Quick Links : Search PubMed , Finding Full Text , PubMed Advanced Search , Clinical Queries , Single Citation Matcher , FAQs & User Guide , Explore MeSH Database , Explore PubMed Journals
Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE286709 t6A tRNA modification defines RIG-I mediated anti-tumour immune response [RNA-seq1] December 8, 2025Contributors : Cléa Dziagwa ; Pierre CloseSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe immune response in cancer, particularly in melanoma, is often hindered by tumour-induced immune evasion strategies, but the precise mechanisms for this remains unclear. Here, we reveal how the tRNA modification threonine-6-aden […]
- GSE292094 NFAT Mediates Pro-Tumorigenic Inflammation in Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma [mouse multiome] December 8, 2025Contributors : Chuner Guo ; Michelle F Griffin ; Annah G Morgan ; Michael T Longaker ; Jeffrey A NortonSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusPancreatic ductal adenocarcinoma (PDAC) is characterized by a dense stroma, low immunogenicity, and res […]
- GSE288397 Integrating Machine Learning and Transcriptomics to Enhance β-Carotene Production in Yeast December 8, 2025Contributors : Peerapat Khamwachirapithak ; Kittapong Sae-Tang ; Suriyaporn Bubphasawan ; Jongrak Choompuper ; Xin-Qing Zhao ; Verawat Champreda ; Weerawat RunguphanSeries Type : Expression profiling by high throughput sequencingOrganism : Saccharomyces cerevisiaeOptimization of microbial production is essential for the application of synthetic biology in in […]
- GSE300895 High resolution spatial trancrioptomics combined with deep learning-based image segmentation enables single-cell spatial profiling of archival FFPE kidney tissue from patients with idiopathic nephrotic syndrome December 8, 2025Contributors : Simen F Pettersen ; Eleni Skandalou ; Jessica Furriol ; Tarig Osman ; Hans-Peter Marti ; Øystein S EikremSeries Type : OtherOrganism : Homo sapiensWe have perfomed Visium HD spatial transcriptomics on archival FFPE kidney biopsies from patients with different manifistations of nephrotic syndrome, i.e., steriod sensitive, frequent relapsing and […]
- GSE292096 NFAT Mediates Pro-Tumorigenic Inflammation in Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma [mouse VIVIT] December 8, 2025Contributors : Chuner Guo ; Michelle F Griffin ; Annah G Morgan ; Michael T Longaker ; Jeffrey A NortonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPancreatic ductal adenocarcinoma (PDAC) is characterized by a dense stroma, low immunogenicity, and resistance to therapy. Cancer-associated fibroblasts (CAFs) are key st […]
- GSE312570 Primate gut microbiota induce evolutionarily salient changes in mouse neurodevelopment December 8, 2025Contributors : Alex DeCasien ; Jacob Arnoff ; Elizabeth Mallot ; Sahana Kuthyar ; Sriram Chitta ; Brian Layden ; Maria Savo Sardaro ; Stanton Grey ; Lawrence Williams ; Emma Leichty ; Hyo Lee ; Won Lee ; James Curly ; Christopher Kuzawa ; Katherine AmatoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMultiple primate sp […]
- GSE305423 The single cell landscape of the human vein after arteriovenous fistula creation and implications for maturation failure. December 8, 2025Contributors : Laisel Martinez ; Roberto I Vazquez-Padron ; Anthony J GriswoldSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe performed single-cell RNA sequencing of venous samples from 20 patients, including 6 pre-access veins, 2 early AVF resections, and 12 second-stage AVFs that matured (6) or failed (6).
- GSE312367 BACH2 regulates T cell lineage states to enhance CAR T cell function [Cut & Run] December 8, 2025Contributors : Tien-Ching Chang ; John M Warrington ; Nathan A SinghSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensNearly all chimeric antigen receptors (CARs) signal in the absence of antigen, referred to as “tonic signaling”. Tonic signaling of CARs containing the CD28 costimulatory domain has been show […]
- GSE312344 Whole transcriptome analysis in obstetric antiphospholipid syndrome December 8, 2025Contributors : Lan Zhang ; Lan ZhangSeries Type : Expression profiling by arrayOrganism : Homo sapiensThis study aims to investigate the expression profiles of coding and non-coding RNA in OAPS, thereby deepening our understanding of the potential mechanisms of OAPS. Plasma samples were collected from 3 OAPS patients and 3 healthy controls. Then, exosomes we […]
- GSE312385 Response of gingival keratinocytes challenged with Selenomonas sputigena December 8, 2025Contributor : Daniel P MillerSeries Type : Expression profiling by arrayOrganism : Homo sapiensNanoString nCounter analysis using the human Host Response Panel was used to determine the expression of 618 genes involved in host response to infection from telomerase immortalized gingival keratinocytes (TIGKs) incubated with the oral pathogen Selenomonas sputig […]
- GSE312384 BACH2 regulates T cell lineage states to enhance CAR T cell function [ATAC-seq] December 8, 2025Contributors : Tien-Ching Chang ; John M Warrington ; Nathan A SinghSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensNearly all chimeric antigen receptors (CARs) signal in the absence of antigen, referred to as “tonic signaling”. Tonic signaling of CARs containing the CD28 costimulatory domain has been show […]
- GSE312389 Delineating the role of co-stimulatory signals on human virus-specific memory CD8+ T cell activation and expansion using highly selective T cell receptor-targeted biologics December 8, 2025Contributors : Christopher Hiner ; Hong Hur ; April Mueller ; Manoj Kandpal ; Harris GoldsteinSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo delineate the minimum signals required to activate and expand antigen-specific memory CD8+ T cells, we recapitulated the discrete activation signals delivered by antigen-presen […]
- GSE312439 CD51 expression delineates functionally distinct astrocyte subpopulations in neural circuits December 8, 2025Contributors : Michael R Williamson ; Junsung Woo ; Akdes Serin Harmanci ; Benjamin DeneenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAstrocytes execute a diverse range of tasks that facilitate brain physiology, raising the possibility that these diverse astrocytic roles are enabled by functionally distinct subtypes […]
- GSE312502 CTDP1 governs a unique RNAPII phospho-form and coordinates Mediator recruitment, transcription efficiency, and splicing December 8, 2025Contributors : Haonan Zheng ; Dexun Ji ; Yuanhan Sui ; Qiqin XuSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Mus musculusWe previously reported that the RNA polymerase II (Pol II) subunit RPB7 interacts with the phosphatase CTDP1 to regulate transcription terminat […]
- GSE283956 CD8αα+ intraepithelial lymphocytes recruited from peripheral CD4+ and CD8+ T cells represent functionally distinct lineages December 8, 2025Contributors : Nicholas R Gascoigne ; Lukasz Wojciech ; Kandhadayar G SrinivasanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe TCRαβ CD8αα+ intraepithelial lymphocytes (IELs) play a significant role in primary immune defence in the small intestine. The canonical model of their development distinguishes TCRαβ IELs i […]