jianming ShaoSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThe survival and proper function of the neural retina depend on the support of two underlying tissues: the retinal pigment epithelium (RPE) and the choroid. D […]
- GSE276180 Single-cell temporal landscape of tumor microenvironment of lung cancer and lung metastases August 26, 2026Contributors : Huijuan Wu ; Chen Ai ; Zemin ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusFour time points of scRNA-seq of CD45+ and CD45- (1:1) for TME of lung cancer model and lung metastasis models.
- GSE324010 Neutralization of Pathogenic PC-OxPL by AAV-Delivered scFv as a Therapeutic Strategy for Amyotrophic Lateral Sclerosis August 26, 2026Contributors : Andreia Duarte-Gomez ; Alessandro Moro ; Sander van DeventerSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease marked by motor neuron loss and TDP‑43 proteinopathy, but its upstream causes remain unclear. We identify a distinct signatur […]
- GSE345051 DIPTAR: A synthetic biology platform for functional interrogation of protein degradation August 26, 2026Contributors : Patrick M Exconde ; William Yoo ; Madhura Kulkarni ; Ashutosh Mahale ; Benjamin E Myers ; Robert C Patio ; Christopher M Bourne ; Bohdana M Discher ; Cornelius Y TaabazuingSeries Type : OtherOrganism : Homo sapiensProtein degradation regulates cellular homeostasis, yet many degradation events are difficult to study because they lack a readily […]
- GSE345045 Comparative transcriptomic and immune profiling identifies a shared molecular identity in clear cell odontogenic carcinoma and hyalinizing clear cell carcinoma [1] August 26, 2026Contributors : Helen X Hou ; Bidish K Patel ; Emily E Ackerman ; Tom Bisson ; Samyukta Singh ; Peter M Richieri ; A J IafrateSeries Type : OtherOrganism : Homo sapiensClear cell odontogenic carcinoma (CCOC) and hyalinizing clear cell carcinoma (HCCC) are rare head-and-neck malignancies with recurrent EWSR1::CREB family fusions that show overlapping morpholog […]
- GSE345080 ER-targeted Bcl2 reactivates developmental programs to promote survival and axon regeneration of adult retinal ganglion cells August 26, 2026Contributor : Yaqi YangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAxon regeneration in retinal ganglion cells (RGCs) holds great promise for reestablishing retina-to-brain connectivity and restoring visual function in RGC-related disorders such as glaucoma. However, the severely limited survival and regenerative ca […]
- GSE345058 A multimodal perturbation atlas defines the phenotypic resolution of cellular morphology. August 26, 2026Contributors : Chad Liu ; Alexander Hillsley ; Madhurya Sekhar ; Cassidy Jones ; Gabriel Sturm ; Taihei Fujimori ; Karen Cheng ; Duo Peng ; Max Frank ; Leah Dorman ; Yiyun Rao ; Giovanni Palla ; Norma Neff ; Manuel LeonettiSeries Type : OtherOrganism : Homo sapiensModeling cellular behavior requires measurements that capture how cells evolve across time, env […]
- GSE345103 Brain Penetration Optimization and Anti-Neuroinflammation Evaluation of Potent 6-Methyl-7-azaindol-3-yl-quinazoline DYRK1A Inhibitors for Alzheimer’s Disease August 26, 2026Contributor : Huanhua ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTargeting dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) to regulate microglia-mediated neuroinflammation represents a promising therapeutic strategy for Alzheimer’s disease (AD).
- GSE345112 Comparative transcriptomic and immune profiling identifies a shared molecular identity in clear cell odontogenic carcinoma and hyalinizing clear cell carcinoma [2] August 26, 2026Contributors : Helen X Hou ; Bidish K Patel ; Emily E Ackerman ; Tom Bisson ; Samyukta Singh ; Peter M Richieri ; A J IafrateSeries Type : OtherOrganism : Homo sapiensClear cell odontogenic carcinoma (CCOC) and hyalinizing clear cell carcinoma (HCCC) are rare head-and-neck malignancies with recurrent EWSR1::CREB family fusions that show overlapping morpholog […]
- GSE345117 Sulfonylurea receptor 1 deficiency alleviates acute lung injury by activating PARP1 in epithelial cells August 26, 2026Contributors : Xiaojuan Yin ; Qiaoqiao Zhu ; Li Zhao ; Wenqing Ma ; Liying Wang ; Huiling Li ; Chao Wang ; Yipin Wang ; Lin Xu ; Haijun Zhang ; Xuerong Wang ; Wenbin HuangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAcute lung injury (ALI) is a critical disease with high mortality, yet its mechanisms remain incomplet […]
- GSE301566 tRNA dosage regulates lineage plasticity and therapy resistance in prostate cancer through codon bias [Polysome-seq] August 26, 2026Contributors : Yeon Soo Kim ; Andrew C Hsieh ; Sonali AroraSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensLineage plasticity underlies therapeutic resistance in cancer, yet the translational mechanisms enabling this phenotypic flexibility remain largely unknown. Using prostate cancer as a paradigm of lineage dependence […]