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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE287058 Cellular Quiescence Displays a Transcriptional Inflammatory Phenotype Similar to the One in Cellular Senescence [bulk RNA-seq] January 15, 2026Contributors : Azucena Rocha ; Radha L Kalekar ; John Sedivy ; Nicola NerettiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCellular senescence, traditionally viewed as the irreversible arrest of proliferating cells in response to stress and DNA damage, is a key mechanism underlying cellular aging. Several studies have […]
- GSE283746 Comparative Single-Cell Analyses in Infants Revealed RSV-Specific Declines in NK Cell Responses and COVID-19-Specific Increases in Inflammatory Responses [COVID_RSV_scRNA] January 15, 2026Contributors : Asa Thibodeau ; Asunción Mejías ; Djamel Nehar-Belaid ; Radu Marches ; Virginia Pascual ; Jacques Banchereau ; Octavio Ramilo ; Duygu UcarSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe clinical phenotype of infants infected with respiratory syncytial virus (RSV) differs from that of severe acute resp […]
- GSE290459 A Polyamine-mediated Posttranslational Modification Required for Macrophage Tissue Residency [Ribo-seq] January 15, 2026Contributors : Erika L Pearce ; David E Sanin ; Gustavo CarrizoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTissue-resident macrophages (RTMs) form during embryogenesis, self-renew locally, and regulate tissue homeostasis by clearing dead cells and debris. During tissue damage, however, bone marrow-derived monocytes […]
- GSE287139 Programmable RNA-triggered counterselection in eukaryotic cells using CRISPR-Cas12a2 January 15, 2026Contributors : Jared Thompson ; Emily R Wilson ; Xiaoyang Zhang ; Yang LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo identify upregulated gene sets and pathways enriched by GeCas12a2 activation.
- GSE304654 Engineered miR-122 inhibitors enhance endothelial mitochondrial efficiency and improve vascular function January 15, 2026Contributors : Ravinder-Reddy Gaddam ; Ajit VikramSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMicroRNA-122-5p (miR-122) is primarily expressed by the liver and is increasingly released into the bloodstream during obesity. It impacts the function of non-liver tissues, such as vascular endothelial cells, and increases […]
- GSE298064 Metabolic control of innate immune activation in TET2-mutant clonal hematopoiesis January 15, 2026Contributors : Peter G Kim ; Christopher Hergott ; Aidan Miller ; Amy Deik ; Meaghan Boileau ; Kevin Bullock ; Kerry Pierce ; Angeline Choy ; Wesley Shin ; Marie McConkey ; Justin Loke ; Birgitta Ryback ; Michael Trinh ; Hong Yue ; Hojong Yoon ; Paul Park ; Shourya Burman ; Matthew Vander Heiden ; Eric Fisher ; Scott Armstrong ; Clary Clish ; Benjamin EbertS […]
- GSE316152 Effect of depletion of USP16 on gene expression of HGC-27 cells January 15, 2026Contributors : Yehua Li ; Siying Ren ; Huanhuan ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGastric cancer has emerged as one of the malignant tumors with increasing incidence in recent years, posing significant challenges to global health. However, effective targeted therapies for gastric cancer remain limited. […]
- GSE220637 RecQ dysfunction contributes to social and depressive-like behavior and aldolase activity changes in mice January 15, 2026Series Type : OtherOrganism : Mus ; Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE316181 5′ UTR length regulates the production of alternative N-terminal protein isoforms in health and disease January 15, 2026Contributors : Jimmy Ly ; Iain CheesemanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe 5′ untranslated region (5′ UTR) of an mRNA is classically viewed as a regulatory region that controls the amount of protein production, but not the resulting protein sequence. Here, we demonstrate that 5′ UTR length also plays a […]
- GSE316172 scRNA-sequence of NeuroD1-astrocyte therapy post-TBI mouse January 15, 2026Contributor : Shuo ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAstrocytes, the most abundant glial cells in the central nervous system (CNS), play a critical role in brain injury responses. While NeuroD1 overexpression in astrocytes has been shown to reverse glial scar formation and promote tissue repair in mou […]
- GSE316183 Efficient transgene-free multiplexed genome editing via viral delivery of an engineered TnpB January 15, 2026Contributors : Honglue Shi ; Kamakshi Vohra ; Marena I TrinidadSeries Type : Expression profiling by high throughput sequencingOrganism : Escherichia coliVirus-induced genome editing (VIGE) using compact RNA-guided endonucleases is a transformational new approach in plant biotechnology, enabling tissue-culture-independent and transgene-free genome editing. W […]
- GSE316213 Oxidative Stress-Induced Immunogenic Cell Death Enhances Whole-Cell Vaccine Efficacy in a Syngeneic Pancreatic Cancer Model January 15, 2026Contributors : Maryam Katoueezadeh ; SoFong Cam Ngan ; Siu Kwan SzeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRNA sequencing was performed to characterize transcriptional changes induced by sub-lethal oxidative stress in murine pancreatic cancer cells. Panc02 cells were exposed to low-dose hydrogen peroxide and com […]
- GSE316477 Tumor Cell Clustering Enhances Metastatic Competence by Regulating the H3K36 Histone Demethylase KDM2A January 15, 2026Contributors : Carolyn Kravitz ; Kiran D Patel ; Emily Wingrove ; Dejian Zhao ; Tang Tang ; Sampada Chande ; Yuchen Huo ; Thomas F Westbrook ; Qin Yan ; Don X NguyenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDisseminated tumor cells can form clusters via cell-cell adhesion, which increases their capacity to initiat […]
- GSE274998 Sensing steroid hormone 17α-hydroxypregnenolone by GPR56 enables protection from ferroptosis-induced liver injury January 15, 2026Contributors : Xiao Zhuang ; Shuo Liu ; Dong Liu ; Bo ChuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensG-protein-coupled receptors (GPCRs) mediate most cellular responses to hormones, neurotransmitters as well as environmental stimulants. However, whether GPCRs participate in modulation of tissue homeostasis through f […]
- GSE316120 Comparative multi-omic analysis reveals conserved and derived mechanisms of fin and limb regeneration January 15, 2026Contributors : Josane F Sousa ; Gabriela Lima ; Louise Perez ; Hannah Schof ; Igor SchneiderSeries Type : Expression profiling by high throughput sequencingOrganism : Polypterus senegalusComparative studies of vertebrate appendages offer a powerful framework for uncovering shared components of an ancestral regeneration toolkit. Here, we employed a multi-omic […]