Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE283112 Large-scale reorganization of DNA methylation and upregulation of extracellular matrix genes in cocaine reward-related hippocampal learning [RNA-seq] July 26, 2026
  Contributors : Madelyn Baker ; Elizabeth Brindley ; Kyle Windisch ; Anjali Rajadhyaksha ; Miklos TothSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCocaine addiction is characterized by compulsive drug use and relapse triggered by drug-related cues and contexts. Though previous research on substance use disorders has p […]
• GSE286395 A SPDYA Mutation Causes Meiotic Arrest in Non-Obstructive Azoospermia July 26, 2026
  Contributors : Huimei Zheng ; Yunbo Wang ; Xiaohang Yang ; Fan Jin ; Yongmei Xi ; Jingping LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMaturation arrest (MA) is a typical pathologic phenotype in men with Non-obstructive azoospermia (NOA), one of the most severe forms of male infertility. However, relationships bet […]
• GSE283146 Large-scale reorganization of DNA methylation and upregulation of extracellular matrix genes in cocaine reward-related hippocampal learning [RRBS] July 26, 2026
  Contributors : Madelyn Baker ; Elizabeth Brindley ; Kyle Windisch ; Anjali Rajadhyaksha ; Miklos TothSeries Type : Methylation profiling by high throughput sequencingOrganism : Mus musculusCocaine addiction is characterized by compulsive drug use and relapse triggered by drug-related cues and contexts. Though previous research on substance use disorders has […]
• GSE301653 Single-allele nanoscale mapping of regulatory variants [Micro-C] July 26, 2026
  Contributors : Joseph C Hamley ; Nicholas Denny ; James DaviesSeries Type : OtherOrganism : Homo sapiensMillions of genetic variants are linked to human disease but identifying underlying mechanisms is challenging because most variants lie within the non-coding genome. We developed a Micro Capture-C variant-to-function platform (MCCv) based on analysis of si […]
• GSE301652 Single-allele nanoscale mapping of regulatory variants [Capture-C] July 26, 2026
  Contributors : Joseph C Hamley ; James DaviesSeries Type : OtherOrganism : Homo sapiensMillions of genetic variants are linked to human disease but identifying underlying mechanisms is challenging because most variants lie within the non-coding genome. We developed a Micro Capture-C variant-to-function platform (MCCv) based on analysis of single-allele chrom […]
• GSE339419 Multi-omics profiling links epigenetic and lncRNA changes to early human endochondral ossification priming July 26, 2026
  Contributors : David Hidalgo Gil ; Paul BourgineSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiensDifferentiation programs remain incompletely understood across stem cell types, including for human bone marrow mesenchymal stromal/stem (BM-MSCs) cells, a he […]
• GSE301655 Single-allele nanoscale mapping of regulatory variants [RNA-Seq] July 26, 2026
  Contributors : Joseph C Hamley ; James DaviesSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMillions of genetic variants are linked to human disease but identifying underlying mechanisms is challenging because most variants lie within the non-coding genome. We developed a Micro Capture-C variant-to-function platform (M […]
• GSE317575 Single-allele nanoscale mapping of regulatory variants [ATAC] July 26, 2026
  Contributors : Joseph C Hamley ; James DaviesSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensMillions of genetic variants are linked to human disease but identifying underlying mechanisms is challenging because most variants lie within the non-coding genome. We developed a Micro Capture-C variant-to-functi […]
• GSE316496 Research advance on unexpected plasticity in the life cycle of Trypanosoma brucei July 26, 2026
  Contributors : Jaime N Lisack ; Anna Sophie Kreis ; Laura Hauf ; Johanna Krenzer ; Fabian Imdahl ; Markus EngstlerSeries Type : Expression profiling by high throughput sequencingOrganism : Trypanosoma brucei bruceiWe have previously shown that the slender form of Trypanosoma (T.) brucei is able to infect teneral tsetse flies, develop to the first fly form, w […]
• GSE339282 BPAF-induced inflammatory response via estrogen signaling: insights from in vivo and in vitro evidence July 26, 2026
  Contributors : Jiaying Li ; Mengjie Yu ; Xiaoyu Lu ; Junmei Xia ; Fen Lu ; Shufang Lou ; Bingli LeiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis study investigated the effects of BPAF on the indicators related to inflammatory response and explored the roles of G protein estrogen membrane receptor 1 (GPER1) in thi […]
• GSE317736 RNA-seq analysis of rat liver under drug treatment July 26, 2026
  Contributors : Hua He ; Kun Hao ; Sasa Zhang ; Hayaki H M Hamidu ; Jiaqi Sun ; Shuyu Yang ; Jianheng ZhengSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusEpimedii Folium (EF) is widely used in traditional Chinese medicine, yet its hepatotoxic risk is increasingly recognized to be highly context dependent. This stud […]
• GSE339333 CHI3L1 regulates gene methylation modifications in ovarian cancer cells July 26, 2026
  Contributor : Yaodi ShaoSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensAdipocyte-tumor interaction plays a critical role in tumor microenvironment. Typically, high-grade serous ovarian carcinoma (HGSOC) preferentially metastasizes to the omentum, an adipocyte-rich tissue, and obesity correlates with worse […]
• GSE339404 Bulk RNA sequencing of human forebrain organoids following Aβ42 treatment July 26, 2026
  Contributor : Yilin FengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHuman iPSC-derived forebrain organoids were exposed to amyloid-β42 (Aβ42) at day90 to model Alzheimer's disease-associated pathology. Bulk RNA sequencing was performed to characterize transcriptional changes induced by Aβ42 treatment. The resul […]
• GSE339408 Caloric restriction suppresses colorectal tumors and melanoma through CD8 T cells in aged mice July 26, 2026
  Contributors : Taichi Horino ; Haruki Horiguchi ; Yuichi OikeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCaloric restriction (CR) has shown the potential to extend lifespan and reduce cancer risk; however, mechanisms underlying CR-mediated tumor suppression are not fully understood. Here, we investigate age-dependen […]
• GSE273283 Synergistic Ultrasound-Activable Artificial Enzyme and Precision Gene Therapy to Suppress Redox Homeostasis and Malignant Phenotypes for Controllably Combacting Hepatocellular Carcinoma July 26, 2026
  Contributors : Yinghao Lyu ; Qian Li ; Sinan Xie ; Zhenyang Zhao ; Lang Ma ; Yunshi Cai ; Hu Liu ; Haorong He ; Kunlin Xie ; Fengwei Gao ; Ying Yang ; Pu Wu ; Kaipeng Wang ; Xinye Dai ; Tian Lan ; Hong Wu ; Chong ChengSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHepatocellular carcinoma (HCC) remains one of the most […]