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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE284026 NR2F6 deletion revives CAR‑T cell function and induces antigen‑agnostic immune memory in solid tumors January 23, 2026Contributors : Dominik Humer ; Victoria Klepsch ; Dietmar Rieder ; Gottfried BaierSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCAR‑T cell therapy is effective in hematologic malignancies but remains challenging in solid tumors owing to antigen heterogeneity and tumor microenvironment‑induced exhaustion. Here, gene ed […]
- GSE287857 LDHA induces β cell dedifferentiation in diabetes through metabolic epigenetic reprogramming [RNA-Seq] January 23, 2026Contributors : Xirui Li ; Haoqiang Gong ; Can Xiong ; Xinyue Huang ; Mei He ; Liangjun Sun ; Wenyue Yin ; Suyun Zou ; Min Sha ; Wanhua Guo ; Tijun Wu ; Qingguo Li ; Yaqin Zhang ; Fang ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAims/hypothesis Pancreatic β cell dedifferentiation underlies the reversible reductio […]
- GSE287823 Commonalities in gene expression and methylation changes across two rat models of acquired epilepsy [RNA-seq] January 23, 2026Contributors : Benton Purnel ; Junguk Hur ; Detlev BoisonSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusEpileptogenesis, the process by which a normal brain develops epilepsy, is characterized by complex changes in DNA methylation and gene expression. In this study, RNA sequencing and reduced-representation bisulf […]
- GSE288033 Functional dissection of ovarian aging-associated genes NDUFS5 and UBE2L3 through integrated genomic analyses and validation January 23, 2026Contributors : Yifei Lv ; Yunlong Ma ; Yizhou Huang ; Linjuan Ma ; Jianhong ZhouSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensOvarian aging, culminating in menopause, involves a gradual decline in ovarian function. Genetic factors influencing age at natural menopause (ANM) especially premature ovarian insufficiency (P […]
- GSE287891 The transcription factor Traffic jam orchestrates the somatic piRNA pathway in Drosophila ovaries [RNA-seq] January 23, 2026Contributors : Azad Alizada ; Aline Martins ; Nolwenn Mouniée ; Julia V Rodriguez Suarez ; Benjamin Bertin ; Nathalie Gueguen ; Vincent Mirouse ; Anna-Maria Papameletiou ; Austin J Rivera ; Nelson C Lau ; Abdou Akkouche ; Stéphanie Maupetit-Mehouas ; Gregory J Hannon ; Benjamin Czech Nicholson ; Emilie BrassetSeries Type : Expression profiling by high throug […]
- GSE263687 Ageing promotes metastasis via activation of the integrated stress response (ATAC-Seq) January 23, 2026Contributors : Angana H Patel ; Clotilde Wiel ; Volkan I SayinSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusLung cancer predominantly affects older individuals, yet how physiological aging influences tumor evolution remains poorly understood. Here, we show that aging reprograms the evolutionary trajector […]
- GSE290575 G549 EP300_KO RNA-seq January 23, 2026Contributors : Fatemeh Molaei ; Graham MacLeod ; Stephane AngersSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEP300 was identified as potential regulator of Injury-response/Mesenchymal state in Glioblastoma stem cells. Our objective was to identify the effect of EP300 KO on transcriptomic signature of Injury-response/ […]
- GSE315326 Genome-wide identification of transcriptional targets for H4K12 lactylation in ccRCC cells January 23, 2026Contributors : Kenan Zhang ; Lin HeSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the genome-wide transcription targets of H4K12 lactylation in ccRCC cells, cleavage under targets and tagmentation (CUT&Tag) was performed in 786-O and Caki-1 cells using antibody against H4K12 lactylation […]
- GSE314501 Comprehensive transcriptome analysis of the Mettl18-deficient embryos January 23, 2026Contributors : Jun-Dal Kim ; Akiyoshi FukamizuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHistidine methylation is an evolutionarily conserved but poorly understood post-translational modification. METTL18 is known to catalyze histidine Nτ-methylation in vitro, yet its physiological functions in mammals remain uncle […]
- GSE316562 Cyanidin-3-rutinoside(C3R) Attenuates Free Fatty Acid-Induced Hepatic Lipid Accumulation in HepG2 Cells January 23, 2026Contributors : Jingxu Duan ; Wancong Yu ; Yujia Niu ; Jiao Li ; Zhaohui XueSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNon-alcoholic fatty liver disease (NAFLD) is characteristic by pathological lipid accumulation in hepatocytes. This study investigates how Cyanidin-3-rutinoside(C3R), a natural anthocyanin with anti […]
- GSE315629 Genome-wide identification of transcriptional targets of H4K12 lactylation and GR in 786-O cells with or without dexamethasone treatment. January 23, 2026Contributors : Kenan Zhang ; Lin HeSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the genome-wide transcriptional targets associated with H4K12 lactylation in renal cell carcinoma, cleavage under targets and tagmentation (CUT&Tag) was performed in 786-O cells with or without dexamethaso […]
- GSE316915 Decoding and Rewiring Promoter Architecture Using Large Language Models and Diffusion Frameworks January 23, 2026Contributors : Xin Lei ; Xing Wang ; Yuzhong Liu ; Yangyu Zhang ; Jiesheng Huang ; Tianjiao Peng ; Ce Liang ; Quhuan Li ; Huaiguang Jiang ; Wei XiongSeries Type : Expression profiling by high throughput sequencingOrganism : Escherichia coli DH5[alpha]High-performance promoters are essential tools for precisely regulating gene expres-sion, yet their rational […]
- GSE316934 Single-cell RNA-seq of eWAT stromal vascular fraction cells from WT and Camk2d myeloid conditional knockout mice after high-fat diet January 23, 2026Contributors : Yifan Tu ; Ke Sui ; Zheng Wang ; Jiawei Zhang ; Ying GuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusEpididymal white adipose tissue (eWAT) stromal vascular fraction (SVF) cells were profiled by 10x Genomics Chromium Single Cell 3′ v1 scRNA-seq to characterize immune-cell states in diet-induced obesity. […]
- GSE317187 A novel pyrrolidine-chalcone derivative exhibits synergistic anti-cervical cancer activity by dual-targeting MDM2-p53 axis and ferroptosis pathway January 23, 2026Contributor : Xinyi DengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCervical cancer remains a serious threat to women’s health, driving the need for effective and low-toxicity therapeutics.
- GSE281507 Chronic variable mild stress alters the transcriptome and signaling properties of the anterodorsal bed nuceleus of the stria terminalis in a sex-dependent manner January 23, 2026Contributors : Thomas J Degroat ; Sarah Paladino ; Benjamin A Samuels ; Troy A RoepkeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusChronic stress is a physiological state marked by dysregulation of the hypo-pituitary-adrenal axis and high circulating levels of stress hormones, such as corticosterone in mice or cortiso […]