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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE318294 Lung cancer-enriched p53 mutants occupy canonical p53 target genes without activating transcription, revealing a distinct loss-of-function behavior [RNA-Seq] February 4, 2026Contributors : Mason A Tracewell ; Hailey N Shankle ; Samantha M Barnada ; Khushali S Vyas ; Kevin M Kim ; Theodhora Qyshkollari ; Jonathan E Karlin ; Julie A Barta ; Steven B McMahonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensLung cancer is the most common cause of cancer-related death in the U.S. and globally. Cig […]
- GSE288696 Multiple defects in mouse pseudo-embryos lacking all Hox function [ATAC-seq] February 4, 2026Contributors : Hocine Rekaik ; Lucille Lopez-Delisle ; Alexandre Mayran ; Yuliia Romaniuk ; Cynthia Diabanza ; Anne-Catherine Cossy ; Denis DubouleSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusMammals have four genomic copies of an ancestral Hox cluster, with a total of 39 genes. While gene inactivation […]
- GSE274858 Hyaluronic acid networks and emergent tissue mechanics orchestrate mammalian limb regeneration February 4, 2026Contributors : Byron W Mui ; Joseph J Wong ; Mekayla A StorerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn mammals, only distal amputations of the terminal digit regenerate, while more proximal ones result in non-regenerative, fibrotic scarring, underscoring the limits of our regenerative capacity. The mechanisms t […]
- GSE293226 Isolated DNA repeat units nucleate heterochromatin through Integrator-coupled transcriptional attenuation February 4, 2026Contributors : Yi-Hsuan Lo ; Galina Erikson ; Thomas JenuweinSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusHeterochromatin defines a transcription-repressive chromatin state. In mouse cells, heterochromatin is associated with underlying arrays of A/T-rich, 234 bp DNA repeat elements, called the major sat […]
- GSE288700 Ventricles of wild type and TRPC6 knockout hearts February 4, 2026Contributors : Yohei Yamaguchi ; Toshiyuki KanekoSeries Type : Expression profiling by arrayOrganism : Mus musculusTo determine the effect of genetic deletion of TRPC6 in the cardiomyocytes, we compared the mRNA expression levels in the ventricle of a wild-type mouse and a TRPC6 genetic deletion mouse.
- GSE305468 Early cAMP signaling orchestrates single-cell synchronicity throughout Dictyostelium development February 4, 2026Contributors : Mariko Katoh-Kurasawa ; Gad Shaulsky ; Lena Trnovec ; Blaz ZupanSeries Type : Expression profiling by high throughput sequencingOrganism : Dictyostelium discoideumSynchronicity is a fascinating biological property observed across many organizational levels, from physiological functions such as heartbeat, breathing, and brain activity, to circa […]
- GSE300664 Transcriptional competence defines the heterochromatin nucleating potential of isolated MSR copies [H3K9me3_ChIP] February 4, 2026Contributors : Yi-Hsuan Lo ; Galina Erikson ; Thomas JenuweinSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusHeterochromatin defines a transcription-repressive chromatin state. In mouse cells, heterochromatin is associated with underlying arrays of A/T-rich, 234 bp DNA repeat elements, called the major sat […]
- GSE318214 Integrative proteomics identifies a conserved Ab amyloid responsome, novel plaque proteins, and pathology modifiers in Alzheimer’s disease February 4, 2026Contributors : Karen N McFarland ; Yona Levites ; Todd E GoldeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAlzheimer’s disease (AD) is a complex neurodegenerative disorder that develops over decades. AD brain proteomics reveals vast alterations in protein levels and numerous altered biologic pathways. Here, we compar […]
- GSE318211 RNA-seq of human aortic smooth muscle cells treated with recombinant sST2 and angiotensin II February 4, 2026Contributors : Chenfeng Wang ; Shengyan Pu ; Ruogu LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSoluble ST2 (sST2) is a well-established prognostic biomarker for aortic aneurysm (AA); however, its direct contribution to AA pathogenesis remains obscure. While traditionally characterized as a decoy receptor for IL-33 […]
- GSE318246 Optimized Protocol for Culturing Porcine Retinal Explants and RNA Isolation February 4, 2026Contributors : siavash khosravi ; Nina ZippleSeries Type : Expression profiling by high throughput sequencingOrganism : Sus scrofaThe culture of porcine retinal explants serves as a valuable cellular model for studying retinal pathologies and their underlying molecular mechanisms. This protocol provides a detailed, step-by-step guide for dissecting the eye, […]
- GSE318217 Gene Expression profiling of TgCRND8 brains at 18 months February 4, 2026Contributors : Karen N McFarland ; Yona Levites ; Todd E GoldeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTau tangles and amyloid plaques are pathological hallmarkes of Alzheimer's disease (AD). To understand transcriptomics changes that occur in response to amyloid deposition, we have analyzed the brains of 18 […]
- GSE318252 Sox9-dependent acquisition of a drug resistant "memory state" induces reciprocal expression of Sox6 and Sox7 in BRAF melanoma February 4, 2026Contributors : Samuel Delisle ; John Abou-Hamad ; Luc SabourinSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn melanoma, SOX9 and SOX10 are markers of the mesenchymal and melanocytic state, respectively. Using a panel of BRAFV600E positive YUMM lines, we find that, following chronic vemurafenib treatment, SOX10 is los […]
- GSE318258 Global knockout of VEGFB improves lipoprotein lipase activity leading to an improved lipid profile during diabetes February 4, 2026Contributors : Hualin Wang ; Rui Shang ; Chae Syng Lee ; Bahira Hussein ; Brian RodriguesSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusDiabetes affects over half a billion people worldwide, with cardiovascular disease Q7 being its leading cause of death, either occurring secondary to atherosclerosis or due to an […]
- GSE318292 Lung cancer-enriched p53 mutants occupy canonical p53 target genes without activating transcription, revealing a distinct loss-of-function behavior [ChIP-Seq] February 4, 2026Contributors : Mason A Tracewell ; Hailey N Shankle ; Samantha M Barnada ; Khushali S Vyas ; Kevin M Kim ; Theodhora Qyshkollari ; Jonathan E Karlin ; Julie A Barta ; Steven B McMahonSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensLung cancer is the most common cause of cancer-related death in the U.S. and […]
- GSE310443 Single-cell Spatial Transcriptomics Reveals Hepatocyte Metabolic Reprogramming in Fontan Associated Liver Disease February 4, 2026Contributors : Brandon M Lehrich ; Jordann N Lewis ; Vik Meadows ; Lori Schmitt ; Mylarappa B Ningappa ; Jia-Jun Liu ; Silvia Liu ; Catherine Gestrich ; Victor O Morell ; Rakesh Sindhi ; Satdarshan P Monga ; Anita SarafSeries Type : OtherOrganism : Homo sapiensBackground: Fontan-associated liver disease (FALD) is a common sequelae of single-ventricle patient […]