Category: pubmed

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE296433 Engineered probiotics limit T-cell driven CNS autoimmunity by activating AHR-KLF4-FADS3 signaling in intestinal dendritic cells May 5, 2026
  Contributors : Carolina Polonio ; Zhaorong Li ; Francisco QuintanaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDendritic cells (DCs) control the induction of effector immune responses and tolerance. The development and function of DCs is regulated by transcriptional, epigenetic and metabolic programs, but the mechani […]
• GSE241527 Osteopontin links acquired resistance to hypoxia-inducing antiangiogenics with refractoriness to anti-PD-L1 agents in breast cancer [I] May 5, 2026
  Contributors : José L Ruiz-Sepúlveda ; María Bueno ; Silvana Mouron ; Verónica Jiménez-Renard ; Manuel Muñoz ; Manuel Moradiellos ; Leonardo Garma ; Luis García-Jimeno ; Adam Watson ; Ghassan Mouneimne ; Solip Park ; Rebeca Jimeno ; Miguel Quintela-FandinoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusResistance to ant […]
• GSE329643 Host-Botrytis co-transcriptomics reveals finely tuned interactions with closely related legumes May 5, 2026
  Contributors : Anna J Muhich ; Ritu Singh ; Cloe Tom ; Celine Caseys ; Daniel J KliebensteinSeries Type : Expression profiling by high throughput sequencingOrganism : Phaseolus vulgaris ; Vigna unguiculataGeneralist pathogens infect diverse plants, yet how these interactions differ across hosts is poorly understood. Here, we conduct a molecular analysis of a […]
• GSE266553 HOXB13 expression in T47D cells in presence/absence of estradiol May 5, 2026
  Contributors : Dennis Sgroi ; Michael S Lawrence ; Preshita DaveSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHOXB13 gene expression in human ER+ breast cancer predicts the likelihood of benefit from extended adjuvant hormonal therapy benefit. However, the gene expression changes associated with ectopic HOXB13 express […]
• GSE241539 Osteopontin links acquired resistance to hypoxia-inducing antiangiogenics with refractoriness to anti-PD-L1 agents in breast cancer May 5, 2026
  Contributors : José L Ruiz-Sepúlveda ; María J Bueno ; Silvana Mouron ; Verónica Jiménez-Renard ; Manuel Muñoz ; Manuel Moradiellos ; Leonardo Garma ; Luis García-Jimeno ; Adam Watson ; Ghassan Mouneimne ; Solip Park ; Rebeca Jimeno ; Miguel Quintela-FandinoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSerie […]
• GSE290040 single-cell spatial analysis reveals molecular mechanisms underlying immune cell organization and cancer cell heterogeneity in HPV-associated oropharyngeal carcinoma May 5, 2026
  Contributors : Cem Sievers ; Clint Allen ; Charalampos FloudasSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe combined spatial gene expression profiling with single-cell RNA-sequencing to study cellular organization in HPV-associated oropharyngeal carcinoma. The single-cell RNA-sequencing portion of the study is desc […]
• GSE270920 Ketogenic regulation of histone modification by CDK4 promotes leukemogenesis [ChIP-seq] May 5, 2026
  Contributors : Jin Xu ; Guoliang Qing ; Hudan LiuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensWhile ketogenic nutrition shows promise as an adjunct to conventional cancer therapies, its efficacy varies depending on the type of cancer and its specific metabolic characteristics. How ketone bodies affect t […]
• GSE329170 MAPT-derived circTau6 induces tau pathogenesis and neurodegeneration by encoding Tau variants May 5, 2026
  Contributors : Guangtong Jiang ; Lin ShaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusImbalanced accumulation of microtubule-associated protein tau containing three or four repeat domains (3R or 4R tau species) is a core feature of tauopathies, which may result from alternative splicing of the MAPT mRNA. However, spe […]
• GSE329135 A conserved Notch-Meis1-Pbx cascade specifies secretory progenitors into spatially diverse intestinal best4+ cells May 5, 2026
  Contributors : Abhinav Sur ; Jeffrey FarrellSeries Type : Expression profiling by high throughput sequencingOrganism : Danio reriobest4+ cells are a recently described vertebrate intestinal epithelial cell type. best4+ cells are reduced in inflammatory bowel disease and transcriptionally altered in colorectal cancer, suggesting that stimulation of their home […]
• GSE329346 Trajectory-resolved human kidney organoid model defines OPFR developmental toxicity linked to adult CKD May 5, 2026
  Contributors : Chenke Xu ; Lei Xu ; Xianlei Jiang ; Cheng Xu ; Jianying HuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHuman kidneys are highly vulnerable to environmental insults from gestation into adulthood, yet causal links between fetal chemical exposure and adult chronic kidney disease (CKD) remain difficult to […]
• GSE329299 A NOTCH2 Pathogenic Variant Alters the Osteoblast and Vascular Cell Transcriptome of Mouse Femurs May 5, 2026
  Contributors : Ernesto Canalis ; Lauren Schilling ; Emily DenkerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPathogenic variants of NOTCH2 that lead to a gain or loss of function are associated with serious clinical consequences. A recently reported novel NOTCH2 4006G>C variant was associated with decreased Notch […]
• GSE329594 Targeted Degradation of SETDB1 by an Aptamer-CRBNL PROTAC as a Novel Therapeutic Strategy for Breast Cancer May 5, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPROteolysis TArgeting Chimeras (PROTACs) represent a novel therapeutic strategy that leverages the ubiquitin-proteasome system for targeted protein degradation. Aptamers, with their high specificity and binding affinity, have recently been explored as alternative recogniti […]
• GSE329609 Mouse embryo transcriptomes after two-cell blastomere separation May 5, 2026
  Contributors : Leoti Jiawei Wang ; Jingye Zhang ; Jinzhu Song ; Chuanxin Zhang ; Shiyu Liu ; Zhenzhen Hou ; Jiayin Gao ; Shuiying Ma ; Boyang Liu ; Keliang Wu ; Zijiang ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study profiled mouse preimplantation embryos by Smart-seq2 RNA-seq to assess whether separation […]
• GSE329637 NanoString nCounter Mouse PanCancer Immune Profiling of B16F10 tumors treated with DC vaccines May 5, 2026
  Contributors : Jin Muk Kang ; Seunghwan LimSeries Type : OtherOrganism : Mus musculusTo examine the effect of PROTEXI vaccination on the immunosuppressive nature of the tumor microenvironment (TME), the transcriptional signature of B16F10 tumors in the PROTEXI group with that of the control and DCTAA-vaccinated groups were compared at day 13. Total RNA was e […]
• GSE296334 NeuID is a novel neuron-specific lncRNA that regulates neuronal function in Alzheimer’s disease [ChIP-seq] May 5, 2026
  Contributors : Ranjit Pradhan ; Sadman M Sakib ; Iga Grzadzielewska ; Eren Diniz ; Dennis M Krueger ; Sophie Schroeder ; Susanne Burkhardt ; Anna-Lena Schuetz ; Jelena Radulovic ; Farahnaz Sananbenesi ; André FischerSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusNon-coding RNAs are transcripts that do not […]