Category: PubMeD- NCBI2

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE273650 mTORC1 inhibition activates the integrated stress response (ISR) in TALL-1 cell line July 9, 2025
  Contributors : Loredana Urso ; Micol Silic-Benussi ; Alberto Corradin ; Vincenzo CiminaleSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensmTOR sensitized T-ALL cell lines and patient-derived xenografts (PDX) from patients with R/R T-ALL to the BCL-2 inhibitor Venetoclax.
• GSE301951 Response gene to complement 32 promotes tumorigenesis by mediating DNA damage repair and inhibits CD8+ T cells infiltration in diffuse large B-cell lymphoma July 9, 2025
  Contributors : Xiyuan Zhang ; Tiange Lu ; Chunlei Shi ; Mengfei Ding ; Ling Wang ; Xinting Hu ; Xin WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: Response gene to complement 32 (RGC32), a complement activation-inducible factor broadly expressed in normal human tissues, has been implicated in tumorigene […]
• GSE289949 Transcriptomic profiling of thymocytes in CDC42-deficient and wild-type mice using single-cell RNA-seq July 9, 2025
  Contributors : Changduk Jun ; Sangmoo Park ; Hatice Karabulut ; Wonchang SohSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe performed single-cell RNA sequencing (scRNA-seq) on thymocytes isolated from wild-type (WT) and CDC42 knockout (CDC42 KO) mice to investigate the role of CDC42 in thymocyte development. This dat […]
• GSE270236 Chromatin Accessibility Dynamics in the Reprogramming of Somatic Cells to Pluripotency July 9, 2025
  Contributors : Stefan J Pietrzak ; Rupa SridharanSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusPluripotent stem cells have the incredible ability to self-renew indefinitely and to differentiate into all the cell types of the body. Remarkably, somatic cells can transition back into a pluripotent state thr […]
• GSE252891 INTESTINAL EPITHELIAL-DERIVED IL-34 REGULATES MACROPHAGE POLARIZATION AND GASTROINTESTINAL TRACT GRAFT VERSUS HOST DISEASE July 9, 2025
  Contributors : Aditya Rayasam ; Alison Moe ; Ravi K Shah ; Chengyin Yuan ; James M Miller ; Mary Rau ; Mollie Patton ; Marco Colonna ; Anthony E Zamora ; William R DrobyskiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGastrointestinal (GI) tract graft versus host disease (GVHD) is a major complication after allogeneic […]
• GSE271865 Transcriptomic Responses to chronic psychological stress: Insights from Mouse Liver, Brain, and Testis July 9, 2025
  Contributors : Jianbo Zheng ; Fang Yu ; Jianhua Shi ; Zhenhua Li ; Xiaoguo Zheng ; Hui WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusChronic psychological stress become synonymous with modern life. It can disrupt homeostasis and lead to numerous health risks. However, the molecular basis is still in its infancy. H […]
• GSE271688 Role of LINC01235 on transcriptional output in HCC1954 HER2 positive breast cancer cells July 9, 2025
  Contributors : Qi Zhang ; Xuliren Wang ; Zhibo Shao ; Bingqiu XiuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensLINC01235 plays a crucial role in HER2-positive breast cancer by regulating global histone modifications (H3K27ac, H3K9ac, H3K36me3) and promoting H2A.Z expression in its regulatory regions. It enhances the a […]
• GSE301586 A population of  Regulatory T cells controls nociception through enkephalins to restrain skin inflammation [fixed scRNA-seq] July 9, 2025
  Contributors : Stanislav Dikiy ; Juan Sebastian Jara ; Alejandra Mendoza ; Regina Bou Puerto ; Paolo Giovanelli ; Alexander Y RudenskySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe skin integrates diverse signals discerned by sensory neurons and immune cells to elicit adaptive responses to a range of stresses. Cons […]
• GSE301486 Spatial transcriptomics data of EMP2-progressive symmetric erythrokeratoderma July 9, 2025
  Contributors : Xingyuan Jiang ; Ryland Mortlock ; Keith ChoateSeries Type : OtherOrganism : Homo sapiensGenetic investigation in Mendelian skin disorders featuring generalized or localized skin scaling and redness, known as the ichthyoses, has revealed novel pathways relevant to epidermal integrity, barrier function, and desquamation. Here we show that a rec […]
• GSE301743 mTORC1 hyperactivation blocks pluripotent stem cells fate transitions through TFE3-NuRD association July 9, 2025
  Contributors : Peizhi Li ; Xueting Xu ; BaoMing Qin ; Shuhui XuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusAs an evolutionarily conserved master regulator of metabolism, mechanistic target of rapamycin complex 1 (mTORC1) regulates cell states and fates in development, cancer and aging. mTORC1 activity […]
• GSE301699 A population of Regulatory T cells controls nociception through enkephalins to restrain skin inflammation. July 9, 2025
  Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
• GSE301759 Subfamily-Selective PCR primers for the Human LINE1 L1PA Lineage July 9, 2025
  Contributors : Marcel Misak ; Amitava Basu ; Christof NiehrsSeries Type : OtherOrganism : Homo sapiensLong interspersed nuclear element-1 (LINE1) retrotransposons are classified into different subfamilies based on evolutionary history. For human biology, the L1PA lineage of LINE1s is particularly significant. This lineage contains both retrotransposition-com […]
• GSE301803 Studies on the mechanisms underlying human epidermal stem cell differentiation by epigallocatechin gallate July 9, 2025
  Contributors : Ruixing Hou ; Zuohua LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo elucidate the mechanism by which epigallocatechin gallate (EGCG) promotes the differentiation of epidermal stem cells (EpSCs), we performed RNA sequencing (RNA-seq) on EpSCs treated with or without 2 μM EGCG for 3 days. This analys […]
• GSE301822 In vivo CRISPR Screening Identifies ITGA8 as a Therapeutic Target to Sensitize Anti-PD-1 Immunotherapy in Non-small Cell Lung Cancer July 9, 2025
  Contributors : Minlin Jiang ; Congli Hu ; Jiawei Dai ; Haowei Wang ; Hui Lu ; Guanghui Gao ; Xuefei Li ; Lei Cheng ; Chao Zhao ; Yunhuan Liu ; Fei Zhou ; Fei Li ; Caicun ZhouSeries Type : OtherOrganism : Mus musculusAlthough immunotherapy has achieved great success in lung adenocarcinoma (LUAD), only a subset of patients exhibit a favorable response. Leverag […]
• GSE272513 Next generation trophoblast organoids with apical-out trophoblast polarity and central villous core-like cavity July 9, 2025
  Contributors : Hongmei Wang ; Hao Wu ; Shufan Fan ; Yan ZhaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHuman trophoblast organoid serves as a revolutionary tool for studying trophoblast cell development and maternal-fetal interactions. However, currently reported trophoblast organoids exhibited opposite trophoblast […]