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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE290690 Depletion of the E3 ubiquitin ligase HUWE1 impairs Kras-induced lung adenocarcinoma tumorigenesis and induces a senescent phenotype February 27, 2026Contributors : Joshua Searle ; Matteo Menotti ; Martin J Baker ; Anshuman Chaturvedi ; Mathew Carter ; Fiona Blackhall ; Angeliki Malliri ; Colin R LindsaySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe E3 ubiquitin ligase HUWE1 modifies a diverse network of substrate proteins by ubiquitination, through which it reg […]
- GSE290688 Targeting Keap1/Nrf2/ARE Signaling Pathway by Esculin in Zebrafish Larvae February 27, 2026Contributors : Ekambaram Perumal ; Srija BabuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Danio rerioNuclear factor E2-related factor 2 (Nrf2) is a basic leucine zipper (bZIP) transcription factor that plays a crucial role in cellular defense mechanisms by regulating the expression of phase II detoxification enzyme […]
- GSE290824 Targeted genes of Isl1 in E13.5 mouse retina with CUT&Tag February 27, 2026Contributors : Li Shuchun ; Gan Lin ; Biswas ShionaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThe transcription factor ISL1 regulates a unique set of genes in retinal ganglion cells. KEGG Pathway analysis of differentially expressed genes in Isl1 cKO retina revealed multiple genes involved in axon gui […]
- GSE290712 Targeting mitochondrial stress responses: Terbinafine and Miglustat as novel lifespan and healthspan modulators February 27, 2026Contributors : Amélia Lalou ; Sandra Rodríguez-López ; Jean-David Morel ; Giorgia Benegiamo ; Adrien Faure ; Arwen W Gao ; Joaquim Barmaz ; Qi Wang ; Terytty Yang Li ; Feng Gao ; Danaé Broustail ; Kristina Schoonjans ; Johan AuwerxSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansMitochondria are key regulators […]
- GSE320206 Reinforced immunotherapy of M1 macrophage-derived exosomes with CEL on TNBC via regulating macrophage functions February 27, 2026Contributor : Xinyi LuoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTriple-negative breast cancer (TNBC) demonstrates poor prognosis due to its heterogeneity-related biological barrier, immunosuppressive tumor microenvironment (TME) and escape of cancer cells on immune surveillance. Exosomes are membrane-encased vehi […]
- GSE295123 Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle [A549_cell_lines_RNAseq] February 27, 2026Contributors : Abigail Xie ; Julia S Brunner ; Lydia W FinleySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRNA-sequencing of A549 cell lines with CRISPR/Cas9-mediated editing of AAVS1, ACO2, or both ACO2 and CS treated with vehicle (water) or pyruvate 5mM for 24 h.
- GSE316115 RNA-seq analysis of E18.5 mouse embryonic lungs reveals impaired saccular maturation and airway differentiation in Svep1 knockout embryos February 27, 2026Contributor : Maria LoscertalesSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusLoss of Svep1, an extracellular matrix protein, leads to severe defects in airway patterning and alveolar differentiation during lung development. To investigate transcriptional changes associated with impaired saccular maturation, we perform […]
- GSE284673 Effect of L-leucine uptake inhibitor on whole-genome transcriptomic profile of Mtb mc2 6206 February 27, 2026Contributor : Agarwal NisheethSeries Type : Expression profiling by high throughput sequencingOrganism : Mycobacterium tuberculosisThe main objective of this study is to analyze changes in whole-genome transcriptomic profile of mc2 6206 strain of Mycobacterium tuberculosis H37Rv after treatment with a drug which blocks L-leucine uptake. By RNASeq, it was obs […]
- GSE317730 CLIPPER Regulates LPIN1-Mediated Mitochondrial Biogenesis and Heart Regeneration [RNAseq_differentiation] February 27, 2026Contributors : Chang Jie Mick Lee ; Roger SY Foo ; Francesco Ruberto ; Thierry PedrazziniSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe adult mammalian heart lacks the significant regenerative potential needed to cope with the massive loss of cardiomyocytes following myocardial infarction. Ultimately, irreversible […]
- GSE317535 CLIPPER Regulates LPIN1-Mediated Mitochondrial Biogenesis and Heart Regeneration February 27, 2026Contributors : Chang Jie Mick Lee ; Roger SY Foo ; Francesco Ruberto ; Thierry PedrazziniSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe adult mammalian heart lacks the significant regenerative potential needed to cope with the massive loss of cardiomyocytes following myocardial infarction. Ultimately, irreversible […]
- GSE319472 scRNAseq analysis of human brochial epithelial cell air liquid interface cultures infected with the A/Perth/16/2009 H3N2 with and without PA-X February 27, 2026Contributors : Marta Maria Gaglia ; Alessandra SetaroSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe goal of this analysis was to examine the impact of PA-X activity during infection in a model of the human airway epithelium, using primary airway cells from two different donors. We profiled the effects of infection […]
- GSE320026 A Proteostasis Checkpoint Governs EGFR Stability and Cell Fitness, Defined by an lncRNA [RNA-seq] February 27, 2026Contributor : Taewan KimSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe protein abundance of receptor tyrosine kinases such as EGFR is actively maintained under basal conditions by mechanisms that are distinct from ligand-induced signaling and degradation, yet the molecular basis of this regulation remains poorly un […]
- GSE320108 Integrating copy number, methylation, and fusion detection in one assay: A Nanopore sequencing approach for pediatric and adults’ rare tumors diagnosis February 27, 2026Series Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensRecent advances in sequencing technologies have significantly refined tumor characterization by enabling detailed analysis of genetic alterations, transcriptomic profiles, and DNA methylation patterns. Combined with pathological data, these molecular insights have become […]
- GSE290687 RNA-Seq of E13.5 control and Isl1 cKO retinae February 27, 2026Contributors : Li Shuchun ; Gan Lin ; Biswas ShionaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe transcription factor ISL1 regulates a unique set of genes in retinal ganglion cells. KEGG Pathway analysis of differentially expressed genes in Isl1 cKO retina revealed multiple genes involved in axon guidance, extrace […]
- GSE310717 Effects of a temporary period on pasture on the transcriptomic signature of horses housed in individual boxes. February 27, 2026Contributors : Aline Foury ; Alice Ruet ; Nuria Mach ; Léa Lansade ; Marie-Pierre MoisanSeries Type : Expression profiling by arrayOrganism : Equus caballusOver the past two decades, improving horse welfare through better housing conditions has emerged as a major concern. Different studies suggest that group living on pasture supports a higher welfare state […]