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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE235524 Mechanism of Nootkatone in U251 June 21, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNootkatone can induce the changes of gene expression in U251 cells
- GSE297633 IRE1 activity regulates tumour and microenvironment cell lineage states while stratifying localised and metastatic prostate cancer June 21, 2026Contributors : Dimitrios Doultsinos ; Ian Mills ; Ingrid Tomljanovic ; Eleftherios Pilalis ; Aristotelis ChatziioannouSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensProstate cancer (PCa) is an androgen receptor (AR) driven, high-incidence disease significantly contributing to cancer mortality. PCa is in need of better […]
- GSE290315 Nuclear condensates formed by truncated mutant NEK1s impede ribosomal RNA biogenesis and drive motor dysfunction June 21, 2026Contributors : Yixin Wang ; Wen Hu ; Rui Huang ; Fanmin Wu ; Haopeng Su ; Jianye Zang ; Xiaolei Huang ; Yanli Liu ; Haigang Ren ; Jian Li ; Min Zhang ; Yong Zhang ; Guanghui Wang ; Zongbing HaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNIMA-related kinase 1 (NEK1), a serine/threonine kinase, is a risk variant in am […]
- GSE306320 RNA immunoprecipitation sequencing identifies RNA targets of Lin28b in PDAC cancer-associated fibroblasts June 21, 2026Series Type : OtherOrganism : Mus musculusThis study uses RNA immunoprecipitation followed by sequencing (RIP-seq) to identify RNA targets of Lin28b in PDAC cancer-associated fibroblasts (CAFs). CAFs expressing either Flag-wild-type Lin28b (Lin28b-WT) or an RNA-binding deficient mutant (Flag-Lin28b-MU) were subjected to RIP-seq. Our analysis revealed that ST […]
- GSE300992 Phosphatase-independent suppression of mucosal inflammation and disease progression by Salmonella SopB June 21, 2026Contributors : Nour Diab ; Matthias Schmitz ; Narasimha Murthy Keshava Prasad Gubbi ; Geonomics Core Facility University Hospital RWTH Aachen ; Kaiyi Zhang ; Mathias W. HornefSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe results of our current study show that Salmonella oter protein (SopB) suppresses early epithel […]
- GSE310281 RPL22L1-dependent translational control of DNA repair confers chemoresistance June 21, 2026Contributors : Wentao Yu ; Xiangwei GaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRibosome heterogeneity has emerged as a regulatory layer in gene expression, yet its biological roles in cancers remain poorly understood. Here, we identify RPL22L1, a paralog of the ribosomal protein RPL22, as a key modulator of DNA […]
- GSE306321 Single-cell RNA sequencing reveals Lin28b-dependent immune modulation in the PDAC tumor microenvironment June 21, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCancer-associated fibroblasts (CAFs) play a crucial role in shaping the pancreatic ductal adenocarcinoma (PDAC) tumor microenvironment (TME). This study investigates the impact of an RNA-binding protein Lin28b on the immune landscape of PDAC. Single-cell RNA sequencing (sc […]
- GSE326580 A Biodegradable Piezoelectric Vertebral Implant for Programmable Electro-neuromodulation in Spinal Cord Injury June 21, 2026Contributors : Wanru Duan ; Qing Cai ; Yingjie Yu ; Penghao Liu ; Xinyu Wang ; Yanchun LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusSpinal cord stimulation is a promising strategy for functional recovery after spinal cord injury (SCI), but conventional electronic implants pose surgical and long-term risks. He […]
- GSE314657 Two translocation mechanisms drive neural stem cell dissemination into the human fetal cortex June 21, 2026Contributors : Ryszard Wimmer ; Clarisse Brunet Avalos ; Alexandre BaffetSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe strong size increase of the human neocortex is supported by a neural stem cell population, the basal radial glial (bRG) cells. Using live imaging of human fetal tissue and cortical organoids, we i […]
- GSE335534 HBcAg-Induced IL-17F Drives Liver Fibrosis in Occult HBV Infection June 21, 2026Contributor : Bochao LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWhile occult hepatitis B virus infection is a known risk factor for progressive liver diseases, the mechanistic basis for this association is poorly understood. To investigate this, we conducted a comparative study involving 40 OBI blood donors and […]
- GSE335539 High-throughput transcriptome sequencing of DNAJC2-knockdown clear cell renal cell carcinoma cells（shDNAJC2 vs shCtrl） June 21, 2026Contributor : Yunkai YangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis project was designed to characterize transcriptomic changes caused by DNAJC2 knockdown in clear cell renal cell carcinoma (ccRCC) cells using high-throughput RNA sequencing. Cells transduced with control shRNA and cells with DNAJC2 knockdown w […]
- GSE335612 Pharmacological Destabilization of ZEB2 Attenuates Atherosclerosis via Restoration of Lipid Catabolism June 21, 2026Contributor : Lingdan ZhaoSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Rattus norvegicusThe pathogenesis of atherosclerosis involves phenotypic reprogramming of vascular smooth muscle cells (VSMCs) coupled with profound lipid metabolic dysfunction; however, the critical transcriptional regulators governing this pro […]
- GSE335668 Mutant p53 binds RNA to drive mitochondrial dysfunction June 21, 2026Contributors : Wuyue Zhou ; Alice Long ; Cameron J Douglas ; Dalila Gallegos ; James M Burke ; David MacMillan ; Ezgi Hacisuleyman ; Ciaran P SeathSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTumor suppressor protein 53 (p53) is a transcription factor that is deregulated in 50% of cancers. Often termed the guardian o […]
- GSE335752 Characterization of human M2-like (TGFbeta/IL10) vs M0 monocyte-derived macrophages June 21, 2026Contributors : Jennifer Yinuo Cao ; Giovanni C ForcinaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPeripheral human monocytes from different human donors were differentiated into M2-like (TGFbeta/IL10) or M0 and analyzed by RNAseq.