Gene Expression Omnibus Announcements -Study Releases

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE212855 HOT3/eIF5B1 confers Kozak motif-dependent translational control of photosynthesis-associated nuclear genes for chloroplast biogenesis October 3, 2024
  Contributors : Runlai Hang ; Ye Xu ; Hao Hu ; Chenjiang You ; Xuemei ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaPhotosynthesis requires chloroplasts, where most proteins are nucleus-encoded and produced via cytoplasmic translation. The translation initiation factor eIF5B gates the transition from initia […]
• GSE278685 USP22 promotes the proliferation and inhibits Sorafenib-induced ferroptosis of hepatocellular carcinoma cells through its deubiquitinase activity [ChIP-seq] October 3, 2024
  Contributor : Xiaochen WangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensHepatocellular carcinoma (HCC) remains one of the most lethal cancers, characterized by poor prognosis and low life expectancy. Unfortunately, there are very few molecular therapeutic options available for advanced HCC. Sorafenib is […]
• GSE236144 Translation of zinc finger domains induces ribosome collision and Znf598-dependent mRNA decay in zebrafish [Ribo-seq] October 3, 2024
  Contributors : Kota Ishibashi ; Yuichi Shichino ; Penxun Han ; Shintaro Iwasaki ; Yuichiro MishimaSeries Type : Other ; Expression profiling by high throughput sequencingOrganism : Danio rerioQuality control of translation is crucial for maintaining cellular and organismal homeostasis. Obstacles in translation elongation induce ribosome collision, which is m […]
• GSE224089 Microarray analysis of human cord blood derived mast cells (hCBMC) activated by Interleukin-33 (IL-33) October 3, 2024
  Contributors : Sherin Bakhashab ; Ghalya H Banafea ; Farid Ahmed ; Nadia Bagatian ; Ohoud Subhi ; Kalamegam Gauthaman ; Mahmood Rasool ; Hans-Juergen Schulten ; Peter N PushparajSeries Type : Expression profiling by arrayOrganism : Homo sapiensMast cells respond to acute and chronic exposure to IL-33 by differing the expression of their receptors, cytokines […]
• GSE250236 Heterogeneous expression of cell surface markers in human myeloma cell lines: implications for disease modelling and therapeutic targeting October 3, 2024
  Contributors : Kristine Misund ; Toril HolienSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis RNAseq analysis is performed as a part of the work "Heterogeneous expression of cell surface markers in human myeloma cell lines: implications for disease modelling and therapeutic targeting", where expression lev […]
• GSE237161 Transcriptomic RNA structure mapping unveils the structure dynamic induced by DHX36 binding October 3, 2024
  Series Type : OtherOrganism : Homo sapiens ; Mus musculus ; synthetic constructThis SuperSeries is composed of the SubSeries listed below.
• GSE278319 The transcriptional response of prostate cells to infection with Trichomonas vaginalis and Mycoplasma hominis October 3, 2024
  Contributors : Joshua A Kochanowsky ; Patricia J JohnsonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe sexually transmitted parasite Trichomonas vaginalis is often found in symbiosis with the obligate intracellular pathogen Mycoplasma hominis. M. hominis is itself an opportunistic pathogen of the female reproductiv […]
• GSE252687 CaClust: a probabilistic model for intraclonal heterogeneity (K4B) October 3, 2024
  Contributors : Cornelis van Bergen ; Hendrik Veelken ; Kazimierz Oksza-Orzechowski ; Ewa SzczurekSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensClones in the cancer tissue exhibit different genotypes and phenotypes, which can be linked with their evolution, future progression, and possible treatment methods. The develo […]
• GSE278360 The transcriptional response of prostate cells to Trichomonas vaginalis extracellular vehicles October 3, 2024
  Contributors : Joshua A Kochanowsky ; Patricia J JohnsonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe sexually transmitted parasite Trichomonas vaginalis secretes extracellular vesicles (TvEVs) that are internalized by human host cells. The goal of this experiment was to identify the effects of TvEV uptake on host […]
• GSE278326 Klf9 is essential for cardiac mitochondrial homeostasis October 3, 2024
  Contributors : Lei Zhang ; Menglin ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMitochondrial dynamics and mitophagy are intimately linked physiological processes that are essential for cardiac homeostasis. Here we show that cardiac Klf9 is dysregulated in human and rodent cardiomyopathy. Young adult global Klf9 […]
• GSE278579 Drosha loss drives pineoblastoma by upregulating Ccnd2 [RNA-seq of Dicer1 tumors] October 3, 2024
  Contributors : Claudette R Fraire ; Kavita Desai ; Lindsay Mendyka ; Uma Obalaparum ; Teja Sebastian ; Veena Rajaram ; Kenneth S ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMutations in the microRNA processing genes DICER1 and DROSHA drive childhood cancers such as pineoblastoma, a brain tumor that resembles und […]
• GSE278675 The neurotrophic factor MANF regulates autophagic flux and lysosome function to promote proteostasis in C. elegans October 3, 2024
  Contributors : Hartman Jessica ; Taylor Shane ; Gupta BhagwatiSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansMesencephalic astrocyte-derived neurotrophic factor (MANF) is the only neurotrophic factor to be conserved between C. elegans and humans. MANF is a unique neutrotophic factor, as it is a resident ER pr […]
• GSE278684 USP22 promotes the proliferation and inhibits Sorafenib-induced ferroptosis of hepatocellular carcinoma cells through its deubiquitinase activity October 3, 2024
  Contributor : Yijie SuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHepatocellular carcinoma (HCC) remains one of the most lethal cancers, characterized by poor prognosis and low life expectancy. Unfortunately, there are very few molecular therapeutic options available for advanced HCC. Sorafenib is a current standard […]
• GSE255908 Drosha loss drives pineoblastoma by upregulating Ccnd2 [CUT&RUN] October 3, 2024
  Contributors : Claudette R Fraire ; Kavita Desai ; Lindsay Mendyka ; Uma Obalaparum ; Teja Sebastian ; Veena Rajaram ; Kenneth S ChenSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusMutations in the microRNA processing genes DICER1 and DROSHA drive childhood cancers such as pineoblastoma, a brain tumor that […]
• GSE278118 A heterodimer of hemoglobin identifies theranostic targets on brain-metastasizing melanoma cells October 3, 2024
  Contributors : Maharrish Chelladurai ; Orit Sagi-Assif ; Shlomit Ben-Menachem ; Tsipi Meshel ; Metsada Pasmanik-Chor ; Sivan Izraely ; Dave S Hoon ; Isaac P WitzSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensInnate factors such as β-defensins may exhibit anti-cancer functions, serving as a first line of defense against […]