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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE297780 Chronic Salmonella Infection Impairs Hematopoietic Stem Cell Transplant Potency Transiently May 7, 2026Contributors : Erez Elfassy ; Omri Koren ; Pasha Likhterov ; Ofir Cohen ; Roi GazitSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHematopoietic stem cells (HSCs) are essential for maintaining blood and immune cell production by balancing self-renewal and differentiation. Typically residing in a quiescent state in the b […]
- GSE305103 RNA-seq of liver, kidney, and quadriceps muscle from corylin-treated and control C57BL/6J mice May 7, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo elucidate the transcriptional mechanisms underlying longevity and sex-specific responses to pharmacological intervention, we performed RNA sequencing on liver, kidney, and quadriceps muscle tissues from male and female C57BL/6J mice subjected to long-term dietary admini […]
- GSE303184 Transcriptomic profiling of Pseudomonas aeruginosa wild-type and ΔlasB strains exposed to host-mimicking conditions May 7, 2026Contributors : Youssouf Sereme ; Delphine Beury ; Florence Maurier ; Ségolène Caboche ; David Hot ; Jean-Michel SallenaveSeries Type : Expression profiling by high throughput sequencingOrganism : Pseudomonas aeruginosa PAO1We performed stranded bulk RNA-seq to compare the transcriptomic response of Pseudomonas aeruginosa wild-type and ΔlasB mutant strains ex […]
- GSE281700 Disease correlation mapping based discovery of 2-methoxyestradiol as an endogenous ligand of the orphan nuclear receptor Nur77 May 7, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIdentifying endogenous ligands for orphan nuclear receptors is pivotal for understanding their roles in disease pathogenesis. In this study, we introduce DCM-Endo, a novel computational tool employing a deep clustering algorithm to analyze disease correlations from PubMed […]
- GSE233321 Single-cell map of the healthy human immune system across the lifespan reveals unique infant immune signatures May 7, 2026Contributors : Djamel Nehar-Belaid ; Asa Thibodeau ; George Kuchel ; Octavio Ramilo ; Jacques Banchereau ; Duygu UcarSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThe human immune system undergoes dynamic remodeling from infancy through old age. We pro […]
- GSE293072 Pioneer factors orchestrate tissue-specific cohesin-NIPBL chromatin entry and 3D genome organization [ATAC-seq] May 7, 2026Contributors : Haiyang Guo ; Song Wang ; Tianwei Jia ; Xianglin ZhangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensCohesin complex shapes 3D genome organization by extruding DNA loops, yet the mechanisms underlying its chromatin entry remain poorly understood. Here, we reveal that the cohesin loader NIPB […]
- GSE292054 Local glycan engineering induces systemic antitumor immune reactions via antigen cross-presentation May 7, 2026Contributors : Natalia Mantuano ; Michael T Sandholzer ; Heinz LäubliSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusThe advent of immune checkpoint inhibition (ICI) has revolutionized cancer treatment, yet response rates remain modest, and mechanisms of resistance are poorly understood. Recent studies highlight […]
- GSE329776 Bulk RNA-sequencing of the dorsal and ventral hippocampus across age and parity in female rats May 7, 2026Contributors : Andrew J McGovern ; Paula Duarte-Guterman ; Liisa A GaleaSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusThe hippocampus undergoes extensive cellular remodelling throughout life. Aging affects hippocampal structure, contributing to cognitive decline and neurodegenerative disease risk. Parity, as the […]
- GSE329627 Mutation of RNA polymerase sigma factor (RpoD) confers broad‑spectrum antimicrobial tolerance through global transcriptional reprogramming May 7, 2026Contributors : Shouqiang Hong ; Jingwen Yang ; Xilin ZhaoSeries Type : Expression profiling by high throughput sequencingOrganism : Escherichia coli K-12The extensive use of antimicrobials has driven the emergence of multidrug‑resistant strains, posing a serious threat to public health. Less obvious is the problem of tolerance, a situation in which antimicro […]
- GSE329824 A novel selective strategy for bioactive limbal stem cells primary culture using deep-cryopreservation and IL-1β precondition May 7, 2026Contributors : Yinglin Liu ; Liling Xu ; Yanmei Li ; Cheng Lu ; Zepei Fan ; Jun Ling ; Yingwei Wang ; Zheng WuSeries Type : Expression profiling by high throughput sequencingOrganism : Oryctolagus cuniculusBy combining cryogenic preservation with IL-1β induction, we established an optimized approach that yields LSCs with a higher stem cell proportion and enh […]
- GSE329809 The Effect of Weight Loss on Metabolic Processes of the Abdominal Subcutaneous Adipose Tissue: An Exploratory Study using total RNA Next Generation Sequencing May 7, 2026Contributor : Tom A HuyghebaertSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensObesity induces profound alterations in adipose tissue biology, yet the extent to which these transcriptional changes resolve after weight loss remains unclear. This exploratory study investigated molecular remodeling of abdominal subcutaneou […]
- GSE329858 Mutant IDH1 blocks neutropoiesis by repressing myeloid progenitor programs [ATAC-seq] May 7, 2026Contributors : Mariam Hakobyan ; Daniel B LipkaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusIDH1 and IDH2 are frequently mutated in various cancers, including acute leukemias. However, the distinct mechanisms by which mutant IDH1 or IDH2 drive hematopoietic neoplasms remain poorly understood. Here, we a […]
- GSE329878 Mutant IDH1 blocks neutropoiesis by repressing myeloid progenitor programs [bulk RNA-Seq] May 7, 2026Contributors : Mariam Hakobyan ; Jens Langstein ; Daniel B LipkaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIDH1 and IDH2 are frequently mutated in various cancers, including acute leukemias. However, the distinct mechanisms by which mutant IDH1 or IDH2 drive hematopoietic neoplasms remain poorly understood. Here, w […]
- GSE329880 Mutant IDH1 blocks neutropoiesis by repressing myeloid progenitor programs [Nanopore sequencing] May 7, 2026Contributors : Mariam Hakobyan ; Melissa Türe ; Maximilian Schönung ; Daniel B LipkaSeries Type : OtherOrganism : Mus musculusIDH1 and IDH2 are frequently mutated in various cancers, including acute leukemias. However, the distinct mechanisms by which mutant IDH1 or IDH2 drive hematopoietic neoplasms remain poorly understood. Here, we analyzed DNA methylatio […]
- GSE296489 Clinical Phenotype and Genetic Analysis of a Family with 17q12 Microdeletion Syndrome May 7, 2026Contributors : Yongxue Lyu ; Wei Jin ; Qi Jiang ; Zhenghua FeiSeries Type : Genome variation profiling by SNP array ; SNP genotyping by SNP arrayOrganism : Homo sapiensTo clarify the genetic etiology of a 17q12 microdeletion syndrome fetus in a family and analyze the correlation between the genetic and clinical phenotypes within the family.The child and […]