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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE264672 EPOP Restricts PRC2.1 Targeting to Chromatin by Directly Modulating Enzyme Complex Dimerization (ChIP-Seq) December 12, 2025Contributors : Xiuli Liu ; Ze Yu ; Chao Xing ; Xin LiuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusPolycomb repressive complex 2 (PRC2) mediates developmental gene repression as two classes of holocomplexes, PRC2.1 and PRC2.2. EPOP is an accessory subunit specific to PRC2.1, which also contains PCL prot […]
- GSE285564 Single-cell transcriptome comparison of myeloid cells’ in the retina in response to transplantation of human stem-cell derived neurons and to ocular damage reveals the reversibility of the microglia activation. December 12, 2025Contributors : Emil Kriukov ; Anthony Mukwaya ; Milica Margeta ; Petr BaranovSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusRetinal ganglion cells (RGCs) play a critical role in the transmission of visual signals from the retina to the brain required for proper vision. The optic neuropathies, including g […]
- GSE271245 Airway epithelial hyperactivation of JAK-STAT signaling impairs type-III IFN responses during RSV infection in Down Syndrome [Bulk RNA-seq] December 12, 2025Contributors : Elizabeth Chorvinsky ; Surajit Bhattacharya ; Betelehem Solomon Bera ; Allison Welham ; Claire M Lawlor ; Diego Preciado ; Jose L Gomez ; Maria J Gutierrez ; Hiroki Morizono ; Jyoti Jaiswal ; Gustavo NinoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTrisomy 21 (TS21), commonly known as Down syndrome (DS […]
- GSE289027 DNA methylation and lncRNA expression control asynchronous DNA replication at specific imprinted gene domains [Capture Repli-seq] December 12, 2025Contributors : Yui Imaizumi ; François Charon ; Benoit Moindrot ; Daan Noordermeer ; Robert FeilSeries Type : OtherOrganism : Mus musculusBesides genome-wide patterns of replication timing (RT), some genes display allelic replication asynchrony in stem cells, brought about by stochastic events and genetic polymorphisms. Whether epigenetic modifications contr […]
- GSE287510 Gene expression analysis of HepG2 cells overexpressing TAF2 December 12, 2025Contributors : Devanand Sarkar ; Mikhail DozmorovSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTaf2 is a transcription co-factor and a member of TFIID complex. To better understand gene regulation of Taf2 we generated stable clones of HepG2 cells overexpressing either eGFP or TAF2-V5. The analysis shows that overexpre […]
- GSE302643 Tumor-associated macrophages (TAMs) with or without HRS knockdown (KD) December 12, 2025Contributors : Wenqun Zhong ; Wei GuoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo study the mechanism by which HRS regulates macrophage polarization, we performed bulk RNA sequencing on TAMs with or without HRS KD.
- GSE295225 Transcriptomic changes in human SCC-25 Parental and RARG knockout cells in response to 6h and 48h treatments with RARγ agonists CD1530 or all-trans retinoic acid (RA). December 12, 2025Contributors : Helen R Hoxie ; Xiao-Han Tang ; Lorraine J GudasSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensVitamin A (retinol) metabolism and signaling through nuclear retinoic acid receptors (RARs α,β,γ) regulate embryonic development, immune functions, and cell differentiation in most cell types. RAR gamma (RARγ) […]
- GSE313379 Discovery of Competent Chromatin Regions in Human Embryonic Stem Cells [ChIP-Seq 2] December 12, 2025Contributors : Julian Pulecio ; Danwei HuangfuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensIt remains unclear how ESCs rapidly establish enhancer regulatory elements to activate lineage-specific genes at the earliest differentiation stages. Previous studies suggest that some tissue-specific enhancers ar […]
- GSE313377 HnRNPA2B1 tunes antimycobacterial immune responses in macrophages through alternative splicing of Irgm1 December 12, 2025Contributors : Morgan J Chapman ; Jessie B Huskey ; Kaitlyn S Armijo ; Jaylen T Spellman-Reliford ; Aja K Coleman ; Cory J Mabry ; Stacy Hahn ; Robert O Watson ; Kristin L PatrickSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAlternative splicing (AS) has been implicated in host responses to diverse pathogens, but our […]
- GSE313503 NRF2 upregulation by CDDO-Me protects AC16 human cardiomyocytes against doxorubicin-induced toxicity_3. December 12, 2025Contributors : James Roberts ; Mihcael Batie ; Parveen SharmaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSequencing study was performed to elucidate the mechanisms underpinning doxorubicin-induced toxicity in human AC16 cells and the protection afforded by the NRF2 inducer CDDO-Me.
- GSE313499 Identification of Novel Regulators of LINE-1 Expression via CRISPR/Cas9 Screening December 12, 2025Contributors : Ozgur Oksuz ; Chong Chu ; Cedric Arisdakessian ; Liyang Diao ; Dennis Zaller ; Kimberly K Long ; Heike Keilhack ; Sarah KnutsonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground Long Interspersed Nuclear Elements-1 (LINE-1, L1) are transposable elements that make up roughly 17% of the human genome […]
- GSE313504 NRF2 upregulation by CDDO-Me protects AC16 human cardiomyocytes against doxorubicin-induced toxicity_1. December 12, 2025Contributors : James Roberts ; Mihcael Batie ; Parveen SharmaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensElucidation of the mechanisms underpinning doxorubicin-induced toxicity in human AC16 cells and the protection afforded by the NRF2 inducer CDDO-Me.
- GSE313524 Positional Interpretation of Cis-Regulatory Code and Nucleosome Organization with Deep Learning Models December 12, 2025Contributors : Charles McAnany ; Melanie Weilert ; Grishma Mehta ; Fahad Kamulegeya ; Jennifer Gardner ; Schreiber Jacob ; Anshul Kundaje ; Julia ZeitlingerSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Saccharomyces cerevisiaeSequence-to-function neural networks learn cis-regulatory sequence rules driving many types […]
- GSE313552 NRF2 upregulation by CDDO-Me protects AC16 human cardiomyocytes against doxorubicin-induced toxicity_2. December 12, 2025Contributors : James Roberts ; Mihcael Batie ; Parveen SharmaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSequencing study was performed to elucidate the mechanisms underpinning doxorubicin-induced toxicity in human AC16 cells and the protection afforded by the NRF2 inducer CDDO-Me.
- GSE220752 Transcriptome of the liver tissue from Hyal1-knock out mice December 12, 2025Contributors : Xi Chen ; Michelle Dias ; Hari Yalamanchili ; Yi ZhuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHyaluronidase-1 (Hyal1) is a lysosomal hyaluronidase that intracellularly hydrolyzes hyaluronan. The analysis of Hyal1's roles in hepatic gluconeogenesis from standard and obese conditions benefits fro […]