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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE278348 CEBPB drives endothelial pathological phenotype and promotes atherosclerosis by directly upregulating TGFBR1 expression [CUT&Tag-Seq] December 10, 2025Contributors : Cong Qiu ; Linge Fan ; Yingyi ZhuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensEndothelial cell (EC) dysfunction is crucial in chronic vascular inflammation and diseases like atherosclerosis. An unknown endothelial pathological phenotype potentially driving atherosclerosis was hinted in ou […]
- GSE267937 Parkinson’s disease-associated shifts between DNA methylation and DNA hydroxymethylation in human brain December 10, 2025Contributors : Joseph Kochmanski ; Juliana I Choza ; Mahek Virani ; Nathan C Kuhn ; Marie Adams ; Alison I BernsteinSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensThe large majority of Parkinson’s disease (PD) cases are due to a complex interaction between aging, genetics, and environmental factors and epigenetic mechanisms […]
- GSE290189 SHMT2 modulates the transcriptome and metabolism profiles to promote the tumor phenotypes of bladder cancer HT-1376 cells December 10, 2025Contributors : Xiaobo Guo ; Gang LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBladder cancer (BLCA) is a common malignant tumor of the urinary system. The development and progression of BLCA are controlled by multiple regulatory molecules, which have not been widely investigated. In this study, we explored the func […]
- GSE285878 Reproduction-associated and sex determining genes expressed differently in testes of genotypic and temperature-induced males of gibel carp (Carassius gibelio): the molecular mechanisms underlying the reproductive plasticity and invasiveness December 10, 2025Contributors : Florian Jaques ; Lukáš Vetešník ; Iva Dyková ; Andrea ŠimkováSeries Type : Expression profiling by high throughput sequencingOrganism : Carassius gibelioSex in vertebrates is commonly determined by genotype and in some cases by environmental conditions, such as temperature. A few vertebrate species display intermediate conditions of sex determ […]
- GSE297070 LOSS OF MFAP5 AND ITS EFFECT ON SKIN HOMEOSTASIS AND WOUND HEALING December 10, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMFAP5, also known as microfibrillar-associated glycoprotein-2 (MAGP2), may influence parameters of skin wound healing related to scar formation. To further elucidate its role in skin wound healing, we assessed skin wound repair in Mfap5-/- mice. Loss of MFAP5 significantly […]
- GSE293122 BCL-11 enables adaptive stress responses to environmental challenges December 10, 2025Contributors : Patrizia Niedworok ; Rossella Erminia Ciliberti ; Beijia Xie ; Amal John Mathew ; Elena De-Domenico ; Stefan Paulusch ; Marc Beyer ; Daniele BanoSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansThis study investigated the transcriptional impact of hypomorphic bcl-11 mutations.
- GSE313145 Up-regulation of an epithelial miRNA is associated with immune evasion in progressive bronchial premalignant lesions [PCGA_miRNA_BX] December 10, 2025Contributors : Boting Ning ; Darren Chiu ; Jennifer BeaneSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensBronchial premalignant lesions (PMLs), precursors of lung squamous cell carcinoma, have distinct molecular subtypes. The proliferative subtype, enriched with bronchial dysplasia, had decreased expression of an an […]
- GSE298611 Glutamine Synthetase Loss in β-Catenin-Mutant Hepatocellular Carcinoma Rewires Glutamine Metabolism to Promote Immunosuppressive Macrophage Adaptation [dataset1.Spatial.Transcriptomics] December 10, 2025Contributors : Evan R Dalgado ; Panari Patel ; Junyan Tao ; Yekaterina Krutsenko ; Silvia Liu ; Daniel Green ; Raghad Alzubali ; Brandon M Lehrich ; Jia-Jun Liu ; Tyler Yasaka ; Minakshi Poddar ; Sucha Singh ; Vik Meadows ; Aaron W Bell ; Aatur Singhi ; Satdarshan MongaSeries Type : OtherOrganism : Mus musculusRecent therapeutic strategies using immune check […]
- GSE313173 E. coli Pathobionts and Crohn’s Disease: Varied genetic paths leading to similar phenotypes December 10, 2025Contributors : Melissa Arroyo-Mendoza ; Hernan Lorenzi ; Gregory J Phillips ; Deborah M HintonSeries Type : Expression profiling by high throughput sequencingOrganism : Escherichia coli LF82Crohn’s disease (CD), an inflammatory bowel disease that arises from an immune attack of the GI tract, affects roughly 1.6 million Americans. The etiology of CD and the o […]
- GSE313146 Up-regulation of an epithelial miRNA is associated with immune evasion in progressive bronchial premalignant lesions. December 10, 2025Series Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE313176 Müller cell glutamine metabolism links photoreceptor and endothelial injury in diabetic retinopathy December 10, 2025Contributors : Katia Corano Scheri ; Yi-Wen Hsieh ; Thomas Tedeschi ; James B Hurley ; Amani A FawziSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe characterized the timeline of molecular dysfunction in diabetic retinopathy (DR) and diabetic retinal disease (DRD) by studying the streptozotocin (STZ)-induced mouse ret […]
- GSE313234 GATA6 coordinates cross‑talk between BMP10 and oxidative stress axis in pulmonary arterial hypertension December 10, 2025Contributors : Tetsuo Toyama ; Maria TrojanowskaSeries Type : Expression profiling by arrayOrganism : Homo sapiensPulmonary arterial hypertension (PAH) is a life-threatening condition characterized by a progressive increase in pulmonary vascular resistance leading to right ventricular failure and often death. Here we report that deficiency of transcription f […]
- GSE313259 Apoe3 Enhances Acetylcholine Receptor Clustering via Lrp4 December 10, 2025Contributors : James T Redden ; Sophie Kothe ; David J Cohen ; Zvi Schwartz ; Michael J McClureSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusC2C12 myoblasts were co-cultured with NSC-34 motor neurons. Both muscle cells and motor neurons were isolated and RNA collected for sequencing.
- GSE236691 CSAG1 Knock out in clone E3 from colon cancer CC14 primary culture December 10, 2025Contributors : Ariel Ruiz i Altaba ; Yann TapponnierSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn order to explore the role of CSAG1 in the metastatic potential of the highly metastatic clone E3 we knocked it out using CRISPR/Cas9 system . Here we aimed to explore the transcriptome of E3 cells on which the expressi […]
- GSE313144 Up-regulation of an epithelial miRNA is associated with immune evasion in progressive bronchial premalignant lesions [PCGA_miRNA_BR] December 10, 2025Contributors : Boting Ning ; Darren Chiu ; Jennifer BeaneSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensBronchial premalignant lesions (PMLs), precursors of lung squamous cell carcinoma, have distinct molecular subtypes. The proliferative subtype, enriched with bronchial dysplasia, had decreased expression of an an […]