Category: pubmed

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE298027 A Conserved NLRC5 Signaling Pathway in Developing Human Cortical Neurons is Required for Interferon Gamma Driven Changes in HLA Class I Expression and Neural Activity May 4, 2026
  Contributors : Michelle K Drews ; Jimena Andersen ; Ji-il Kim ; Melissa Stafford ; Anca M Pasca ; Sergiu P Pasca ; Carla J ShatzSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMaternal infection and inflammation are linked to increased risk of neurodevelopmental disorders. Here we show that MHC Class I molecules (human: […]
• GSE173882 ELF5 regulates epithelial integrity independently of EHF [RNA-seq] May 4, 2026
  Contributors : Hannah Swahn ; Alekh Paranjapye ; Jey S Ebron ; James Browne ; Ann HarrisSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensE74-like ETS transcription factor 5 (ELF5) is one of three epithelial ETS family transcription factors. The ELF5 gene maps to chr11p13 where it is located adjacent to another epithelial […]
• GSE329567 Transcriptomic profiling of Visceral Adipose Tissue (VAT) in a neonatal STZ-induced diabetes model: modulatory effects of Curcumin. [RNA-Seq] May 4, 2026
  Contributors : Juan Miguel Mendoza-Bello ; Yaccil Adilene Flores-Cortez ; Brenda De la Cruz-Concepción ; Monica Espinoza-RojoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusVisceral Adipose Tissue (VAT) plays a pivotal role in the systemic metabolic complications of Type 2 Diabetes, acting as a primary site for pro-infl […]
• GSE266989 NAT10-mediated mRNA N4-acetylcytidine Modifications in Mouse Oocytes Constitute a Checkpoint of Ovarian Follicle Development [NAT10-smart-seq2] May 4, 2026
  Contributors : Wenjing Wang ; Yuke Wu ; Lu Chen ; Shaoyuan Liu ; Hengyu FanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDuring mammalian follicular development, the correct establishment of the epitranscriptome in oocytes is essential for precise gene repression and the acquisition of developmental competence. N4-ace […]
• GSE231733 Bulk RNA-sequencing of A549 cells transduced with Ad5 empty vector (GFP) or Ad5 expressing SARS-CcV-2 nucleocapsid (AdN) May 4, 2026
  Contributors : Haiyun Yu ; Chaohong LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate how the abundant expression of SARS-CoV-2 nucleocapsid might change the transcriptome, A549 human lung carcinoma cells were transduced with replication-deficient recombinant human adenovirus type‐5 expressing SARS-CcV-2 […]
• GSE297264 TRMT5/NES Coordinated Activity Drives Pancreatic Cancer Growth and Metastasis [RIP-seq I] May 4, 2026
  Contributors : Carlos A Melo ; Francisco J Campos-LaborieSeries Type : OtherOrganism : Homo sapiensPancreatic cancer is a disease of urgent unmet clinical need with a 94% death rate, predicted to become the second leading cause of cancer-related death by 2030. Despite increased efforts, effective therapies have not materialised. Here, we uncover a new molecu […]
• GSE284447 Cytotoxic Tissue-Resident NK Cells Infiltrate and Control Solid Epithelial Tumor Growth [CITE-Seq] May 4, 2026
  Contributors : John B Sunwoo ; Jennifer A Foltz ; Imran MohammadSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensHuman tissue-resident natural killer (trNK) cells – broadly defined by markers of tissue-residency, such as CD49a (integrin alpha1, ITGA1) and CD103 (integrin alpha E, ITGAE) – are increasingly recogni […]
• GSE329229 Analysis of mouse livers fed with high cholesterol diet and alcohol by spatial transcriptomics May 4, 2026
  Contributors : Irina Tikhanovich ; Michael SchonfeldSeries Type : OtherOrganism : Mus musculusBackground & Aims: Alcohol-associated liver disease (ALD) heavily contributes to global alcohol related mortality. Alcohol can synergize with other causes of liver disease such as metabolic syndrome induced by western diet (high fat, high fructose, high choleste […]
• GSE329212 Epigenome and Chromatin Analyses Uncover SPATC1L-COL6A as a Novel Causal Locus in Childhood Obesity May 4, 2026
  Contributor : Josep C Jimenez-ChillaronSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensChildhood obesity is a major public health challenge, that increases the risk of comorbidities such as type 2 diabetes and cardiovascular disease, which collectively reduce life expectancy. Epigenetic mechanisms have been proposed as contri […]
• GSE329449 Tumor cells with cholangiocytic phenotype form oncogenic niches with fibroblasts in hepatocellular carcinoma May 4, 2026
  Contributors : Liwen Chiou ; Yulin Jhuang ; Zhongzhe Lin ; Chingyao Yang ; Yungming JengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: A subset of hepatocellular carcinoma (HCC) exhibits cholangiocytic features associated with aggressive behavior, poor prognosis, and treatment resistance, but the underlying […]
• GSE329416 RNAP-seq: in vitro genome-scale transcription reveals preferential RNA polymerase pausing on Clostridioides difficile antisense DNA May 4, 2026
  Contributors : Ping Shen ; Michael B Wolfe ; Xinyun CaoSeries Type : Expression profiling by high throughput sequencingOrganism : Clostridioides difficile ; Escherichia coliMechanistic dissection of gene transcription and its regulation in diverse organisms remains a central challenge for molecular biology. In vivo analyses using high-throughput DNA sequenci […]
• GSE329469 Human iPSC-Derived Cardiac Progenitor Cells Recapitulate Endogenous CPC Function and Offer a Rejuvenated Cell Source for Cardiac Regeneration May 4, 2026
  Contributors : Gowtham Reddy Cheruku ; Alia Hafiz Abbas Gasim ; Laura Deelen ; Mohammed Elbadawi ; Ken Suzuki ; Wael Awad ; Fiona Lewis-McDougallSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCardiac progenitor cells (CPCs) derived from human induced pluripotent stem cells (hiPSCs) represent a promising alternative to […]
• GSE329534 Comparative transcriptome analysis of Pantoea, Micrococcus, Pseudomonas, and Herbaspirillum under ferric chloride (FeCl3) treatment May 4, 2026
  Contributor : Hyo Jung LeeSeries Type : Expression profiling by high throughput sequencingOrganism : Herbaspirillum ; Micrococcus ; Pantoea ; PseudomonasThis study provides comparative RNA-seq datasets for four freshwater bacterial isolates, Pseudomonas sp. FBCC-B13192, Herbaspirillum sp. FBCC-B12834, Pantoea sp. FBCC-B5559, and Micrococcus sp. FBCC-B5738, c […]
• GSE329555 Transcriptomic profiling of the hypothalamus in a neonatal STZ-induced diabetes model: effects of Curcumin and Aged Garlic Extract. May 4, 2026
  Contributors : Juan Miguel Mendoza-Bello ; Yaccil Adilene Flores-Cortez ; Brenda De la Cruz-Concepcion ; Monica Espinoza-RojoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusType 2 Diabetes Mellitus (T2DM) is associated with a state of chronic low-grade inflammation that severely affects the central nervous system, parti […]
• GSE297266 TRMT5/NES Coordinated Activity Drives Pancreatic Cancer Growth and Metastasis [Ribo-seq] May 4, 2026
  Contributors : Carlos A Melo ; Francisco J Campos-LaborieSeries Type : OtherOrganism : Homo sapiensPancreatic cancer is a disease of urgent unmet clinical need with a 94% death rate, predicted to become the second leading cause of cancer-related death by 2030. Despite increased efforts, effective therapies have not materialised. Here, we uncover a new molecu […]