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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE289113 Synergistic Effects of Retinol and Retinyl Palmitate in Alleviating UVB-Induced DNA Damage and Promoting the Homologous Recombination Repair in Keratinocytes February 7, 2026Contributors : Jiangming Zhong ; Ling Liang ; Nan Zhao ; Jing Wang ; Peng ShuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensUltraviolet B (UVB) rays are a type of ultraviolet radiation emitted by the sun, primarily responsible for skin photodamage. These rays mainly affect the epidermis, leading to direct damage to DNA […]
- GSE286432 An EGFR Co-amplified Long Noncoding RNA HELDR Promotes Glioblastoma Malignancy through KAT7-driven gene programs [ChIRP] February 7, 2026Contributors : Xiaozhou Yu ; Bo Hu ; Shi-Yuan ChengSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; OtherOrganism : Homo sapiensEGFR amplification at extrachromosome DNAs (ecDNAs) is a major driving mutation in glioblastoma (GBM). However, targeting EGFR for GBM treatments remain unsatisfied. Here we identify a de novo long no […]
- GSE224872 ATAC-seq of OT-I cells co-cultured with vehicle or TAMos under OVA257-264 stimulation February 7, 2026Contributors : Zeliang Yang ; Yuxin YinSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo characterize the regulation of tumor-associated monocytes (TAMos) on the epigenetic map of T cells, we conducted the assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq) of OT-I cells co-cultured wi […]
- GSE318451 SND1-Tudor Recognition of Methylated S6K2 Regulates Pancreatic Homeostasis February 7, 2026Contributors : Yalong Wang ; Mark T Bedford ; Bin LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusStaphylococcal nuclease and Tudor domain containing 1 (SND1) is a multifunctional protein with four SN domains and a Tudor domain that recognizes symmetric dimethylarginine (SDMA) modifications. Although highly enriched […]
- GSE286179 An EGFR Co-amplified Long Noncoding RNA HELDR Promotes Glioblastoma Malignancy through KAT7-driven gene programs February 7, 2026Contributors : Xiaozhou Yu ; Bo Hu ; Shi-Yuan ChengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEGFR amplification at extrachromosome DNAs (ecDNAs) is a major driving mutation in glioblastoma (GBM). However, targeting EGFR for GBM treatments remain unsatisfied. Here we identify a de novo long non-coding RNA (lncRNA) […]
- GSE252636 RNA sequencing of naïve T cells, central memory T cells and effector memory T cells derived from mouse spleens February 7, 2026Contributors : Zeliang Yang ; Yuxin YinSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo explore the relationship between OT-I cells co-cultured with tumor-associated monocytes (TAMos) and conventional T cell subsets, we conducted RNA transcriptome profiling of naïve T cells, central memory T cells, and effector memory […]
- GSE318325 Reversibility of Nuclear and 3D Genomic Changes in Non-Cancerous Fibroblasts After Constricted Migration February 7, 2026Contributors : Christopher Playter ; Samuel J Benson ; Renata Dos Reis Marques ; Preston Young ; Timothy Simmons ; Kathryn Perry ; Amanda K Swets ; Rachel P McCordSeries Type : OtherOrganism : Homo sapiensMetastatic cancer cells and healthy fibroblasts must traverse constrictive spaces to reach secondary sites. After passing through multiple constrictions, c […]
- GSE286318 An EGFR Co-amplified Long Noncoding RNA HELDR Promotes Glioblastoma Malignancy through KAT7-driven gene programs [HELDR] February 7, 2026Contributors : Xiaozhou Yu ; Bo Hu ; Shi-Yuan ChengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEGFR amplification at extrachromosome DNAs (ecDNAs) is a major driving mutation in glioblastoma (GBM). However, targeting EGFR for GBM treatments remain unsatisfied. Here we identify a de novo long non-coding RNA (lncRNA) […]
- GSE318399 Isoliensinine promotes the clearance of senescent vascular smooth muscle cells by natural killer cells [VSMC] February 7, 2026Contributor : XiaoNi MaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAtherosclerosis (AS) is an age-related disease whose incidence increases with advancing age. During disease pathogenesis, vascular smooth muscle cells (VSMCs) undergo senescence within the plaques and secrete senescence-associated secretory phenotype […]
- GSE318371 Peripheral blood mononuclear cells single-cell landscape of newly diagnosed NK/T cell lymphoma patients February 7, 2026Contributors : Xiaozhen Liang ; Rong Tao ; Ran Jia ; Chuanxu LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNatural killer/T cell lymphoma (NKTCL) is a rare and aggressive form of non-Hodgkin's lymphoma associated with Epstein-Barr Virus (EBV) infection.The recent advancement of multi-omics technologies has sig […]
- GSE318401 Isoliensinine promotes the clearance of senescent vascular smooth muscle cells by natural killer cells [MOVAS] February 7, 2026Contributor : XiaoNi MaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAtherosclerosis (AS) is an age-related disease whose incidence increases with advancing age. During disease pathogenesis, vascular smooth muscle cells (VSMCs) undergo senescence within the plaques and secrete senescence-associated secretory phenotype […]
- GSE318448 Pharmacological elevation of lactate alleviates sepsis via histone lactylation-induced IL-10 production February 7, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDespite that lactate accumulation is deemed to be a marker of severe sepsis, lactate-driven histone lactylation induces transcription of homeostatic genes. Thus, the biological roles of lactate in sepsis remain unknown. Here, we report that amlexanox, an anti-inflammatory […]
- GSE318449 A Wnt7a-Hoxa13 pathway for Müllerian duct fusion at the body midline for uterine morphogenesis February 7, 2026Contributors : Richard R Behringer ; Bin Liu ; Diana A MachadoSeries Type : OtherOrganism : Mus musculusDuring embryonic development, the Müllerian ducts and adjacent mesenchyme differentiate into the tissues of the oviducts, uterus, cervix, and upper vagina. Variations in the fusion process can alter typical uterine morphology, correlating with an increased […]
- GSE286320 An EGFR Co-amplified Long Noncoding RNA HELDR Promotes Glioblastoma Malignancy through KAT7-driven gene programs [Long-reads, GBM6] February 7, 2026Contributors : Xiaozhou Yu ; Bo Hu ; Shi-Yuan ChengSeries Type : OtherOrganism : Homo sapiensEGFR amplification at extrachromosome DNAs (ecDNAs) is a major driving mutation in glioblastoma (GBM). However, targeting EGFR for GBM treatments remain unsatisfied. Here we identify a de novo long non-coding RNA (lncRNA) that is co-amplified with EGFR which we named […]
- GSE318320 Gene expression response in sulfur-starved pine seedlings subjected to a sulfate pulse February 7, 2026Contributors : Rafael A Cañas ; Javier Canales ; Juan C Aledo ; Francisco R CantónSeries Type : Expression profiling by high throughput sequencingOrganism : Pinus pinasterThis study analyzed changes in gene expression in the organs (needles, cotyledons, stem, and roots) of maritime pine seedlings 24 hours after being watered with 0.5 mM potassium sulfate. Se […]