Healthcare updates

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE333984 OsELP3/ELP4, rice Elongator factor complex subunits, epigenetically regulates rice blast resistance June 6, 2026
  Contributors : Yanfei Wu ; Zhenshneg Qiao ; Yuquan Fu ; Zixiang Li ; Zhichao Wang ; Xuezhu Du ; Feng ShengSeries Type : Expression profiling by high throughput sequencingOrganism : Oryza sativaRice blast, caused by Magnaporthe oryzae (M.oryzae), is one of the three most devastating rice diseases, significantly reducing both yield and grain quality. The Elong […]
• GSE269233 The roles of Nudt15 in leukemic and hematopoietic stem cells June 6, 2026
  Contributor : Zhonghui ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNUDT15 encodes nucleotide triphosphate diphosphatase that is responsible for metabolizing purine analog drugs, and its genetic mutation results in severe side effects from thiopurine therapy. However, the functions of Nudt15 in leukemic stem cel […]
• GSE235016 RNA-seq revealed the anti-pyroptotic effect of suramin by suppressing NLRP3/caspase-1/GSDMD pathway in LPS-induced MH-S alveolar macrophages June 6, 2026
  Contributors : Yuhui Zhu ; Haidong ZhouSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground:Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), acting as one common sepsis-associated organ injury, induces uncontrolled and self-amplifies pulmonary inflammation. Given the lack of clinically effective […]
• GSE299019 Innate immunocompetent iNSpheroids: A hiPSC-derived 3D model to study the central nervous system captures an early CNS response to rAAV June 6, 2026
  Contributors : Catarina M Gomes ; Gabriela Silva ; Mafalda Aleixo ; Daniel Simão ; Stephan Holtkamp ; Diana D Lobo ; Pradeep Harish ; Lekh Dahal ; Rui J Nobre ; Luís P Almeida ; Mark Trautwein ; Paula M Alves ; Catarina BritoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGene therapies using adeno-associated viruses (A […]
• GSE272962 Co-transcriptional RNA processing boosts zygotic genes and restrains noncoding transcription June 6, 2026
  Contributors : Jingzhao Xu ; Xiaohua ShenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTranscription decodes protein-coding genes and interprets regulatory information embedded in the genome by generating RNA. In eukaryotes, gene transcription is coupled with RNA processing via the carboxyl terminal domain (CTD) of RN […]
• GSE299451 Cardiomyocyte-Specific Smad7 protects the pressure-overloaded heart, inhibiting the TbR1/Smad2/3 cascade [Smad7 knockout] June 6, 2026
  Contributors : Claudio Humeres ; Izabela Tuleta ; Arti V Shinde ; Anis Hanna ; Aadya Deepak ; Nikolaos G FrangogiannisSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCardiomyocytes are the major effectors of cardiac remodeling under pressure overload, undergoing hypertrophy and contractile dysfunction in response to sus […]
• GSE299267 Single cell gene expression profiling of triple negative breast cancer organoids June 6, 2026
  Contributors : Michael P East ; Jose F Olivares-Quintero ; Gary L JohnsonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTriple negative breast cancer (TNBC) is a heterogenous disease driven by aberrant activation of receptor tyrosine kinases and the proliferative MEK-ERK signaling pathway. Heterogeneity in kinase expre […]
• GSE326120 Single-cell RNA sequencing (scRNA-seq) of murine hematopoietic stem and progenitor cells (HSPCs) and mesenchymal stromal cells (MSCs) under cardiac stress induced by transverse aortic constriction. June 6, 2026
  Contributors : Manabe Ichiro ; Nakayama Yukiteru ; Goto KohsakuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe performed scRNA-seq using the 10x Genomics platform to investigate how cardiac stress influences the transcriptional profiles of murine HSPCs and MSCs. HSPCs and MSCs were isolated from bone marrow of contro […]
• GSE313448 Nynrin Sustains Leukemia Stem Cell Viability via TXNIP Destabilization to Maintain Redox Homeostasis and Confer Venetoclax Resistance [KG-1a RNA-Seq] June 6, 2026
  Contributor : Jianming WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAcute myeloid leukemia (AML) is driven by chemotherapy-resistant leukemia stem cells (LSCs), which rely on precise regulation of reactive oxygen species (ROS) for survival. We identify NYNRIN as a novel post-transcriptional regulator of LSC redox […]
• GSE326308 Bulk RNA sequencing of murine mesenchymal stromal cells (MSCs) under cardiac stress induced by transverse aortic constriction. June 6, 2026
  Contributors : Manabe Ichiro ; Nakayama Yukiteru ; Goto KohsakuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe performed bulk RNA-seq to investigate how cardiac stress influences the transcriptional profiles of murine MSCs. MSCs were isolated from bone marrow of control (sham-operated) and mice subjected to transvers […]
• GSE326121 Single-cell RNA sequencing (scRNA-seq) of murine mesenchymal stromal cells (MSCs) under cardiac stress induced by transverse aortic constriction. June 6, 2026
  Contributors : Manabe Ichiro ; Nakayama Yukiteru ; Goto KohsakuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe performed scRNA-seq using the 10x Genomics platform to investigate how cardiac stress influences the transcriptional profiles of female murine MSCs. MSCs were isolated from bone marrow of control (sham-opera […]
• GSE333495 SETDB1 regulates gene expression in mouse brown adipose tissue and primary brown adipocytes June 6, 2026
  Contributor : Qiang ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSETDB1 is a histone methyltransferase that catalyzes H3K9me3 and plays critical roles in transcriptional repression. To investigate its function in brown adipose tissue (BAT), we performed RNA-seq across three complementary models: (1) BAT tissue fr […]
• GSE333910 Transcriptomic profiling of C2C12 myotubes treated with D-galactose and red ginseng-derived interventions June 6, 2026
  Contributors : Byeong-Don Min ; Aeyung Kim ; Seokwon Kim ; No soo Kim ; Sang-Min ParkSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study investigated transcriptomic alterations in differentiated C2C12 myotubes following treatment with D-galactose and red ginseng-derived interventions. Fully differentiated C2C12 m […]
• GSE333980 Knockouts of sulfur metabolism genes induce chronic inflammation and immune dysregulation in Drosophila melanogaster June 6, 2026
  Contributors : O.G Zatsepina ; V.A Shilova ; M.B. Evgen’ev ; A.P Rezvykh ; D.G GarbuzSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterIn this study, we examined a unique collection of Drosophila melanogaster strains with knockouts of three key genes involved in H₂S synthesis and metabolism, with the aim of elu […]
• GSE300538 Generation of Tetraploid Organs in Mice [liver scRNA-seq] June 6, 2026
  Contributors : Shu Wei ; Guowei Zou ; Yanyan Zhang ; Shuaipeng Li ; Mei Hu ; Juan Du ; Jiawen Liu ; Lin Ran ; Chikai Zhou ; Jiangwei LinSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTetraploidy is rare in mammals but common in plants and fish, a phenomenon that offers evolutionary benefits. In mammals, tetraploid cell […]