Category: pubmed

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE275606 PNET2_A and PNET2_B function redundantly with CRWN protein. August 15, 2026
  Contributors : Yu Tang ; Xiao LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaPurpose: To understand the molecular mechanism between PNET2 and CRWNs, we generated higher-order mutants of crwn1;4pnet2_a, crwn1;4 pnet2_b, and compare them with wild-type, crwn1;4 using whole genome transcriptome analysis on 4-we […]
• GSE289506 Coding and non-coding expression profile of ex vivo treated CLL primary cells August 15, 2026
  Contributor : Lluís HernandezSeries Type : Expression profiling by arrayOrganism : Homo sapiensSamples were splitted in 4 conditions: (A) control without Agonist mix and with NGS beads, (B) control with Agonist mix and NGS beads, (C) With Agonist mix and NGS beads, (D) With Agonist mix and IGM beads. Agonist mix (microenviroment stimuli): CpG-ODN2006-CD40L+I […]
• GSE288926 Coding and non-coding expression profile of in vitro silencing of 3 different lncRNAS in MEC-1 CLL cells August 15, 2026
  Contributor : Lluís HernandezSeries Type : Expression profiling by arrayOrganism : Homo sapiensSilencing in MEC-1 cell line of lncRNA best candidates found to be involved in microenviroment stimulation on primary CLL cells treated ex vivo with CpG-ODN-CD40L+IL10Samples were normalised (log2) with TAC (v4.0.2) using SST-RMA algorithm
• GSE300611 YTHDF1-mediated m6A RNA regulation controls cardiomyocyte remodeling through KLF11-HIF1α [RIP-Seq] August 15, 2026
  Contributors : Lijun Wang ; Jiaqi Wang ; Junjie XiaoSeries Type : OtherOrganism : Mus musculusCardiovascular disease remains the leading cause of mortality globally. While cardiac hypertrophy initially arises as a compensatory adaptation of cardiomyocytes to stress, physiological and pathological cardiac hypertrophy exhibit distinct underlying mechanisms and […]
• GSE300276 YTHDF1-mediated m6A RNA regulation controls cardiomyocyte remodeling through KLF11-HIF1α (ChIP-seq) August 15, 2026
  Contributors : Lijun Wang ; Jiaqi Wang ; Junjie XiaoSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusCardiovascular disease remains the leading cause of mortality globally. While cardiac hypertrophy initially arises as a compensatory adaptation of cardiomyocytes to stress, physiological and pathological car […]
• GSE343206 Transcriptomic Characterisation of Mouse Embryonic Stem Cell-Derived Hepatocyte-Like Cells Generated Using an Advanced Hepatic-Inducing Cocktail (A-HIC) August 15, 2026
  Contributors : Beatrice Villani ; Wenduo Qi ; Sari PenningsSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusReliable generation of hepatocyte-like cells (HLCs) from pluripotent stem cells remains limited by cellular heterogeneity and incomplete maturation. In this study, we evaluated an advanced hepatic-inducing cocktail […]
• GSE304158 Gene expression of two Ewing sarcoma cell lines (SK-N-MC, TC-71), transfected with inducible re-expression of CIAP1 August 15, 2026
  Contributors : Florencia Cidre-Aranaz ; Thomas G GrünewaldSeries Type : Expression profiling by arrayOrganism : Homo sapiensThis dataset comprises trnscriptome data of two Ewing sarcoma cell lines (SK-N-MC and TC-71) after re-expression of the gene CIAP1
• GSE305533 Effects of 4 mixture of cytokines including TNF-alpha, IL-1beta IFN-gamma, and TGF-bata1 on rhematoid arthritis synovial fibroblasts August 15, 2026
  Contributors : Tetsuya Saito ; Motohiko Sato ; Takahiro Nakahara ; Shinsuke YasudaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate effects of 4 mixture of cytokines including TNF-alpha, IL-1beta IFN-gamma, and TGF-bata1 on rhematoid arthritis synovial fibroblasts (RASFs), we treated RASFs (n = 3) with TNF- […]
• GSE305532 Effects of TEAD4 knockdown on rhematoid arthritis synovial fibroblasts stimulated with 4 mixture of cytokines including TNF-alpha, IL-1beta IFN-gamma, and TGF-bata1 August 15, 2026
  Contributors : Tetsuya Saito ; Motohiko Sato ; Takahiro Nakahara ; Shinsuke YasudaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate effects of TEAD4 knockdown on rhematoid arthritis synovial fibroblasts (RASFs) stimulated with 4 mixture of cytokines including TNF-alpha, IL-1beta IFN-gamma, and TGF-bata1 , w […]
• GSE306632 Effects of pan-TEAD inhibitor K975 on rhematoid arthritis synovial fibroblasts August 15, 2026
  Contributors : Tetsuya Saito ; Motohiko Sato ; Takahiro Nakahara ; Shinsuke YasudaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate effects of pan-TEAD inhibitor K975 on rhematoid arthritis synovial fibroblasts (RASFs), we treated RASFs (n = 3) with K975 (0.5 microM) for 24 hours and conducted RNA-seq analy […]
• GSE305608 Dual molecular mechanisms and functional compensation by RBMXL1 retrocopy underlie RBMX-associated neurodevelopmental syndrome August 15, 2026
  Contributors : Pierre Tilliole ; Carolin Mattausch ; Peggy Tilly ; Elsa Leitão ; Lucile Boutaud ; Daphné Lehalle ; Isabelle An ; Emanuela Argilli ; Sharon Aufox ; Bert Callewaert ; Perrine Charles ; Jessica K. Cinkornpumin ; Thomas Courtin ; Marco Dalla Vecchia ; Erica Davis ; William Dobyns ; Ekaterina Epifanova ; Erwan Grandgirard ; Matthieu Jung ; Sarah J […]
• GSE330240 Septin Complexes Regulate Microtubule Organization and Synaptic Function at the Neuromuscular Junction August 15, 2026
  Contributors : Farzaneh Larti ; Taha Akkülah ; Gencay K Polat ; Arzu ÇelikSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterSeptins are GTP-binding cytoskeletal proteins that form filamentous structures and play key roles in cell division, membrane organisation, and cytoskeletal regulation. In Drosophila melano […]
• GSE334669 Rg1 improves motor recovery after spinal cord injury by suppressing astrocytic NLRP2 inflammasome via the TLR4–MyD88–NF-κB pathway August 15, 2026
  Contributors : Baihan Sun ; Kelv Shen ; Yin Zhu ; Wenjun ZouSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSpinal cord injury (SCI)-induced neuroinflammation and astrocyte pyroptosis severely impede motor functional recovery. Here, we report that ginsenoside Rg1 attenuates astrocyte pyroptosis by regulating the TLR4‑My […]
• GSE343131 Differential bioenergetic reprogramming driven by sorafenib reveals therapeutic vulnerabilities in biliary tract cancers August 15, 2026
  Contributors : Wenhua Zhang ; Beixuan He ; Lei Zhang ; Zixin Li ; Meilin Ma ; Jiaying Xie ; Xinyu Wang ; Zhen Fang ; Zhuying Yue ; Ziru Xue ; Ning Tang ; Jie Li ; Ziming Yin ; Yanjing Li ; Yingbin LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBiliary tract cancers (BTCs) comprise biologically heterogeneous subtypes […]
• GSE241919 Analysing the Noncoding RNAs Involved in Rehabilitation Exercise Ameliorating Acute Myocardial Infarction-induced Cardiac Remodelling August 15, 2026
  Contributors : Xueying Chen ; Mingrui Chen ; Yugang Yan ; Lijun GanSeries Type : Expression profiling by high throughput sequencing ; Non-coding RNA profiling by high throughput sequencingOrganism : Mus musculusRehabilitation exercise (RE) can reduce cardiac remodeling and improve cardiac function in patients with acute myocardial infarction (AMI). However, […]