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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE271774 Expression data from primary mouse fibroblasts from E18.5 embryos treated with vehicle, Dexamethasone, Ciclesonide, Des-Isobutrylciclesonide July 8, 2026Contributors : Paula Monaghan Nichols ; Timothy J ColeSeries Type : Expression profiling by arrayOrganism : Mus musculusComparative analysis of synthetic glucocorticoids in the embryonic lung fibroblastsAffymetrix whole genome expression studies were performed using microchips
- GSE273952 GABA promotes resistance to immunotherapy of patients with TLS-positive tumors [Spatial Transcriptomics] July 8, 2026Contributors : Isaias Hernandez-Verdin ; Anne Calvez ; Cheng-Ming Sun ; Antoine Bougoüin ; Pierre Hirt ; Eric Pinaud ; Matthew J Smith ; Craig E Wheelock ; Virginie Verkarre ; Yann-Alexandre Vano ; Lucie Garnier ; Théo Bouloudani ; Guilhem Pupier ; Dahbia Djaroun ; Christian Wu ; Asmat Ullah ; Lucile Vanhersecke ; Alban Bessede ; Jean-Philippe Guegan ; Laure […]
- GSE273829 GABA promotes resistance to immunotherapy of patients with TLS-positive tumors [RNA-seq] July 8, 2026Contributors : Isaias Hernandez-Verdin ; Anne Calvez ; Cheng-Ming Sun ; Antoine Bougoüin ; Pierre Hirt ; Eric Pinaud ; Matthew J Smith ; Craig E Wheelock ; Virginie Verkarre ; Yann-Alexandre Vano ; Lucie Garnier ; Théo Bouloudani ; Guilhem Pupier ; Dahbia Djaroun ; Christian Wu ; Asmat Ullah ; Lucile Vanhersecke ; Alban Bessede ; Jean-Philippe Guegan ; Laure […]
- GSE302168 GLI2 mediates response to paclitaxel in triple-negative breast cancer July 8, 2026Contributors : Jade S Miller ; Emily A Jaremba ; Julie A RhoadesSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBone is the most frequent site of both metastasis and recurrence for patients with breast cancer, and there are currently no FDA-approved therapeutics which target cancer in bone. Skeletal metastases upregulat […]
- GSE277836 Effects of dexamethasone and desisobutyryl ciclesonide on gene expression July 8, 2026Series Type : Expression profiling by array ; Expression profiling by high throughput sequencingOrganism : Mus musculus ; Rattus norvegicusThis SuperSeries is composed of the SubSeries listed below.
- GSE337703 p300/CBP inhibition promotes apoptosis in mouse embryos by impairing H1K75ac-mediated DNA repair from the 4-cell to blastocyst stage July 8, 2026Contributors : Nannan Wang ; Qianhui Zeng ; Rong ZhengSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDefective pre-implantation embryonic development is a major cause of implantation failure and early embryonic arrest. p300/CBP is known to influence blastocyst formation; nevertheless, its molecular regulatory cascades […]
- GSE305945 Mov10 suppresses excessive inflammation by regulating the TNFα–NF-KB pathway July 8, 2026Series Type : OtherOrganism : Mus musculusWe next sought to explore the underlying mechanism by which Mov10 regulates HSC function.We isolated Lin-c-kit+ cell from mice 12 days after 4.5 Gy IR and performed RNA immunoprecipi-tation sequencing (RIP-seq). Bioinformatics analysis identified Mov10-bound transcripts as po-tential Mov10 targets, with GO pathway en […]
- GSE326856 Single-cell RNA-seq profiles of intestinal mucosa in IBS-D rats to explore the mechanism of immune barrier regulation in pathogenesis July 8, 2026Contributors : Liyan Ji ; Yongquan Huang ; Jiahe Zhang ; Jiaman Lin ; Zefang Yang ; Xiling Yang ; Fengbin Liu ; Qiuke HouSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusWe have employed a single cell sequencing approach using 10x Genomics scRNAseq to study isolated endothelial cells, immune cells and stromal cells […]
- GSE307782 PRDM16 Modulates Aspects of Cell-Cycle Dynamics and Maturation in Human iPSC-Derived Cardiomyocytes July 8, 2026Contributors : Kanae Tani ; Yasuko Matsumura ; Megumi Narita ; Antonio Lucena-Cacace ; Yoshinori YoshidaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensUnderstanding the molecular mechanisms that mediate entry into quiescent states of cardiac tissues, along with their associated metabolic rewiring, is crucial for compre […]
- GSE335783 A non-enzymatic role for METTL3 as an Androgen Receptor co-regulator promoting prostate cancer proliferation. July 8, 2026Contributors : Kregel Steven ; Kostlan Raymond J ; Phoenix John TSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensMetastatic prostate cancer (PCa) continues to be a major cause of death in males, despite advances in treatment. Most treatment focuses on targeting the Androgen Receptor (AR), the main oncogene […]
- GSE334095 Palmitate drives mitochondrial and ER stress through disruption of the CD73-Adenosine axis July 8, 2026Contributors : S Dawson ; S Batan ; N Adams ; S Bombin ; ES Ramos-Junior ; AC MorandiniSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBulk RNA sequencing was used to characterize transcriptional changes associated with the dysfunctional metabolic state in murine gingival fibroblasts (mGF). The mGF were treated with BSA […]
- GSE337204 Pannexin 1 inhibition reduces tumorigenic properties of patient-derived glioblastoma cells through the HIPPO and Wnt signalling pathways July 8, 2026Contributors : Silvia Penuela ; Danielle JohnstonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGlioblastoma (GBM) is the most common primary brain tumour, with a median survival of 12-18 months, highlighting a need for new treatment targets. We observed that pannexin 1 (PANX1), a channel-forming glycoprotein important […]
- GSE337492 CD300A drives glioblastoma progression by orchestrating M2 macrophage polarization via the JAK2/STAT3 signaling axis July 8, 2026Contributors : Fengjing Wang ; Chunfa Wu ; Ying Shao ; Xile Pei ; Boyuan Zhang ; Ying Sui ; Tao Yang ; Dahai WanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGlioblastoma (GBM) is the most lethal primary intracranial malignancy, characterized by aggressive recurrence and a dismal prognosis. Despite the implementation […]
- GSE337539 scRNAseq of LCMV-specific P14 cells: WT, P2RX7-KO and NKG7-KO July 8, 2026Contributors : Salgado Caio L. ; Borges da Silva HenriqueSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe have used Parse Biosciences to generate single-cell RNAseq libraries from P14 CD8+ T cells (wild-type - WT, P2RX7-KO and NKG7-KO) collected from mice infected with either LCMV-Armstrong or LCMV-Clone 13 (days 0, 7 […]
- GSE232084 Nonsense mediated decay degrades nonproductive RNAs produced by alternative RNA splicing in response to heat stress in Arabidopsis July 8, 2026Contributors : Zhaoxia Li ; Renu Srivastava ; Sivanandan Chudalayandi ; Andrew Severin ; Stephen H HowellSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaElevated temperature enhances the frequency of alternative RNA splicing (AS) in plants producing RNA isoforms, some of which are productive, likely expanding th […]