Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE287891 The transcription factor Traffic jam orchestrates the somatic piRNA pathway in Drosophila ovaries [RNA-seq] January 23, 2026
  Contributors : Azad Alizada ; Aline Martins ; Nolwenn Mouniée ; Julia V Rodriguez Suarez ; Benjamin Bertin ; Nathalie Gueguen ; Vincent Mirouse ; Anna-Maria Papameletiou ; Austin J Rivera ; Nelson C Lau ; Abdou Akkouche ; Stéphanie Maupetit-Mehouas ; Gregory J Hannon ; Benjamin Czech Nicholson ; Emilie BrassetSeries Type : Expression profiling by high throug […]
• GSE290575 G549 EP300_KO RNA-seq January 23, 2026
  Contributors : Fatemeh Molaei ; Graham MacLeod ; Stephane AngersSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEP300 was identified as potential regulator of Injury-response/Mesenchymal state in Glioblastoma stem cells. Our objective was to identify the effect of EP300 KO on transcriptomic signature of Injury-response/ […]
• GSE288033 Functional dissection of ovarian aging-associated genes NDUFS5 and UBE2L3 through integrated genomic analyses and validation January 23, 2026
  Contributors : Yifei Lv ; Yunlong Ma ; Yizhou Huang ; Linjuan Ma ; Jianhong ZhouSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensOvarian aging, culminating in menopause, involves a gradual decline in ovarian function. Genetic factors influencing age at natural menopause (ANM) especially premature ovarian insufficiency (P […]
• GSE255517 Rational design of immune gene therapy combinations via in vivo CRISPR activation screening of tumor microenvironment modulators January 23, 2026
  Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiens ; Mus musculusThis SuperSeries is composed of the SubSeries listed below.
• GSE291732 Identification of β-catenin dependent and independent genes in an orthotopic model of pancreatic cancer January 23, 2026
  Contributors : Nathan Harmston ; David Virshup ; Babita MadanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWnt signaling regulates metazoan development and homeostasis, in part by β-catenin dependent activation and repression of a large number of genes. However, Wnt signaling also regulates genes independent of β-cate […]
• GSE284026 NR2F6 deletion revives CAR‑T cell function and induces antigen‑agnostic immune memory in solid tumors January 23, 2026
  Contributors : Dominik Humer ; Victoria Klepsch ; Dietmar Rieder ; Gottfried BaierSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCAR‑T cell therapy is effective in hematologic malignancies but remains challenging in solid tumors owing to antigen heterogeneity and tumor microenvironment‑induced exhaustion. Here, gene ed […]
• GSE270946 Effect of IVNS1ABP mutation, knockout on gene expression during iPSCs differentiation to Neural Progenitors January 23, 2026
  Contributors : Fang Yuan ; Haofei Wang ; Su-Chun ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe identified a new disease characterized by severe neurological deficits in addition to progeria symptoms. It is caused by IVNSABP gene mutation. The association between IVNS1ABP and aging has never been reported befor […]
• GSE315629 Genome-wide identification of transcriptional targets of H4K12 lactylation and GR in 786-O cells with or without dexamethasone treatment. January 23, 2026
  Contributors : Kenan Zhang ; Lin HeSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the genome-wide transcriptional targets associated with H4K12 lactylation in renal cell carcinoma, cleavage under targets and tagmentation (CUT&Tag) was performed in 786-O cells with or without dexamethaso […]
• GSE315326 Genome-wide identification of transcriptional targets for H4K12 lactylation in ccRCC cells January 23, 2026
  Contributors : Kenan Zhang ; Lin HeSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the genome-wide transcription targets of H4K12 lactylation in ccRCC cells, cleavage under targets and tagmentation (CUT&Tag) was performed in 786-O and Caki-1 cells using antibody against H4K12 lactylation […]
• GSE316915 Decoding and Rewiring Promoter Architecture Using Large Language Models and Diffusion Frameworks January 23, 2026
  Contributors : Xin Lei ; Xing Wang ; Yuzhong Liu ; Yangyu Zhang ; Jiesheng Huang ; Tianjiao Peng ; Ce Liang ; Quhuan Li ; Huaiguang Jiang ; Wei XiongSeries Type : Expression profiling by high throughput sequencingOrganism : Escherichia coli DH5[alpha]High-performance promoters are essential tools for precisely regulating gene expres-sion, yet their rational […]
• GSE316562 Cyanidin-3-rutinoside(C3R) Attenuates Free Fatty Acid-Induced Hepatic Lipid Accumulation in HepG2 Cells January 23, 2026
  Contributors : Jingxu Duan ; Wancong Yu ; Yujia Niu ; Jiao Li ; Zhaohui XueSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNon-alcoholic fatty liver disease (NAFLD) is characteristic by pathological lipid accumulation in hepatocytes. This study investigates how Cyanidin-3-rutinoside(C3R), a natural anthocyanin with anti […]
• GSE316934 Single-cell RNA-seq of eWAT stromal vascular fraction cells from WT and Camk2d myeloid conditional knockout mice after high-fat diet January 23, 2026
  Contributors : Yifan Tu ; Ke Sui ; Zheng Wang ; Jiawei Zhang ; Ying GuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusEpididymal white adipose tissue (eWAT) stromal vascular fraction (SVF) cells were profiled by 10x Genomics Chromium Single Cell 3′ v1 scRNA-seq to characterize immune-cell states in diet-induced obesity. […]
• GSE317187 A novel pyrrolidine-chalcone derivative exhibits synergistic anti-cervical cancer activity by dual-targeting MDM2-p53 axis and ferroptosis pathway January 23, 2026
  Contributor : Xinyi DengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCervical cancer remains a serious threat to women’s health, driving the need for effective and low-toxicity therapeutics.
• GSE317324 Type 2 lymphocytes restrict type 3 lymphocytes during liver fibrosis and co-localize in fibroblast niches January 23, 2026
  Contributors : Julia Sbierski-Kind ; Kelly M Cautivo ; Julia Nilsson ; Jun-Hoe Lee ; Taeeun Gu ; Hyeewon Seo ; Hyun Je Kim ; Ari MolofskySeries Type : OtherOrganism : Mus musculusFibroblasts are dynamic structural cells that direct both beneficial tissue repair and pathologic organ fibrosis through interactions with tissue-resident type 2 and type 3/17 lymph […]
• GSE287857 LDHA induces β cell dedifferentiation in diabetes through metabolic epigenetic reprogramming [RNA-Seq] January 23, 2026
  Contributors : Xirui Li ; Haoqiang Gong ; Can Xiong ; Xinyue Huang ; Mei He ; Liangjun Sun ; Wenyue Yin ; Suyun Zou ; Min Sha ; Wanhua Guo ; Tijun Wu ; Qingguo Li ; Yaqin Zhang ; Fang ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAims/hypothesis Pancreatic β cell dedifferentiation underlies the reversible reductio […]