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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE299641 Maternal IntS11 primes embryonic totipotency by organizing early zygotic transcription initiation [ATAC-seq] April 13, 2026Contributors : Liangliang Wang ; Yiru Wang ; Yaqi Miao ; Yuan Song ; Jialiang Zhou ; Yuanxiang Zhu ; Ying Cheng ; Wenxin Zhang ; Qinmiao Sun ; Fan Lai ; Guoqiang Zhang ; Dahua ChenSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Drosophila melanogasterZygotic genome activation (ZGA) marks the first transcriptional mile […]
- GSE300345 H3K9me3 controls epidermis development by repressing RNA Pol II initiation on key promoters and enhancers [PReCISseq] April 13, 2026Contributors : Chris K Bai ; Tudorita TumbarSeries Type : OtherOrganism : Mus musculusHistone H3 lysine 9 trimethylation (H3K9me3) is a heterochromatin mark important for silencing repetitive DNA elements and for repressing lineage-inappropriate genes during early murine development, but its role in later organogenesis remains understudied. Here, we simultan […]
- GSE300267 Loss of WWOX Drives Cutaneous Squamous Cell Carcinoma (cSCC) through Regulating EMT [ChIP-Seq] April 13, 2026Contributors : Tirza Bidany-Mizrahi ; Osama Hidmi ; Jonathan Monin ; Abed Nasereddin ; Rami I AqeilanSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensCutaneous Squamous Cell Carcinoma (cSCC) is the second most common skin cancer, with a rising incidence in recent years. Through protein-protein interactions, […]
- GSE230305 Targeting CBX3 by a dual BET/PLK1 inhibitor enhances the anti-tumor efficacy of CDK4/6 inhibitors in prostate cancer April 13, 2026Contributors : Xin Jin ; Huaiyuan LiangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCastration-resistant prostate cancer (CRPC) after commencement of Androgen deprivation therapy (ADT) seriously shorten the life span of patients with prostate cancer. The BET inhibitors and CDK4/6 inhibitors have shown efficacy in pre […]
- GSE327911 Pilot NanoString targeted mRNA profiling of neonatal saliva following prenatal opioid exposure April 13, 2026Contributors : Tomoko Kaneko-Tarui ; Elizabeth YenSeries Type : Expression profiling by arrayOrganism : Homo sapiensThis study profiles targeted mRNA expression in neonatal saliva to investigate the sex-specific effects of prenatal opioid exposure. Saliva samples collected within 48 hours of birth from opioid-exposed and non-exposed neonates were analyzed us […]
- GSE292257 Low inflammation correlates with protumor Tim4+ TREM1+ resident macrophage expansion and limited monocyte-derived macrophage formation during peritoneal colorectal cancer April 13, 2026Contributors : Margarita Ferriz ; Natalia Ã�lvarez-Ladrón ; Alejandra Gutiérrez-González ; Marta H. Fernández-Sesma ; Adrián Vega-Pérez ; Juan C Oliveros ; Ana Cayuela López ; Eduard Batlle ; Daniele Tauriello ; Carlos ArdavÃnSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusResearch based essentially on mouse mod […]
- GSE271054 A forward genetic screen identifies Sirtuin1 as a driver of neuroendocrine prostate cancer April 13, 2026Contributors : Alessandro Vasciaveo ; Francisca N de Almeida ; Andrea Califano ; Cory Abate-ShenSeries Type : OtherOrganism : Mus musculusAdvanced prostate cancer is often associated with the emergence of more aggressive disease phenotypes, including neuroendocrine prostate cancer (NEPC), which are currently incurable. To identify drivers of aggressive prost […]
- GSE327581 Single-cell spatial transcriptomic profiling of 3xTg-AD mouse brains following fecal microbiota transplantation from stroke and healthy human donors April 13, 2026Contributors : Chetan Aware ; Carter Woods ; Pavlo Khodakivskyi ; Alok Dwivedi ; Amitai Zuckerman ; Maalavika Govindarajan ; Kira Ivanich ; Wenyan Yu ; Jiankun Cui ; Zezong Gu ; Elena Goun ; Aaron Ericsson ; Priti Balchandani ; Ai-ling LinSeries Type : OtherOrganism : Mus musculusStroke-induced gut dysbiosis has been linked to accelerated neurodegeneration, […]
- GSE327397 Distantly metastatic differentiated thyroid carcinoma is kinase-driven and enriched for DNA repair and DNA methylation gene alterations April 13, 2026Contributors : Weimao Kong ; Longnv BaoSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensAlthough distant metastasis is uncommon in differentiated thyroid carcinoma (DTC), it remains the leading cause of thyroid cancer-related mortality. The genetic landscape of distantly metastatic DTC (DMDTC) has not been well characterized i […]
- GSE327753 Immunological tolerance is maintained by self-reactive CD8 T cells April 13, 2026Contributors : Yadan Bai ; Pengfei Wang ; Yuzhen Liu ; Yuwen Shao ; Di Sun ; Yu Zheng ; Linrong LuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCD8 T cells play a critical role in immune tolerance maintenance after immune activation. They have recently been reported to target activated CD4 T cells in an MHC-Ia–restr […]
- GSE327752 Human breast milk-derived extracellular vesicles alleviate Alzheimer’s disease phenotypes through delivering CD36 April 13, 2026Contributors : Zhanping Liang ; Xiaohuan Xia ; Shaomin Wang ; Jiangqin Liu ; Xuanran Feng ; Guangzhi Shi ; Mingyuan Li ; Wanting Xu ; Yi Wang ; Jialin C ZhengSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAlzheimer's disease (AD) is an age-related progressive neurodegenerative disease that is the most common cause […]
- GSE327767 Reconstructing signaling histories of single cells via perturbation screens and transfer learning [scRNA] April 13, 2026Contributors : Nicholas Hutchins ; Miram Meziane ; Claire Lu ; Maisam Mitalipova ; David Fischer ; Pulin LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensManipulating the signaling environment is an effective approach to alter cellular states for broad-ranging applications, from engineering tissues to treating diseases […]
- GSE327798 Dual regulation of chemical stress-induced DDI2/3 expression by a transcription factor Fzf1 and nucleosome in Saccharomyces cerevisiae April 13, 2026Contributor : LeAnn HoweSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Saccharomyces cerevisiaeDDI2 and DDI3 (DDI2/3) are duplicated genes in Saccharomyces cerevisiae that exhibit strong induction by a transcription factor Fzf1 in response to chemical treatments like cyanamide (CY) and methyl methanesulfonate (MMS). […]
- GSE327880 Neuronal activation triggers rapid biphasic FMRP-mediated translational control linking synaptic and nuclear regulation April 13, 2026Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE298543 Persistent dopamine-dependent remodeling of the neural transcriptome in response to pregnancy and postpartum [CUT&RUN] April 13, 2026Contributors : Jennifer Chan ; Giuseppina di Salvo ; Ashley Cunningham ; Sohini Dutta ; Elizabeth Brindley ; Weekley Benjamin ; Ethan Wan ; Cindy Zhang ; Turecki Gustavo ; Ian MazeSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusPregnancy and postpartum experiences represent transformative ph […]