Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE295775 RNA-seq for AML cell line in either the absence or presence of ENO1 July 29, 2026
  Contributors : Fang Fang ; Jian Pan ; Yijun Wu ; Chun Yang ; Shaoyan HuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNext-generation sequencing (NGS) has revolutionized systems-based analysis of cellular pathways. The goals of this study are to compare RNA-seq results for AML cell line in either the absence or presenc […]
• GSE284360 Co-deficiency of the BLM and RECQL1 Helicases Causes Synthetic Lethality, Pronounced Replication Stress, and Loss of Chromatid Cohesion July 29, 2026
  Contributors : Lauren Herr ; Srijita Dhar ; Martina Rossi ; Ethan D Schaffer ; Kajal Biswas ; Sandra S Burkett ; Swagata Mukhopadhyay ; Arindam Datta ; Miguel Calvo-Rubio ; Donna O Butcher ; Daniel R McNeill ; Kotb Abdelmohsen ; Myriam Gorospe ; Claudia M Nicolae ; Tanay Thakar ; George-Lucian Moldovan ; Simonetta Camandola ; Cristopher Dunn ; Rafael de Cabo […]
• GSE303969 OXTR Overexpression Induces Polycystic Ovary Syndrome-like Phenotype via prolactin/p-STAT3 Signaling in Mice. [RNA-seq] July 29, 2026
  Contributors : Dan Li ; ShuiLian Wang ; XinYue Bao ; Ziying LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPolycystic ovary syndrome (PCOS), a prevalent endocrine disorder, represents the most common cause of anovulatory infertility. While the oxytocin receptor (OXTR) is well-characterized in parturition and lactati […]
• GSE302032 Transcripts identified by microarray analysis that were deregulated in E12.5+18h cultures of murine ureters upon treatment with IWP-2. July 29, 2026
  Contributors : Andreas Kispert ; Mark-Oliver TroweSeries Type : Expression profiling by arrayOrganism : Mus musculusEvaluation of the transcriptional changes in murine E12.5+18h ureters upon treatment with IWP-2.
• GSE309156 Mannose-Modified Tobacco Mosaic Virus-Mediated Macrophage Regulation Inhibits Pulmonary Fibrosis Progression July 29, 2026
  Contributors : Jiaodan Jin ; Ren Xu ; Huaixiu Fu ; Wei Qian ; Yu Liu ; Jinzhao Ou ; Meng Zhu ; Yunzhi Zhou ; Ye Tian ; Zhongwei NiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIdiopathic pulmonary fibrosis (IPF) is a chronic disease, causing irreversible lung scarring and respiratory failure. CD206+ M2 macrophages pl […]
• GSE307972 Anti-CD19 CAR-NK cells coexpressing GITRL to enhance antitumor activity for the treatment of leukemias and lymphomas. July 29, 2026
  Contributors : Dayane Schmidt ; Virginia P CastroSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCAR-T cell therapy has transformed the treatment of hematological malignancies; however, its broad application is limited due to toxicities and high cost. As an alternative, NK cells offer advantages, including allogeneic us […]
• GSE341293 Distinct activation programs in naïve and memory CD8 T cells govern progeny stemness and effector persistence (single cell experiment, OT-I mice, Lm-OVA infection, Day 6) July 29, 2026
  Contributors : Eva Salyova ; Darina Paprckova ; Juraj Michalik ; Veronika Niederlova ; Ondrej StepanekSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusWe longitudinally profiled gene expression in naive and central and effector memory CD8+ T cells across multiple models of acute cognate infection to reveal subset […]
• GSE341780 ERα/miR-26a/ANKRD52 axis regulates progression of MASH- associated HCC in HDTVi HCC models July 29, 2026
  Contributor : Renji WeiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe lack of robust mouse models for metabolic dysfunction-associated steatohepatitis-hepatocellular carcinoma (MASH-HCC) severely hinders mechanistic investigation and therapeutic drug development. Conventional MASH-HCC animal models require a length […]
• GSE341390 Distinct activation programs in naïve and memory CD8 T cells govern progeny stemness and effector persistence (mixed) [memory_scRNAseq_exp34] July 29, 2026
  Contributors : Eva Salyova ; Darina Paprckova ; Juraj Michalik ; Veronika Niederlova ; Ondrej StepanekSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusWe longitudinally profiled gene expression in naive and central and effector memory CD8+ T cells across multiple models of acute cognate infection to reveal subset […]
• GSE341377 Single-nucleus transcriptomic analysis of aging and hepatocyte-specific ADK reduction in mouse liver July 29, 2026
  Contributors : Chaodong Wu ; Honggui Li ; Xinlei Guo ; Xiaojing Li ; Miaoyun ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAging is associated with extensive transcriptional and cellular changes in the liver, including the emergence of metabolically dysfunctional and stress-responsive hepatocyte states. Adenosine […]
• GSE341391 Distinct activation programs in naïve and memory CD8 T cells govern progeny stemness and effector persistence (multiome, OT-I. Day 0 as control, Day 7 and Day 12) July 29, 2026
  Contributors : Eva Salyova ; Darina Paprckova ; Juraj Michalik ; Veronika Niederlova ; Ondrej StepanekSeries Type : Expression profiling by high throughput sequencing ; Other ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusWe longitudinally profiled gene expression in naive and central and effector memory CD8+ T cells […]
• GSE341563 Interrogating DNA methylation associated with Lewy body pathology in a cross brain-region and multi-cohort study July 29, 2026
  Contributors : Joshua Harvey ; Jennifer Imm ; Katie Lunnon ; Ehsan PishvaSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensIn this study we investigated DNA methylation association with Lewy body pathology, profiled genome wide using this Illumina EPIC bead chip array in a set of brain samples sourced from the UK Brain Bank Net […]
• GSE341741 Genomic profiling of estrogen-related receptor identifies adult adipocyte-specific targets in Drosophila July 29, 2026
  Contributor : Lesley N WeaverSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Drosophila melanogasterEstrogen-related receptor (ERR) is a conserved nuclear receptor required for energy homeostasis. Here, we took a modified DamID genomic profiling approach (NanoDam) to identify ERR-specific targets in adult Drosophila m […]
• GSE266023 Nrf2-mediated chromatin activation of hyperosmotic response genes attenuates heat-induced renal injury [RNA-seq] July 29, 2026
  Contributors : YI Lu ; Lirong ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe escalating frequency and duration of extreme weather events, driven by ongoing climate change, are heightening health hazards associated with heat stress. Heat stress can cause whole-body hyperosmolarity and increase risk of chronic k […]
• GSE341292 Distinct activation programs in naïve and memory CD8 T cells govern progeny stemness and effector persistence (single cell experiment, OT-I mice, Lm-OVA infection,Week 12) July 29, 2026
  Contributors : Eva Salyova ; Darina Paprckova ; Juraj Michalik ; Veronika Niederlova ; Ondrej StepanekSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusWe longitudinally profiled gene expression in naive and central and effector memory CD8+ T cells across multiple models of acute cognate infection to reveal subset […]