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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE342610 Methylation array of cultured GBM models to create surrogate CNV profiles August 7, 2026Contributors : Bart Westerman ; Yoran Broersma ; Megan HouwelingSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensBackground: Epidermal growth factor receptor (EGFR) amplification occurs in ~50% of IDH-wildtype glioblastoma (GBM) cases, frequently accompanied by expression of the oncogenic EGFRvIII variant. Although EGFR repres […]
- GSE272424 Rejuvenating endogenous antitumor immunity via a chimeric receptor-engineered oncolytic virus targeting tumor-associated macrophages August 7, 2026Contributors : Chaolong Lin ; Shaopeng Li ; Rui Lou ; Wenzhong Teng ; Yang Tian ; Naizhen Wang ; Chenxi Feng ; Lu Li ; Xiaoxuan Huang ; Yisen Lin ; Yipeng Rao ; Jun Zhang ; Chenghao Huang ; Ningshao XiaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusImmunosuppressive tumor-associated macrophages (TAMs) create a barrier […]
- GSE249984 Androgen receptor action in mouse granulosa cells in response to LH surge August 7, 2026Contributors : Thao Dinh ; Darryl RussellSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusAndrogen receptor (AR) plays a prominent role in folliculogenesis and steroidogenesis, as well as ensuring the responsiveness to luteinising hormone (LH) surge in granulosa cells. The irregular elevation of canonical l […]
- GSE294124 Bioengineered 3D human heart valve tissues with enhanced maturational properties for disease modelling and therapeutic applications August 7, 2026Contributors : Holly K Voges ; Jessica Durrant-Whyte ; Michael See ; Serene Yeow ; Benjamin L Parker ; Kaitlyn Bibby ; Ellen Keen ; Ingrid King ; Adam T Piers ; Anita Thomas ; Daniel G Donner ; Akriti Varshney ; Natalie Charitakis ; Lina Le ; James Burgess ; Sean Humphrey ; Salvatore Pepe ; Hazem Alkazemi ; Daniel E Heath ; Fernando J Rossello ; Mirana Ramia […]
- GSE281001 The C3-C3aR axis modulates trained immunity in alveolar macrophages August 7, 2026Contributors : Alexander P Earhart ; Alberto E Lopez ; Josue I Hernandez ; Aasritha Nallapu ; Hrishikesh S KulkarniSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusComplement protein C3 is crucial for immune responses in mucosal sites like the respiratory system, where it aids in microbe elimination and enhances inflamma […]
- GSE303011 Preliminary Screening and Application of Quorum Quenching Genes Targeting the Phc System in Ralstonia solanacearum August 7, 2026Contributors : Huagui Gao ; Xiangtao ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Pseudomonas sp. HS-18The signal 3-OH-PAME produced by the phc QS system in Ralstonia solanacearum is a conserved and important quorum sensing signal molecule in this genus. This signal participates in the activation of signal transduction by th […]
- GSE299692 Chilling Accumulation Shapes Transcriptomic Responses to Warming Exposure During Grapevine Deacclimation August 7, 2026Contributors : Hongrui Wang ; Jason P. LondoSeries Type : Expression profiling by high throughput sequencingOrganism : Vitis viniferaDormancy transitions in grapevine (Vitis vinifera) buds during winter are regulated by chilling accumulation and temperature cues, but the underlying molecular mechanisms remain unclear. We conducted time-series RNA-seq on ‘Cab […]
- GSE334311 CCR10-Regulated Mucosal Immune Responses Support Restoration of Lung Tissue Homeostasis after SARS-CoV-2 infection. August 7, 2026Contributors : Juan Garcia ; Austin W Todd ; Alexei V Tumanov ; Yong Ge ; Yan Xiang ; Na XiongSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the COVID-19 pandemic. While most patients can clear the infection and recover, some develop severe […]
- GSE328496 Gene expression + ATAC profiling of trisomic hippocampal neurons upon SAHA treatment [RNA-seq] August 7, 2026Contributors : Cesar Sierra ; René A Crans ; Mara DierssenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDown syndrome (DS) is associated with widespread molecular alterations, including aberrant gene expression, which not only affects chromosome 21 genes but perturbs the whole transcriptome. The genome-wide nature of […]
- GSE342036 Acute viral infection with influenza A virus and SARS-CoV-2 accelerates the progression of ALS in SOD1G93A mice. August 7, 2026Contributor : Anna D GhevaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWhile several viral infections have been associated with amyotrophic lateral sclerosis (ALS), the mechanism(s) through which they promote disease has remained almost entirely elusive. This study investigated the impact of common, acute viral infec […]
- GSE334940 Tissue nanotransfection-mediated induction of neurogenic programs promotes myoprotective responses in denervated skeletal muscle August 7, 2026Contributors : Ana I Salazar-Puerta ; Sara Kheirkhah ; Jordan T Moore ; Carlos A Vasquez-Martinez ; Carolina Velasquez-Quintero ; Hallie Harris ; Manami Fukuda ; Megumi Fukuda ; Jonathan P Stranan ; Kavya Dathathreya ; Jared Albert ; Prameela Bobbili ; Fangli Zhao ; Charles D Wendt ; Jonathan Winograd ; Ian L Valerio ; Candice Askwith ; Amy M Moore ; William […]
- GSE342037 Targeting NCAM1/FGFR1 signaling to alleviate sleep disturbance-induced neuroinflammation in the hypothalamus August 7, 2026Contributors : Yanxiang Qu ; Bo Li ; Shixuan Yan ; Chuanjie Zhang ; Guohua Ji ; Kai Li ; Yujie Zhao ; Zuoyang Wang ; Bo Song ; Xiaopeng Li ; Lina QuSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusSleep disturbance is a prevalent public health concern linked to cognitive deficits and emotional dysregulation, yet the […]
- GSE342137 Comparison of NK cell transcriptomes between C57BL6 and NOD mouse strains August 7, 2026Contributors : Peter J Thompson ; Jasmine PipellaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNatural Killer (NK) cells are essential for surveillance of stressed, infected and malignant cells in the body. The autoimmune diabetes prone nonobese diabetic (NOD) mouse has a deficiency and dysfunction of NK cells compare […]
- GSE342321 Senescent Fibroblast-derived SASP Drives Chemotherapy-Induced Peripheral Neuropathy August 7, 2026Contributors : Taylor Malachowski ; Sheila A StewartSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHindpaw skin from mice treated with vehicle solution or PTX followed by normal or MK2i compounded chow were digested with 2mg/mL Collagenase A, 1mg/mL hyaluronidase and 2U/mL Dnase I.
- GSE304391 Global identification of ER stress-regulated RNA binding Proteins in clonal pancreatic beta-cells, reveals an important role for DEAD-box helicase 3 X-linked (DDX3X) in the execution of the Unfolded Protein Response and the determination of cell fate. August 7, 2026Contributors : Wei See ; Chutima Charoensuk ; Razan Al-Momani ; Terence P HerbertSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusEndoplasmic reticulum (ER) stress plays an important role in pancreatic β-cell dysfunction and death, contributing to both type 1 and type 2 diabetes. The Unfolded Protein Response (UPR) is a […]