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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE267579 MRE11 proximal polyadenylation site-mediated looping impacts transcription and genomic stability [RNA-seq] April 6, 2026Contributors : Kaimeng Huang ; Dipanjan ChowdhurySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMRE11, a key regulator in maintaining genome integrity, has two main polyadenylation sites (PAS) in 3’UTR. There is a ~3 Kb difference between the proximal PAS (pPAS) and the distal PAS (dPAS). Therefore, using the pPAS can […]
- GSE236432 C2ORF74 ptomotes high fat diet induced obesity I April 6, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGender differences in obesity is widely reported, however, identification of gender specific obese gene and characterization of its role in obesity remain elusive. Here, we identify a germ cell specifically expressed gene C2orf74 (TSP) and demonstrate that TSP promotes hig […]
- GSE293142 Simultaneous orthogonal cell engineering by a single CRISPR-Cas9 polyfunctional editor [BiSulfite-seq] April 6, 2026Contributors : Deborah Cipria ; Tania Baccega ; Miriana Rizzo ; Piergiuseppe Quarato ; Alice Reschigna ; Rita El Khoury ; Martino A Cappelluti ; Sandra Ammann ; Valeria Mollica Poeta ; Matteo Conti ; Sara Valsoni ; Pietro Spinelli ; Ivan Merelli ; Toni Cathomen ; Monica Casucci ; Angelo L LombardoSeries Type : Methylation profiling by high throughput sequenc […]
- GSE291273 The placentalia specific histone H3.4 promotes germ cell development and reproductive fitness [RNA-seq] April 6, 2026Contributors : Antoine H F.M. Peters ; Pavel A. KomarovSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGenes involved in chromatin remodeling during sperm development are under strong evolutionary pressure to optimize reproductive fitness In mice, the histone H3.4 variant, encoded by the single copy H3f4 gene, is essent […]
- GSE309186 Astrocytic NFIX regulates thalamocortical circuits through GABA and Purinergic Signaling April 6, 2026Contributors : Sanjana Murali ; Manuel S Perez ; Junsung Woo ; Priyanka Patel ; Yeunjung Ko ; Wookbing Kwon ; Kaitlyn Sanchez ; Jin Park ; Henrique B DaSilva ; Richard Gronostajski ; Jeannie Chin ; Benjamin DeneenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAstrocytes play essential roles in brain function by support […]
- GSE298228 The PLAGL1-KLF4-IRX5 axis promotes the osteogenesis of periosteal progenitors during mandible regeneration [ATAC-seq] April 6, 2026Contributor : Jiahui DuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusTranscription factor (TF) networks are pivotal in regulating the fate of stem/progenitor cells. However, the intricate regulatory mechanisms mediated by key TFs in adult periosteal stem/progenitor cells (PSPCs) remain poorly understood, […]
- GSE326978 Essential lncRNAs in the human transcriptome [CRISPR] April 6, 2026Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensMammalian genomes host a diverse array of RNA that includes protein-coding and noncoding transcripts. However, the functional roles of most long noncoding RNAs (lncRNAs) remain elusive. Using RNA-targeting CRISPR-Cas13 screens, we probed how loss of ~5,500 lncRNAs […]
- GSE309806 MRE11 proximal polyadenylation site-mediated looping impacts transcription and genomic stability April 6, 2026Contributors : Kaimeng Huang ; Dipanjan ChowdhurySeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensAlternative polyadenylation (APA) generates transcript isoforms with variable 3' UTR lengths, but its regulatory role in DNA damage response (DDR) genes remains poorly understood. Here, we demonstrate that […]
- GSE327033 HyDRA: a pipeline for integrating long- and short-read RNAseq data for custom transcriptome assembly April 6, 2026Contributors : Isabela Almeida ; Xue Lu ; Stacey Edwards ; Juliet French ; Mainá BitarSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensShort-read RNA sequencing (RNAseq) remains a cornerstone for transcriptome profiling, but is limited in reconstructing full-length transcripts and capturing transcript diversity. While lo […]
- GSE326989 Discovery of a primed endothelial progenitor that requires VEGF/ERK inhibition to complete vein differentiation [kairos_timecourse_bulkrnaseq] April 6, 2026Contributors : Lay Teng Ang ; Sherry Li Zheng ; Kevin J Liu ; Anastasiia Masaltseva ; Kyle M LohSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensExtracellular signals and cell-fate trajectories during vein development remain elusive, despite trailblazing insights into artery development. Here we exploit human pluripotent […]
- GSE327057 Systematically characterizing the roles of E3-ligase family members in inflammatory responses with massively parallel Perturb-seq April 6, 2026Contributors : Kathryn Geiger-Schuller ; Basak Eraslan ; Olena Kuksenko ; Anugraha Rajagopalan ; Ana M Meireles ; Markus Brown ; Kushal K Dey ; Karthik A Jagadeesh ; Pratiksha I Thakore ; Ozge Karayel ; Andrea R Yung ; Simone Haag ; Karren Dai Yang ; Liat Amir-Zilberstein ; Toni Delorey ; Devan Phillips ; Raktima Raychowdhury ; Christine Moussion ; Alkes L P […]
- GSE327062 Adjuvant personalized multivalent neoantigen DNA vaccination for MGMT unmethylated glioblastoma: a phase I trial April 6, 2026Contributors : Elizabeth A Garfinkle ; Katherine E Miller ; Gavin P Dunn ; Tanner M JohannsSeries Type : OtherOrganism : Homo sapiensGlioblastoma is a fatal disease with a median prognosis of 12-18 months. Recent studies have shown encouraging results using neoantigen-based vaccines to stimulate glioblastoma-directed immune responses, but overall immunogenic […]
- GSE327103 Glabridin Promotes Melanosome Degradation and Alleviates Melanosome-Induced Mitochondrial Dysfunction in Keratinocytes via Autophagy April 6, 2026Contributor : Nie XinSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: The excessive accumulation of melanosomes within keratinocytes contributes to skin hyperpigmentation and disrupts normal epidermal proliferation. Glabridin, an isoflavone derived from Glycyrrhiza glabra L., is a potent skin-lightening agent […]
- GSE327129 Subcellular mRNA localization patterns across tissues resolved with spatial transcriptomics April 6, 2026Contributors : Roy Novoselsky ; Ofra Golani ; Tal Barkai ; Merav Kedmi ; Inna Goliand ; Shalev ItzkovitzSeries Type : OtherOrganism : Mus musculusSubcellular RNA localization, including nuclear retention and apical-basal compartmentalization in polarized epithelia plays a central role in post-transcriptional regulation. However, methods for high-throughput m […]
- GSE326938 Discovery of a primed endothelial progenitor that requires VEGF/ERK inhibition to complete vein differentiation [kairos_timecourse_scrnaseq] April 6, 2026Contributors : Lay Teng Ang ; Sherry Li Zheng ; Kevin J Liu ; Anastasiia Masaltseva ; Kyle M LohSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensExtracellular signals and cell-fate trajectories during vein development remain elusive, despite trailblazing insights into artery development. Here we exploit human pluripotent […]