Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE309283 Changes in tRNA wobble modifications under a norepinephrine gradient coincide with codon-biased translation and induction of virulence in EHEC O157:H7 April 17, 2026
  Contributors : Abigail McShane ; Peter DedonSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Escherichia coliThe goal of this study was to investigate how Enterohemorrhagic Escherichia coli O157:H7 (EHEC) strain EDL933 remodels its tRNA pool in response to the catecholamine hormone norepinephrine, a host-derived cue that stimula […]
• GSE295327 The role of miR-10b-5p/Brain-derived Neurotrophic Factor Axis Deregulation in Poststroke Epileptogenesis April 17, 2026
  Contributors : Anna R Tröscher ; Rainer Dormann ; Joachim Gruber ; Mariia Ragozina ; David Demmel ; Daniel Wallinger ; Franziska Ammer-Pickhardt ; Raimund Helbok ; Tim von ÖrtzenSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensObjective: Poststroke epilepsy (PSE) is a common complication following stroke, associated […]
• GSE315844 EBNA1 inhibitors reveal CDC7 and POU2F1 as direct functional targets in EBV epithelial cancers [ChIP-Seq] April 17, 2026
  Contributors : Songtao HE ; Niseno Terhuja ; Bhanu Chandra Karisetty ; Paul LiebermanSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensEpstein-Barr virus (EBV) latent infection is ubiquitously associated with nasopharyngeal carcinoma and gastric cancer, expressing very few viral protein components (EBNA1 and […]
• GSE311383 High-resolution spatial transcriptomics of human liver with VisiumHD April 17, 2026
  Contributors : Faizan Hasan ; Rachel D Edgar ; Gary D Bader ; Sonya A MacParlandSeries Type : OtherOrganism : Homo sapiensThe liver plays a critical role in metabolism and immune function. These crucial functions are diminished in chronic liver diseases, leading to over two million deaths annually worldwide due to liver failure. Single-cell transcriptomics h […]
• GSE281938 Porphyromonas gingivalis inhibits Respiratory Syncytial Virus infection while suppressing anti-viral immunity April 17, 2026
  Contributors : Carlos J Rodriguez-Hernandez ; Phylip Chen ; Marina Terekhova ; John D Perpich ; Barbara Potempa ; Mark E Peeples ; Mitchell H Grayson ; Jan Potempa ; Maxim N Artyomov ; Richard J Lamont ; Juhi BagaitkarSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensColonizing microbiota can differentially impact the out […]
• GSE317310 scRNA-seq of bone marrow and splenic emergency granulopoiesis April 17, 2026
  Contributors : Carlos Silvestre-Roig ; Raphael Chevre ; Alexander BenderSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusWe performed scRNA-seq analysis using the 10X genomics platform of mice following a model of extramedullary hematopoiesis or control. Here, we isolated bone marrow, spleen and blood Gr1+and cKi […]
• GSE327665 Ustekinumab Resistance in Individuals with Ulcerative Colitis is Associated with an Alteration of a Subset of Pro-inflammatory Mucosal Regulatory T cells April 17, 2026
  Contributor : Kristi BriggsSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground & Aims: Ustekinumab is a monoclonal antibody therapy targeting interleukin 12 and 23 for the treatment of inflammatory bowel diseases, including ulcerative colitis (UC). While these pathways remain quite attractive for UC therapy, […]
• GSE290636 RNAseq analysis of blood specimens from ART-suppressed people with HIV prior to analytical treatment interruption April 17, 2026
  Contributors : Tongcui Ma ; Mauricio Montano ; Yusuke Matsui ; Reuben Thomas ; Warner C Greene ; Nadia R RoanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBlood from ART-suppressed people with HIV (PWH) were characterized by bulk RNAseq analysis of total PBMCs, or of purified CD4+ T cells from PBMCs. Specimens were ob […]
• GSE327756 TET2-mutant clonal hematopoiesis prevents T-cell exhaustion and suppresses cancer metastasis April 17, 2026
  Contributors : Ai-Nhan T Le ; Mamiko Sakata-Yanagimoto ; Robert J Vanner ; Miura Fumihito ; Hiromitsu Araki ; Tran B NguyenSeries Type : Methylation profiling by high throughput sequencingOrganism : Mus musculusTET2-mutant clonal hematopoiesis (CH) is associated with reduced cancer metastasis in human cohorts. Whole genome bisulfite sequencing (WGBS) of PD-1 […]
• GSE327697 Mast cells interact directly with colorectal cancer cells to promote epithelial-to-mesenchymal transition April 17, 2026
  Contributors : Heather O'Hagan ; Rosie LanzlothSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMast cells (MCs), a type of granulocytic immune cell, can be both pro- and anti-tumorigenic in colorectal cancer (CRC). We hypothesized that these contrasting findings may be in part due to differential interactions of MC […]
• GSE327789 KIAA1199 aggravates sepsis-induced lung injury by promoting complement activation April 17, 2026
  Contributors : Yang Qin ; Jiani Zhang ; Yanwen Zhang ; Sunwang Ling ; Weikang Ren ; Li Liu ; Xinyu YangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSepsis-induced acute lung injury (ALI) is a life-threatening condition associated with high mortality rates. While emerging evidence suggests that KIAA1199 (also known as […]
• GSE327886 Disruption of the Brain-Spleen Axis Impairs Monocyte-Microglia Communication and Accelerates Disease Progression in a Mouse Model of Amyloidosis April 17, 2026
  Contributors : Tommaso Croese ; Miguel A Abellanas ; Hodaya Polonsky ; Michal Arad ; Javier M Peralta Ramos ; Yuliya Androsova ; Serena Riccitelli ; Sedi Medina ; Francesca Palmas ; Romano Strobel ; Giulia Castellani ; Denise Kviatcovsky ; Sarah Phoebeluc-Colaiuta ; Miriam Adam ; Sama Murad ; Hannah Partney ; Daniel Kitsberg ; Alexander Dieter ; Tomer-Meir S […]
• GSE327961 Immune-skewed stromal–immune axis defined by antigen-presenting-like adipose stromal cells in lymphedema April 17, 2026
  Contributors : Nam Hyunsung ; Choi Una ; Ha Eun Hee ; Lee Brian Hyohyong ; Ko Jaecheon ; Kim Hyun Je ; Hong Ki YongSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground Lymphedema, a chronic and progressive disease, is characterized by lymphatic dysfunction, persistent inflammation, fibrosis, and pathological adipo […]
• GSE295104 Analysis of a pfap2-g reporter line provides insight into the epigenetic mechanisms regulating sexual commitment in the malaria parasite Plasmodium falciparum [ChIP-seq] April 17, 2026
  Contributors : Elvira Carrió ; Martijn van den Broek ; Beatriz Graça ; Jonas Gockel ; Sylwia D boltryk ; Richárd Bártfai ; Till VossSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Plasmodium falciparumThis study aimed to investigate the changes occuring in parasites that are commited to express the sexual commitment t […]
• GSE327656 Endothelial FGF13 impairs angiogenesis by accelerating oxygen-independent HIF-1α degradation April 17, 2026
  Contributors : Zhaohang Wu ; Weitao CongSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAngiogenesis is a tightly regulated process essential for both development and disease, yet the role of fibroblast growth factor 13 (FGF13) in vascular remodeling has remained unclear. Here, we identify FGF13 as a key negative regula […]