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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE306643 ZC3H14 mediates the regulatory mechanism of nuclear speckles assembly in early embryonic development of mice [scRNA-Seq] August 21, 2026Contributor : Yang WangSeries Type : Expression profiling by high throughput sequencingOrganism : During zygote genome activation (ZGA) in embryos, large amounts of precursor mRNA undergo complex post-transcriptional regulation such as splicing in nuclear speckles, and are eventually transported into the cytoplasm for translation into proteins. However, it i […]
- GSE275425 Injectable Nerve-Selective Cold Neurolysis for Pain Management: Sensory Neuron Modulation and Clinical Translation August 21, 2026Contributors : Selwyn Jayakar ; Ke Zhang ; Ying Wang ; Qing Wang ; Samuel Bunga ; Ramana Naidu ; Dan Bates ; Murray Taverner ; Riki Kawaguchi ; R Rox Anderson ; Clifford J Woolf ; Lilit GaribyanSeries Type : Expression profiling by high throughput sequencingOrganism : Long-lasting, non-opioid therapies are urgently needed for safe and effective pain manageme […]
- GSE251839 Integrative single cell analysis of progressive multiple sclerosis induced neural stem cells reveals epigenetically dysregulated type-I-interferon signaling [WGBS] August 21, 2026Contributors : Bongsoo Park ; Alexandra M Nicaise ; Dimitrios Tsitsipatis ; Liviu Pirvan ; Miguel Larraz ; Lopez De Novales ; Pranathi Prasad ; Julia Whitten ; Luka Culig ; Joseph Llewellyn ; Rosana-Bristena Ionescu ; Jinshui Fan ; Supriyo De ; Marta Suarez Cubero ; Tommaso Leonardi ; Valentina Fossati ; Frank Edenhofer ; Myriam Gorospe ; Irina Mohorianu ; S […]
- GSE303611 Single cell analysis of injured muscle August 21, 2026Contributors : Celine KEIME ; Delphine DUTEIL ; Joe RIZKSeries Type : Expression profiling by high throughput sequencingOrganism : Determine the cell populations present in cardiotoxin-injured tibialis muscle in the presence or absence of the androgen receptor (AR).
- GSE280925 ZCCHC10 promotes RBM39 degradation to suppress RBM39-mediated mis-splicing in acute myeloid leukemia August 21, 2026Contributors : Hao Zhou ; Yichong Ning ; Xing Zhang ; Jianlin ZhouSeries Type : Expression profiling by high throughput sequencingOrganism : Our previous studies have shown that CCHC-type zinc finger containing 10 (ZCCHC10) plays a tumor suppressive role in acute myeloid leukemia (AML) and lung cancer by activating the tumor suppressor p53. Here we report th […]
- GSE306068 Gas6 promotes Cardiomyocyte Proliferation and Heart Regeneration August 21, 2026Contributors : Yu Liu ; Yang Xu ; Wenfeng Zhou ; Yi Fan ; Genshan MaSeries Type : Expression profiling by high throughput sequencingOrganism : Ischemic heart disease remains a leading cause of mortality, with limited adult cardiac regeneration due to insufficient cardiomyocyte proliferation. This study investigates the role of Growth Arrest-Specific Gene 6 ( […]
- GSE303618 CUT & RUN Analysis in Satellite Cells 7 days after Cardiotoxin Injury of Skeletal Muscle August 21, 2026Contributors : Joe RIZK ; Delphine DUTEIL ; Tao YESeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : The aim of this project is to assess the open chromatin regions, as well as the androgen (AR) and the glucocorticoid (GR) targets in satellite cells 7 days after cardiotoxin injury. Satellite cells were FACS-isolated and […]
- GSE343826 CircATP5C1 drives papillary thyroid carcinoma progression through HNRNPR nuclear export and BCL2L1 upregulation in a ubiquitination‑dependent manner August 21, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Papillary thyroid carcinoma (PTC) is the most prevalent endocrine malignancy, and aggressive PTC phenotypes contribute to poor patient prognosis. Circular RNAs (circRNAs) are stable non-coding RNAs critically involved in tumor progression, yet their regulatory mechanisms in PTC remain […]
- GSE343805 KLF2-dependent chromatin accessibility changes in hepatic stellate cells August 21, 2026Contributors : Sirui Lu ; Yining Li ; Yunjie Liu ; Hua Yu ; Shuo Tu ; Xiaohua YanSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Krüppel-like factor 2 (KLF2) is a transcription factor involved in regulating cellular homeostasis and diverse signaling responses. To investigate KLF2-associated changes in chromatin access […]
- GSE344020 Skeletal Muscle Transcriptome Alterations Associated with Ketosis in Postpartum Dairy Cows August 21, 2026Contributors : Lisa M Avila ; Theresa M Casey ; Jyothi Thimmapuram ; Natnicha Taechachokevivat ; Rafael C NevesSeries Type : Expression profiling by high throughput sequencingOrganism : Excessive body fat mobilization during the transition period overwhelms hepatic fatty acid (FA) oxidative capacity, leading to increased ketone body production and ketosis in […]
- GSE343951 Skeletal muscle fatigue resistance is differentially affected in 8-month-old male and female hAβ-KI mice. August 21, 2026Contributors : Emily N Copeland ; Evelin Melekh ; Val FajardoSeries Type : Expression profiling by high throughput sequencingOrganism : Approximately 95% of Alzheimer’s disease (AD) diagnoses are sporadic onset, present after the age of 65, and arising from a combination of non-modifiable and modifiable factors. This underscores the potential to identify ear […]
- GSE344240 Inhibiting Cyclin D1–CDK6 Suppresses Senescence-Associated Inflammatory Gene Expression and Age-Related Functional Decline August 21, 2026Contributors : Allen Wang ; Emily Eisner ; Michael Miller ; Qian Yang ; Elizabeth Smoot ; Lauren Thomas ; Jacinta Lucero ; Henry Jiao ; Charlene Miciano ; Bin Li ; Jesus FloresSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Cellular senescence contributes to aging a […]
- GSE344470 Reconstructing the single-cell spatiotemporal dynamics of glioblastoma invasion August 21, 2026Contributors : Hitesh B Mangukiya ; Madeleine Skeppås ; André L Armatowski ; Irem Uppman ; Linnea Hallin ; Filippa Kruse ; Clara Nordquist ; Soumi Kundu ; Maria Berglund ; Adam A Malik ; Cecilia Krona ; Rebecka Jörnsten ; Sven NelanderSeries Type : Expression profiling by high throughput sequencingOrganism : Glioblastoma invasion into healthy brain tissue re […]
- GSE344566 Effect of HDAC3 knockdown on H3K9ac in osteosarcoma cells August 21, 2026Contributors : Huang Jing ; Wang Shasha ; Yan HualongSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : The dearth of molecular and cellular knowledge regarding the etiology of osteosarcoma (OS) impedes the advancement of innovative therapeutic interventions, such as immune therapy, for this debilitating childhood malign […]
- GSE306182 M2 microglia-derived exosomes inhibit p38 MAPK signaling pathways and GPX4-mediated neuronal ferroptosis in neuropathic pain [N2A_miRNA-seq] August 21, 2026Contributors : Sheng Gao ; Yuyan Sun ; Shu Jia ; Nianhu Li ; Chunyang MengSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : This study aimed to investigate the regulatory mechanism of M2 microglial exosomes (M2-exosomes) on neuronal ferroptosis during the progression of neuropathic pain (NP). IL-4 was used to induce M2 polarizati […]