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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE296559 Molecular markers of response of ENzalutamide in combination with PAClitaxel in a phase II trial for advanced or recurrent endometrioid endometrial adenocarcinoma (ENPAC) May 1, 2026Contributors : Shannon N Westin ; Anil K SoodSeries Type : OtherOrganism : Homo sapiensWe evaluated the efficacy of paclitaxel, carboplatin, and the androgen receptor (AR) inhibitor, enzalutamide, in a phase II study of advanced or recurrent endometrioid endometrial cancer and identified biomarkers associated with response to therapy. A safety lead-in study […]
- GSE297704 Cell Membrane Maintenance by PhoP is Critical for Methyylglyoxal Resistance in Mycobacterium tuberculosis May 1, 2026Contributors : Phuong M Tran ; Andrea Anaya-Sanchez ; Daisy Ji ; Mary Jackson ; Sarah A Stanley ; K H DarwinSeries Type : Expression profiling by high throughput sequencingOrganism : Mycobacterium tuberculosisThe human pathogen Mycobacterium tuberculosis primarily infects macrophages. Upon activation by IFNγ, infected macrophages produce higher levels of met […]
- GSE296908 Neuronal gap junction inhibition induces neuroprotection and partially restores visual function II May 1, 2026Contributor : Duan Peiyun The Second Xiangya Hospital of Central South UniversitySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapienshuman induced pluripotent stem cell (iPSC)–derived CNS-type neural progenitor cells (NPCs) have the potential to improve understanding of the translational significance of our finding, we also […]
- GSE263009 mTORC1-Dependent Regulation of the CCL24-CCR3 Axis Controls Granuloma Formation and Maintenance in Sarcoidosis [scRNAseq] May 1, 2026Contributors : Xiongjian X Rao ; Jinpeng J LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSarcoidosis is a chronic inflammatory disorder characterized by the presence of tiny collections of immune cells known as granulomas. An incomplete understanding of etiology and immune-pathologic pathways have limited the devel […]
- GSE211406 Retinal waves are required for state-dependent visual processing May 1, 2026Contributor : Lucas CheadleSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSpontaneous activity in the form of retinal waves propagates throughout the developing visual system during the first two weeks of life in the mouse. Here, we apply a range of approaches to the visual cortex of a unique mouse model, the Beta2fl/f […]
- GSE292838 Dlx1&2 Directly Promote Expression of Cxcl14 to Control Synapse Development and Interneuron Survival [scRNA-seq] May 1, 2026Contributors : Yurong Wang ; Alex Nord ; John Rubenstein ; Jia HuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDlx genes have fundamental roles in the generation, differentiation and functions of virtually all forebrain GABAergic neurons. Here we focused on defining the key genes that are dysregulated in Dlx1/2 condit […]
- GSE274618 The spatial architecture of pancreatic pre-invasive lesions reveal acinar metaplastic cells’ heterogeneity [scRNA-seq] May 1, 2026Contributors : Oren Parnas ; Juan S Arcila-BarreraSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn this project, we utilized single-cell RNA sequencing (scRNA-seq) and MERFISH spatial transcriptomics to profile the development of pancreatic cancer in a mouse model, tracing its progression from the pre-invasive stage t […]
- GSE329149 Transcriptomic Insights into the Adaptive Colonization of Escherichia coli O157:H7 during Production and Storage of Alfalfa Sprout May 1, 2026Contributors : Mostafa G Ali ; Ahmed E Yousef ; Ahmed G AbdelhamidSeries Type : Expression profiling by high throughput sequencingOrganism : Escherichia coli O157:H7 str. EDL933Shiga toxin-producing Escherichia coli (STEC) is a major foodborne pathogen associated with raw produce such as sprouts, where it encounters fluctuating nutrient, temperature, and oxi […]
- GSE329095 Bulk RNA-seq data from the nucleus accumbens of female and male prairie voles May 1, 2026Contributors : Mary A Allen ; Zoe DonaldsonSeries Type : Expression profiling by high throughput sequencingOrganism : Microtus ochrogasterRelationships are shaped by reciprocal interaction and feedback between individuals, where one individual acts, and the other interprets their actions to respond in turn. As relationships mature, pairs share common goals, […]
- GSE329198 PGC-1alpha pathway dysregulation disrupts myofiber specification in a mouse model of SBMA May 1, 2026Contributors : Curtis J Kuo ; Laura B Chopp ; Zhigang Yu ; Luhan Ni ; Hien T Zhao ; Janghoo Lim ; Andrew P LiebermanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSkeletal muscle pathology is a critical but poorly understood contributor to neuromuscular degeneration in spinal and bulbar muscular atrophy (SBMA), a CAG/p […]
- GSE329151 Transcriptome of mouse brain perivascular macrophages (PVM) by RNA-seq May 1, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis project includes transcriptome sequencing (RNA-seq) data of perivasccular macrophages (PVM) isolated from mouse brain. The goal is to compare the gene expression of PVM between young adult and aged mice to investigate aging-related changes.
- GSE329231 Epigenomic profiling of H3K9me3 and H3K27ac across melanoma cell lines with different mutational backgrounds May 1, 2026Contributors : Gongjie Wu ; Ferdinand KappesSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensMelanoma is a genetically and phenotypically heterogeneous cancer, and changes in chromatin state have been implicated in melanoma progression, phenotypic plasticity, and tumor behavior. To investigate the epigeneti […]
- GSE329420 Endothelial exosomes remodel chromatin accessibility and superenhancer in cancer cells to promote liver metastatic colonization May 1, 2026Contributors : Jin Bei ; Liu Shenglan ; Huang Hongke ; Yang Luo ; Wei Dong ; Dai Wei ; Zhou Jingfeng ; Wang Yun ; Zhang Ping ; Ye Qianyun ; Pan JingxuanSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensLiver-organotropic metastasis occurs in cancers such a […]
- GSE329498 Antigen-scaffolds loaded with hyper-stable Neoleukin-2/15 expand antigen-specific T cells with a favorable phenotype for adoptive cell therapy May 1, 2026Contributors : Maria Ormhøj ; Kamilla K Munk ; Siri Tvingsholm ; Keerthana Ramanathan ; Amalie K Bentzen ; Georgios Kladis ; Gitte N Aasbjerg ; Grigorii Nos ; Tripti Tamhane ; Hólmfridur R Halldórsdóttir ; Søren N Jakobsen ; Marcus S Frej ; Kristoffer H Johansen ; Mohammad Kadivar ; Sine R HadrupSeries Type : Expression profiling by high throughput sequencin […]
- GSE296186 Projections of BLAFgf2+-VMH and BLANotch2+-DMS distinctly decode visceral pain and itch May 1, 2026Contributors : Qiuying Zhao ; Yongchang Li ; Jiahe Yao ; Ruixia Weng ; Xue Xu ; Shufen Hu ; Honghong ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDistinct representation of visceral pain and itch by unique BLA neuronal ensembles and suggested that BLA as a sorting center that distinctly processes visceral pain a […]