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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE229907 Mesenchymal WNT2B is required for the maintenance of the human small intestinal epithelium April 13, 2026Contributors : Akaljot Singh ; Holly Poling ; Abid Al RezaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn this study, we compare the transcriptional patterns of tHIOs derived from a control stem cell line with those derived from a patient with Diarrhea-9. We also compare the transcriptional patterns of enteroids deri […]
- GSE276889 Mitochondria isolated from male skeletal muscle contain a small and distinct population of microRNA that are differentially expressed following acute endurance exercise April 13, 2026Contributors : Jessica Silver ; Stella Loke ; Danielle Hiam ; Larry Croft ; Megan Soria ; Soren Nielsen ; Severine Lamon ; Glenn WadleySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensInitially thought to localise at the cytosol and nucleus only, emerging evidence indicates that miRNAs also localise within the mitochondr […]
- GSE230305 Targeting CBX3 by a dual BET/PLK1 inhibitor enhances the anti-tumor efficacy of CDK4/6 inhibitors in prostate cancer April 13, 2026Contributors : Xin Jin ; Huaiyuan LiangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCastration-resistant prostate cancer (CRPC) after commencement of Androgen deprivation therapy (ADT) seriously shorten the life span of patients with prostate cancer. The BET inhibitors and CDK4/6 inhibitors have shown efficacy in pre […]
- GSE294588 Studing chemo- and immuno-resistance in non-small cell lung cancer (NSCLC) NCI-H2228 cell line April 13, 2026Contributors : Tatiana Chontorotzea ; Elisa Balmas ; Alessandro Bertero ; Simona Fontana ; Sabrina Digiovanni ; Joanna Kopecka ; Iris C Salaroglio ; Luca Alessandri ; Raffaele A Calogero ; Chiara RigantiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNon-small cell lung cancer (NSCLC) has a chemo-immuno-resistant phenot […]
- GSE281727 Gene expression analysis of Subperitoneal Fibroblast (SPF) by knockdown of Transgelin. April 13, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTransgelin expression in colorectal cancer has been reported to correlate with patient prognosis. The aim of this study was to investigate the function of Transgelin in fibroblasts of colorectal cancer. As a method, we assessed whether knockdown of Transgelin alters the ex […]
- GSE327581 Single-cell spatial transcriptomic profiling of 3xTg-AD mouse brains following fecal microbiota transplantation from stroke and healthy human donors April 13, 2026Contributors : Chetan Aware ; Carter Woods ; Pavlo Khodakivskyi ; Alok Dwivedi ; Amitai Zuckerman ; Maalavika Govindarajan ; Kira Ivanich ; Wenyan Yu ; Jiankun Cui ; Zezong Gu ; Elena Goun ; Aaron Ericsson ; Priti Balchandani ; Ai-ling LinSeries Type : OtherOrganism : Mus musculusStroke-induced gut dysbiosis has been linked to accelerated neurodegeneration, […]
- GSE294908 Evaluation of gene expressions in epididymal white adipose tissue (eWAT) of adipocyte-specific LTA4H overexpression mice. April 13, 2026Contributors : Yusei Hosokawa ; Wataru Ogawa ; Tetsuya HosookaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the alteration of eWAT gene expression in adipocyte-specific Lta4h overexpression mice(A-LTA4HOE mice), we collected the eWAT of control mice and A-LTA4HOE mice fed high-fat diet for 4 weeks or 16 […]
- GSE327304 Transcriptomic characterization of Wild type mouse Embryonic Stem Cells (mESCs), β-actin Knock out mESC and upon rescue with a nuclear localization signal β-actin April 13, 2026Contributors : Nadine Hosny El Said ; Colin Campbell ; Amani Nuairi ; Sabrina Desbordes ; Piergiorgio PercipalleSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPluripotency and lineage commitment in embryonic stem cells depend on coordinated regulation of chromatin architecture and extracellular matrix (ECM) signaling. […]
- GSE327303 Spatiotemporal transcriptomics characterizes immune microenvironment during mouse liver aging [snRNA-Seq] April 13, 2026Contributors : Jiahua Lu ; Yuqian Wang ; Wenxue Zhao ; Zihao Zhao ; Zhaoya Gao ; Jin Gu ; Cheng Li ; Jie ChengSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe liver is a major metabolic organ, responsible for synthesizing and breaking down diverse metabolites. Recently, the liver's immunological functions have g […]
- GSE327336 iCNG99: a validated genome-scale metabolic model of Cryptococcus neoformans strain H99 April 13, 2026Contributors : Chun Feng ; Pengjie Hu ; Yin Zhu ; Weixin Ke ; Xindi Gao ; Chen Ding ; Bing Zhai ; Linqi Wang ; Ziwei DaiSeries Type : Expression profiling by high throughput sequencingOrganism : Cryptococcus neoformans ; Mus musculusCryptococcus neoformans is a ubiquitous environmental fungus that can also cause life-threatening infections in immunocompromis […]
- GSE327330 PrPC-facilitated cell signaling activates phospholipase CÉ£1 and triggers an Arc/Arg3.1 response in mouse neurons and human iPSC-derived neurons April 13, 2026Contributors : Daniel Ojeda-Juarez ; Gail Funk ; Daniel B McClatchy ; Emily Richards ; Alexander J Rajic ; Katrin Soldau ; Michael D Geschwind ; Xu Chen ; John R Yates III ; Steven L Gonias ; Christina J SigurdsonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSynapse loss is an early feature of prion disease, yet the u […]
- GSE327369 Bacteria-mimicking cancer cells reprogram macrophages via multiple PRR pathways for cancer immunotherapy April 13, 2026Contributors : Seoyoon Song ; Dongjun Yu ; Haneul Kang ; Deborah Lee ; Jiye Lee ; Sungjun Kwak ; Jinhee Park ; Lifeng Kang ; Stanislav Y Emelianov ; Jong-Ho Cha ; Yun Suk Huh ; Sun Min Kim ; Tae-Joon JeonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAlthough macrophages are a powerful cell-based platform for cancer im […]
- GSE327386 RNA-Seq of paired diagnosis and relapse AML specimens with healthy controls April 13, 2026Contributors : Garrett-Bakelman Francine ; Neelamraju Yaseswini ; Dunham Nicholas ; Prajapati SubhashSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDespite therapeutic advances, acute myeloid leukemia (AML) patients remains a clinically challenging malignancy, highlighting the continued need for identification of previ […]
- GSE327397 Distantly metastatic differentiated thyroid carcinoma is kinase-driven and enriched for DNA repair and DNA methylation gene alterations April 13, 2026Contributors : Weimao Kong ; Longnv BaoSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensAlthough distant metastasis is uncommon in differentiated thyroid carcinoma (DTC), it remains the leading cause of thyroid cancer-related mortality. The genetic landscape of distantly metastatic DTC (DMDTC) has not been well characterized i […]
- GSE229606 Effect of overexpression of PPFIA1 on gene expression in HepG2 cells April 13, 2026Contributor : Yixiao LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the function PPFIA1 protein in the regulation of HepG2 cells, we established HepG2 cell lines in which PPFIA1 target gene has been overexpressed.We then performed gene expression profiling analysis using data obtained from RNA-seq of 2 […]