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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE303707 Decoding Schwann cell activation in pancreatic cancer neural invasion by mimicking nerve injury responses and using spatial transcriptomics July 25, 2026Contributors : Luju Jiang ; Shuqi Cai ; Zheqi Weng ; Zhiwei Cai ; Shan Zhang ; Shu-Heng JiangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPerineural invasion (PNI) is a critical neuropathic change in pancreatic cancer, driven by cancer-nerve interactions, where Schwann cells (SC) undergo reprogramming similar to nerv […]
- GSE339349 Physiological YAP activation alleviate ER stress to mitigate alcohol-induced liver damage by promoting ATF6 transcriptional activation July 25, 2026Contributors : Yuchen Liu ; Xiaohui Wang ; Yingzi YangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAlcohol-associated liver disease (ALD) is a major global health concern driven by chronic metabolic stress. Alcohol-induced ER stress is an early event in hepatocytes, which disrupts lipid metabolism and contributes to […]
- GSE314060 Lymphotoxin Beta Receptor Activity in Fibroblasts Regulates Collagen Synthesis and is Crucial for Lung Fibrosis July 25, 2026Contributors : Nandita Ghosh ; Rinkesh K Gupta ; Gurupreet S Sethi ; Kai Fung ; Jeamin Jung ; Ann J Balancio ; Michael CroftSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensFibroblast-specific deletion of LTβR in mice exposed to allergen significantly reduces lung collagen deposition and inflammation, despite unchanged f […]
- GSE303925 RNA-seq of HT and ST14-knockout B-cell lymphoma xenografts July 25, 2026Contributors : Yi-Lin Chiu ; Xin-Jie Lu ; Hsing-Fan LaiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis dataset presents RNA sequencing (RNA-seq) data from human B-cell lymphoma HT wild type and ST14 knockout tumors established in immunodeficient mice. The study aimed to investigate alterations in tumour biology, tr […]
- GSE339169 KRAS-Mutation Driven RASA2 Promotes Pancreatic Cancer Metastasis via TGFB2-Dependent Non-Canonical Hedgehog/GLI1 Activation [CUT&Tag] July 25, 2026Contributors : Taochen He ; Qiangda Chen ; Yanfei An ; Zhihang Xu ; Zhenlai Jiang ; Jiande Han ; Yuqi XieSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensKRAS mutations are a major driver of pancreatic ductal adenocarcinoma (PDAC), promoting tumor initiation, progression, and metastasis. RASA2, a Ras GTPase […]
- GSE338460 Immune hallmarks of recurrent immune checkpoint inhibitor-mediated inflammatory arthritis July 25, 2026Contributors : Synat Keam ; Yanshuo Chu ; Sang Taek Kim ; Roza NurievaSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensImmune checkpoint inhibitor (ICI) therapy is often associated with immune-related adverse events including inflammatory arthritis (ICI-IA). However, the mechanisms underlying ICI-IA, especially i […]
- GSE339268 PBX1 knockdown RNA-seq in HUCCT1 and RBE cells July 25, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRNA-seq was performed to profile transcriptomic changes after siRNA-mediated PBX1 knockdown in HUCCT1 and RBE human cell lines. Each cell line includes siNC and siPBX1 groups with three biological replicates per group.
- GSE339176 The Role of Brucine A in Renal Fibrosis July 25, 2026Contributor : Shuangyu LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRenal fibrosis is the common pathological basis for the progression of various chronic kidney diseases to end-stage renal disease, which is mainly manifested as renal tissue inflammatory infiltration, oxidative stress imbalance, renal tubular epith […]
- GSE339272 An Injectable ROS-Responsive Nanozyme Hydrogel Regulates the Uterine Microenvironment to Reverse Intrauterine Adhesions July 25, 2026Contributors : Peixian Cheng ; Xuemin Liu ; Xuetao Shi ; Yong FanSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusIntrauterine injury can induce a self-reinforcing vicious cycle involving inflammation, oxidative stress, and fibrosis, ultimately leading to intrauterine adhesions (IUA), which severely impair women’s r […]
- GSE339271 Genome-wide PBX1 binding profiling by CUT&Tag in HUCCT1 and RBE cells July 25, 2026Series Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensCUT&Tag was performed to profile PBX1 genomic binding landscapes in untreated HUCCT1 and RBE human cholangiocarcinoma cell lines. Three biological replicates were analyzed for each cell line using an anti-PBX1 antibody.
- GSE339287 Medin-Induced Pro-inflammatory and Prothrombotic Activation of Coronary Artery Endothelial Cells: A Potential Novel Mediator Linking Aging and Atherosclerosis July 25, 2026Contributors : Kaleb Morrow ; Nina Karamanova ; Randy Woltjer ; Victoria Krajbich ; Jingmin Shu ; Ming Li ; Chengyun Tang ; Alana Maerivoet ; Jillian Madine ; Yabing Chen ; Raymond Q MigrinoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: Age is the most important risk factor for coronary artery disease (CAD) […]
- GSE339291 Unleashed condensation by recurrent mutations of an epigenetic regulator promotes cancer July 25, 2026Contributors : Yansu Song ; Yi Hao ; Maria Latacz ; Marta Cykowiak ; Jiazheng Lin ; Hao JiangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThe pathological mechanisms and significance for the prevalent hotspot mutations in disordered protein regions are poorly understood. ASXL1 is an obligate co-factor f […]
- GSE339298 Transcriptomic profiling of ATP6AP1 knockdown in activated human hepatic stellate LX-2 cells July 25, 2026Contributor : Hanlin BaiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHepatic stellate cell activation is a major driver of extracellular matrix deposition during liver fibrosis. This study investigated the transcriptional changes induced by ATP6AP1 depletion in human hepatic stellate LX-2 cells. LX-2 cells were trans […]
- GSE339196 Transcription-dependent heterochromatin at the Xist promoter shapes the random choice of the inactive X chromosome [TX-Maged1-2tag_CutnTag] July 25, 2026Contributors : Eleni Kanata ; Ingrid Pelaez-Conde ; Gemma Noviello ; Ilona Dunkel ; Lena Milanowska ; Till Schwämmle ; Melissa Bothe ; Rutger A Gjaltema ; Edda G SchulzSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusIn female mammals, Xist, the master regulator of X-chromosome inactivation (XCI), is expres […]
- GSE339247 RNA-seq transcriptomic profiling reveals renoprotective mechanism of novel Psidium meroterpenoid derivatives (d)-G8 and (d)-G4 against cisplatin-induced acute kidney injury in human HK2 tubular epithelial cells July 25, 2026Contributors : Ying-Da Zang ; Hai-Jie Wu ; Xin-Yi Chen ; Zhi-Ling Ma ; Chuang-Jun Li ; Jie Ma ; Xiao-Guang Chen ; Li Sheng ; Sen Zhang ; Dong-Ming ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCisplatin is a first-line chemotherapeutic agent for multiple solid tumors, but its severe nephrotoxicity severely limits […]