Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE283467 Derivation of elephant induced pluripotent stem cells [ATAC-seq] March 3, 2026
  Contributors : Evan Appleton ; Nataly Korover ; Kyunghee Hong ; Xochitl Ambriz-Peña ; Yoshiaki Tanaka ; Asaf Ashkenazy-Titelman ; Cody Rasmussen-Ivey ; Cristina Rodriguez-Caycedo ; Ketaki Bhide ; Hao Bai ; Ana Queiroz ; Jorgen W Nelson ; Grishma Rathod ; Miles Morgan ; Anthony Mastracci ; Theodore M Nelson ; Greg Knox ; Brody McNutt ; Nandini Malviya ; Kairu […]
• GSE275879 ESCRT-mediated machinery directly drives cardiac T-tubule formation March 3, 2026
  Contributors : Xinjian Wang ; Hongkun Wu ; Peidong HanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCardiac transverse tubules (T-tubules) are regular spaced plasma membrane invaginations that play an essential role in establishing excitation-contraction coupling of cardiomyocytes, yet the molecular machinery that con […]
• GSE290947 The molecular mechanism of on-demand sterol biosynthesis at organelle contact sites March 3, 2026
  Contributors : Naama Zung ; Gilad Yaakov ; Felix Jonas ; Naama Barkai ; Maya SchuldinerSeries Type : Expression profiling by high throughput sequencingOrganism : Saccharomyces cerevisiaeThe effect of Yet3 knock out or overexpression on RNA expression profiles.
• GSE290919 Transcriptome analysis of Kdm7a-deficient RAW264.7 cells during macrophage polarization. March 3, 2026
  Contributors : Naofumi Funagura ; Tomoaki Koga ; Mitsuyoshi NakaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTranscriptome analysis of Kdm7a-deficient RAW264.7 cells revealed that Kdm7a suppresses excessive polarization toward M2 macrophages.
• GSE226704 Effect of COQ6 D316Y homozygosity on BMDM transcriptome March 3, 2026
  Contributors : Sharon C Morley ; Emma C WalkerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the effect of the COQ6 D316Y SNV on BMDM function, we performed RNA-seq on BMDMs from WT and homozygous D316Y mice at baseline and 24h after LPS stimulation
• GSE290958 Transforming growth factor-β1 induces super-enhancers at the loci of the epithelial-mesenchymal transition-related genes in human keratinocyte HaCaT cells March 3, 2026
  Contributors : Kana Takeda ; Yoshiyuki Nagaoka ; Sachio Tamaoki ; Mitsutoki HattaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensAn enhancer is a genomic DNA sequence that substantially enhances the transcriptional activity of a target gene by recruiting transcription factors. The large clusters of enhance […]
• GSE317750 E1A transactivation through superinfection turns iPSC-derived macrophages from a quiescent to a productive adenovirus cell state March 3, 2026
  Contributors : Maarit Suomalainen ; Walther Haenseler ; Urs F GreberSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMacrophages are a first line defense against pathogens. Human adenovirus C5 (AdV-C5) infection is inefficient in human iPSC-derived macrophages, partially due to poor activity of the enhancer/promoter (e/p […]
• GSE243272 3D Chromatin Remodeling in B-cell Development and B-cell Acute Lymphoblastic Leukemia [ChIP-seq] March 3, 2026
  Contributors : Yohana E Ghebrechristos ; Nikki A Evensen ; Soobeom Lee ; Finnegan Clark ; Stanley Clarke ; Matthew T Witkowski ; Ziyan Lin ; Hua Zhou ; Elizabeth A Raetz ; David T Teachey ; Timothée Lionnet ; Aristotelis Tsirigos ; William L Carroll ; Iannis AifantisSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo […]
• GSE320327 Retrotransposon-driven co-transcriptional chromatin remodelling rewires Ash2l isoform usage to prime developmental promoters [ChIP-seq] March 3, 2026
  Contributors : Eleanor Elgood Hunt ; Claudia Vivori ; Richard Mitter ; Folkert van WervenSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusTranscription start site (TSS) selection diversifies the transcriptome and proteome, yet the mechanisms and functional consequences of alternative TSSs in development rem […]
• GSE318490 Single-cell RNA-seq of tumor samples from six advanced HGSOC patients across treatment stages (pre-NACT, post-NACT and platinum-sensitive recurrence) March 3, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHigh-grade serous ovarian cancer (HGSOC) is characterized by pronounced cellular heterogeneity and dynamic changes during treatment and recurrence. In this study, we collected 10 tumor samples from six patients with advanced-stage HGSOC and performed single-cell RNA sequen […]
• GSE320328 Retrotransposon-driven co-transcriptional chromatin remodelling rewires Ash2l isoform usage to prime developmental promoters [Timecourse] March 3, 2026
  Contributors : Eleanor Elgood Hunt ; Claudia Vivori ; Richard Mitter ; Folkert van WervenSeries Type : OtherOrganism : Mus musculusTranscription start site (TSS) selection diversifies the transcriptome and proteome, yet the mechanisms and functional consequences of alternative TSSs in development remain poorly understood. Here, we show that the chromatin reg […]
• GSE320330 Fetal growth restriction leads to prolonged nephrogenesis and persistent developmental gene dysregulation in the adult kidney March 3, 2026
  Contributors : Sage Timberline ; Rachel K Dailey ; Wyatt Johnson ; Ayyappa Kameshwar ; Jaya Isaac ; Kimberly deRonde ; Mark Conaway ; Aleksandra Cwiek ; Kevin M Bennett ; Edwin J Baldelomar ; Teng Li ; Teresa Wu ; Matthew R Hoch ; Meredith P Schuh ; Shalini Indugula ; Masako Suzuki ; Kimberly J Reidy ; Jennifer R CharltonSeries Type : Expression profiling by […]
• GSE320561 Effect of eIF5B silencing on KSHV-reactivated human iSLK.219 cells from 0-72 Hours reactivation March 3, 2026
  Contributors : Christian McDonald ; Yuan-De Tan ; Enrique A Mesri ; Noula ShembadeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensKaposi’s Sarcoma (KS) Herpesvirus (KSHV) is the etiological agent of KS, an AIDS-defining illness. Recent studies have demonstrated that even during normoxic conditions, KSHV facilitates repl […]
• GSE261122 The OsCCT22- OsSh1-OsCAD2 module facilitate seed shattering by suppress lignin biosynthesis in rice [ChIP-seq] March 3, 2026
  Contributor : Wei HeSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Oryza sativaOsCCT22, physically interacted with OsSh1 to regulate the abscission development.
• GSE308694 TOX3 in hypothalamic POMC-lineage cells regulates energy balance via the PTEN-AKT signaling axis March 3, 2026
  Contributors : Qin Tang ; Juan Pang ; Jinhang Zhang ; Qinhui Liu ; Jiahui Li ; Ailin Zhang ; Ying Xu ; Haiying Song ; Haifeng Zeng ; Xiandan Jing ; Na Yang ; Yimin Xiong ; Zijing Zhang ; Yining Xu ; Yanping Li ; Li Mo ; Jinhan HeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusObesity and its associated metabolic disorde […]