Category: pubmed

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE298941 Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating β-Thalassemia [ATAC-seq] March 4, 2026
  Contributors : Yijie Shen ; Jiale Wei ; Shibing Tang ; Dongliang Wu ; Liangyi Zong ; Shuyuan Ma ; Ruijie Gong ; Siyuan Xu ; Chuxuan Peng ; Qin Feng ; Songchen Liu ; Qitong Liu ; Yuhua Ye ; Quan Zhao ; Cheng Luo ; Zhihai Li ; Xiangqian Kong ; Xianjiang LanSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThe […]
• GSE298066 Ligature-induced periodontitis (LIP) induces rapid alveolar bone loss followed by gingival immunosuppressive conditions March 4, 2026
  Contributors : Netanely Yasmin ; Hovav Avi-HaiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusLigature-induced periodontitis (LIP) induces rapid alveolar bone loss followed by gingival immunosuppressive conditions
• GSE261671 Pim1 exacerbates inflammatory arthritis by mediating Th17 differentiation March 4, 2026
  Contributors : Zhongyu Xie ; Zepeng Su ; Huiyong ShenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe present study demonstrated that pim1-promoted mito-Ca2+ influx enhanced the activity of mitochondrial OXPHOS, bringing about the differentiation of Th17 and driving the pathogenic progression of inflammatory arthriti […]
• GSE322767 Myofibroblast programming blocks differentiation of TLS-organizing fibroblastic reticular cells in pancreatic cancer March 4, 2026
  Contributors : Gunderson Andrew ; Kirschstein Elijah ; Harder Olivia ; Krull Jordan ; Ma QinSeries Type : OtherOrganism : Homo sapiensPancreatic ductal adenocarcinoma (PDAC) is considered an immunologically cold cancer type. This perception is due to its rapid progression, strong presence of immunosuppressive cells and lack of response to current immunothera […]
• GSE291074 Single-Tubule RNA-Seq Reveals Signaling regulated by phosphorylated T551/S552 on beta-catenin March 4, 2026
  Contributors : Shuo-Ming Ou ; Hiroaki Kikuchi ; Euijung Park ; Chin-Rang Yang ; Viswanathan Raghuram ; Shaza Khan ; Adrian R Murillo de Ozores ; Lihe Chen ; Chung-Lin Chou ; Mark A KnepperSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPurpose: Experiments were done in WT mice and Mutant (T551A/S552A at beta-catenin) mi […]
• GSE287514 Psmd13, a proteosome regulatory subunit for co-transcriptional miR-29a processing during neurogenesis [miRNA-seq] March 4, 2026
  Contributor : Diji KuriakoseSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Mus musculusmiR-29a plays a critical role in neuronal development and is associated with neurodegenerative diseases, but its regulatory mechanisms remain unclear. To identify genes that influence miR-29a expression, we utilized the genetically diverse C […]
• GSE321690 Neddylation E2 enzyme UBE2F promotes colitis and colon tumorigenesis by targeting the PTPRN-pSTAT5 axis March 4, 2026
  Contributors : Zhijian Li ; Yi SunSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe inflammatory bowel diseases (IBDs) and colitis-associated colon cancers are common human diseases. Whether and how neddylation enzyme mechanistically regulates the process of these diseases are largely elusive. Here we report that UBE2 […]
• GSE291245 Chronic ER Stress Induced of Cell-surface Chaperones as the Therapeutic Targets of CAR Cells in Acute Myeloid Leukemia March 4, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAcute myeloid leukemia (AML) is a heterogeneous disease characterized by a clonal expansion of myeloid progenitors that affects the bone marrow. Despite advancements, survival rates of the treatments for AML remain still low, due to the heterogeneity and lack of specific t […]
• GSE322198 Female iPSC X-chromosome inactivation (XCI) erosion and its transcriptomic effects during CRISPR gene editing and neural differentiation March 4, 2026
  Contributors : Jubao Duan ; Zhiping Pang ; Hanwen Zhang ; Christina ThapaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHuman induced pluripotent stem cells (hiPSC) and iPSC-differentiated neural cells, in combination with CRISPR editing, are commonly used for studying neurodevelopmental and other brain disorders. Fema […]
• GSE321693 Diagnostic performance comparison of SE-SPTM-PCR and miRNA deep sequencing using 2-fold gradient dilutions of simulated HCMV viral infection samples March 4, 2026
  Contributors : Zecheng Zhong ; Weida Huang ; Shiyin ZhangSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensMicroRNAs are promising liquid biopsy biomarkers, but their clinical translation is hindered by detection challenges, including low abundance, high sequence similarity, and background interference. We developed S […]
• GSE322654 RNA-seq analysis of carbon framework-mediated metabolic reprogramming in senescent cells: effects of C3N nanosheets and photoactivation March 4, 2026
  Contributors : Xuelian Wang ; Hanyu Ma ; Zhen LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis RNA-seq dataset investigates the senolytic effects of carbon nitride quantum dots (C3N QDs) combined with irradiation on senescent human umbilical vein endothelial cells (HUVECs). The study compares three experimental co […]
• GSE322706 2026_Warmuth_Doetsch_affinity-combined-CAR-T_cell-products_scRNAseq March 4, 2026
  Contributors : Linda Warmuth ; Sarah Doetsch ; Adrian Straub ; Mateusz Poltorak ; Elvira D'Ippolito ; Dirk Busch ; Sabrina WagnerSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAdoptive cell therapy with genetically engineered T cells expressing Chimeric Antigen Receptors (CARs) of high binding affinity has proven […]
• GSE322753 M2 Macrophage-Derived Exosomes Ameliorate BPD by Inhibiting Ferroptosis via Suppression of the ZAKα-p38 Signaling Pathway March 4, 2026
  Contributors : Yahan Pu ; Mingyue Lv ; Ru Yan ; Honglian Zhang ; Lihui Yu ; Weilai Jin ; Le Zhang ; Zhiwei Yu ; Yahui ZhouSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground: Bronchopulmonary dysplasia (BPD) is a common lung disease in premature infants. Hyperoxia-induced oxidative stress and ferroptosis are key […]
• GSE295467 Single-cell sequencing of human PBMCs are exposure to CPMV March 4, 2026
  Contributors : Nicole F Steinmetz ; Marina A Dobrovolskaia ; Bao Tran ; Yongmei Zhao ; Shaojun XieSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCowpea mosaic virus (CPMV) is a potent immunomodulator with anti-tumor function. CPMV is being developed as an intratumoral immunotherapy candidate for clinical translation. A […]
• GSE321676 Dural scRNA-seq in two organoids derived from malignant ascites of the same gastric cancer patient before (Primary) and after (Resistance) resistant to paclitaxel March 4, 2026
  Contributors : Leilei Guo ; Wenshuai LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe have employed a single sequencing(scRNA-seq) approach using 10× Genomics scRNAseq of organoids to study paclitaxel resistance in gastric cancer(GC). Patient-derived organoids (PDOs) can recapitulate majority aspects of tissue wher […]