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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE237113 RNA seq of mouse tissue samples from AEW animal models : Effect of MMP9 on gene expression. July 12, 2026Contributors : Ruizhen Wang ; Jianghui MengSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn the present study, RNA-seq technique were performed to explore biological significance of MMP9 in the neuro-cutaneous signaling network of chronic itch. We performed high-throughput sequencing of mouse tissue samples from AEW a […]
- GSE237112 Next generation sequencing facilitates quantitative analysis of transcriptional profiling of clinical strain Candida albicans CA10 with iravacycline hydrochloride and fluconazole treament alone or in combination. July 12, 2026Contributors : Shicun zheng ; Xiuyun liSeries Type : Expression profiling by high throughput sequencingOrganism : Candida albicansmRNA profiles of Candida albicans clinical strain CA10, which treated with iravacycline hydrochloride and fluconazole alone or in combination, were generated by deep sequencing, in triplicate, using Illumina NovaSeq 6000 . The seq […]
- GSE302567 Nicotine and quercetin alleviate ulcerative colitis through inhibition of PI3K/AKT and NF-κB pathways July 12, 2026Contributors : huanhuan ma ; hongjuan wang ; huan chen ; hongwei hou ; qingyuan huSeries Type : Expression profiling by high throughput sequencingOrganism : MusculusUlcerative colitis (UC) remains a therapeutic challenge due to its chronicity, adverse effects of current drugs, and high relapse rates. Smoking inversely correlates with UC risk. Nicotine (NIC) […]
- GSE302508 Exploitation of KAT6A for the treatment of PPP2R1A-mutated cancers July 12, 2026Contributors : Mitsutake Yano ; Rugang ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPPP2R1A, encoding a subunit of the protein phosphatase 2A (PP2A) enzyme, is mutated in >1% of cases across diverse human cancer types 1. Notably, PPP2R1A mutations are often observed in gynecological cancers 1. To date, clinic […]
- GSE317428 PGK1 acts as a non-catalytic gatekeeper of ferroptosis by stabilizing SLC7A11 July 12, 2026Contributors : Guixian Wu ; Yuanze Zhou ; Chengxin Luo ; Yaqun Ding ; Xi Li ; Hui Li ; Shuangnian XuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensFerroptosis is restrained by layered antioxidant defenses, yet whether glycolytic enzymes directly constitute ferroptosis-defense machinery remains unclear. Here we identify […]
- GSE303490 The novel nano-selenium supplement extends lifespan and delays multi-organs aging by regulating the Sik1 pathway through maintaining calcium homeostasis July 12, 2026Contributors : Yang Yu ; Jintao Song ; Mengjiao GuoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAging involves progressive physiological decline and increased disease susceptibility, creating demand for effective interventions. While selenium regulates redox homeostasis and aging, its therapeutic use is limited by bi […]
- GSE328457 Pooled combinatorial screening identifies transcription factor sets that drive hematopoietic progenitor-like cell fate July 12, 2026Contributors : James Briggs ; Janghwan Cho ; Daniel Strebinger ; Julia Joung ; Tatum Braun ; Rhiannon Macrae ; Hojun Li ; Feng ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMammalian cells can be directed towards specific fates by overexpression of transcription factors (TFs). However, discovering and optimizing […]
- GSE317778 PGK1 acts as a non-catalytic gatekeeper of ferroptosis by stabilizing SLC7A11 July 12, 2026Contributors : Guixian Wu ; Yuanze Zhou ; Chengxin Luo ; Yaqun Ding ; Xi Li ; Hui Li ; Shuangnian XuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusComparative gene expression profiling analysis of scRNA-seq data for PGK1 KO and PGK1 WT HCC cells
- GSE337117 Overlapped transcription targets of cGAS and JunB in MDA-MB-231 cells July 12, 2026Contributor : Deng YuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn addition to serving as a cytosolic dsDNA sensor, we found cGAS also participates into transcriptional control on chromatin independent of nucleosomal binding. cGAS is recruited to chromatin by AP-1 factors such as JunB. The goal of this analysis is […]
- GSE337818 Distinct macroH2A variant dynamics reveal temporal mH2A2 displacement at cell-cycle regulatory elements July 12, 2026Contributors : Yongzhuo Deng ; Zeqian Xu ; Jinling Liu ; Zhifeng Shao ; Xinhui LiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensMacroH2A (mH2A) variants have traditionally been viewed as transcriptional repressors, with mH2A2 specifically implicated in modulating enhancer accessibility to suppress transcr […]
- GSE337826 The impact of PAX5 overexpression on gene expression profile in PC-9 cells July 12, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPAX5, a transcription factor, is expressed exclusively in pro B cells. To understand the genes regulated by PAX5 in NSCLC cells, we overexpressed PAX5 in PC-9 cells and examined the change of transcription profile.
- GSE337830 Single-cell transcriptomic profiling of mouse kidneys in contrast-induced acute kidney injury July 12, 2026Contributors : Mengqing Ma ; Hao Zhang ; Weijuan Deng ; Xia Du ; Ting Chen ; Zhaowei Wang ; Chuxian Chen ; Mengxing Chen ; Binbin Pan ; Dawei Chen ; Qing Sun ; Mengting Lu ; Yimin Li ; Wenjuan Huang ; Rui Tang ; Zhibin Qiu ; Xin Wan ; Changchun CaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study generated sing […]
- GSE337832 STING Drives CD4+T Cell Differentiation via JAK-STAT Signaling in Bullous Pemphigoid July 12, 2026Contributors : Weiwei Jiang ; Mengke Sun ; Junchen He ; Tianxue Wang ; Tao Guo ; Lizhi HuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBullous pemphigoid (BP) is an autoimmune blistering disease with an increasing incidence in recent years; however, the underlying immune regulatory mechanisms remain largely unclear. A […]