Category: pubmed

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE293680 Campylobacter jejuni regulates cell cycle progression to potentiate host cell invasion April 2, 2026
  Contributors : Prabhat K Talukdar ; Megan C Dines ; Amruta S Kale ; Ryan R Driskell ; Lisa M Gloss ; Michael E KonkelSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo assess the effects of C. jejuni infection on cell cycle progression, INT407 cells were synchronized, then infected with either wild-type C. jejuni, or a […]
• GSE293572 CAF drives spheroid formation and pleural dissemination in NSCLC April 2, 2026
  Contributors : Naoki Matsuda ; Ken Suzawa ; Yin Min Thu ; Shuta TomidaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPleural dissemination in non-small cell lung cancer (NSCLC) refers to the direct spread of cancer cells from the primary tumor site to the extrapulmonary thoracic cavity, where they colonize the pleura. […]
• GSE309886 Mitochondrial L-2-hydroxyglutarate is a physiologic signaling metabolite [CUT&Run] April 2, 2026
  Contributors : Yuki Aoi ; Ram P Chakrabarty ; Navdeep S ChandelSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusL-2-hydroxyglutarate (L-2-HG) is a low-abundance metabolite in mammals due to the mitochondrial enzyme L-2-HG dehydrogenase (L2HGDH), which oxidizes L-2-HG to 2-oxoglutarate (2-OG) to prevent its […]
• GSE294730 Tumor suppressor genotype influences the extent and mode of immunosurveillance in lung cancer April 2, 2026
  Contributors : Keren M Adler ; Haiqing Xu ; Amy C Gladstein ; Valerie Irizarry-Negron ; Maggie Robertson ; Katherine R Doerig ; Dmitri A Petrov ; Monte M Winslow ; David M FeldserSeries Type : OtherOrganism : Escherichia coli ; Mus musculusThe impact of cancer driving mutations in regulating immunosurveillance throughout tumor development remains poorly unde […]
• GSE325706 GPNMB as a viable CAR Target for MITF pathognomonic fusion-driven cancers: A first-in-person GCAR1 Trial [ASPS-02_VisiumHD] April 2, 2026
  Contributors : Gill Gurveer ; Morrissy SoranaSeries Type : OtherOrganism : Homo sapiensCAR T therapy for solid tumours is limited by a lack of safe and uniformly expressed cell-surface targets. We identify the MITF-driven gene GPNMB as being highly, homogeneously and stably expressed from primary and relapsed translocation-positive alveolar soft part sarcoma […]
• GSE322639 C-type natriuretic peptide pre-maturation culture affects cytoplasmic maturation in bovine oocytes April 2, 2026
  Contributors : Emily Girka ; Hao Ming ; Zongliang Jiang ; Kenneth R BondioliSeries Type : Expression profiling by high throughput sequencingOrganism : Bos taurusIn vitro oocyte maturation (IVM) is a vital step for many assisted reproductive technologies including in vitro embryo production. Modulation of ribonucleic acid (RNA) transcripts, lipids, mitochondr […]
• GSE326293 Mitochondrial L-2-hydroxyglutarate is a physiologic signaling metabolite [ATAC-seq] April 2, 2026
  Contributors : Ram P Chakrabarty ; Qiushi Jin ; Dongmei Wang ; Rogan A Grant ; Feng Yue ; Navdeep S ChandelSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusL-2-hydroxyglutarate (L-2-HG) is a low-abundance metabolite in mammals due to the mitochondrial enzyme L-2-HG dehydrogenase (L2HGDH), which oxidizes L-2 […]
• GSE273473 Mitochondrial L-2-hydroxyglutarate is a physiologic signaling metabolite [ChIP-seq] April 2, 2026
  Contributors : Ram P Chakrabarty ; Jonathan G van Vranken ; Yuki Aoi ; Marta Iwanaszko ; Ali Shilatifard ; Navdeep S ChandelSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusL-2-hydroxyglutarate (L-2-HG) is a low-abundance metabolite in mammals, due to the mitochondrial enzyme L-2-HG dehydrogenase (L2HGDH), […]
• GSE326312 Development and first-in-human CAR T therapy targeting the pathognomonic MiT-fusion driven protein GPNMB April 2, 2026
  Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensCAR T therapy for solid tumors is constrained by the scarcity of safe, uniformly expressed cell-surface targets. Here we identify GPNMB, a MiT fusion-driven protein, as highly, homogeneously, and stably expressed in primary and relapsed translocation-positive alveo […]
• GSE326294 Mitochondrial L-2-hydroxyglutarate is a physiologic signaling metabolite [m6A-seq] April 2, 2026
  Contributors : Ram P Chakrabarty ; Michael Kahl ; Zhaofa Xu ; Rogan A Grant ; Yongchao C Ma ; Navdeep S ChandelSeries Type : OtherOrganism : Mus musculusL-2-hydroxyglutarate (L-2-HG) is a low-abundance metabolite in mammals due to the mitochondrial enzyme L-2-HG dehydrogenase (L2HGDH), which oxidizes L-2-HG to 2-oxoglutarate (2-OG) to prevent its accumulatio […]
• GSE326369 ONX-0914 Ameliorates Hepatic Steatosis in MASLD by Stabilizing HDAC2 and Inhibiting SREBP1 Acetylation via PSMB8 Inhibition April 2, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the mechanism by which ONX‑0914 ameliorates MASLD, HFD‑fed mice were randomized to receive the selective PSMB8 inhibitor ONX‑0914 (10 mg/kg in 10% captisol, s.c., every other day) or vehicle control for an additional 6 weeks while remaining on the HFD. At th […]
• GSE326397 A study for intratumoral heterogeneity of glioblastoma [scRNA-seq] April 2, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIntratumoral heterogeneity (ITH) is a key driver of therapy resistance in glioblastoma (GBM). This study established a five-gene signature-based gITH classifier through multi-omics analysis, demonstrating robust prognostic predictive value. High-gITH tumors exhibited enhan […]
• GSE326636 Spatial transcriptomic analysis of mouse liver in a high-fat diet model with kimchi supplementation April 2, 2026
  Contributors : Ha-Rin Moon ; Wooje LeeSeries Type : OtherOrganism : Mus musculusThis study generated 10x Genomics Visium spatial transcriptomic profiles from mouse liver sections to investigate the effects of high-fat diet and kimchi supplementation on hepatic gene expression organization. Samples were obtained from male C57BL/6J mice assigned to normal diet […]
• GSE292992 MDM2 degradation overcomes feedback regulation of p53 signaling in Merkel cell carcinoma April 2, 2026
  Contributors : Varsha Ananthapadmanabhan ; Simone Bruno ; Leonard Vonk ; Yu-Chen Cheng ; Abeba Teshager ; Benjamin K Eschle ; Charles L Howarth ; Joana S Rodrigues ; Julia Schnabel ; Ananya Kodali ; Prafulla C Gokhale ; Rujuta Kshirsagar ; Susanne B Breitkopf ; Kirti Sharma ; Joao A Paulio ; Yvonne Li ; Andrew D Cherniack ; Franziska Michor ; Yogesh Chutake […]
• GSE326292 Mitochondrial L-2-hydroxyglutarate is a physiologic signaling metabolite [mRRBS] April 2, 2026
  Contributors : Ram P Chakrabarty ; Kathryn A Helmin ; Rogan A Grant ; Benjamin D Singer ; Navdeep S ChandelSeries Type : Methylation profiling by high throughput sequencingOrganism : Mus musculusL-2-hydroxyglutarate (L-2-HG) is a low-abundance metabolite in mammals due to the mitochondrial enzyme L-2-HG dehydrogenase (L2HGDH), which oxidizes L-2-HG to 2-oxog […]