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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE279603 Disease-Defining Catalytically Inactive Protein Kinase C alpha Mutation is a Driver in Chordoid Glioma by Dominant-Negative Mechanism July 21, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensChordoid glioma (ChG) is a rare low-grade brain tumor, characterised by a novel recurrent point mutation PRKCA p.D463H, a substitution in the kinase domain of Protein kinase C alpha (PKCα). This study demonstrates the role of this mutated kinase in the development of ChGs. […]
- GSE295540 RNA-seq result of human skin derived from patients with psoriasis and healthy controls. July 21, 2026Contributors : Tae-Gyun Kim ; Chang Ook ParkSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis study aimed to identify disease-specific transcriptomic signatures and compare them with those of psoriasis and healthy controls to distinct molecular markers. Differential expression analysis revealed key genes associated w […]
- GSE293040 Single-cell transcriptome analysis of wildtype, TREM2 knockout, GPR34 knock-out or TREM2/GPR34 double knock-out primary microglia from wildtype and APP knock-in mice (4 months) July 21, 2026Contributors : Karthik Raju ; Sophia M Guldberg ; David Tatarakis ; Shan V Andrews ; Connie Ha ; Thomas Sandmann ; Joseph W Lewcock ; Jim Ray ; Kathryn M MonroeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMicroglia are broadly implicated in modifying disease risk in the central nervous system (CNS). Identifying regul […]
- GSE308569 Drosophila Rumpelstiltskin alters Polycomb chromatin association and maintains proper 3D genome organization and barrier activity of the Homie insulator [ChIP-Seq] July 21, 2026Contributors : Savanna F Lyda ; Catherine E McManus ; Juan Manuel Caravaca ; Dagyeong Yang ; Yuejun Wang ; Hernan A Lorenzi ; Fedor Kouzine ; David Levens ; Leah F Rosin ; Elissa LeiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Drosophila melanogasterThree-dimensional genome organization is maintained in part by chr […]
- GSE305967 Integrative single-cell analysis reveals malignant archetypes and proliferative hierarchies in multiple myeloma [Part 1 of 4: Illumina NovaSeq 6000; MARS] July 21, 2026Contributors : Mor Zada ; Anna Kurilovich ; Noam Shapira ; Shuang-Yin Wang ; Reut Sharet-Eshed ; Paulina Chalan ; Florian Ingelfinger ; Shlomit Kfir-Erenfeld ; Nathalie Asherie ; Chamutal Gur ; Anna Gurevich-Shapiro ; Iuliana Vaxman ; Rotem Shalita ; Maya Ben Yehuda ; Pascale Zwicky ; Michelle von Locquenghien ; Kfir Mazuz ; Eyal David ; Natan Melamed ; Irit […]
- GSE324107 Comparable Transcriptomic Profiles of HepaRG and HuH7 Cells Cultured in Chemically Defined and Serum-Based Media Using Primary Human Hepatocytes as Reference July 21, 2026Contributors : Ahmed S M Ali ; Heike Sprenger ; Albert Braeuning ; Jens KurreckSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe composition of culture medium is a major, yet frequently undercontrolled, determinant of hepatic cell state in vitro. For decades, fetal bovine serum (FBS) has been routinely incorporated in […]
- GSE311678 B cell depletion with anti-CD20 promotes mucosal-originating regulatory IgA-secreting cells in multiple sclerosis July 21, 2026Contributors : Anne-Katrin Pröbstel ; Tradite Neziraj ; Elisabeth Pößnecker ; Paul SaarySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate gut-mucosal IgA B cell trafficking during anti-CD20 treatment, we performed paired scRNA-seq and B cell receptor-seq (BCR-seq) on blood samples and gut biopsies from four […]
- GSE339012 Mega-Enhancers Compartmentalize Transcriptionally Active Long Genes in the Brain [ChIP-Seq] July 21, 2026Contributors : Ziyu Zhao ; Omar A Payán Parra ; Shin-ichiro Fujita ; Francesco Musella ; Nicolas Scrutton Alvarado ; Frank Alber ; Yue Yang ; Tomoko YamadaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusExceptionally long genes and cis-regulatory enhancers are selectively activated in mammalian brain neuro […]
- GSE338964 Computational modeling and preclinical evaluation support targeting somatic instability for Huntington’s disease treatment. July 21, 2026Contributors : Paul T Ranum ; Bryan P SimpsonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHuntington’s disease (HD) is caused by an expanded CAG trinucleotide repeat within the huntingtin (HTT) gene. Genetic modifiers of disease onset and progression in HD implicate somatic instability (SI) of the expanded CAG repeat […]
- GSE339018 Mega-Enhancers Compartmentalize Transcriptionally Active Long Genes in the Brain [Hi-C] July 21, 2026Contributors : Ziyu Zhao ; Omar A Payán Parra ; Shin-ichiro Fujita ; Francesco Musella ; Nicolas Scrutton Alvarado ; Frank Alber ; Yue Yang ; Tomoko YamadaSeries Type : OtherOrganism : Mus musculusExceptionally long genes and cis-regulatory enhancers are selectively activated in mammalian brain neurons, and these loci are mutation hotspots in neurological di […]
- GSE339015 Mega-Enhancers Compartmentalize Transcriptionally Active Long Genes in the Brain [SPRITE] July 21, 2026Contributors : Ziyu Zhao ; Omar A Payán Parra ; Shin-ichiro Fujita ; Francesco Musella ; Nicolas Scrutton Alvarado ; Frank Alber ; Yue Yang ; Tomoko YamadaSeries Type : OtherOrganism : Mus musculusExceptionally long genes and cis-regulatory enhancers are selectively activated in mammalian brain neurons, and these loci are mutation hotspots in neurological di […]
- GSE339044 Mega-Enhancers Compartmentalize Transcriptionally Active Long Genes in the Brain [RNA-Seq] July 21, 2026Contributors : Ziyu Zhao ; Omar A Payán Parra ; Shin-ichiro Fujita ; Francesco Musella ; Nicolas Scrutton Alvarado ; Frank Alber ; Yue Yang ; Tomoko YamadaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusExceptionally long genes and cis-regulatory enhancers are selectively activated in mammalian brain neurons, and these […]
- GSE339045 Mega-Enhancers Compartmentalize Transcriptionally Active Long Genes in the Brain July 21, 2026Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Other ; Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE339326 Modeling the active proteome by context-matched perturbation signatures July 21, 2026Contributors : Mohammad Zaid Khan ; Igor Cima ; Ulrich Sure ; Björn SchefflerSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMeasuring protein activity on a global scale remains a central challenge in molecular biology. We hypothesized that the functional contribution of proteins to cellular processes can be inferred fr […]
- GSE272739 SUCLG1-deficiency causes hypersuccinylation and impairs leukemia development [ChIP-seq] July 21, 2026Contributors : Mengqing Gao ; Domenico Iuso ; Xiaoyu ZhuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensSuccinyl-CoA synthetase was reported to sustain mitochondrial respiration and enhance leukemia proliferation in acute myeloid leukemia (AML). However, the biological mechanisms of mitochondrial metabolis […]