Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE304811 RHOAY42C-driven cell lineage plasticity and immune remodeling of diffuse gastric cancer July 27, 2026
  Series Type : OtherOrganism : Mus musculusDiffuse gastric adenocarcinoma (DGA) is an aggressive gastric cancer subtype with a poor prognosis. RHOAY42C is a recurrent mutation in DGA, yet its independent oncogenic role remains unclear. We used genetically engineered gastric organoid models to demonstrate that RHOAY42C, along with KrasG12D activation and Trp53 […]
• GSE301391 MYD88 maintains skin homeostasis in filaggrin-dificient mice, wild-type mice July 27, 2026
  Contributors : Wu Meng-Jen ; Tsoi Alex ; Gudjohnsson Johann ; Archer NathanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis dataset contains RNA-seq profiles from wild-type balb/c mouse eye-skin and was generated as a control cohort for comparison with a previously published MyD88-deficient dataset. These data provi […]
• GSE311690 Deconvolution of Low-count RNA Sequencing Data for Tumor Cells Using Embedded Negative Binomial Distributions July 27, 2026
  Contributors : Matthew Montierth ; Kinga Nemeth ; Wenyi Wang ; George CalinSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensA major challenge in studying tumor heterogeneity is the presence of mixed signals in gene expression data, especially when working with sparse count datasets such as microRNA and spatial transc […]
• GSE308210 Macrophage Reprogramming Induced by Hypertensive Stress Underlies Pathogenesis of Non-Obese Heart Failure with Preserved Ejection Fraction July 27, 2026
  Contributors : Manami Katoh ; Michio Sato ; Yuichi OikeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHeart failure with preserved ejection fraction (HFpEF) is a leading cause of morbidity and mortality worldwide; nonetheless, effective therapies remain elusive. In Western populations, HFpEF is typically obesity-relate […]
• GSE252953 Tumor Cell JAGGED-1 Promotes Lymph Node Metastasis and Predicts Recurrence in Lymph Node Positive Breast Cancer Patients [hdLEC_JAG1_TLA] July 27, 2026
  Contributors : Gordon Benjamin ; Swaminathan Bhairavi ; Vadakath Rahul ; Teneqexhi Pamela ; Youn Seock Won ; Alvarez-Lopez Isabel ; Rezola Marta ; Xu Ziqiao ; Chen Zhengjia ; Er Ekrem Emrah ; Naiche LA ; Caffarel María Muñoz ; Kitajewski JanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPurpose: Lymph node invasion is […]
• GSE311875 RNA-Seq analysis of 2C genes in mESC lines with overexpression of full length NELFA, MERVL-NELFA and IDR-deletion mutant (NELFA-IDR-Del). July 27, 2026
  Contributors : Dennis Eng Kiat Tan ; Oleg V Grinchuk ; Wee Wei TeeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusZygotic genome activation (ZGA) in early embryos is driven by extensive chromatin remodeling initiated by maternal factors, enabling the activation of cleavage-stage gene programs that underpin totipotency. […]
• GSE341155 CHI3L1 promotes proliferation and metastasis of ovarian cancer cells July 27, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAdipocyte-tumor interaction plays a critical role in tumor microenvironment. Typically, high-grade serous ovarian carcinoma (HGSOC) preferentially metastasizes to the omentum, an adipocyte-rich tissue, and obesity correlates with worse patient prognosis. However, the under […]
• GSE278745 The Effects of Refined Carbohydrates on Systemic Immunity: Results from a Randomized Controlled Feeding Trial July 27, 2026
  Contributors : Ezequiel Dantas ; Marcus GoncalvesSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensObjectiveTo explore the effects of three diets differing in amount and type of refined carbohydrates on peripheral immunity.MethodsAfter a weight loss of 15% with a very low carbohydrate diet (VLCD), participants were random […]
• GSE341318 A Transcriptomic Biomarker to Classify Chemical-Induced Histone Deacetylase Inhibition in Human HepaRG Cells July 27, 2026
  Contributors : Julie K Buick ; Eunnara Cho ; Anouck Thienpont ; Andrew Williams ; Birgit Mertens ; Vera Rogiers ; Tamara Vanhaecke ; Carole L Yauk ; Matthew J MeierSeries Type : OtherOrganism : Homo sapiensNew approach methods (NAMs), such as human-derived in vitro models integrated with transcriptomic biomarkers, offer an efficient, animal-free means to pre […]
• GSE341181 Distinct activation programs in naïve and memory CD8 T cells govern progeny stemness and effector persistence (single cell experiment, NupHox mice, LCMV-OVA infection, Day 3 and Day 5) July 27, 2026
  Contributors : Eva Salyova ; Darina Paprckova ; Juraj Michalik ; Veronika Niederlova ; Ondrej StepanekSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusWe longitudinally profiled gene expression in naive and central and effector memory CD8+ T cells across multiple models of acute cognate infection to reveal subset […]
• GSE341379 Distinct histone 3 lysine methylation states underlie tumor immune surveillance July 27, 2026
  Contributors : Amy Gladstein ; David FeldserSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusMutations in histone 3 at or near lysine 36 (H3K36) have dominantly acting oncogenic effects in multiple tumor types by limiting H3K36-directed methyltransferases […]
• GSE341485 Heterogeneous epigenetic variation converges on splicing dysregulation in opioid addiction July 27, 2026
  Contributors : Fatir Qureshi ; Chesna Apere ; Chidera Okeke ; Bibi S Kassim ; Marina Iskhakova ; Richard Sallari ; Maharshi Chakraborty ; Laura Morgan ; Zia Barnard ; Xochitl Luna ; Megan E Madden ; Pavana G Rotti ; Sofia E Agueldo-Viales ; Yike Huang ; Yasmine N Sami ; Scott McCallum ; An T Hoang ; Hannah K Ramcharan ; Bryan Quach ; Caryn Willis ; Brion S M […]
• GSE341507 Transcriptional response to enoxolone treatment in larval zebrafish July 27, 2026
  Contributors : Daniel J Kelpsch ; Liyun Zhang ; James H Thierer ; Adrian G Rivera Cruz ; Kobe Koren ; Urmi Kumar ; Yuki Lin ; Monica R Hensley ; Mira Sohn ; Jun O Liu ; Thomas Lectka ; Jeff S Mumm ; Steven A FarberSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioExcess apolipoprotein B-containing lipoproteins (B-lps) are […]
• GSE289280 SnRK2.4 and SnRK2.10 redundantly control developmental leaf senescence by sustaining ABA production and signaling July 27, 2026
  Contributors : Anna Anielska-Mazur ; Julia Rachowka ; Michal Krzyszton ; Anna KulikSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaPlants constantly and precisely control their growth by inducing distinct developmental programs to survive and produce high-quality offspring in the changing environment. The fine-t […]
• GSE341147 Magnolol triggers ferroptosis in triple-negative breast cancer through modulation of the ETS2/SLC7A11/GPX4 signaling axis July 27, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation (LPO), represents a promising therapeutic strategy. Magnolia officinalis, a traditional herb for resolving dampness and phlegm, is known to modulate cellular metabolism. Wh […]