Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE253213 Plastic state transitions and developmental potential predict response to Notch inhibition January 14, 2026
  Contributors : Valeriya Dimitrova ; Julia Frede ; Anna Montanaro ; Noori Sotoudeh Chafi ; Hannah Stuart ; Huiyoung Yun ; Sayalee Potdar ; Alexandria Van Scoyk ; Shruti Bhatt ; Stephan R Bohl ; Praveen Anand ; Jake Kloeber ; Antonis Kokkalis ; Johannes M Waldschmidt ; Anthony G Letai ; David M Weinstock ; Jon C Aster ; Jens G Lohr ; Birgit KnoechelSeries Type […]
• GSE277708 Transcriptional profiling of isolated T cells of healthy individuals after treatment with supernatant of peripheral blood mononuclear cells (PBMCs) of the same individuals treated overnight with soluble CD14 (sCD14) January 14, 2026
  Contributors : Shima Shahbaz ; Shokrollah Elahi ; Amirhossein RahmatiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn this study, we treated PBMCs of 6 healthy individuals with sCD14 overnight. The day after, the supernatant of treated PBMCs was collected and isolated T cells from the same individuals were stimulated […]
• GSE274634 MYOD1L122R induces cancer stem cell pathways to impart chemotherapy and radiation-resistance in aggressive rhabdomyosarcoma [RNA-seq_HDR] January 14, 2026
  Contributors : Yun Wei ; Luis A Sanchez ; Shuze Wang ; Esther Rheinbay ; David M LangenauSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRhabdomyosarcoma (RMS) is a common pediatric soft tissue sarcoma of skeletal muscle. Worse outcomes are associated with specific subtypes of RMS, including the 10% of fusion-negative t […]
• GSE288585 Jk DNA GAGA MOTIFS ARE REQUIRED FOR LOCAL NUCLEOSOME REMODELING AND Vk-Jk RECOMBINATION [ATAC-Seq] January 14, 2026
  Contributors : Margaret Veselits ; Kaitlin McLean ; Nathaniel E Wright ; Michael Okoreeh ; Jacob Veselits ; Mark Maienshein-Cline ; Malay Mandal ; Marcus ClarkSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusImmunoreceptor gene recombination requires complementary 12 bp and 23 bp recombination signal sequen […]
• GSE285445 Disruption of jejunal and ileum homeostasis by malnutrition in systemic jejunal and ileum microbiota-host interactions in a pregnant sheep model [miRNA-Seq] January 14, 2026
  Contributors : Peng Jiao ; Weibin Wu ; Shengyong Mao ; Yanfeng XueSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Ovis ariesIn the current study, five late gestation multiparous ewes were restricted to a 30% feeding level to create a model of malnutrition, while five other ewes were fed normally as controls. All ewes were sacri […]
• GSE294580 Transcriptomic Insights into the effect of Mesenchymal Stromal Cells Culture Medium on the Hematopoietic Stem/Progenitor Cells Co-culture January 14, 2026
  Contributors : Maria Catarina Carreira ; André Branco ; Miguel Casanova ; Carolina Smet ; Cláudia Lobato da Silva ; Ana Fernandes-PlatzgummerSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the molecular mechanisms underlying the altered hematopoietic support of mesenchymal stromal cells (MSC) expanded in […]
• GSE291367 A conserved function of EZH2-PRC2 in the repression of primitive endoderm cell fate [RNA-Seq - human] January 14, 2026
  Contributors : Man Zhang ; Junyu ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn early blastocyst, inner cell mass (ICM) initiates the second wave of cell fate decisions to generate epiblast and primitive endoderm (PrE), crucial for proper embryo development. However, the epigenetic mechanisms underlying this seg […]
• GSE316097 Heliophilum fasciatum regulation in response to available sulfate and thiosulfate concentrations. January 14, 2026
  Contributors : Calissa S Carlisle ; Justin A North ; Kelly S BenderSeries Type : Expression profiling by high throughput sequencingOrganism : Heliophilum fasciatumHeliophilum fasciatum is an anoxygenic photosynthetic bacteria isolated from rice soil. Previous work outlined the existence of five nitrogen-fixation-like gene clusters potentially involved in sul […]
• GSE316049 KMT2D maintains Treg homeostasis and protects against inflammatory diseases by regulating the purinergic channel P2X7 level January 14, 2026
  Contributor : Peng WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRegulatory T (Treg) cells are essential for maintaining immune homeostasis and tolerance through the prevention of inflammatory and autoimmune responses. The histone methyltransferase KMT2D is indispensable for induced Treg (iTreg) cell differentiati […]
• GSE316149 Monocyte-derived IL-10 drives sex differences in pain duration January 14, 2026
  Contributors : Jaewon Sim ; Elizabeth O’Guin ; Chiho Sugimoto ; Sophie Laumet ; Karli Monahan ; Matthew P Bernard ; Samuel A McLean ; Liz M Albertorio-Sáez ; Ying Zhao ; Hariharan Ramakrishnan ; Sabrina de Souza ; Olivia C Eller ; Christine J Smoyer ; Kyle M Baumbauer ; Matthias Mack ; Joseph K Folger ; Alfred J Robison ; Sarah D Linnstaedt ; Geoffroy Laumet […]
• GSE316112 RiboBright reveals cell-type specific differences in ribosome organization and movement January 14, 2026
  Contributors : Georgia Poulladofonou ; Carmen Grandi ; Xinyu Hu ; Phillip Yesley ; Willem Velema ; Maike HansenSeries Type : OtherOrganism : Homo sapiensRibosomes are responsible for protein synthesis in all living systems. Determining their cellular organization, movement and translational activity is crucial for dissecting ribosomes’ complex functions. In […]
• GSE316190 Targeting HMGB2 acts as dual immunomodulator by bolstering CD8+ T cell function and inhibiting tumor growth in hepatocellular carcinoma [RNA-Seq] January 14, 2026
  Contributors : Weifeng Qu ; Guiqi Zhu ; Yinghong ShiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTranscriptional features were detected in NC versus HMGB2-knockout CD8+ T cells of C57BL/6J mice.
• GSE316333 CUT&Tag profiling of JUND chromatin binding in human mast cell line LAD2 under SCF stimulation and imatinib perturbation January 14, 2026
  Contributors : Tianyu Cao ; Yfeng JingSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensMast cells respond to cytokine cues through rapid transcriptional rewiring. Here we generated CUT&Tag profiles of the transcription factor JUND in the human mast cell line LAD2 under three culture conditions: SCF with […]
• GSE316356 A quadrivalent in vivo CAR-macrophage serve as cell vaccine to repress solid tumors and overcome tumor heterogeneity through antigen spreading January 14, 2026
  Contributors : Shaolong Zhang ; Hengxing Lu ; Hailing Zhang ; Qixin Wu ; Xizhong DingSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusWe designed a quadrivalent in vivo CAR-engineered macrophage for treating solid tumors by the LNP-mRNA system. Mechanically, we found that in vivo engineered CAR macrophages can pr […]
• GSE239300 Aging-declined RNA Exportation Impairs Hematopoietic Stem Cells by Inducing R-Loop January 14, 2026
  Contributors : Ruiqing Chen ; Qiongye Dong ; Qianwen Sun ; Jianwei WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIt is well acknowledged that aging-induced DNA damage accumulation impairs hematopoietic stem cell (HSC). While, how DNA damage is accumulated and how to eliminate it to rejuvenate aged HSCs are largely […]