Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE262204 CRISPR-free RNA Base Editing Mediated PTC-readthrough Restores Hearing in Humanized Mice with Otof Nonsense Mutation [PRAISE] October 27, 2025
  Series Type : Expression profiling by high throughput sequencingOrganism : MusToday, the gene editing for hereditary deafness is becoming a promising field with global interest. Among them, AAV-mediated otoferlin overexpression is undoubtedly the most successful representative of deaf-related gene therapy. However, it remains challenging to realize physiolog […]
• GSE266589 Endothelial SRSF1 directly regulates ATF3-KLF2 pathway to promote ischemia-induced angiogenesis October 27, 2025
  Contributors : Wenting Zhu ; Ning Xie ; Chun-Mei CaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPeripheral artery disease is a severe ischemic vascular pathology without effective pharmacological approaches and improving angiogenesis to recover blood perfusion is a promising therapeutic strategy. Endothelial cells ( […]
• GSE262206 CRISPR-free RNA Base Editing Mediated PTC-readthrough Restores Hearing in Humanized Mice with Otof Nonsense Mutation [TargetSeq] October 27, 2025
  Series Type : OtherOrganism : Homo sapiens ; MusToday, the gene editing for hereditary deafness is becoming a promising field with global interest. Among them, AAV-mediated otoferlin overexpression is undoubtedly the most successful representative of deaf-related gene therapy. However, it remains challenging to realize physiological, endogenous pattern of ot […]
• GSE275147 A catecholamine-independent pathway controlling adaptive adipocyte lipolysis October 27, 2025
  Contributors : Xiao Zhang ; Sreejith S Panicker ; Jordan M Bollinger ; Anurag Majumdar ; Rami Kheireddine ; Lila Dabill ; Clara Kim ; Brian Kleiboeker ; Fengrui Zhang ; Yongbin Chen ; Kristann L Magee ; Brian S Learman ; Adam Kepecs ; Gretchen A Meyer ; Jun Liu ; Steven A Thomas ; Irfan J Lodhi ; Ormond A MacDougald ; Erica L SchellerSeries Type : Expression […]
• GSE270723 Lack of single amino acids transcriptionally tunes sensory systems to enhance microbiota intake October 27, 2025
  Contributors : Gili Ezra-Nevo ; Silvia Henriques ; Daniel Münch ; Francisco A Patricia ; Celia Baltazar ; Ana-Paula Elias ; Bart Deplancke ; Carlos RibeiroSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterMaintaining sufficient levels of Amino acids (AAs) from the diet is essential for the organism to maintain […]
• GSE285367 Endothelial SRSF1 directly regulates ATF3-KLF2 pathway to promote ischemia-induced angiogenesis [ALP_RNA-seq] October 27, 2025
  Contributors : Wenting Zhu ; Ning Xie ; Chun-Mei CaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMechanistically, SRSF1 modulated ATF3 alternative splicing, wherein SRSF1 directly bound to ATF3 pre-mRNA and elevated full-length ATF3 transcript at the expense of truncated ATF3Δzip2 transcript, and in turn, ATF3 direct […]
• GSE279839 IG_Sickle_ExRNA1 October 27, 2025
  Contributors : Ionita Ghiran ; Moua Yang ; Vivian TranSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Mus musculusTo investigate changes in small RNA quantity in Sickle cell disease in mice versus non-diseased mice with or without carbon monoxide treatment.
• GSE293200 Regulated TRESLIN-MTBP loading governs initiation zones and replication timing in human DNA replication [RNA-Seq] October 27, 2025
  Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensReplication origins in human cells form clusters ranging from tens to hundreds of kilobases called initiation zones (IZs), typically located in intergenic regions between active genes. On a larger megabase scale, chromosomes replicate in a temporally defined replication ti […]
• GSE293198 Regulated TRESLIN-MTBP loading governs initiation zones and replication timing in human DNA replication [LD-OK-seq] October 27, 2025
  Series Type : OtherOrganism : Homo sapiensReplication origins in human cells form clusters ranging from tens to hundreds of kilobases called initiation zones (IZs), typically located in intergenic regions between active genes. On a larger megabase scale, chromosomes replicate in a temporally defined replication timing (RT) pattern, where euchromatic regions […]
• GSE305927 Multi-omics Analysis and Evidence of IL1R1 as a Potential Biomarker for Diabetes-related Intervertebral Disc Degeneration October 27, 2025
  Contributors : Meng Yi ; Shijie Liu ; Yao Zhang ; Wancheng Lin ; Lixiang DingSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study employs 10x Genomics single-cell RNA sequencing (scRNA-seq) to profile cellular changes within the intervertebral discs of diabetic mice. Diabetes mellitus is a systemic inflammatory di […]
• GSE295033 Transcriptional profiling of sensory cells of the murine gut and vagus nerve October 27, 2025
  Contributors : Robert J Lovelett ; Maja Engelstoft ; John Whang ; Maximilian G Lombardo ; Adrian Heilbut ; Shirly PintoSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusSensory cells of the gut epithelium and vagus nerve are key regulators of various physiological processes including satiety and metabolism. In thi […]
• GSE306900 C44H9.4/HZL-1 AMPK mutant dauer transcriptome October 27, 2025
  Contributors : Rashid Sabih ; Roy RichardSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansC. elegans lacking AMPK do not exhibit reproductive defects during normal growth, but when passaged through dauer, exhibit germline hyperplasia and premature spermatogenesis, followed by complete sterility post-dauer (Narb […]
• GSE309436 Identification of ALKBH5-interacting RNAs in lung cancer cells by RNA immunoprecipitation sequencing (RIP-Seq) October 27, 2025
  Contributors : Tianyu Tao ; Yi Yang ; Xianming Feng ; Bangdong Liu ; Junchao Cai ; Mengfeng LiSeries Type : OtherOrganism : Homo sapiensThis experiment was performed to identify the RNAs, particularly lncRNAs, that bind to the m6A demethylase ALKBH5 under nutrient stress. Lysates from 95D cells cultured under glucose- or glutamine-deficient conditions were s […]
• GSE309437 Identification of DAMER-interacting RNAs by RNA-RNA pulldown assay and sequencing [RNA-Seq] October 27, 2025
  Contributors : Tianyu Tao ; Yi Yang ; Xianming Feng ; Bangdong Liu ; Junchao Cai ; Mengfeng LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis experiment aimed to identify all transcripts that directly interact with the lncRNA DAMER. Full-length DAMER was transcribed in vitro and biotinylated at the 3' end. The […]
• GSE216726 Gene expression profile at single cell level of Normal Colonic Epithelial Stem Cells (NCE-SC) October 27, 2025
  Contributors : Fumihiko Kakizaki ; Hiroyuki Miyoshi ; M M TaketoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNCE-SC are inferred as a homogeneous population cultured in the eL-WRN medium (Miyoshi H, Oncotarget 2018;9(31):21950-64.). We used single-cell RNA sequencing (scRNA-seq) to confirm the homogeneity of NCE-SCs. […]