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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE335537 The T-cell niche tunes immune function through modulation of the cytoskeleton and TCR-antigen forces June 20, 2026Contributors : Maya Jaffe ; Karmella A Haynes ; Anna V Kellner ; Khalid SalaitaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusObesity has become a major public health crisis given its rampant growth and association with an increased risk for cancer. Cancer patients who present with obesity tend to have increased tumor […]
- GSE271232 An Optimized Methods for Reconstruction of Transcriptional Regulatory Networks in Bacteria Using ChIP-exo and RNA-seq Datasets [RNA-seq] June 20, 2026Contributors : Minchang Jang ; Joon Y Park ; Donghyuk KimSeries Type : Expression profiling by high throughput sequencingOrganism : Escherichia coli K-12We propose an optimized protocol to reconstruct bacterial transcriptional regulatory networks (TRNs) using ChIP-exo and RNA-seq datasets. For the reconstruction of TRNs, the omics datasets were targeted to R […]
- GSE235422 Serine and glycine deprivation-induced gene expression in glioblastoma cell June 20, 2026Contributor : Jong-Ho LeeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo determine whether glioblastoma cells have altered gene expression profiles under limited serine and glycine conditions of extracellular environment.We performed gene expression profiling analysis using data obtained from RNA-seq at two condition […]
- GSE306636 Maintenance of H3K9me2 heterochromatin in the pollen vegetative nucleus requires ARID1 nuclear body formation June 20, 2026Contributors : Yi Zhao ; Lei Li ; Binglian ZhengSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Arabidopsis thalianaMature pollen contains a vegetative nucleus with decondensed chromatin and two sperm cells engulfed within the vegetative cytoplasm. Chromatin de-condensation in plants usually accompanies a decrease in […]
- GSE300407 Single-Nuclei RNA Sequencing Reveals Obesity-Driven Reprogramming of Estrogen Signaling in Endometrioid Adenocarcinoma June 20, 2026Contributors : Jessica L Long ; Sophia Agrusa ; Sworna Pukhrambam ; Sanjeev Ganesh ; Mark Gregory ; Areebah Qazi ; Myegenet Faris ; Anna Gottschlich ; Ayesha Alvero ; Charlie Fehl ; Robert T Morris ; John J Wallbillich ; Heather M Gibson ; Katherine Gurdziel ; Julie L Boerner ; Mike R WilsonSeries Type : Expression profiling by high throughput sequencingOrga […]
- GSE318716 In vivo engineering of hematopoietic stem cells by targeted lipid nanoparticles within humanized mice June 20, 2026Contributors : Jingjing Du ; Zijin Luo ; Dan Xie ; Yan Chen ; Ming Yang ; Qiang Li ; Lisha Wang ; Lu Han ; Yiming Zhang ; Haiwei Li ; Zilin Lan ; Haoping Shi ; Yinghui Li ; Qiang Cheng ; Fang Dong ; Yingdai Gao ; Yao Yao ; Tao Cheng ; Tuo Wei ; Shuquan RaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn vivo genetic e […]
- GSE311488 Chemotherapeutic Induction of Single-Stranded DNA Accumulation Sensitizes Triple-Negative Breast Cancer to Immunotherapy [scRNA-seq] June 20, 2026Contributors : Yong Du ; Shiaw-Yih LinSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDespite the widespread adoption of chemo-immunotherapy in triple-negative breast cancer (TNBC), how cytotoxic chemotherapy engages antitumor immunity remains poorly defined. Here, we identify cytosolic single-stranded DNA (ssDNA) accum […]
- GSE335460 Differentially expressed genes (DEGs) in HEK-293T cells treated with the culture supernatant of yeast-form Candida albicans June 20, 2026Contributors : Deyan Chen ; Enhui Yang ; Yajie Qian ; Xiancheng Chen ; Qin Qin ; Jing WuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe yeast-form of Candida albicansis known to secrete bioactive metabolites that modulate host cellular responses. In this study, we investigated the transcriptional impact of yeast-for […]
- GSE335431 H4R3me2a ChIP-seq in HCT116 cells June 20, 2026Series Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensChIP-seq was performed to profile H4R3me2a occupancy in HCT116 colorectal cancer cells with matched input DNA control. Libraries were sequenced as paired-end 150 bp reads on an Illumina NovaSeq 6000. Reads were aligned to GRCh38 with Bowtie2, peaks were calle […]
- GSE335485 Human-specific paralogs of SRGAP2 induce neotenic features of microglia maturation and impact synaptic development June 20, 2026Contributor : Carlos Diaz-SalazarSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusOne of the most salient features of human brain development is the considerably prolonged, neotenic, timing of synaptic development compared to other mammals including non-human primates. Microglia play key roles in shaping synaptic connect […]
- GSE335461 Differentially expressed genes (DEGs) in the corneas of Muc13 KO mice versus wild-type controls June 20, 2026Contributors : Deyan Chen ; Enhui Yang ; Yajie Qian ; Xiancheng Chen ; Qin Qin ; Jing WuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe mucosal barrier protein MUC13 plays a critical role in maintaining epithelial homeostasis, yet its function remains poorly defined. In this study, we utilized a combination of genet […]
- GSE335516 CDK7 inhibition suppresses Hippo-YAP signaling to reverse CDK4/6 inhibitor resistance in hormone receptor-positive breast cancer June 20, 2026Contributors : Chung-Jen Yu ; Chih-Yi Lin ; Yong-Ji Zhuang ; Yi-Ru Tseng ; Chun-Yu Liu ; Yi-Fang Tsai ; Chi-Cheng Huang ; Ling-Ming Tseng ; Ta-Chung Chao ; Jiun-I LaiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHormone receptor-positive (HR+) breast cancer is the most prevalent breast cancer subtype, and cyclin-depen […]
- GSE335518 CDK7 inhibition suppresses Hippo-YAP signaling to reverse CDK4/6 inhibitor resistance in hormone receptor-positive breast cancer [ChIP-seq] June 20, 2026Contributors : Chung-Jen Yu ; Chih-Yi Lin ; Yong-Ji Zhuang ; Yi-Ru Tseng ; Chun-Yu Liu ; Yi-Fang Tsai ; Chi-Cheng Huang ; Ling-Ming Tseng ; Ta-Chung Chao ; Jiun-I LaiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensHormone receptor-positive (HR+) breast cancer is the most prevalent breast cancer subtype, an […]
- GSE335535 Drug repurposing via ultra-high throughput 3D spheroids screening in rare cancer treatment June 20, 2026Contributors : Marybeth Yonk ; Hannah Nuszen ; Muhibullah Tora ; Yuhong Du ; Megan Lim ; Thais Federci ; Kimberly Hoang ; Stewart Neill ; Yilin Wang ; Yangping Li ; Bing Yao ; Nicholas Boulis ; Daniel Brat ; Kecheng LeiSeries Type : Expression profiling by high throughput sequencingOrganism : Sus scrofaRare cancers comprise over 200 distinct types accounting […]
- GSE329337 ATAD3A Limits Aortic Dissection via Mito-Lysosome Contacts and Lipoylation June 20, 2026Contributors : Jie Lin ; Shengjun Xiong ; Ying An ; Lin Wu ; Yuxin Du ; Yiran E. Li ; Yujie Wu ; Zunhui Du ; Wenjun Yu ; Junbo Ge ; Yingmei Zhang ; Jun RenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground: Aortic aneurysm and dissection (AAD) is a fatal vascular emergency with limited mechanism-based therapies. […]