Quick Links : Search PubMed , Finding Full Text , PubMed Advanced Search , Clinical Queries , Single Citation Matcher , FAQs & User Guide , Explore MeSH Database , Explore PubMed Journals
Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE286039 Multi-Omic Atlas reveals cytotoxic phenotype and ROS-linked metabolic quiescence as key features of CTL-resistant HIV-infected CD4+ T-cells January 6, 2026Contributors : Richard B Jones ; Alberto Herrera ; Paul ZumboSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensHIV, although manageable as a chronic condition, currently lacks a safe or scalable cure. Antiretroviral therapy (ART) effectively suppresses HIV replication, preventing disease progression and transmissi […]
- GSE292269 Disrupted Energy Metabolism is Associated with Retinal Ganglion Cell Degeneration in Autosomal Dominant Optic Atrophy January 6, 2026Contributors : Eugene Yu-Chuan Kang ; Yun-Ju Tseng ; Nan-Kai Wang ; Chyuan-Sheng LinSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study investigated the impact of an Opa1 variant on mitochondrial function and retinal metabolism using a novel knock-in mouse model (Opa1V291D/+) that mirrored autosomal dominant opti […]
- GSE287728 BRD2 bridging TFIID and histone acetylation in transcriptional initiation [ChIP-Seq] January 6, 2026Contributors : Bin Zheng ; Ruxuan Qiu ; Yuki Aoi ; Marta Iwanaszko ; Ali ShilatifardSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensMembers of the bromodomain and extraterminal domain (BET) transcription factor family play a central role in the regulation of gene expression. BET domain factors have also be […]
- GSE315692 Small nucleolar RNA Snora61 drives self-renewal of small intestinal stem cells via initiation of Lgr5 transcription January 6, 2026Series Type : OtherOrganism : Mus musculusIntestinal epithelium relies on intestinal stem cells (ISCs) for rapid and precise tissue replenishment to maintain gut normal function. The self-renewal maintenance of ISCs is finely regulated by multiple stemness factors and signaling pathways. However, the transcription mechanisms of some key stemness factors rema […]
- GSE294900 Astrocytic Sox9 preserves cognitive function in models of Alsheimer's Disease [RNA-Seq] January 6, 2026Contributors : Dongjoo Choi ; Yi-Ting Chen ; Teng-Wei Huang ; Brittney Lozzi ; Benjamin DeneenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAstrocytes play essential roles in the brain and their dysfunction is associated with nearly every form of neurological disease. Despite their ubiquity, our knowledge of how astro […]
- GSE269305 Mechanistic basis of gene regulation by SRCAP and H2A.Z (CUT&Tag) January 6, 2026Contributors : Armelle Tollenaere ; Enes Ugur ; Cedric Deluz ; Heinrich Leonhardt ; David M SuterSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusA central problem in gene regulation is to discriminate gene regulatory functions of chromatin composition from the one of chromatin-modifying complexes. This que […]
- GSE262967 Assessment of OSMR dependency in normal human lung fibroblasts [NGS4564] January 6, 2026Contributors : Rojo A Ratsimandresy ; Salil Uttarwar ; Mark S Wilson ; Jason A Vander HeidenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate OSMR dependency in normal human lung fibroblasts, cells were preincubated with anti-OSM, or (one of 2) anti-OSMR, or anti-OSM+anti-OSMR antibodies, then stimulated wi […]
- GSE315435 Rhythmic nephron formation in the developing kidney January 6, 2026Contributors : Alex Hughes ; Samuel Grindel ; Sachin DavisSeries Type : OtherOrganism : Homo sapiens ; Mus musculusThe mammalian kidney achieves massive parallelization of function by exponentially duplicating nephron-forming niches during development. Each niche caps a tip of the ureteric bud epithelium (the future urinary collecting duct tree) as it underg […]
- GSE315367 Blood-based epigenetic instability linked to human aging and disease [longitudinal_AML] January 6, 2026Contributors : Sagi Abelson ; Steven M Chan ; Mark D MindenSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensThe abundance, dynamics, and context-dependent heterogeneity of DNA methylation, where a pattern considered abnormal in one cell type may be normal in another, complicate the identification of early methylation changes t […]
- GSE315505 Prenatal diisononyl phthalate exposure induces the development of pulmonary dysplasia in offspring January 6, 2026Contributors : Dan Li ; Chengyu Zhao ; Fu Xu ; Yao Yuan ; Sihan Zhang ; Yuanyuan Tian ; Meiqiong WuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAs a widely used plasticizer, Diisononyl phthalate (DINP) has been considered an emerging environmental pollutant. Epidemiological evidence shows that prenatal DINP exposure […]
- GSE315451 Blood-based epigenetic instability linked to human aging and disease [MDS_CML] January 6, 2026Contributors : Sagi Abelson ; Dennis Kim ; Jae-Sook AhnSeries Type : Methylation profiling by arrayOrganism : Homo sapiensThe abundance, dynamics, and context-dependent heterogeneity of DNA methylation, where a pattern considered abnormal in one cell type may be normal in another, complicate the identification of early methylation changes that drive or signa […]
- GSE315569 Aptamer-modified 5-fluorouracil encapsulated metal-organic framework nanodrugs for enhanced therapy of colorectal cancer via peroxidative induced cell death January 6, 2026Contributors : Guangzhao Lv ; Rongxin Zhang ; Duanping SunSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensColorectal cancer (CRC) remains one of the most devastating malignancies worldwide. 5-Fluorouracil (5-FU) is a widely used therapeutic agent in CRC treatment. Here, we report a PTK-7–targeted, MOF-based nanodrug (AF […]
- GSE315628 Single-cell data for FGFR3-driven gene regulatory network analysis reveals a pro-tumoral role for p63 in luminal bladder tumors January 6, 2026Contributors : Isabelle Bernard-Pierrot ; Xiang-Yu Meng ; Lilia Estrada-Virrueta ; Guerric Gilbert ; Helene Neyret-KahnSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusFGFR3 (Fibroblast Growth Factor Receptor 3) is one of the most frequently altered genes in bladder cancer, primarily through activating mut […]
- GSE315646 Humanized and Charge-Optimized CSPG4-Specific CAR-T Cells Show Enhanced Efficacy Against Head and Neck Squamous Cell Carcinoma January 6, 2026Contributors : Jian Chen ; Xiang Xu ; Shizhen Qiu ; Zhitong Wang ; Haopeng WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensChimeric antigen receptor (CAR) T cell therapy for head and neck squamous cell carcinoma (HNSCC) is hampered by the lack of a robust tumor antigen and a suitable CAR design.CSPG4 is highly expre […]
- GSE283858 KMT2A is a prerequisite of malignant transformation during IDH-mutant gliomagenesis [RNA-Seq] January 6, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRationale: IDH1R132H is the defining mutation of low-grade gliomas (LGGs), inflicting broad epigenetic rewiring that leads to malignant transformation. Recent studies demonstrated that cell fate change from astrocyte to LGG is accompanied by redistribution of H3K4 methylat […]