Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE302366 Comparative scRNA-seq analysis of bone marrow stromal cells in control, naive, exhausted, aged, aged-injury condition June 16, 2026
  Contributors : Yuki Matsushita ; Sixun WuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSingle-cell transcriptional profiles of femoral bone marrow stromal cells from control, naive (single-injured), exhausted (repeatedly injured), aged, and aged-injury (single-injured) mice labeled with Lepr-cre; tdTomato.
• GSE299953 Single-cell omics analysis of age-related immune signatures induced by Omicron sublineage breakthrough infection June 16, 2026
  Contributors : George F Gao ; Yanhua Li ; Shijie Qin ; Lei DongSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAlthough COVID-19 is no longer a panic-inducing virus, immunocompromised populations, such as the elderly and those with underlying health conditions, remain at higher risk of severe illness. However, current d […]
• GSE310338 Transcriptomic analysis of macrophages June 16, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe clinical efficacy of cytotoxic nanomedicines is often limited by rapid hepatic clearance, yet the endogenous biological regulators of this process remain incompletely understood. Here, we identify the gut microbiota as a central determinant of nanomedicine biodistribut […]
• GSE306738 Childhood Adversity, Allostatic Load, and Epigenetic Signatures in Pediatric and Adult-onset Multiple Sclerosis June 16, 2026
  Contributors : Kimberly A. O’Neill ; Lauren Krupp ; Mirjana Maletic-Savatic ; Kian Koh ; Bernard K. van der VeerSeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensChildhood adversity has an impact on multiple sclerosis (MS) onset, clinical severity and progression, but our understanding of potentially related biological p […]
• GSE327926 PBRM1 RNA-seq [4T1] June 16, 2026
  Contributors : Emily Dykhuizen ; Alisha Dhiman ; Sagar UtturkarSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMammalian SWI/SNF or BAF are multi-subunit complexes that regulate cell-type specific gene expression by modulating chromatin accessibility, in coordination with transcription factors and other chromatin regula […]
• GSE319877 Transcriptomic profiling of human RPTECs following TNFα and IFNγ stimulation at early and late time points June 16, 2026
  Contributors : Yanjuan Hou ; Katalin SusztakSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRenal proximal tubule epithelial cells (RPTECs) were stimulated with TNFα, IFNγ, or a combination of TNFα and IFNγ to characterize cytokine-induced transcriptional responses. Bulk RNA sequencing was performed at 3 h and 12 h foll […]
• GSE335309 Effect of keratinocyte-intrinsic VISTA deletion on UV-induced type I interferon and inflammatory gene expression in mouse epidermis June 16, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
• GSE269428 PBRM1 RNA-seq June 16, 2026
  Contributors : Emily Dykhuizen ; Alisha Dhiman ; Sagar UtturkarSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMammalian SWI/SNF or BAF are multi-subunit complexes that regulate cell-type specific gene expression by modulating chromatin accessibility, in coordination with transcription factors and other chromatin regula […]
• GSE335334 The extreme diversity of retinal amacrine cells has deep evolutionary roots [axolotl] June 16, 2026
  Contributors : Dario Tommasini ; Aboozar Monavarfeshani ; Vishruth Dinesh ; Josh Hahn ; Jared Tangeman ; Olivier Marre ; Seth Blackshaw ; Teresa Puthussery ; Josh R. Sanes ; Karthik ShekharSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Ambystoma mexicanumAmacrine c […]
• GSE335331 The extreme diversity of retinal amacrine cells has deep evolutionary roots [newt] June 16, 2026
  Contributors : Dario Tommasini ; Aboozar Monavarfeshani ; Vishruth Dinesh ; Josh Hahn ; Jared Tangeman ; Olivier Marre ; Seth Blackshaw ; Teresa Puthussery ; Josh R. Sanes ; Karthik ShekharSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Pleurodeles waltlAmacrine cel […]
• GSE335452 Single-cell RNA-seq and spatial transcriptomics characterize CD8+ exhausted T cells in pancreatic ductal adenocarcinoma June 16, 2026
  Contributors : Jing Mao ; Chenxin Yan ; Ying Mei ; Yanjun Yao ; Xingxia Yang ; Jing Zhuang ; Kuai Yu ; Gangzhao Gu ; Hengzhi Zhang ; Yu Zheng ; Yunyao Wei ; Shuwen Han ; Qiang YanSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensPancreatic cancer resists immunotherapy due to a suppressive immune microenvironment w […]
• GSE335464 Integrative single-cell multi-omics profiling of human pancreatic islets identifies T1D-associated genes and regulatory signals [single cell] June 16, 2026
  Contributors : Ricardo D'Oliveira Albanus ; Xiaoshan Zhang ; Zeping Zhao ; Stephen Parker ; Shuibing ChenSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensGenome-wide association studies (GWAS) have identified over 100 signals associated with type 1 d […]
• GSE335490 Single-cell transcriptomic profiling of 4-NQO-induced oral squamous cell carcinoma in a mouse model June 16, 2026
  Contributors : Xing Liu ; Yalun Li ; Lanlan Gao ; Rihui Lu ; Yongjin Fang ; Xiao YangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the cellular heterogeneity and molecular drivers of oral squamous cell carcinoma (OSCC), we performed single-cell RNA sequencing (scRNA-seq) on tongue tissues from a 4-nitro […]
• GSE295391 The fetal specific gene LIN28B is essential for human fetal B-lymphopoiesis and initiation of KMT2A::AFF1 infant leukemia [RIP-Seq] June 16, 2026
  Contributors : Rebecca Ling ; Thomas Jackson ; Thomas Milne ; Anindita RoySeries Type : OtherOrganism : Homo sapiensInfant ALL (iALL) is initiated in utero, most often by rearrangement of the KMT2A gene (KMT2Ar). It carries a very poor prognosis despite a lack of additional oncogenic driver mutations common in childhood ALL. Here, we aimed to identify specif […]
• GSE335307 Effect of keratinocyte-intrinsic VISTA deletion on UV-induced type I interferon and inflammatory gene expression in mouse epidermis [scRNA-seq] June 16, 2026
  Contributors : Zachary Peters ; Sladjana Skopelja-GardnerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusType I interferon (IFN-I) signaling is a central driver of cutaneous lupus erythematosus (CLE), but the keratinocyte-intrinsic checkpoints that restrain UV-triggered IFN-I responses remain poorly defined. Here we rep […]