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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE274443 Transient ER stress cell-autonomously promotes beta cell cycling December 19, 2025Contributors : Stephanie Bourgeois ; Annelore Van Mulders ; Yves Heremans ; Gunter Leuckx ; Lien Willems ; Sophie Coenen ; Laure Degroote ; Julie Pierreux ; Daliya Kancheva ; Isabelle Scheyltjens ; Kiavash Movahedi ; Miriam Cnop ; Xiaoyan Yi ; Chiara Vinci ; Yue Tong ; Eelco de Koning ; Françoise Carlotti ; Heimberg Harry ; Nico De Leu ; Staels WillemSeries […]
- GSE284023 Enhanced non-enzymatic H2S generation extends lifespan and healthspan in male mice December 19, 2025Contributors : María Ángeles Cáliz-Molina ; Raúl López-Fernández Sobrino ; Inmaculada Pino-Pérez ; Concepción Panadero-Morón ; Maria del Carmen Vilches-Pérez ; María Camacho-Cabrera ; Almudena García-Ruíz ; Leopoldo Pérez-Rosendo ; Isabel Espadas ; Alejandro Sola-García ; Mario Soriano-Navarro ; Franz Martin ; Mónica Venegas-Calerón ; Joaquin José Salas ; En […]
- GSE278686 Analysis of miRNA profiles associated with anti-tuberculosis treatment responses December 19, 2025Contributors : Young Ae Kang ; Hyejon Lee ; Jungho KimSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensTo identify potential microRNA candidates for therapeutic response assessment using a transcriptome-based approach, we extracted total RNAs from blood samples of study participants, including a complete set from pat […]
- GSE295934 Spatially distinct cellular and molecular landscapes define prognosis in triple negative breast cancer December 19, 2025Series Type : OtherOrganism : Homo sapiens ; synthetic constructThis SuperSeries is composed of the SubSeries listed below.
- GSE288602 Atherosclerosis licenses for an exceeding immune response in COVID-19 disease by interferon priming in circulating myeloid cells December 19, 2025Contributors : Julian Leberzammer-Deuster ; Carsten Kuenne ; Sebastian CremerSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensAims: Patients with cardiovascular disease (CVD) have an increased risk of developing severe respiratory infections, including COVID-19. However, the underlying molecular mechanisms […]
- GSE314570 Silencing lipid catabolism determines longevity in response to fasting December 19, 2025Contributors : Lexus Tatge ; Peter DouglasSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansOscillations between lipid anabolism and catabolism allow for long-term preservation of cellular health amid systemic metabolic fluctuations. As a conserved aging determinant, fasting can improve disease outcomes and exte […]
- GSE296495 Single-cell mapping of regulatory DNA:Protein interactions December 19, 2025Series Type : Other ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE314254 Optimized multidrug therapy remodels the tumor microenvironment and enhances antitumor immunity in microsatellite-stable colorectal cancer December 19, 2025Contributors : Pablo H Lopez ; Patrycja Nowak-SliwinskaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusFour low-dose tyrosine kinase inhibitor (TKI)–based ODCs were evaluated in murine AKP CRC organoids, co-culture systems with tumor-associated endothelial cells and immune cells, and in vivo syngeneic models. Among thes […]
- GSE314114 Single-cell mapping of regulatory DNA:Protein interactions IV December 19, 2025Contributors : Wei-Yu Chi ; Sang-Ho Yoon ; Evrim Goksel ; Levan Mekerishvili ; Joe Pelt ; Yiyun Lin ; Saravanan Ganesan ; Catherine Potenski ; Franco Izzo ; Dan A. Landau ; Ivan RaimondiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensGene expression is coordinated by a multitude of transcription factors (T […]
- GSE314368 Skeletal Muscle Methylome-Transcriptome Disruptions During the Onset and Progression of Colorectal Cancer-Induced Cachexia December 19, 2025Contributors : Nicholas P. Greene ; Kevin A. Murach ; Ana Regina CabreraSeries Type : Methylation profiling by high throughput sequencingOrganism : Mus musculusCancer cachexia (CC) is experienced by 80% of cancer patients, representing up to 40% of cancer-related deaths. Evidence suggests biological sex dimorphism associated with CC. The initial triggering f […]
- GSE314344 HIV inhibits Warburg metabolism in human macrophages infected with Mycobacterium tuberculosis December 19, 2025Contributors : Gina Leisching ; Aaron M WalshSeries Type : Expression profiling by arrayOrganism : Homo sapiensHIV inhibits Warburg metabolism in human macrophages infected with Mycobacterium tuberculosis
- GSE314459 High-resolution in vivo binding data show that TBP initiates transcription at TATA promoters with and without TFIID [ChIP-nexus] December 19, 2025Contributors : Sergio G-M Alcantara ; Simon Bourdareau ; Melanie Weilert ; Julia ZeitlingerSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Drosophila melanogasterThis study investigates how the general transcription factor TFIID binds to different core promoter types in vivo. We performed high-resolution ChIP-nexus fo […]
- GSE314460 High-resolution in vivo binding data show that TBP initiates transcription at TATA promoters with and without TFIID [RNA-seq] December 19, 2025Contributors : Sergio G-M Alcantara ; Simon Bourdareau ; Melanie Weilert ; Julia ZeitlingerSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterThis study investigates how the general transcription factor TFIID binds to different core promoter types in vivo. We performed high-resolution ChIP-nexus for all 14 subun […]
- GSE314461 High-resolution in vivo binding data show that TBP initiates transcription at TATA promoters with and without TFIID December 19, 2025Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Drosophila melanogasterThis SuperSeries is composed of the SubSeries listed below.
- GSE274430 The nuclear exosome is required for Piwi-piRNA mediated co-transcriptional gene silencing [RNA-seq] December 19, 2025Contributors : Changwei Yu ; Toni Manolova ; Dominik Handler ; Ulrich Hohmann ; Laszlo Tirian ; Filip Nemčko ; Júlia Portell i de Montserrat ; Guillaume Giraud Collet ; Peter Duchek ; Maria Novatchkova ; Elisabeth Roitinger ; Sebastian Falk ; Julius BrenneckeSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterCo- […]