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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE302373 Nociceptive innervation limits tertiary lymphoid structures to promote lung cancer May 19, 2026Contributors : Ya-Hsuan Ho ; Giacomo Bregni ; Paola Peinado ; Leanne LiSeries Type : Expression profiling by high throughput sequencingOrganism : Sensory innervation regulates lung physiology and pathology, but its role in lung cancer is poorly understood. We show that lung adenocarcinoma (LUAD) progression locally amplifies nociceptive sensory innervation a […]
- GSE306034 Paternal early-life stress and diet influence female offspring behavior through sperm DNA methylation and transcriptomic alterations in the Amygdala [F0_Male] May 19, 2026Contributors : Tam Yadid ; Tatiana Kisliouk ; Maayan Ramaty ; Aron Weller ; Noam MeiriSeries Type : Expression profiling by high throughput sequencingOrganism : Obesity is a global epidemic influenced by stress-related experiences during development, which can program behavioral traits, with the amygdala playing a central role in stress regulation. These pro […]
- GSE303640 Effect of chronic fg-TiO2 (also called E171) exposure on hepatic gene expression in male mice fed normal- or western-diet May 19, 2026Contributors : Sandrine Ellero-Simatos ; Bruno Lamas ; Claire Naylies ; Anne-Marie Loustau ; Yannick LippiSeries Type : Expression profiling by arrayOrganism : The food-grade titanium dioxide (fg-TiO2, composed of insoluble particles) is one of the most widely used food coloring worldwide for its whitening and brightening properties, and is included in many […]
- GSE260730 The impact of METTL3 on MDM2 impairs cell cycle homeostasis in podocytes during diabetic kidney diseases May 19, 2026Contributors : Han Wu ; Ziyang Yu ; Zhouting Han ; Qingjun Pan ; Hongyuan Yu ; Ying Chen ; Li XuSeries Type : OtherOrganism : The m6A modification, a prevalent epigenetic change, is implicated in various disease processes. Our previous research has revealed METTL3 abnormal expression in aging kidney tissues, correlating with its role in regulating renal fibr […]
- GSE310858 Different effects of 3-week disuse on the phenotype and gene expression of the calf and thigh muscles May 19, 2026Contributors : Daniil V Popov ; Pavel A MakhnovskiiSeries Type : Expression profiling by high throughput sequencingOrganism : Disuse, like several other pathological conditions, has specific effects on various skeletal muscles. The mechanisms underlying these responses remain unclear. Three-week bed rest resulted in a greater decrease in lean mass, endurance […]
- GSE297163 Uhrf1 determines osteophyte fate by regulating differentiation of synovial mesenchymal progenitor cells [MBD-seq] May 19, 2026Contributors : Akihiro Jono ; Yuta Yanagihara ; Hiroshi Sakai ; Noritaka Saeki ; Tatsuhiko Kutsuna ; Tomofumi Kinoshita ; Akiyoshi Uezumi ; Masaki Takao ; Yuuki ImaiSeries Type : Methylation profiling by high throughput sequencingOrganism : This study investigated the role of Uhrf1 in osteophyte formation, building on previous findings of its role in cartila […]
- GSE280610 Transcriptomic analysis of channel catfish liver response to Aeromonas hydrophila infection correlated to skin integrity and fed state May 19, 2026Contributors : Yesutor K Soku ; Jason W Abernathy ; Miles D Lange ; Mohamed AbdelrahmanSeries Type : Expression profiling by high throughput sequencingOrganism : The liver is a crucial organ involved in both immune regulation and metabolism. This study focuses on the hepatic immune response of channel catfish (Ictalurus punctatus) under varying feeding statu […]
- GSE331008 Single-nucleus RNA sequencing of brain tissue from HIV-infected and uninfected donors. May 19, 2026Contributors : Ciniso S Shabangu ; Guochun JiangSeries Type : Expression profiling by high throughput sequencingOrganism : This project investigates the molecular and cellular mechanisms that enable HIV persistence within the human brain across distinct infection states. Postmortem brain tissues from uninfected controls, viremic individuals, and antiretrovir […]
- GSE330985 Positive and Negative Selection of abT cells (OT-I and OT-II) in the thymus 2 - scRNA-seq, CITE-seq and TCRab May 19, 2026Contributors : Melanie Vacchio ; Alexander Clark ; Ian Magill ; David Zemmour ; Christophe Benoist ; Rémy BosselutSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : This study is part of the immgenT Open Source Project, specifically IGT59, which characterizes activated CD4 and CD8 T cells in the spleen and brain during Toxopla […]
- GSE331070 Inflammatory reprogramming of immature oligodendrocytes perturbs myelination and neurodevelopment in a dual-hit model of preterm brain injury May 19, 2026Contributors : Xueling Ma ; Wen Jia ; Xingdao Zhang ; Yuan ShiSeries Type : Expression profiling by high throughput sequencingOrganism : Background: Preterm infants are highly susceptible to white matter injury, in part due to exposure to perinatal inflammation and/or hypoxia. These insults dis_x0002_rupt oligodendrocyte (OL) lineage maturation, leading to i […]
- GSE331053 SRSF3 plays a key role in liver cancer sex disparity by facilitating hepatocyte expression of ERα and FOXA May 19, 2026Contributors : Lulu Yu ; Masahiko Ajiro ; Vladimir Majerciak ; Zhi-Ming Zheng ; Yafeng HeSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : SRSF3 (SRp20) is an essential RNA splicing factor. By conditional knockout (KO) of Srsf3, we discovered Srsf3 at its physiological level plays a tumor-suppressive role in mouse liver […]
- GSE331097 The extreme diversity of retinal amacrine cells has deep evolutionary roots [rat] May 19, 2026Contributors : Tommasini Dario ; Monavarfeshani Aboozar ; Dinesh Vishruth ; Hahn Josh ; Tangeman Jared ; Blackshaw Seth ; Puthussery Teresa ; Sanes Josh ; Shekhar KarthikSeries Type : Expression profiling by high throughput sequencingOrganism : Amacrine cells (ACs) comprise a heterogeneous class of inhibitory neurons in the vertebrate retina, exhibiting morp […]
- GSE331104 One-Carbon Cycle and Methylation Potential Regulat Behavioral Alcohol Responses via Glutamatergic Neurons May 19, 2026Contributors : Daniel R Lathen ; Alexandra Seguin ; Collin B Merrill ; Miguel A Pabon ; Maggie M Chvilicek ; Aylin R Rodan ; Adrian RothenfluhSeries Type : Expression profiling by high throughput sequencingOrganism : Despite the enormous harms of alcohol use disorder (AUD), many mechanisms, as well as effective prevention or treatment strategies, remain elus […]
- GSE331349 Complex I Drives Glutamine-Dependent TCA Cycle to Support Viability of MYChigh Breast Cancer Cells May 19, 2026Contributors : Johanna M Anttila ; Juha KlefströmSeries Type : Expression profiling by high throughput sequencingOrganism : In many cancers, stably elevated MYC levels drive persistent and concerted activation of cell growth promoting anabolic programs and cell cycle in ways distinct from normal cells. Therefore, synthetic-lethal targeting of MYC-reprogramme […]
- GSE297492 Transcriptomic profiling of monocytes and microglia in WNV encephalitis May 19, 2026Contributors : Wishart Claire L. ; Sptieri Alanna G. ; King Nicholas JCSeries Type : Expression profiling by high throughput sequencingOrganism : Microglia and monocyte-derived cells are key players in West Nile virus (WNV) encephalitis. We used single-cell RNA sequencing (scRNA-seq) using the Rhapsody system to analyse the functional profiles of these cells […]