Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE300724 Organoid modeling of lung branching morphogenesis and epithelial lineage specification [scRNA-Seq] June 23, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn this study, multi-level branching lung organoids (BLOs) were generated from primary tip epithelial cells. Single-cell RNA sequencing demonstrated that BLOs comprise proximal airway and distal alveolar epithelial cell populations, faithfully modeling the developmental tr […]
• GSE303580 DNA methylation and transcriptomic profiles of Wilms tumour reveal new deregulated genes and epigenetic processes relevant for tumour stratification and management June 23, 2026
  Contributors : Abu Saadat ; Francesco Cecere ; Federica Rossetti ; Laura Pignata ; Emilia D’Angelo ; Carlo Giaccari ; Gaetano Verde ; Paola Quarello ; Franca Fagioli ; Josep Roma ; Manel Esteller ; Enrique De Álava ; Flavia Cerrato ; Andrea Riccio ; Angela SparagoSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensWilms tumour (W […]
• GSE300941 Multi-omic analysis reveals distinct endothelial gene expression profiles induced by pathological flow June 23, 2026
  Series Type : Non-coding RNA profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
• GSE305957 Spalt-related is a catabolic switch activated by prolonged starvation June 23, 2026
  Contributors : Onur Deniz ; Krista Kokki ; Ville HietakangasSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterNutrient intake is tightly linked to animal energy metabolism and growth. Inhibition of anabolic processes during nutrient deprivation is a critical stress response necessary for survival. However, how […]
• GSE304033 Tedja et al: Transcriptional regulation of Candida auris morphogenesis [exp 2] June 23, 2026
  Contributors : Ana Traven ; Traude Beilharz ; Irma Tedja ; Harshini Weerasinghe ; Calvin Kraupner-Taylor ; Paul HarrisonSeries Type : Expression profiling by high throughput sequencingOrganism : Candidozyma aurisExperiment 2: This experiment concerns the comparison of smooth and wrinkled versus clinical isolates of Candida auris. RNA-seq experiments were per […]
• GSE281570 RNA-seq study using Karpas422 xenograft tumors after vehicle or PRC2 inhibitor C36 treatment June 23, 2026
  Contributors : Dongdong Liu ; Chenyang Qin ; Yang An ; Wei QiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPolycomb Repressive Complex 2 (PRC2) is the conserved methyltransferase depositing mono-, di-, and tri- methylation (H3K27me1/me2/me3) on the lysine 27 of histone H3 and thereby represses gene transcription. EZH2 […]
• GSE311890 Single-cell transcriptomic and TCR profiling of long-term persisting CD19 CAR-T cells from patient peripheral blood June 23, 2026
  Contributors : Paruzzo Luca ; Zheng Zhixuan ; Ruella MarcoSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensThis study profiles patient peripheral blood mononuclear cells (PBMCs) enriched for CAR-T cells using the 10x Genomics Chromium Single Cell 5′ platform. Two PBMC samples — peak patient #21 and year 9.3 patie […]
• GSE335990 Gene Expression of SlanMo migrating on Immune Complexes June 23, 2026
  Contributors : Michael Hertwig ; Stephanie Oehrl ; Thomas Döbel ; Hao Zhang ; Stefan Meisel ; Amelie List ; Knut SchäkelSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensImmune complexes (ICs) play a central role in autoimmune diseases, where they accumulate in tissues, activate Fc gamma receptor-expressing cells, and promote c […]
• GSE335892 Carotid Body Dysfunction Contributes to Respiratory Dysfunction in Rett Syndrome June 23, 2026
  Contributors : Monica L Strain ; Eliandra N da Silva ; Michelle L Olsen ; Daniel K MulkeySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in MECP2. Disordered breathing is a hallmark feature of RTT that negatively impacts quality of life and can be […]
• GSE336193 Zanidatamab in Patients with Early Stage HER2-positive Breast Cancer: The NeoZanHER Phase 2 Single-Arm Open-Label Trial June 23, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensStrategies are needed to avoid chemotherapy in early stage HER2-positive (HER2+) breast cancer (BC). We conducted a neoadjuvant therapy trial with zanidatamab, a dual HER2-directed bispecific antibody, in patients with 1-3 cm, node-negative HER2+ BC. Primary endpoint was p […]
• GSE336083 A Phase 1/1b Study of the All-Oral Regimen CC-486 and Venetoclax in Acute Myeloid Leukemia June 23, 2026
  Contributors : Maria L Amaya ; Austin E Gillen ; Craig T Jordan ; Daniel A PollyeaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensVenetoclax with azacitidine is the standard of care for newly diagnosed AML patients who are unfit for intensive induction chemotherapy. CC-486 is the oral formulation of azacitidine that is […]
• GSE336197 16S rRNA Datasets of Gut Microbiota in Stent-Based Diverting Technique and Ileostomy from A Prospective, Open-Label, Multicenter Randomized Controlled Trial June 23, 2026
  Contributor : Zhongyu WuSeries Type : OtherOrganism : human feces metagenomeThis study performed gut microbiota 16s rDNA sequencing on patients receiving stent-based diversion technique (SDT) and temporary ileostomy surgery, with fecal samples collected at preoperative baseline and postoperative follow-up time points. This study aims to characterize perioper […]
• GSE336208 From enrichment to inference: a multi-target framework for scalable aptamer discovery June 23, 2026
  Contributors : Shaokang Lv ; Han Guo ; Zhaofeng LuoSeries Type : OtherOrganism : synthetic constructSELEX has greatly advanced aptamer discovery; however, traditional workflows face considerable challenges in scaling due to the labor-intensive screening and validation processes. More critically, in conventional SELEX, sequencing abundance does not always cor […]
• GSE336211 Loss of YY1 in Purkinje Cells Triggers Cerebellar Ataxia via Wnt10b-Mediated Impairment of Dendrite Development June 23, 2026
  Contributors : Ying Lam Lui ; Xiaonan Dong ; Tsz Ho Li ; Ting Fung Chan ; Kin Ming KwanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe cerebellum relies on Purkinje cells (PCs) to coordinate motor functions and maintain neural circuitry. Impaired PC dendritogenesis is linked to neurological disorders, yet intrinsic […]
• GSE300488 Characterizing circulating pharmacodynamic biomarkers of IFNβ-1a biologics [inter] June 23, 2026
  Contributors : Lakshmi Manasa Sakuntala Chekka ; Paula HylandSeries Type : Protein profiling by protein arrayOrganism : Homo sapiensThe current project is designed to evaluate the utility of proteomics in identifying pharmacodynamic (PD) biomarkers for biosimilarity assessment. This is an extension of the data submitted in GSE207945 which profiled longitudin […]