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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE297320 The mRNA levels of Ly6G+ cells from the bone marrow of septic mice after IFN-gamma stimulation. May 15, 2026Contributors : Zhenhao Yu ; Caiyan ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCurrently, immunotherapy represents a promising therapeutic approach for patients with sepsis in the refractory immunosuppressive phase. The pro-inflammatory cytokine interferon-gamma (IFN-γ) has been investigated in both septic pati […]
- GSE297066 Mechanically and Chemically Defined PEG Hydrogels Improve Reproducibility in Human Cardioid Development May 15, 2026Contributors : Yuanhui Song ; Michael Seitz ; Andrew Kowalczewski ; Nhu Y Mai ; Era Jain ; Huaxiao Yang ; Zhen MaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCardioids are three-dimensional self-organized heart organoids directly derived from induced pluripotent stem cells (hiPSCs) aggregates. The growth and culture […]
- GSE325333 RNA-seq analysis of human peripheral blood Treg cells stratified into four equal fractions according to CD38 intensity May 15, 2026Contributor : Takashi SekiyaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSensitivity of regulatory T cells (Tregs) to extracellular nucleotides such as ATP and NAD⁺ differs substantially between mice and humans. Mouse Tregs undergo robust apoptosis in response to even low concentrations of ATP or NAD⁺, whereas human […]
- GSE316716 Effect of knockdown of FLI1 on gene expression in the human glioblastoma cell lines May 15, 2026Contributors : Jiuwei Cui ; Ji-Fan Hu ; Xue WenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo examined the role of FLI1 in glioblastoma cells and identify FLI1-associated target molecules, FLI1 knockdown cells were used for RNA-seq.
- GSE328229 Transcriptome analysis of high- and low-growth Pacific abalone (Haliotis discus hannai) May 15, 2026Contributors : Hyejung Jung ; Eun Soo Noh ; Jungwook ParkSeries Type : Expression profiling by high throughput sequencingOrganism : Haliotis discus hannaiPacific abalone (Haliotis discus hannai) is one of the most important aquaculture species in East Asia, and growth performance is a key trait for stable and efficient production. To better understand the mo […]
- GSE325626 Comparison of the chromatin status of peripheral blood Treg cells with Treg and naive CD4T cells in various tissues. May 15, 2026Contributor : Takashi SekiyaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusDespite their translational importance, peripheral blood (PB) regulatory T (Treg) cells have rarely been subjected to the kind of systematic, cross-tissue comparisons. Thus, to reveal the chromatin status of Treg cells in PB, we pe […]
- GSE330622 CSF2 knockdown alters gene expression profiles in BCPAP papillary thyroid carcinoma cells May 15, 2026Contributors : Xincheng Liu ; Chi Ma ; Jinyao Ning ; Hongtao Qu ; Qi Li ; Aoxiang Peng ; Daoxin ZhangSeries Type : Expression profiling by arrayOrganism : Homo sapiensThis study investigates the transcriptomic changes in BCPAP papillary thyroid carcinoma (PTC) cells following CSF2 knockdown using Affymetrix PrimeView Human Gene Expression Array. CSF2 knockdo […]
- GSE267698 ZNF467 nucleoplasmic condensates enhance human haematopoietic stem cell homing May 15, 2026Contributors : Bin Guo ; Yandan Chen ; Xiashiyao Zhang ; Jun WanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHuman hematopoietic stem cells (HSCs) possess a distinct gene expression profile distinguishing them from progenitor cells. Gaining insight into the distinctive features of these signature genes could accelera […]
- GSE331024 An IRF3-POLR2G axis represses liver FGF21 and metabolic transcriptional programs [CUT&Tag Liver IRF3-2D] May 15, 2026Contributors : Neethu S Alex ; Ashutosh Shukla ; Suraj J PatelSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusInflammatory signaling in the liver reshapes numerous transcriptional programs, but the mechanisms by which innate immune pathways actively repress metabolic gene expression remain poorly understoo […]
- GSE331023 An IRF3-POLR2G axis represses liver FGF21 and metabolic transcriptional programs [CUT&Tag Hepatocytes IRF3-2D] May 15, 2026Contributors : Neethu S Alex ; Ashutosh Shukla ; Suraj J PatelSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusInflammatory signaling in the liver reshapes numerous transcriptional programs, but the mechanisms by which innate immune pathways actively repress metabolic gene expression remain poorly understoo […]
- GSE331025 An IRF3-POLR2G axis represses liver FGF21 and metabolic transcriptional programs [CUT&Tag Liver POLR2G] May 15, 2026Contributors : Neethu S Alex ; Ashutosh Shukla ; Suraj J PatelSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusInflammatory signaling in the liver reshapes numerous transcriptional programs, but the mechanisms by which innate immune pathways actively repress metabolic gene expression remain poorly understoo […]
- GSE331026 An IRF3-POLR2G axis represses liver FGF21 and metabolic transcriptional programs [PRO-seq] May 15, 2026Contributors : Neethu S Alex ; Ashutosh Shukla ; Suraj J PatelSeries Type : OtherOrganism : Mus musculusInflammatory signaling in the liver reshapes numerous transcriptional programs, but the mechanisms by which innate immune pathways actively repress metabolic gene expression remain poorly understood. Here we show that IRF3, a master regulator of innate imm […]
- GSE331028 An IRF3-POLR2G axis represses liver FGF21 and metabolic transcriptional programs [RNA-seq Liver POLR2G] May 15, 2026Contributors : Neethu S Alex ; Ashutosh Shukla ; Suraj J PatelSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusInflammatory signaling in the liver reshapes numerous transcriptional programs, but the mechanisms by which innate immune pathways actively repress metabolic gene expression remain poorly understood. Here we sho […]
- GSE296799 Extracellular vesicles from a model of melanoma cancer-associated fibroblasts induce changes in brain microvascular cells consistent with pre-metastatic niche priming. May 15, 2026Contributors : James R Boyne ; Chinedu A Anene ; Mikayla SheltonSeries Type : Non-coding RNA profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiensMalignant melanoma has one of the lowest 5-year survival rates of any cancer, and is recognised for being particularly invasive and metastatic, with the […]
- GSE330610 Exogenous 24nt siRNAs induce AGO4A-dependent silencing via promoter DNA methylation and H3K9me2 deposition May 15, 2026Contributors : A Hanke ; L Schütz ; M Walz ; N Wunsch ; L Kreis ; L Hohenwarter ; A Baßler ; M Wassenegger ; A Dalakouras ; G Krczal ; A Koch ; VV UsluSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Nicotiana benthamianaTranscriptional Gene Silencing (TGS) is an essential process in plants for development, gene regulation, defe […]