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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE284695 Obesity-mediated intratumoral innervation increases pancreatic cancer tumorigenesis [Spatial Transcriptomics] May 8, 2026Contributors : Prasenjit Dey ; Shyamananda S Mayengbam ; Aftab Alam ; Matthew Witkowski ; Sharon Senchanthisai ; Elif I Bektas ; Min MaSeries Type : OtherOrganism : MusThe incidence of pancreatic ductal adenocarcinoma (PDAC) is on the rise, and host factors like obesity increase risk by 60% and mortality by two-fold; however, the mechanisms that drive obesit […]
- GSE275711 Gene expression profile of immune cells at single cell level from the thalamus of mice after traumatic brain injury and after anti-CD9 Ab treatment May 8, 2026Contributors : Shin-ichi Kano ; David K Crossmann ; Ken Matoba ; Takahiro KochiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusLoss of synapses and cognitive impairment were mitigated by anti-CD9 Ab after cortical injury. We used single-cell RNA-seq (scRNA-seq) to analyze how microglial gene expression was altered by an […]
- GSE284697 Obesity-mediated intratumoral innervation increases pancreatic cancer tumorigenesis [RNA-seq] May 8, 2026Contributors : Prasenjit Dey ; Shyamananda S Mayengbam ; Aftab Alam ; Matthew Witkowski ; Sharon Senchanthisai ; Elif I Bektas ; Min MaSeries Type : Expression profiling by high throughput sequencingOrganism : MusThe incidence of pancreatic ductal adenocarcinoma (PDAC) is on the rise, and host factors like obesity increase risk by 60% and mortality by two-fo […]
- GSE284696 Obesity-mediated intratumoral innervation increases pancreatic cancer tumorigenesis [scRNA-seq] May 8, 2026Contributors : Prasenjit Dey ; Shyamananda S Mayengbam ; Aftab Alam ; Matthew Witkowski ; Sharon Senchanthisai ; Elif I Bektas ; Min MaSeries Type : Expression profiling by high throughput sequencingOrganism : MusThe incidence of pancreatic ductal adenocarcinoma (PDAC) is on the rise, and host factors like obesity increase risk by 60% and mortality by two-fo […]
- GSE296679 Homoharringtonine, a novel senotherapeutic, mitigates diet- and age-associated obesity and insulin resistance and extends the lifespan of mice May 8, 2026Contributors : So-Young Park ; Jae-Ryong Kim ; Hoon-Ki SungSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe accumulation of senescent cells in white adipose tissue (WAT) is closely associated with the functional decline of WAT and plays a causal role in the pathogenesis of metabolic diseases. Therefore, the eliminati […]
- GSE294811 Cytochrome P450 and metallothionein activation in human lung organoids following particulate matter exposure May 8, 2026Contributors : Seri Choi ; Seung-Yeon Kim ; Ji Won Beak ; Won Keun Oh ; Kee K. Kim ; Eun-Mi KimSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensParticulate matter (PM) has raised increasing concerns regarding its adverse impact on respiratory health. Although numerous studies have investigated PM effects under varying co […]
- GSE296764 Transcriptional expression of SCN, liver and heart at CT0 and CT12 after central VIP knockout of Bmal1 May 8, 2026Contributors : chao lu ; chunting zhuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis experiment was designed to identify the autonomous rhythm of peripheral circadian clocks in the absence of a master circadian clock to regulate the rhythm
- GSE329919 Tumor microbial burden drives immune responses through regulation of Interferon signaling May 8, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the mechanisms involved in tumor microbial-associated immunotherapy sensitivity, we performed RNA sequencing on mouse MC38 tumor tissues upon local microbial depletion.
- GSE300034 Estrogen receptor action in mouse granulosa cells in response to LH surge May 8, 2026Series Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE297144 The HFE H63D variant in pancreatic cancer promotes epithelial-to-mesenchymal transition at the expense of cell cycle May 8, 2026Contributors : Federica Rubbino ; Paolo Kunderfranco ; Luca Lambroia ; Luigi LaghiSeries Type : OtherOrganism : Homo sapiensThis study examines the biological and clinical relevance of the HFE H63D variant in pancreatic ductal adenocarcinoma (PDAC), a highly aggressive cancer with limited biomarkers. We analyzed its prevalence in PDAC cohorts and explored as […]
- GSE308448 Gene expression profiling of HBEpCs and Caco-2 cells during infection with WT SARS-CoV-2 or a recombinant SARS-CoV-2 deficient in PLpro deISGylation activity May 8, 2026Contributors : Junji Zhu ; GuanQun Liu ; Michaela GackSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensInterferon-stimulated gene 15 (ISG15) regulates diverse cellular processes, including antiviral immunity, through its conjugation to proteins, a process known as ISGylation. Several pathogens, including SARS-CoV-2, subv […]
- GSE327572 Immune niche analysis in breast tumour derived lung metastasis May 8, 2026Contributors : Luigi Ombrato ; Christos ErmogenousSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe used our Cherry-niche labelling system to specifically isolate immune cells from the metastatic niche of established 4T1 lung metastases and compared their profile with immune cells isolated from the distal lung away fro […]
- GSE329565 Gene expression profiling by RNA-Seq analysis of mice carrying an inner-ear conditional knockout of Esrrg. May 8, 2026Contributor : Lisa S NolanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusEstrogen-related receptor gamma (ESRRG), an orphan nuclear receptor with structural homology to the classical estrogen receptors, is widely recognised as a key metabolic regulator. Clinical studies have suggested a link between ESRRG and auditory […]
- GSE260805 Gene expression profile of immune cells at single cell level from the hippocampus and thalamus of mice after traumatic brain injury May 8, 2026Contributors : Shin-ichi Kano ; David K Crossmann ; Ken MatobaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSubstantial microglial activation in the thalamus is observed after cortical injury. We used single-cell RNA-seq (scRNA-seq) to analyze the diversity of microglia in the hippocampus and thalamus after cortical i […]
- GSE296760 Comparison of the expression levels of AML12-control and AML12-DEX at 17 h and 25 h, and comparison of the expression levels of HL-1-control and HL-1-CM at 16 h and 28 h in the AML12-HL-1 co-culture system in vitro May 8, 2026Contributors : chao lu ; chunting zhuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis experiment was designed to identify the cellular processes of rhythmic communication between hepatocytes and cardiomyocytes in vitro