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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE279901 Gene expression profile at single cell level of endothelial cells (ECs) from the WT and Apoa1bp-/- mice adductors with femoral artery ligation (FAL) injury September 5, 2025Contributors : Yong P Bai ; Long H FangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusEstablishment of collateral circulation (CC) is crucial for the treatment of ischemic disease, such as peripheral artery disease (PAD). We performed single-cell transcriptomic analysis to explore the cellular mechanism underlying CC. […]
- GSE287172 Angel Wing: a class of alternative splicing regulators in animals September 5, 2025Contributors : YiKang Rong ; Ting Zhang ; KaiLi Li ; Ying XiaoSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterWe have discovered a novel splicing regulatory factor. When this gene is knocked out in Drosophila, the flies exhibit drooping wings, disrupted muscle structure, and numerous aberrant splicing events […]
- GSE285773 Single cell RNA profiling of blood CD4+ T cells identifies distinct helper and dysfunctional regulatory clusters in children with SLE [CD4+ T cells] September 5, 2025Contributors : Preetha Balasubramanian ; Uthra Balaji ; Jeanine Baisch ; Cynthia Smitherman ; Lynnette Walters ; Paola Sparagana ; Lorien Nassi ; Katie Stewart ; Julie Fuller ; Terry Means ; Virginia Savova ; Jacques Banchereau ; Tracey Wright ; Virginia Pascual ; Jinghua Gu ; Simone CaielliSeries Type : Expression profiling by high throughput sequencingOrga […]
- GSE212868 Murine kidneys： WT Models vs METTL3-cKO Models September 5, 2025Contributors : Zongyao Hao ; Bingbing HouSeries Type : OtherOrganism : Mus musculusMeRIP and RNA Epitranscriptomic Microarray analysis in kidneys of conditional knockout (cKO) METTL3 mice and wild type mice following glyoxylate-induced CaOx nephrocalcinosis.In METTL3-cKO mice, METTL3 subjected the specific absence from renal tubular epithelial cells. Goal wa […]
- GSE287695 DeepWheat: Predicting the Effects of Genomic Variants on Gene Expression and Regulatory Activities Across Tissues and Varieties in Wheat Using Deep Learning [ATAC-seq] September 5, 2025Contributors : Zefu Lu ; Zhigang Ma ; Jiazi Zhang ; Hongcui Pei ; Yanhong Lui ; Lei WangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Triticum aestivumAccurate prediction of genomic variant effects and gene expression is essential for identifying functional variations and enabling precise genome editing of cis-regul […]
- GSE267163 Systematic discovery of subcellular RNA patterns in the gut epithelium September 5, 2025Contributors : Minkyoung Lee ; Ilhan E Acar ; Davide Eletto ; Srivathsan Adivarahan ; Farah Mhamedi ; Kristina Handler ; Jihyun Lee ; Elena Guido Vinzoni ; Gustavo Aguilar ; Andreas E MoorSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSubcellular RNA localization is crucial for the spatio-temporal control of protein sy […]
- GSE250199 Bulk RNA-seq data of large-scale bone calluses from skeletally immature and mature mice September 5, 2025Contributors : Luciana Y de Almeida ; Daniel Martin ; Natasha Curry ; Xin Gao ; Olivier Duverger ; Janice LeeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAge and skeletal maturity impacts the capacity for bone regeneration. Using a mouse model of large-scale rib resection, we demonstrated that skeletally immature mic […]
- GSE306835 Adipose-Specific GHR Knockout Confers Multidimensional Anti-Aging Advantages via Adipose Tissue Remodeling and Enhanced Metabolic Elasticity September 5, 2025Contributors : Rui Ma ; Li-yuan Ran ; Jin-yang Geng ; Jie Liu ; Bin Liang ; Li Qiang ; Ying-jie WuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe global growth hormone receptor knockout (GHR-/-) extends lifespan but causes adverse effects. Adipose tissue serves as a critical target organ for growth hormone (GH). Rec […]
- GSE306629 Bulk RNA sequencing for various tissues using SENCR-BAC transgenic mice September 5, 2025Contributors : Qing Lyu ; Yuyan Lyu ; Songmao WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSENCR is a vascular-restricted long noncoding RNA specifically expressed in humans. To investigate its biological role in vivo, we generated a transgenic mouse line by introducing a ~220 kb genomic locus encompassing SENCR […]
- GSE307031 Comparative single-cell multiomic analysis reveals evolutionarily conserved and species-specific cellular mechanisms mediating natural retinal aging September 5, 2025Contributors : Pin Lyu ; Isabella Palazzo ; Yang Jin ; Leah J Campbell ; Clayton P Santiago ; Rogger P Carmen-Orozco ; Thanh Hoang ; Jared A Tangemen ; Alexander D Park ; Shawn H Yang ; Jianming Shao ; Rui Chen ; David Hyde ; Jiang Qian ; Seth BlackshawSeries Type : OtherOrganism : Mus musculusWe performed integrated single-cell RNA- and ATAC-Seq analyses of […]
- GSE306837 Unraveling Enteroendocrine Cell lineage dynamics and associated gene regulatory networks during intestinal development September 5, 2025Contributors : Sara Jiménez ; Florence Blot ; Aline Meunier ; Rishabh Kapoor ; Valérie Schreiber ; Colette Giethlen ; Sabitri Ghimire ; Maxime Mahe ; Nacho Molina ; Adèle De Arcangelis ; Gérard GradwohlSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusEnteroendocrine cells (EECs) are rare intestinal epithel […]
- GSE307203 Mechanistic dissection of GRHL2 and PR transcriptional co-regulation in breast cells September 5, 2025Contributors : Marleen T Aarts ; Anna Nordin ; Claudio Cantù ; Antonius L van Boxtel ; Renée van AmerongenSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThis dataset belongs to a study in which we functionally dissect the transcriptional co-regulation by grainyhead-like 2 (GRHL2) and progesterone receptor […]
- GSE307286 Combining brigatinib with mTOR inhibition to effectively treat NF2-SWN-associated and sporadic NF2-deficient meningiomas September 5, 2025Contributors : Long-Sheng Chang ; Janet L Oblinger ; Lai-Man Natalie Wu ; Cecelia Miller ; Sarah S BurnsSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe previously generated an orthotopic, NF2-deficient meningioma model using the luciferase-expressing Ben-Men-1 cell line established from a sporadic tumor and identifie […]
- GSE307290 Mechanistic Study on the Restoration of Intestinal Barrier Integrity and Alleviation of Inflammatory Bowel Disease by Rhynchophylline via the AhR-NR4A1 Pathway September 5, 2025Contributors : Xuwen Mao ; Lufeng Cheng ; Yu Liu ; Yuche WuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRestoring intestinal barrier function is considered an effective strategy for the treatment of Inflammatory Bowel Disease (IBD). Rhynchophylline (Rhy), a bioactive alkaloid sourced from the traditional herbs Uncari […]
- GSE276463 On the way to elucidate the effects of cannabidiol (CBD) on living organisms - assessment of changes in the global transcription profile of the hippocampus in a mouse model September 5, 2025Contributors : Jakub Żurowski ; Sebastian Sawicki ; Ewa Ocłoń ; Tomasz Szmatoła ; Igor Jasielczuk ; Karolina Mizera-Szpilka ; Artur GurgulSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCannabidiol (CBD) is a phytocannabinoid that has anti-inflammatory, immunomodulatory, antioxidant, anxiolytic, antipsychotic, and antic […]