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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE288738 Deciphering the impact of RAC1-SPTAN1 in ARPKD cystogenesis using multifaceted models February 9, 2026Contributors : Shohei Kuraoka ; Ryuji MorizaneSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRNAseq of kidney organoids derived from stem cells with SPTAN1 mutation and cultured under flow conditions.
- GSE289097 IRF7 Modulates Inflammatory Pain through upregulating IFNβ in mice February 9, 2026Contributors : Shilin Jia ; Lijia Mai ; Fang Huang ; Wenguo FanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusInterferon regulatory factors (IRFs) are a family of transcription factors and function primarily in the immune system, which also play critical roles in other biological processes, such as pain. To date little […]
- GSE288853 Transketolase regulates endoplasmic reticulum stress independent of its enzymatic activity in the retina February 9, 2026Contributors : Yingying Chen ; Feipeng Jiang ; Ni Han ; Xinran Wu ; Tengxiao Mao ; Meixia ZhangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusTransketolase is an enzyme in the pentose phosphate pathway, with nuclear localization and non-metabolic functions reported in various cancer and other cell types. […]
- GSE294209 Minor spliceosome inhibition via ablation of its U11 snRNA gene results in multiple defects in murine spermatogenesis February 9, 2026Contributors : Kazumasa Takemoto ; Kaitlin N Girardini ; Abigail Boria ; Jade Rosado ; Taveena Konakanchi ; Shreyesh Vachhani ; Saren Springer ; Rahul N KanadiaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMinor intron-containing genes (MIGs), which require the minor spliceosome (MiS) for their splicing, are highly re […]
- GSE289217 The alterations of gene expression profiling induced by ORM1 knockdown in HCT116 cells. February 9, 2026Contributor : Jiaqiu LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRecently, ORM1 was found to play an oncogenic role in in several cancers. Here we report gene expression profiles of HCT116 cells treated with ORM1 siRNA. This study reveals a novel role of ORM1 in downstream gene regulation and provides a new explan […]
- GSE309567 Duox-driven ROS release by glia promote regeneration in the adult Drosophila brain February 9, 2026Contributors : Carolina S Alves ; Anabel R Simões ; Carmo C Soares ; Beatriz Ferreira ; Marta Neto ; Andreia Augusto ; Christa RhinerSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterTissue damage activates immediate responses to restrict further harm and initiate repair. How injury sensing is coupled to regene […]
- GSE309480 Transcriptome sequencing study of WT iPSCs and R693Q iPSCs February 9, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensObjective: Genome-wide gene expression profiles of patient-derived R693Q iPSCs and wild-type iPSCs were compared by performing a comprehensive RNA-Seq analysis.The goals of the study was to compare the differential gene expression and possible enriched signaling pathways b […]
- GSE318326 Integrated single cell multiomic profiling and functional validation reveal distinct cellular routes to human plasma cell differentiation. February 9, 2026Contributors : Deepta Bhattacharya ; Colin FieldsSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiensUpon activation, B cells undergo profound transcriptional, epigenetic, and metabolic reprogramming to form antibody secreting plasma cells bearing little res […]
- GSE317825 MIB1-mediated H2AK119 mono-ubiquitination chromatin landscapes independent of canonical PRC1 February 9, 2026Contributors : Hyebin Park ; Sang Beom SeoSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensPolycomb repressive complex 1 (PRC1) is a central regulator of transcriptional repression through RING1B-mediated mono-ubiquitination of histone H2A at lysine 119 (H2AK119ub). Recent studies have suggested that the E3 […]
- GSE318377 Effects of Short-Wavelength Light on Retinal Cell Development February 9, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusChanges in the light environment exert a profound impact on vision; however, the specific mechanisms underlying their effects on retinal development remain poorly understood. In this study, we exposed mice to short-wavelength light from eye opening and performed single-cel […]
- GSE318418 Immunosuppressive monocytes are enriched in hepatocellular carcinoma patients with liver dysfunction in a phase II trial of combination sorafenib and nivolumab [scRNA-Seq] February 9, 2026Contributors : Bridget P Keenan ; Zenghua Fan ; Bryan Khuong Le ; Quincy Harris ; Jocelin Chen ; Matthew Clark ; Averey Lea ; Li Zhang ; Alexander Cheung ; Frances Lara ; John D Gordan ; Paige Bracci ; Spencer C Behr ; Lawrence Fong ; Alan P Venook ; Edward J Kim ; Robin K KelleySeries Type : Expression profiling by high throughput sequencingOrganism : Homo […]
- GSE318493 Sialylated CD43 forms a glyco-immune barrier that restrains anti-leukemic immunity February 9, 2026Contributors : Jooho Chung ; Mounica Vallurupalli ; Ashwin V Kammula ; Todd R Golub ; Robert T MangusoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMacrophages exert anti-tumorigenic activity through phagocytosis, but phagocytosis-enhancing therapeutics have not improved acute myeloid leukemia (AML) outcomes. To ident […]
- GSE318550 Early events in transcription and genome organization after STAG2 reconstitution in human cancer cells [Hi-C] February 9, 2026Contributors : Tianyi Yang ; Jung-Sik Kim ; Clara Mellows ; Wanying Xu ; Alvin Ya ; Lisa Sadzewicz ; Luke Tallon ; Jann Sarkaria ; Fulai Jin ; Todd WaldmanSeries Type : OtherOrganism : Homo sapiensTruncating mutations of the tumor suppressor gene STAG2, encoding a component of the chromatin-bound cohesin complex, are present in many human cancer types. Here […]
- GSE318552 Early events in transcription and genome organization after STAG2 reconstitution in human cancer cells [RNA-Seq] February 9, 2026Contributors : Tianyi Yang ; Jung-Sik Kim ; Clara Mellows ; Wanying Xu ; Alvin Ya ; Lisa Sadzewicz ; Luke Tallon ; Jann Sarkaria ; Fulai Jin ; Todd WaldmanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTruncating mutations of the tumor suppressor gene STAG2, encoding a component of the chromatin-bound cohesin complex, […]