Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE297894 RNA-seq in C4.2B prostate cancer cell line treated with AKTi (ipatasertib) and EZH2i (tazemetostat). May 18, 2026
  Contributors : Rhea Sahu ; Karen CichowskiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMen with advanced prostate cancer are typically treated with androgen deprivation therapy, but most ultimately develop resistance and incurable disease (e.g. castration-resistant prostate cancer (CRPC)). The majority of CRPCs overe […]
• GSE302179 Umbilical Cord Blood Cell Transcriptional and Methylation Signatures at Birth Are Associated with BPD Development [RRBS] May 18, 2026
  Contributors : Qianli Liu ; Benjamin D SingerSeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensBronchopulmonary dysplasia (BPD) is the most common respiratory disease in preterm infants born at less than 28 weeks gestation. Most existing clinical prediction models for BPD show limited accuracy in predicting BPD developme […]
• GSE300472 Defective Autophagy in GNE Myopathy is Reversed by Inhibition of Supplementary mTOR Activation May 18, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusThis SuperSeries is composed of the SubSeries listed below.
• GSE306043 Cattle and human organoids recapitulate the trans-species transmission of H5N1 2.3.4.4b virus and reveal cross-reactive neutralizing antibodies in humans May 18, 2026
  Contributors : Cun Li ; Yifei Yu ; Zhixin Wan ; Jianpiao Cai ; Jingjing Huang ; Xiaoxin Zhu ; Jiali Wu ; Wei Xue ; Ying Zhou ; Manchun Chiu ; Qiaoshuai Lan ; Shuxin Zhang ; Zijun Zhao ; Yidong Yang ; Yuhong Liu ; Pui Wang ; Shaofeng Deng ; Ming Yue ; Longchao Zhu ; Keshan Zhang ; Mengmeng Zhao ; Jieshi Yu ; Wen-kang Wei ; Xiang Gao ; Lin Huang ; Hin Chu ; Ga […]
• GSE303486 Transcriptome-guided development of a fibrosis-reversal compound reduces skin scarring and allows regeneration via mitochondrial uncoupling [DRUG-seq2] May 18, 2026
  Contributors : Chunye Chen ; Ruilin Xu ; Jiahao Wu ; Jun Chi ; Zhangrui Wu ; Yi Wang ; Xincao Zhong ; Xiaoying Lin ; Zhongya Song ; Yang Liu ; Yong Yang ; Weiqiang Tan ; Yang ZhaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSkin scarring impairs function and aesthetics. Current therapies show limited efficacy and cau […]
• GSE267821 4-1BB causes CAR-T cell death via sequestration of the ubiquitin-modifying enzyme A20 May 18, 2026
  Contributors : Xin Zhou ; Mark G Woodcock ; Gianpietro DottiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCD28 and 4-1BB costimulatory endodomains included in chimeric antigen receptor (CAR) molecules play a critical role in promoting sustained antitumor activity of CAR-T cells. However, the molecular events associate […]
• GSE315654 Integrated Multi-omics Analysis Reveals that Hybrid Rice Reprograms Carbon Metabolism to Confer Drought Resistance May 18, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Oryza sativaDrought severely limits global rice production, and exploiting heterosis offers a promising route to improve drought resistance. However, the molecular mechanisms underlying drought resistant heterosis remain largely unknown. Here, we integrated multi-omics analyses of the […]
• GSE330931 Radiopharmaceuticals enhance CAR T-cells against radio-sensitive and radio-resistant neuroblastoma by tumor sensitization and TME remodeling May 18, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
• GSE330930 Radiopharmaceuticals enhance CAR T-cells against radio-sensitive and radio-resistant neuroblastoma by tumor sensitization and TME remodeling [scRNA-Seq] May 18, 2026
  Contributors : Rosa Nguyen ; Robert Edinger ; Constanza Rodriguez ; Xiyuan ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensChimeric antigen receptor (CAR) T-cell therapy has limited efficacy against solid tumors such as neuroblastoma (NB). Key obstacles include extensive tumor burden and the presence of an immunosu […]
• GSE331137 Methylation Mesa define functional regulatory elements for targeted gene activation May 18, 2026
  Series Type : Expression profiling by high throughput sequencing ; Methylation profiling by high throughput sequencing ; OtherOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
• GSE331007 Effects of T cell–specific IL-21 isoform expression on gene expression in mammary epithelial cells. May 18, 2026
  Contributors : Risako Yamaguchi ; Junji Yokozawa ; Hironobu AsaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusInterleukin-21 (IL-21) is a pleiotropic cytokine produced by CD4⁺ T cells that critically regulates the differentiation and functions of various adaptive and innate immune cells. In this study, to investigate […]
• GSE331185 Artificial light at night reshapes diel brain transcriptomics in Dascyllus aruanus damselfish May 18, 2026
  Contributors : Shachaf Ben-Ezra ; Dana Sagie ; Jasmin Lynn Mellijor ; Saki Harii ; Frederic Sinniger ; Lior Appelbaum ; Oren LevySeries Type : Expression profiling by high throughput sequencingOrganism : Dascyllus aruanusArtificial light at night (ALAN) disrupts natural light cycles and interferes with light-dependent biological processes, yet its cellular-l […]
• GSE331193 CD4+ Tregs drive post-ischemic sprouting angiogenesis via endothelial YY1/MAML1 reactivation [RNA-seq] May 18, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMicrovascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T-cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient […]
• GSE331194 CD4+ Tregs drive post-ischemic sprouting angiogenesis via endothelial YY1/MAML1 reactivation [ChIP-seq] May 18, 2026
  Series Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusMicrovascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T-cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in im […]
• GSE297009 Targeting NAT10 inhibits hepatocarcinogenesis via ac4C-mediated May 18, 2026
  Contributors : Yigan Zhang ; Hao DengSeries Type : OtherOrganism : Homo sapiensHepatocellular carcinoma (HCC) is characterized by high morbidity and mortality, withlimited effective treatment options. NAT10 is the only known acetyltransferase formRNA ac4C modification and is recognized as a biomarker for HCC, promoting itsprogression. However, the critical r […]