Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE299692 Chilling Accumulation Shapes Transcriptomic Responses to Warming Exposure During Grapevine Deacclimation August 7, 2026
  Contributors : Hongrui Wang ; Jason P. LondoSeries Type : Expression profiling by high throughput sequencingOrganism : Vitis viniferaDormancy transitions in grapevine (Vitis vinifera) buds during winter are regulated by chilling accumulation and temperature cues, but the underlying molecular mechanisms remain unclear. We conducted time-series RNA-seq on ‘Cab […]
• GSE291477 Decaying and expanding Erk gradients process memory of skeletal size during zebrafish fin regeneration [Fin tip] August 7, 2026
  Contributors : Ashley Rich ; Ziqi Lu ; Alessandro De Simone ; Lucas Garcia ; Jacqueline Janssen ; Kazunori Ando ; Jianhong Ou ; Massimo Vergassola ; Kenneth D Poss ; Stefano Di TaliaSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioRegeneration of amputated salamander limbs or fish fins restores pre-injury size, illustrati […]
• GSE304862 Semaglutide and exercise synergy in obesity: preserving muscle mass and uncovering organ crosstalk August 7, 2026
  Contributors : José A Inia ; Simone Droog ; Jessica Snabel ; Aswin L Menke ; Martien P Caspers ; Jelle C de Jong ; J W Jukema ; Hans M Princen ; Anita M van den HoekSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground and aims: The glucagon-like peptide-1 receptor agonist semaglutide is an antidiabetic medication […]
• GSE301351 The single-cell transcriptome defines an effector Vd1 gd T cell-dependent anti-tumor immunity in human gastrointestinal stromal tumor (GIST) [10X] August 7, 2026
  Contributors : Shan Zeng ; Jonathan H Sussman ; Yuntian Fu ; Juan Esteban Perez ; Jiazhen Rong ; Katherine Tardy ; Hyunjee Kwak ; Taylor Hartlein ; Kevin Do ; Ferdinando Rossi ; Jennifer Q Zhang ; Ronald P DeMatteoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGamma-delta (gd) T cells bridge innate and adaptive immunit […]
• GSE316989 Targeting CDK12/CYCLIN K induces a gene activation program which is mediated by P-TEFb [Cut&RUN] August 7, 2026
  Contributors : Praveenkumar Murugavelu ; Jagrity Rani ; Heli Glebko ; Nili Tickotsky ; Liron Levin ; Alona Kuzmina ; Ran TaubeSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensRegulation of transcription in human cells is a multistep process controlled by coordinated actions of host transcription factors and […]
• GSE308077 Profiling the RNA-Binding Proteome of KSHV-Infected Cells Uncovers a Viral Strategy for Hijacking Host Signaling via RNA-Dependent Interactions. August 7, 2026
  Contributors : Xiang Ye ; Ruilin Zhang ; Hayes McDonald ; John KarijolichSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensViruses encode RNA-binding proteins (RBPs) to manipulate host processes and promote infection. However, due to limited genomic space, many viral proteins are multifunctional and may engage RNA through […]
• GSE342363 Multi-platform reassessment of human mitochondrial DNA methylation reveals signals consistent with technical artifacts August 7, 2026
  Contributor : Sagi AbelsonSeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensThe existence and functional relevance of mitochondrial DNA methylation remain controversial. Here, we systematically profiled cytosine methylation and hydroxymethylation across human brain and blood tissues spanning healthy and malignant states […]
• GSE318107 CAD-C: An engineered nuclease enables repair-free in situ proximity ligation and nucleosome-resolution chromosome walks in human cells [Cut & Tag] August 7, 2026
  Series Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensChromosome conformation capture (3C)-derived methods have become an indispensable tool in the study of gene regulation. The three-dimensional contacts can probe depend strongly on the properties of the enzyme used to fragment chromatin prior to proximity-driv […]
• GSE342610 Methylation array of cultured GBM models to create surrogate CNV profiles August 7, 2026
  Contributors : Bart Westerman ; Yoran Broersma ; Megan HouwelingSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensBackground: Epidermal growth factor receptor (EGFR) amplification occurs in ~50% of IDH-wildtype glioblastoma (GBM) cases, frequently accompanied by expression of the oncogenic EGFRvIII variant. Although EGFR repres […]
• GSE342540 Store-operated calcium signaling modulators improve a dendritic cell-based vaccine against melanoma August 7, 2026
  Contributors : María Cruz Cobo ; Laure Garnier ; Marion Mandavit ; Maral Azam ; Isabelle Dentand Quadri ; Julien Angelillo ; Dale Brighouse ; Mathilde Bausart ; Valérie Dutoit ; Achille Schild ; Valeria M Oliva ; Martin Lochner ; Bénédicte Manoury ; Stéphanie Hugues ; Paula Nunes-HaslerSeries Type : Expression profiling by high throughput sequencingOrganism […]
• GSE342640 Insulin resistance is associated with mammary mitochondrial dysfunction at the onset of human lactation August 7, 2026
  Contributors : Xin Meng ; Taha Elajnaf ; Hussam Rostom ; Michelle Ma ; Annalee Furst ; Bryony Davies ; Isabella R Honess ; Gaurav Pandey ; Isadora C Furigo ; Craig L Doig ; Jayne F Martin Carli ; Rajesh V Thakker ; Lars Bode ; Kelsey E Johnson ; Fadil M HannanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus muscul […]
• GSE342790 Development-inspired approach for the derivation of functional and transplantable salivary gland organoids from human pluripotent stem cells [RNA-Seq] August 7, 2026
  Contributors : Sai Harsha Bhamidipati ; Laura Sherwood ; Stylianos Andreadis ; Ronel Z SamuelSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSalivary gland (SG) hypofunction significantly affects the life quality of patients with hyposalivation. Current treatment options for these conditions are limited and often result […]
• GSE342791 Development-inspired approach for the derivation of functional and transplantable salivary gland organoids from human pluripotent stem cells [scRNA-Seq] August 7, 2026
  Contributors : Sai Harsha Bhamidipati ; Laura Sherwood ; Ronel Z Samuel ; Stylianos AndreadisSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSalivary gland (SG) hypofunction significantly affects the life quality of patients with hyposalivation. Current treatment options for these conditions are limited and often result […]
• GSE272424 Rejuvenating endogenous antitumor immunity via a chimeric receptor-engineered oncolytic virus targeting tumor-associated macrophages August 7, 2026
  Contributors : Chaolong Lin ; Shaopeng Li ; Rui Lou ; Wenzhong Teng ; Yang Tian ; Naizhen Wang ; Chenxi Feng ; Lu Li ; Xiaoxuan Huang ; Yisen Lin ; Yipeng Rao ; Jun Zhang ; Chenghao Huang ; Ningshao XiaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusImmunosuppressive tumor-associated macrophages (TAMs) create a barrier […]
• GSE342321 Senescent Fibroblast-derived SASP Drives Chemotherapy-Induced Peripheral Neuropathy August 7, 2026
  Contributors : Taylor Malachowski ; Sheila A StewartSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHindpaw skin from mice treated with vehicle solution or PTX followed by normal or MK2i compounded chow were digested with 2mg/mL Collagenase A, 1mg/mL hyaluronidase and 2U/mL Dnase I.