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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE291967 Chromatin does not fully acquire the properties of post-mortem neurons during iPSCs-to-neurons differentiation. June 17, 2026Contributor : Anna D KononkovaSeries Type : OtherOrganism : Homo sapiensInduced pluripotent stem cells (iPSCs) have fundamentally advanced the field of neuroscience, offering a highly adaptable methodology for generating patient-specific neurons and modeling neurological diseases. However, a critical question remains: how accurately do iPSC-derived neurons m […]
- GSE302342 Lack of cortistatin drives neuroimmune and vascular dysfunction in brain ischemia June 17, 2026Contributors : J Castillo-González ; P Vargas-Rodríguez ; I Serrano-Martínez ; A Cuenca-Martagón ; I Forte-Lago ; M Price ; L Buscemi ; L Hirt ; J L Ruiz ; E González-ReySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIschemic stroke remains a leading cause of death and disability, with limited therapies addressing itsp […]
- GSE299461 Processing and release of the maize phytocytokine Zip1 June 17, 2026Contributors : Maurice König ; Zarah Sorger ; Melissa Mantz ; Andreas Perrar ; Carmen Castell ; Pitter Huesgen ; Simon Stael ; Johana Misas-Villamil ; Gunther DoehlemannSeries Type : Expression profiling by high throughput sequencingOrganism : Zea maysPhytocytokines are peptide signaling molecules in plant immunity. Several extracellular phytocytokines and t […]
- GSE325768 Beyond motif recognition: Specificity of human transcription factors in yeast June 17, 2026Contributors : Joshua Bugis ; Dan R Zlotnik-Weinberg ; Wajd Manadre ; Vladimir Mindel ; Yunwei Lu ; Juan I Fuxman Bass ; Naama BarkaiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Saccharomyces cerevisiaeTranscription factors (TFs) bind DNA through sequence-specific DNA-binding domains (DBDs), yet genome-wide analyse […]
- GSE311084 Single-cell RNA sequencing reveals chondrocyte heterogeneity and fibrocartilage transition in osteonecrosis of the femoral head June 17, 2026Contributors : Tun Liu ; Kai Nan ; Xiaoqian Dang ; Wei Wang ; Jidong SongSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis study investigates the role of chondrocyte heterogeneity in osteonecrosis of the femoral head (ONFH) through single-cell RNA sequencing of 50,851 chondrocytes from 10 ONFH patients and 10 control […]
- GSE272884 In vivo double knockout CAR-T screen identifies synergistic gene pairs that enhance anti-tumor immunity [crispr_screen] June 17, 2026Contributors : Paul Renauer ; Liqun Zhou ; Sidi ChenSeries Type : OtherOrganism : Homo sapiens ; synthetic constructChimeric antigen receptor (CAR) T cell therapy has revolutionized the treatment of hematological malignancies. However, its efficacy against solid tumors is hindered by multifaceted negative regulatory mechanisms intrinsic to T cells. Although […]
- GSE335569 Targeting the translation complex eIF4F disrupts BCR::ABL1 tranlstion and overcomes drug resistance in CML June 17, 2026Contributors : Ryan Yen ; Lambert Yue ; Steven Pelech ; Xiaoyan JiangSeries Type : Protein profiling by protein arrayOrganism : Mus musculusChronic myeloid leukemia (CML) is driven by the constitutively active BCR::ABL1 kinase, which promotes uncontrolled cell proliferation. While tyrosine kinase inhibitors (TKIs) such as imatinib (IM) have revolutionized CM […]
- GSE335282 Empowering macrophage to bridge innate and adaptive antitumor immunity through dual targeting of PCSK9 and innate immune checkpoint June 17, 2026Contributors : Caili Xu ; Kaicheng Zhou ; Xiaozhi Hu ; Yanyang Nan ; Yun Sun ; Zihan Dou ; Rui Zhou ; Wenjing Xue ; Qinchao Hu ; Xiting Huang ; Xianxin Hua ; Dianwen Ju ; Xuyao ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMacrophage-directed immunotherapy has emerged as a promising strategy to eliminate tumors b […]
- GSE335126 10x Genomics Xenium analysis of adult and aged mouse brain control and heat stress cohorts June 17, 2026Contributors : Roy Subhajit ; Trivedi Ayushi ; Sarkar Subham ; Kumar Ram ; Chatterjee SaurabhSeries Type : OtherOrganism : Mus musculus10x Genomics Xenium in situ targeted gene expression was performed on FFPE mouse brain tissue using the Xenium Mouse Brain Gene Expression panel (mBrain_v1.1). The staged dataset contains adult and aged cohorts with control a […]
- GSE335319 Microbiome-Derived RNA Promotes Heritable Defense Against Intracellular Pathogens in Caenorhabditis elegans June 17, 2026Contributors : Jordan D West ; Samuel A Schwartz ; Samuel Li ; Peri Roper ; Vladimir LažetićSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansIntestinal microbiota shape host immunity, but whether they can pre-activate defense against intracellular pathogens remains unclear. Here, we identify a natural microbiom […]
- GSE335283 Hemin Impairs Interferon Signaling in Periodontal Cells June 17, 2026Contributors : Xiaoyu Huang ; Panahipour Layla ; Reinhard GruberSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHemin has been shown to exert potent immunomodulatory effects in the oral microenvironment, yet its global transcriptional targets remain elusive. In this study, we performed high-throughput Bulk RNA-sequencin […]
- GSE335427 Bulk RNA-seq of male mouse endothelial cells after vehicle or LPS stimulation June 17, 2026Contributors : Molokotina Iuliia ; Ford Josh ; Byzova TatianaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study profiles transcriptional responses of male wild-type mouse endothelial cells following inflammatory stimulation with LPS relative to vehicle controls. Three independent male endothelial cell isolations […]
- GSE335432 Glial cell states bias the regeneration of neuron types across the newt life cycle June 17, 2026Contributors : Alonso Ortega Gurrola ; Mayra Kalaora ; Dreyton Amador ; Jamie Woych ; Maria Antonietta ToschesSeries Type : Expression profiling by high throughput sequencingOrganism : Pleurodeles waltlSalamanders have outstanding regenerative abilities, which tend to decline in post-metamorphic life stages. Among various tissues, these amphibians can regene […]
- GSE335434 P-SSP7 infection of Prochlorococcus MED4 under standard light, high light, and darkness June 17, 2026Contributors : Pavlo Bohutskyi ; Zachary Johnson ; Lindsey N Anderson ; Margaret CheungSeries Type : Expression profiling by high throughput sequencingOrganism : Prochlorococcus marinus subsp. pastoris str. CCMP1986Cyanophage infection outcomes depend strongly on host physiological state, yet the transcriptional dynamics of the P-SSP7–Prochlorococcus MED4 in […]
- GSE279941 Deletion of Egfr in myeloid cells counteracts an immuno-suppressive tumor microenvironment in CRC June 17, 2026Contributors : Ourania Fari ; Angelika Neuhofer ; Martin Holcmannn ; Tatiana Chontorotzea ; Iros Barozzi ; Thomas Mohr ; Bernadette Blauensteiner ; Dana Krauss ; Dario Frey ; Michaela Lang ; Barbara Helm ; Ursula Klingmüller ; Matthias Farlik ; Marina SibiliaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAnalysis of Tu […]