Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE289650 Blockade of insulin signaling cooperates with PI3K inhibitors to suppress MYCN pediatric high grade glioma growth [RNA-seq2] March 21, 2026
  Contributors : Sameer Agnihotri ; Taylor A Gatesman ; Srinidhi Varadharajan ; Brenden J JohnsonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusUtilizing a MYCN overexpressing, P53/PTEN knockdown mouse neural progenitor cell line model of MYCN-amplfiied pediatric high grade glioma, we compared treatment naïve (DMSO) vs G […]
• GSE293014 Identifying clones in myelodysplastic syndromes by using single-cell RNA sequencing March 21, 2026
  Contributors : Roy Pollak ; Hadas Ner-Gaon ; Leonid Olender ; Itai Levi ; Roi Gazit ; Tal Shay ; Uri GreenbaumSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe employed single-cell RNA sequencing to sequence hematopoietic stem cells (HSC) derived from bone marrow aspirations of seven patients with myelodysplastic syndr […]
• GSE291299 AN465: A Novel Therapeutic Targeting METTL3 Inhibition in Hand, Foot, and Mouth Disease March 21, 2026
  Series Type : OtherOrganism : Homo sapiensAbstract: Hand, foot, and mouth disease (HFMD) is a widespread viral infection predominantly affecting young children, for which specific therapies remain elusive despite extensive research efforts. N6-methyladenosine (m6A) modifications, prevalent in eukaryotic mRNA and long non-coding RNAs, are also found in variou […]
• GSE276135 The ac4C acetyltransferase Nat10 promotes RNA stability to support hematopoietic stem cell fate [eCLIP-seq] March 21, 2026
  Contributors : Weiqian Li ; Yue Huo ; Zhaoru ZhangSeries Type : OtherOrganism : Mus musculusThe control of gene expression program is believed to underlie hematopoietic stem cell (HSC) homeostasis. However, a comprehensive molecular understanding of the RNA level regulation is currently lacking. Here we provide evidence that the HSC-associated transcripts ha […]
• GSE325175 Genome-wide discovery of cis-regulatory elements in a large genome [bulk ATAC-seq] March 21, 2026
  Contributors : Gillian Forbes ; Emilia Skafida ; Çağrı Çevrim ; Michalis Averof ; Mathilde ParisSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Parhyale hawaiensisIdentifying non-coding regulatory elements in the genome poses a challenge in most organisms. Classical methods rely on trial and error to test the regulato […]
• GSE285333 Simultaneous mapping of RNA secondary, tertiary, and quaternary structure in living cells by multi-site DMS probing I March 21, 2026
  Contributors : Irfana Saleem ; Thomas M Miller ; Lucas Kearns ; Anthony Hoang ; Joshua Meehan ; Ritwika Bose ; David Mitchell ; David H Price ; Calla M Olson ; Chase A Weidmann ; Anthony M MustoeSeries Type : OtherOrganism : Escherichia coli ; Homo sapiens ; TetrahymenaIdentifying tertiary structures and protein binding sites on RNA molecules remains a key c […]
• GSE276137 The ac4C acetyltransferase Nat10 promotes RNA stability to support hematopoietic stem cell fate [RNA-seq-32D] March 21, 2026
  Contributors : Weiqian Li ; Yue Huo ; Zhaoru ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe control of gene expression program is believed to underlie hematopoietic stem cell (HSC) homeostasis. However, a comprehensive molecular understanding of the RNA level regulation is currently lacking. Here we provide ev […]
• GSE322686 Longitudinal Multiomic and Spatial Transcriptomic Profiling of Lupus Nephritis Progression in a Murine Model March 21, 2026
  Contributors : Eduardo Patino-Martinez ; Morteza Hajihossein ; Kan Jiang ; Saumyadipta Pyne ; Mariana J. KaplanSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusLupus nephritis (LN) is characterized by progressive renal inflammation and tissue injury. Bulk RNA sequencing was performed on kidneys from lupus-prone f […]
• GSE319686 Co-mutations of CTNNB1 and PTEN Synergistically Promote EMT and Drive Aggressive Tumor Progression in Endometrial Cancer. March 21, 2026
  Contributors : TaeHoon Kim ; JaeWook JeongSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusEndometrioid endometrial cancer (EEC) is the most common gynecologic malignancy, with poor outcomes in advanced stages. Co-mutations in PTEN and CTNNB1 are frequent and linked to poor prognosis, but their functional roles remain un […]
• GSE324961 microRNA-132 attenuates inflammation in induced pluripotent stem-cell derived microglia from Alzheimer’s disease patients March 21, 2026
  Contributors : Amber Penning ; Sarah Snoeck ; Olmo Ruiz Ormaechea ; Dilara Ayyildiz ; Oliver Polzer ; Martin Buitrago-Arango ; Raffaella Copabianco ; Fred de Winter ; Sriram Balusu ; Joost Verhaagen ; Carlos P. Fitzsimons ; Constantin d'Ydewalle ; Paul J. Lucassen ; Dieder Moechars ; Lujia Zhou ; Salta EvgeniaSeries Type : Expression profiling by high t […]
• GSE324916 Phosphorylation of serines 287/288 in DEK regulates cell-type-specific chromatin occupancy and compaction [ChIP-Seq] March 21, 2026
  Contributors : Gongjie Wu ; Ferdinand KappesSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThe conserved multifunctional chromatin modulator and oncogene DEK exhibits context-dependent genomic binding and function, but how these activities are regulated in cancer remains poorly understood. Using multi-omi […]
• GSE324996 Dual-Coupling Amplified Electrostimulaton Drives In Situ Bone Regeneration March 21, 2026
  Contributors : Seung Cheol Lee ; Dong Hyun Lee ; Byeongsoo Eom ; Jinman KimSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensElectrical stimulation is known to promote bone regeneration, but conventional systems often require wired connections or implanted power sources and provide limited stimulation to deep tissues. To […]
• GSE325023 Transcriptome profiling of Arabidopsis thaliana PsbS and β-carbonic anhydrase overexpression lines in response to bicarbonate fertilization March 21, 2026
  Contributors : Alex Białas ; Joanna Dąbrowska-Bronk ; Piotr Gawroński ; Stanisław KarpińskiSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaPhotosynthetic efficiency and stress tolerance in plants are regulated by complex interactions between photoprotective mechanisms and carbon metabolism. The photosystem II su […]
• GSE325098 GmMYB21a improves male fertility of CMS-based restorer line under high-temperature stress in soybean March 21, 2026
  Contributors : Jilei Gan ; Hongjie Wang ; Yujuan Gu ; Xianlong Ding ; Shouping YangSeries Type : Expression profiling by high throughput sequencingOrganism : Glycine maxHigh-temperature (HT) stress during flowering causes male sterility and yield loss in soybean. MYB transcription factors are key regulators under abiotic stress, yet their function and mechan […]
• GSE289649 Blockade of insulin signaling cooperates with PI3K inhibitors to suppress MYCN pediatric high grade glioma growth [RNA-seq1] March 21, 2026
  Contributors : Sameer Agnihotri ; Taylor A Gatesman ; Srinidhi Varadharajan ; Brenden J JohnsonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMYCN amplification is an adverse genomic feature of several childhood malignancies and has been a challenging therapeutic target. We modeled MYCN amplified high grade gliomas (HG […]