Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE315895 polr3a mutant vs wild-type May 16, 2026
  Contributor : Kristin WattSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioWe examined zebrafish with a mutation in polr3a, encoding the largest subunit of RNA Polymerase III. We then compared transcriptional responses of different cell types in the head of polr3a mutant zebrafish versus wild-type using a single cell RNA- […]
• GSE324517 Computationally Guided Protein-Gold Nanostructures for Targeted Recognition and Cleavage of Human Amyloid-β Plaques May 16, 2026
  Contributors : Tianyi Qi ; Xinglu Huang ; Jingxuan Fu ; Hui WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTargeted clearance of pre-existing amyloid-β (Aβ) aggregation remains a central challenge in Alzheimer’s disease (AD) therapy. Here we report a computationally guided protein-gold hybrid nanostructure, Aβ3FTnA […]
• GSE318778 Ligature-induced periodontitis in mice potentially accelerates CD4+ T cells senescence and exacerbates rheumatoid arthritis May 16, 2026
  Contributors : Jinfeng Li ; Terukazu Sanui ; Miyu Shida ; Karen Yotsumoto ; Mwannes Ahmad ; Ziyu Wang ; Meng Xiao ; Chikako Hayashi ; Takanori Shinjo ; Takaharu Taketomi ; Takao Fukuda ; Fusanori NishimuraSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusObjective: Chronic periodontitis typically affects individuals aged […]
• GSE330469 ChIP-seq and CUT&Tag profiling of the genome binding of YAP/TAZ-TEAD and SMAD3 in the human HCC cell line HCCLM3 [CUT&Tag] May 16, 2026
  Contributors : Yining Li ; Weicheng Luo ; Yunjie Liu ; Hua Yu ; Xiaohua YanSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThis study generated ChIP-seq and CUT&Tag datasets to profile genome-wide occupancy of YAP, TAZ, TEAD1, SMAD3, and VGLL4 in the human hepatocellular carcinoma cell line HCCLM3. Pro […]
• GSE328123 Systematic functional profiling of WD40 proteins reveals Wcp1, a cyclophilin that links CO2/heat tolerance to acidic pH adaptation in Cryptococcus neoformans [RNA-Seq] May 16, 2026
  Contributors : Jin-Tae Choi ; Seong-Ryong Yu ; Jeeseok Oh ; Yu-Byeong Jang ; Yujin Lee ; Hyunjin Cha ; Doyeon Won ; Dohee Kim ; Sungmin Yu ; Soojin Yu ; Kyung-Ah Lee ; Jaeyoung Choi ; Won-Jae Lee ; Kyung-Tae Lee ; Yong-Sun BahnSeries Type : Expression profiling by high throughput sequencingOrganism : Cryptococcus neoformansWD40 domains are major protein–prot […]
• GSE278494 Bidirectional regulation by BACH2 coordinates systemic CXCR5– vs CXCR5+ CD4+ T cell differentiation [ATAC-seq] May 16, 2026
  Contributors : Fangming Zhu ; Andrew R Schroeder ; Hui HuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusATAC-seq results of activated ThNone cells reveal chromatin accessibility changes following the deletion of Bach2 and Stat5.
• GSE331034 Transcriptome study of Talaromyces verruculosus TS63-9 for pectin-degrading CAZymes May 16, 2026
  Contributor : Liwei HuSeries Type : Expression profiling by high throughput sequencingOrganism : Talaromyces verruculosusPectins are a primary structural component of plant cell walls. In a previous study, we isolated a fungal strain, Talaromyces verruculosus TS63-9, which exhibited a high pectinase activity (142.43 U/mL) in a large-scale screening and seque […]
• GSE330629 A humanized monoclonal antibody targeting human ENPP1, an ectonucleotidase expressed in the diseased human kidney, enhances tubular proliferation and kidney repair and is safe in non-human primates May 16, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe human kidney possesses a poor ability to robustly regenerate after acute injury and chronic kidney disease affects millions of individuals worldwide. There are no drugs that enhance tissue repair after acute kidney injury. Here, we demonstrate, in a cohort of individua […]
• GSE330577 Transcriptomic profiling identifies Forl1 as a potential therapeutic target in intracerebral hemorrhage May 16, 2026
  Contributor : Shi ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIntracerebral hemorrhage (ICH) is a severe subtype of stroke characterized by high mortality and disability, while effective therapeutic targets remain limited. To identify key regulatory molecules involved in ICH pathogenesis, we established a mouse […]
• GSE330642 A humanized monoclonal antibody targeting human ENPP1, an ectonucleotidase expressed in the diseased human kidney, enhances tubular proliferation and kidney repair and is safe in non-human primates [scRNA-seq] May 16, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe human kidney possesses a poor ability to robustly regenerate after acute injury and chronic kidney disease affects millions of individuals worldwide. There are no drugs that enhance tissue repair after acute kidney injury. Here, we demonstrate, in a cohort of individua […]
• GSE330634 Study on the Molecular Mechanism of BMP8B in Regulating Trophoblast Cell Function: A Transcriptomic Analysis Based on RNA-seq May 16, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe regulation of trophoblast cell function plays a central role in placental development and pregnancy maintenance. As a member of the bone morphogenetic protein family, BMP8B has been demonstrated to participate in regulating the migration, invasion, and differentiation […]
• GSE330648 A quadrivalent in vivo CAR-macrophage repress solid tumors and overcome tumor heterogeneity through antigen spreading May 16, 2026
  Contributors : Shaolong Zhang ; Hengxing Lu ; Hailing Zhang ; Qixin Wu ; Xizhong DingSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe designed a quadrivalent in vivo CAR-engineered macrophage based on the LNP-mRNA system, delivering FAP CAR-ΔTGFβRII and GPC3 CAR-Super IL2 (LNP-GF CAR) via LNP for the treatment of prim […]
• GSE330966 Repression of DNA Damage Response Sensitizes APL Cells to the Combined Genotoxicity of All-Trans Retinoic Acid and Arsenic Trioxide May 16, 2026
  Contributors : Landing Li ; Huafeng Wang ; Jinghang Wu ; Zhilin Wang ; Jiayi Wang ; Can Yi ; Fan Yang ; Yanjing Xiao ; Sirui Cheng ; Xianghuijun Yin ; Siqian Shi ; Xinxin Wang ; Jiajun Sun ; Hongyan Tong ; Lei LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe synergistic combination of All-Trans Retinoic Acid (ATRA) […]
• GSE331004 Optimization of the Preparation Process of Isoliensinine and the Mechanism of Its Sleep-Improving Effect in Mice May 16, 2026
  Contributor : Xiaolong ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIsoliensinine is a bisbenzylisoquinoline alkaloid extracted from the dried plumules and radicles of the mature seeds of Nelumbo nucifera Gaertn. (Nymphaeaceae). As one of the primary active ingredients in the lotus plumule, it is traditionally r […]
• GSE314290 Application of Type XVII Collagen in the Repair and Healing of Skin Defects May 16, 2026
  Contributor : Xinlei ZhaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis work elucidates the crucial role of type XVII collagen in cutaneous wound healing and discusses the potential mechanisms through which it promotes tissue repair, including modulation of inflammation, enhancement of keratinocyte migration, regu […]