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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE294759 Application of spatial transcriptomics across organoids for a high-resolution spatial whole-transcriptome benchmarking dataset April 8, 2026Contributors : Maria Rosaria Nucera ; Natalie Charitakis ; Ryan F Leung ; Anna Leichter ; Natasha Tuano ; Marzena Walkiewicz ; Vallari Sawant ; Lynn Rowley ; Michelle Scurr ; Pei X Er ; Ker S Tan ; Rebecca Sutton ; Feroz Ahmad ; Ritika Saxena ; Alexander Maytum ; Declan L Turner ; Holly K Voges ; Hieu T Nim ; Kira X Sun ; Bicheng Yang ; Nick L Li ; Gareth Ba […]
- GSE295473 Polycomb Chromatin Topology Enables Long-Range Enhancer Recruitment during Craniofacial Development [PCHi-C] April 8, 2026Contributors : Yousra Ben Zouari ; Onkar Joshi ; Adwait Salvi ; Sandra Kessler ; Sebastien Ducret ; Fiona Ross ; Sojoerd J.B. Holwerda ; Nathalie Vilain ; Soujanya Mamilla-Sanivaram ; Sebastien Smallwood ; Hubertus Kohler ; Michael B Stadler ; Maryline Minoux ; Filippo M RijliSeries Type : OtherOrganism : Mus musculusLittle is known about how three-dimension […]
- GSE295406 Polycomb Chromatin Topology Enables Long-Range Enhancer Recruitment during Craniofacial Development [RNA-seq] April 8, 2026Contributors : Yousra Ben Zouari ; Onkar Joshi ; Adwait Salvi ; Sandra Kessler ; Sebastien Ducret ; Fiona Ross ; Sojoerd J Holwerda ; Nathalie Vilain ; Soujanya Mamilla-Sanivaram ; Sebastien Smallwood ; Hubertus Kohler ; Michael B Stadler ; Maryline Minoux ; Filippo M RijliSeries Type : Expression profiling by high throughput sequencingOrganism : Mus muscul […]
- GSE301736 Circulating Epigenetic Signatures Classifying Brain Insulin Resistance in humans [2] April 8, 2026Contributors : Stephanie Kullmann ; Amandeep Singh ; Britta Wilms ; Markus Jähnert ; Svenja Meyhöfer ; Hubert Preissl ; Martin Heni ; Andreas L Birkenfeld ; Annette Schürmann ; Meriem OuniSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensBrain insulin action plays an important role in metabolic and cognitive health but so far, […]
- GSE299213 Small regulatory RNAs modulate Lactococcal susceptibility to cell wall-targeting antimicrobials April 8, 2026Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Lactococcus cremoris subsp. cremoris MG1363This SuperSeries is composed of the SubSeries listed below.
- GSE327098 EZH2 Blockade Reverses Doxorubicin Resistance by Disrupting Metabolic and DNA Repair Networks in Breast Cancer April 8, 2026Contributors : Xiaomin Wang ; Yunxiao Mai ; Yuhang Ding ; Wenlong ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: Doxorubicin (DOX) resistance remains a major obstacle to effective chemotherapy in breast cancer. However, the pharmacologically actionable regulators sustaining this resistant phenotype and […]
- GSE304277 Alternative End-Joining Activation by miR-21-5p Confers Radiation Resistance in Oral Squamous Cell Carcinoma [RNA-seq of SCC7 mice tumors] April 8, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMarked heterogeneity in radiosensitivity is a major challenge in the treatment of oral squamous cell carcinoma (OSCC), often resulting in poor outcomes for radioresistant tumors. The underlying molecular drivers of this resistance remain elusive. Here, we identify a novel […]
- GSE326942 Spatial transcriptomics links hippocampal synaptic remodeling to microglial phagocytosis in synucleinopathy April 8, 2026Contributors : Min-Tae Jeon ; Jisu Jeong ; Moonseok Choi ; Suhyeon Son ; Wonjin Yang ; Mookyung Cheon ; Do-Geun KimSeries Type : OtherOrganism : Mus musculusSynucleinopathies, including Parkinson’s disease and Lewy body dementia, show region-specific vulnerability across the brain, but the molecular basis of selective regional involvement remains incompletel […]
- GSE326921 The chromatin assembly factor CHAF1b functions as an epigenetic amplifier of RORγt to promote Th17 pathogenicity and autoimmunity April 8, 2026Contributors : Xinyu Li ; Achun Chen ; Kang Cao ; Peiming Huang ; Minghua Chen ; Jianteng Zeng ; Jingjing Luo ; Xin He ; Shuangxin Wu ; Nan Zhou ; Hui Zhang ; Ting PanSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusTh17 cells are double-edged regulators […]
- GSE326968 Spatial transcriptomics of IRF7-dependent pathway in chronic lung allograft dysfunction April 8, 2026Contributors : Banday Mudassir ; Rahman Mizanur ; Goda Yasufumi ; Naito Tatsuhiko ; Potter Andrew ; Mallidi Haripriya ; Surolia Ranu ; Lee Stefi ; Rehman Rakshinda ; Loor Gabriel ; Hayes Don ; Sharma NirmalSeries Type : OtherOrganism : Homo sapiensChronic lung allograft dysfunction (CLAD) remains a major barrier to long-term survival after lung transplantati […]
- GSE326953 FGF23 partial agonism improves rhabdomyolysis-induced acute kidney injury April 8, 2026Contributors : Zhongqian Jin ; Shengnan Zhao ; Kai Zhao ; Shuixin Li ; Fulai Huang ; Kaifeng Chen ; Yixiong Wang ; Lvhua Ai ; Jiru Wu ; Bojun Li ; Lili Fu ; Moosa Mohammadi ; Gaozhi ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusOverexpression of FGF23R176Q/R179Q can improve AKI by inhibiting apoptosis.
- GSE327055 LncRNA Gas5 directs SUV39H2 to establish heterochromatin and maintain genome stability April 8, 2026Contributors : Juntao Liu ; Jiani YangSeries Type : Other ; Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusConstitutive heterochromatin, characterized by histone H3 lysine 9 trimethylation (H3K9me3), is essential for genome stability, pluripotency, and developmental […]
- GSE327064 Metabolic and Transcriptional alterations in Candida auris during Interaction with Pseudomonas aeruginosa April 8, 2026Contributors : Aliz Bozó ; Ágnes Jakab ; Andrea Harmath ; Ágota Ragyák ; Zoltán Tóth ; Andrew M Borman ; Fruzsina Kovács ; Noémi Balla ; Bence Balázs ; László Majoros ; Renátó KovácsSeries Type : Expression profiling by high throughput sequencingOrganism : Candidozyma aurisPolymicrobial bacterial–fungal infections are increasingly recognized as significant c […]
- GSE327065 Persistent Methylmalonate Overload Despite Glycemic Control Drives Mitochondrial Dyshomeostasis and Subclinical Heart Damage in Diabetes April 8, 2026Contributor : Shanjie WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackgroundHeart failure burden is still considerable in diabetes patients despite optimal glycemic control. Metabolic remodeling is involved in this process, but current understanding is still in its infancy. Methylmalonic acid (MMA) is a diagnost […]
- GSE284348 Generation of Stable Chambered Cardioids from human Pluripotent Stem Cells April 8, 2026Contributors : XINLE ZOU ; FANWEN WANG ; HUILING ZHENG ; TIANCI KONGSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe human heart is a vital organ under intense investigation for the hope to improve health and longevity. Recent advances to generate cardiac organoids (cardioids) provide unprecedented opportunities to c […]