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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE288393 sc-RNA-seq study of dedifferentiating intestinal epithelial cells reveals oncogenic reprogramming to heterogeneous stem cell states [dataset 1] February 6, 2026Contributors : Kylee Zgeib ; Thompson Hui ; Atharva Inamdar ; Ansu Perekatt ; Crystal Lim ; Shima Nejati ; Binfeng Lu ; Simon Garcia ; Zahra Hashemi ; Amartya Sigh ; Dahlia Matouba ; Christina LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIntestinal tumors can arise either from mutations sustained in Lgr5⁺ stem cell […]
- GSE288948 Macrophage Smad1 contributes to post-infarction dysfunction, suppressing angiogenic chemokine expression, and stimulating extracellular matrix remodeling February 6, 2026Contributors : Bijun Chen ; Shuaibo Huang ; Anis Hanna ; Silvia C Hernandez ; Nikolaos G FrangogiannisSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn healing infarcts, macrophages undergo dramatic phenotypic changes in response to cytokines and growth factors and serve as central effectors in cardiac repair and remod […]
- GSE288888 Spatial Transcriptomics, Histopathology, and Magnetic Resonance Subfield Segmentation of Hippocampal Sclerosis Compared to Normal Hippocampus: A Proof-of-Concept Study February 6, 2026Contributors : Samuel Guzman ; Ken Jones ; Saman HazanySeries Type : OtherOrganism : Homo sapiensDespite recent major advances in work-up and treatment of Drug Resistant Mesial Temporal Lobe Epilepsy (MTLE) with Hippocampal Sclerosis (HS), the underlying pathophysiology of this disease remains elusive. Depending on the type of HS, as defined by the histopath […]
- GSE289256 Multi-omic landscape of squamous cell lung cancer February 6, 2026Contributors : Paul E Stewart ; Eric B Haura ; Elsa R FloresSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe identified 116 patients consented to the Total Cancer Care (TM) protocol that had donated snap frozen lung squamous cell carcinoma tumor tissues with linked molecular data as well as clinical history, tumor pat […]
- GSE289030 Transcriptome of BAC-transgenic G1- and G0-APOL1 murine CD8+T-cells after ex-vivo stimulation. February 6, 2026Contributors : Madhav C Menon ; Zeguo SunSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBAC-transgenic G1-APOL1 mice ex-vivo stimulated CD8+T-cells show showed enrichment of canonical T-cell receptor (TCR) response pathways including calcium signaling.
- GSE241907 Ago2 protects against diabetic cardiomyopathy via activating mitochondrial gene translation [miRNA-seq] February 6, 2026Contributors : Jiabing Zhan ; Kunying Jin ; Jiahui Fan ; Chen Chen ; Huaping Li ; Dao W WangSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Mus musculusDiabetes is associated with cardiovascular complications. microRNAs translocate into subcellular organelles to modify genes involved in diabetic cardiomyopathy. However, functio […]
- GSE318538 Effect of KIFC1 knockdown on gene expression in H146 small-cell lung cancer cells February 6, 2026Contributors : Natsuki Nakagawa ; Hiroaki Ikushima ; Masanori KawakamiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the function of KIFC1 in small-cell lung cancer, we established the H146 cell line in which KIFC1 was knocked down using siRNA. We then performed gene expression profiling analysis using R […]
- GSE318342 Snail1 Induced Suppression of Proliferation via EGR1, FOXO1, and CEPBg Creates a Vulnerability for Targeting Apoptotic and Cellular Senescence Pathways [ChIP-Seq] February 6, 2026Contributors : Jack Tran ; Cynthia Miranti ; Samyukta Sundaram ; Sukitrti Shivpuri ; Hunain KhawajaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThe annual ~36,000 prostate cancer (PCa) deaths represent a large clinical unmet need and a call for deeper understanding of PCa metastasis. Epithelial-mesenchy […]
- GSE318340 Snail1 Induced Suppression of Proliferation via EGR1, FOXO1, and CEPBg Creates a Vulnerability for Targeting Apoptotic and Cellular Senescence Pathways [RNA-Seq] February 6, 2026Contributors : Jack Tran ; Cynthia Miranti ; Samyukta Sundaram ; Sukitrti Shivpuri ; Hunain KhawajaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe annual ~36,000 prostate cancer (PCa) deaths represent a large clinical unmet need and a call for deeper understanding of PCa metastasis. Epithelial-mesenchymal-transition […]
- GSE318354 Transcriptomic profiling of miR-18a CRISPR knockout melanoma identifies genes associated with therapy resistance and T cell killing February 6, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn melanoma, the knockout of miR-18a not only leads to resistance to monotherapy with BRAF inhibitors but also to combined therapy with BRAF and MEK inhibitors. This resistance is achieved by promoting the expression of YAP in the Hippo pathway. Additionally, the knockout […]
- GSE318353 Single-cell transcriptomic profiling reveals the heterogeneity of miR-18a-mediated resistance to targeted therapy and immunotherapy in melanoma February 6, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn melanoma, the knockout of miR-18a not only leads to resistance to monotherapy with BRAF inhibitors but also to combined therapy with BRAF and MEK inhibitors. This resistance is achieved by promoting the expression of YAP in the Hippo pathway. Additionally, the knockout […]
- GSE318414 Lipid metabolism dysregulation in solar lentigo: a multi-system-level analysis reveals membrane instability and energy homeostasis disruption February 6, 2026Contributors : Soonhyo Kwon ; Man S KimSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSolar lentigo is a common hyperpigmented skin condition caused by chronic ultraviolet exposure, primarily affecting photoaged skin. While previous investigations focused on inflammatory and melanogenic mechanisms, the comprehensive ro […]
- GSE318498 Gene expression differences between LPS, anti-CD36 Abs, or LPS plus anti-CD36 Abs treated RAW264.7 cells. February 6, 2026Contributors : Xin Sun ; Weixuan Wang ; Dan LvSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo comprehensively analyze the transcriptome of macrophages treated with LPS, anti-CD36 Abs, or LPS plus anti-CD36 Abs, respectively, we employed RNA sequencing (RNA-seq) assay
- GSE318501 miRNA-18a screened based on CRISPR can regulate targeted therapy resistance and T-cell killing in melanoma February 6, 2026Series Type : OtherOrganism : Homo sapiensIn melanoma, the knockout of miR-18a not only leads to resistance to monotherapy with BRAF inhibitors but also to combined therapy with BRAF and MEK inhibitors. This resistance is achieved by promoting the expression of YAP in the Hippo pathway. Additionally, the knockout of miR-18a results in high expression of THBS […]
- GSE255561 Tailoring a CRISPR/Cas-based Epigenome Editor for Programmable Chromatin Acylation and Decreased Cytotoxicity [RNA-Seq] February 6, 2026Contributors : Isaac Hilton ; Jacob GoellSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPrecisely engineering histone acylation states can inform mechanistic epigenetics and catalyze new therapeutic epigenome editing opportunities. Here, we developed engineered lysine acyltransferases that enable the deposition of acet […]