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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE311576 A novel role for transcription factor NFE2 in regulating redox responses and chemotherapy resistance in acute myeloid leukemia [ChIP-seq] August 17, 2026Series Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusElevated activity of transcription factor NFE2 is sufficient to cause leukemic transformation in absence of a classical leukemic driver. However, the molecular mechanism promoting NFE2-driven leukemogenesis is not known. Here we report a previously unrecogniz […]
- GSE315247 Immune checkpoint ENPP1 dampens brown adipocyte derived extracellular cGAMP to protect against systemic metabolic dysfunction August 17, 2026Contributors : Songnan Wang ; Yingjie Guo ; Lingyin LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusChronic systemic inflammation has been long recognized as a mediator of metabolic disorders such as obesity and type 2 diabetes. The double stranded DNA (dsDNA)-sensing cyclic GMP-AMP synthase (cGAS)-stimulator of inter […]
- GSE314018 Muco-Obstructive Lung Disease Exhibits Distinct Hypoxic and Inflammatory Airway Epithelial Gene Pathways August 17, 2026Contributors : Yu Mikami ; Ella Burns ; Hong Dang ; Catharina van Heusden ; Ray A Caldwell ; Boris Reidel ; Minako Furusho ; Hiroaki Murano ; Carla M Ribeiro ; Mehmet Kesimer ; Takanori Asakura ; Martina Gentzsch ; Kenichi Okuda ; Scott H Randell ; Wanda K O'Neal ; Richard C BoucherSeries Type : Expression profiling by high throughput sequencingOrganism […]
- GSE320241 Loss of SUMOylation drives aberrant PRC1 clustering and 3D genome rewiring independent of H3K27me3 [CUT&Run] August 17, 2026Contributors : Nazli Akilli ; Paul-Swann Puel ; Marco Di Stefano ; Fernando Muzzopappa ; Lauriane Fritsch ; Fabian Erdel ; Daniel Jost ; Thierry Cheutin ; Giacomo CavalliSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Drosophila melanogasterPolycomb Repressive Complex 1 (PRC1) forms nuclear condensates that organize t […]
- GSE320239 Loss of SUMOylation drives aberrant PRC1 clustering and 3D genome rewiring independent of H3K27me3 [RNA-Seq] August 17, 2026Contributors : Nazli Akilli ; Paul-Swann Puel ; Marco Di Stefano ; Fernando Muzzopappa ; Lauriane Fritsch ; Fabian Erdel ; Daniel Jost ; Thierry Cheutin ; Giacomo CavalliSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterPolycomb Repressive Complex 1 (PRC1) forms nuclear condensates that organize target chromati […]
- GSE305711 A Time Course Analysis of the electrophysiological and biochemical properties during differentiation of hair cell- like cells in culture August 17, 2026Contributors : Ali Asghar Peyvandi ; Shima Davoudi ; Narges Bazgir ; Mahyar Janahmadi ; Alireza Zali ; Shahrokh Khoshsirat ; Somayeh NiknazarSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusBone marrow-derived mesenchymal stromal cells (BMSCs) are multipotent cells that have attracted considerable attention in regen […]
- GSE325203 Engineering epicardium-integrated human iPSC-derived heart tissue for modelling Hutchinson-Gilford Progeria Syndrome August 17, 2026Contributors : Martta Häkli ; Amanda Putri Elvandari ; Yasuko Matsumura ; Shunsuke Funakoshi ; Antonio Lucena-Cacace ; Yoshinori YoshidaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEngineered heart tissues (EHT) have been utilized in research for almost three decades and have become an important tool in cardiovascula […]
- GSE343584 Uremic Serum Alters Gene Expression Profiles and Signaling Pathway Activity August 17, 2026Contributors : Youyou Zheng ; Unimubkh Uriyanghai ; Christine Wai ; Prabir Roy-Chaudhury ; Gang XiSeries Type : Expression profiling by high throughput sequencingOrganism : Sus scrofa domesticusUremic conditions are common in end-stage kidney disease (ESKD) patients. Accelerated vascular diseases in uremic patients lead to heart failure, stroke, and hyperten […]
- GSE343379 Narsoplimab (anti-MASP2) modulates long COVID patient plasma-induced transcriptional responses in human microvascular endothelial cells August 17, 2026Contributors : David Redmond ; Jeffrey LaurenceSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensFourteen percent of SARS-CoV-2-infected individuals suffer multi-organ dysfunction and are unable to resume employment for >2 years post-acute COVID-19. Such "long COVID" cases have been linked to SARS-CoV-2 reser […]
- GSE343610 MACF1 Promotes Colorectal Cancer Progression via ATF4-Mediated ASNS Regulation August 17, 2026Contributors : Xiaoying Wang ; Zhen Han ; Xiang Gao ; Qindan Du ; Jingjie Shen ; Yong Zhao ; Yixin Bian ; Junjie WuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: Microtubule-actin cross-linking factor 1 (MACF1) is a cytoskeletal cross-linker implicated in cancer pathogenesis, yet its role in colorectal canc […]
- GSE343588 Effect of imatinib on cisplatin-induced nephrotoxicity in mice August 17, 2026Contributors : Nahid Tabibzadeh ; Pravina Muthan ; Rémi ToutainSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCisplatin is a chemotherapeutic agent that induces proximal tubule injury in the kidneys. We aimed at exploring the effect of imatinib, a Tyrosine Kinase Inhibitor (THI), on the entry of cisplatin in proximal t […]
- GSE343618 Evaluation of extracellular microRNAs as potential biomarker candidates for assessing chlamydia reinfection risk August 17, 2026Contributors : William M Geisler ; Chloe MeewesSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensWe profiled extracellualr miRNAs derived from extracellular vessicles (EV) and whole serum collected from a cohort of women to identify potential miRNA bioamrkers that could be used to predict chlamydia reinfection risk.
- GSE343650 177Lu-labeled DOTA-EB-RGD as a Candidate for Thyroid Cancer Therapy August 17, 2026Contributors : Sonam Kumari ; Joanna Klubo-GwiezdzinskaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIntegrin αVβ3, a transmembrane receptor involved in tumor growth and metastasis, specifically recognizes and binds proteins with the arginylglycylaspartyl (RGD) peptide sequence. Using mRNA and/or protein expression da […]
- GSE343732 Native American ancestry-enriched eQTLs regulate HER2 amplicon genes and are associated with breast cancer outcomes in Colombian women August 17, 2026Contributors : Laura Rey-Vargas ; Lina Maria Bejarano-Rivera ; Yina T Zambrano ; Wendy Montero-Ovalle ; Carlos A Huertas-Caro ; Patricia Lopez-Correa ; Reggie Garcia-Robles ; I King Jordan ; Silvia J Serrano-Gomez ; Diego Felipe Ballen-LozanoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWomen with higher Native Americ […]
- GSE305949 Lysosomal Stress and Mitochondrial Dysfunction Define the Cellular Response to Photoactivated 1,9-Dimethyl-Methylene Blue August 17, 2026Contributors : Marcia Franco ; Felipe Ravagnani ; Suely Marie ; Sueli Oba-Shinjo ; Leonardo Assis ; Mauricio BaptistaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPhotodynamic therapy (PDT) using 1,9-dimethyl methylene blue (DMMB) induces coordinated mitochondrial and lysosomal damage and results in strong cellular de […]