Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE290327 RNA-seq Profiling of Response to Cisplatin and Gemcitabine Chemotherapy in Advanced Urothelial Carcinoma: An External Validation Cohort February 24, 2026
  Contributors : Kwonoh Park ; Sang-Bo Oh ; Jong Kil Nam ; Tae Un Kim ; Hwaseong Ryu ; Yong Kan KiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis dataset includes RNA sequencing data from formalin-fixed paraffin-embedded (FFPE) tumor samples of advanced urothelial carcinoma patients treated with cisplatin and gemcita […]
• GSE281293 Genome-wide transcriptome analysis upon KSHV lytic reactivation February 24, 2026
  Contributors : SooMi Lee ; Frank J SlackSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPurpose: To characterize genome-wide mRNA expression profiles in the context of Kaposi's sarcoma-associated herpesvirus (KSHV) lytic reactivation.Methods: We utilized a well-established model of KSHV reactivation, the doxycyclin […]
• GSE300821 Transcriptome profiling of secondary hair follicle stem cells during cashmere growth [RNA-Seq] February 24, 2026
  Contributors : Huiling Xue ; Xinyue Liang ; Bohan Liu ; Yanlei Liu ; Shengda ShengSeries Type : Expression profiling by high throughput sequencingOrganism : Capra hircusTo investigate how various histone modifications influence gene expression, transcriptome sequencing was performed on secondary hair follicle stem cells (SHFSCs) collected in parallel with th […]
• GSE295433 Phosphorylation of SF3B1 by CDK11 1 orchestrates spliceosome activation via SNIP1 dependent RES complex recruitment February 24, 2026
  Contributors : Pavla Gajduskova ; Igor Ruiz de Los Mozos ; Milan Hluchy ; Antonina Myskova ; Katerina Zabrady ; Peter Manik ; Neda Dragisic ; Katerina Hanakova ; David Potesil ; Sara Bologna ; Jiri Novacek ; Caroline C Friedel ; Konstantinos Tripsianes ; Zbynek Zdrahal ; Dalibor BlazekSeries Type : OtherOrganism : Homo sapiensSplicing Factor 3b Subunit 1 (SF […]
• GSE305554 m6A epitranscriptome regulates axonogenesis and reprogramming of retinal ganglion cells [RNA-seq] February 24, 2026
  Contributor : Shuyi ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusinduced retinal ganglion cells (iRGCs) is an excellent system to generate RGC-like neurons for translational and theoretical studies. N6-methyladenosine (m6A) is the most prevalent internal modification in mRNAs. Using this iRGC system, we demonstra […]
• GSE301939 Histone methyltransferase DOT1L affects the development of dendritic cell subsets [ChIP-Seq] February 24, 2026
  Contributors : Willem-Jan de Leeuw ; Anne Mensink ; Rianne G Bouma ; Fred van Leeuwen ; Joke M den HaanSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusDendritic cells (DCs) are important orchestrators of immune responses and can be divided into two conventional DC subsets, cDC1s and cDC2s, and a plasmacyto […]
• GSE320007 Oncolytic virotherapy and platinum-based chemotherapy synergize to potentiate anti-tumor immunity through targeted engagement of chemo-persistent bystander CD8+ T cells [scRNA-seq] February 24, 2026
  Contributors : Xiangyu Chen ; Guoshuai Cao ; Shuai YueSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe reported the CD8+ T cell exhaustion differences between chronic viral infection and tumor regarding their transcriptomic and epigenetic landscapes, immune checkpoint blockade responsiveness and underlying molecular m […]
• GSE320308 PD0325901 Alleviates Thrombin-Inhibited Osteogenic Differentiation Through an IL-1β-Activated Feedback Loop between MEK-Erk1/2 and NF-κB Signal Pathways: Insights from Bioinformatics and Experimental Verification February 24, 2026
  Contributors : Yangshuo Ge ; Chunmeng Huang ; Jun Shen ; Tingting Meng ; Minjun Zhao ; Jianli Yin ; Xinhui Huang ; Liaolin Chen ; Jiahui Luo ; Yuqing Zhai ; Jiawei Du ; Yilin Wang ; Xuezong Wang ; Pingping Sun ; Daofang DingSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusThrombin transcriptionally induces inflammat […]
• GSE320035 RNA-seq analysis of liquid-induced suspended animation (LISA) in C. elegans February 24, 2026
  Contributors : Junqiang Liu ; Dengke MaSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansTo elucidate the molecular landscape associated with liquid-induced suspended animation (LISA) in C. elegans, we performed transcriptomic profiling of animals subjected to high-density isosmotic liquid conditions. Wild-type […]
• GSE320030 A selective and augmentable butyrate-FFAR2 signal circuitry programs the cellular identity of enteroendocrine L-cells February 24, 2026
  Contributors : Aanya Hirdaramani ; Chia-Wei Gheng ; Gary Frost ; Aylin HanyalogluSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusActivation of free fatty acid receptor 2 (FFAR2) on enteroendocrine L-cells mediates secretion of glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), key regulators of central appetite contr […]
• GSE320064 Tissue resident memory CD4+ T cells after neonatal or adult HMPV infection February 24, 2026
  Contributors : Taylor Eddens ; Kong Chen ; Li FanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTissue resident memory cells are long-lived sentinels that are generated after exposures at mucosal sites. In this experiment, neonatal (day of life 4-6) or adult (6-8 week old) mice were infected with human metapneumovirus […]
• GSE320090 Genetically targeted mTORC1 inhibitor reveals transcriptional control by nuclear mTORC1 February 24, 2026
  Contributors : Yanghao Zhong ; Ayse Z Sahan ; Zhengyao Shao ; Qianyi Zhang ; Xin Zhou ; Jack G Haggett ; Keiichi Koshizuka ; Samuel A Myers ; Jorge S Gutkind ; Jin ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusmTORC1 is a nutrient sensor which integrates diverse inputs to regulate protein translation and cell gro […]
• GSE320138 Assessing the cellular microenvironment in the skin of mice lacking epidermal Pparg compared with wildtype sibling controls. February 24, 2026
  Contributors : Raymond L Konger ; Xiaoling Xuei ; Ethel Derr-Yellin ; Fang Fang ; Hongyu Gao ; Yunlong LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusB6.129-Ppargtm2Rev/J mice (Stock Number: 004584, The Jackson Laboratory) were crossed with B6N.Cg-Tg(KRT14-cre)1Amc/J mice (Stock Number 018964, The Jackson Laboratory […]
• GSE273231 Co-cultivation of Schizosaccharomyces japonicus-Fusarium graminearum revealed the biocontrol effect of the yeast and the Fusarium-induced transcriptomic changes February 24, 2026
  Contributors : Laszló Attila Papp ; Lajos Ács-Szabó ; Gyula Batta ; Ida MiklósSeries Type : Expression profiling by high throughput sequencingOrganism : Fusarium graminearum ; Schizosaccharomyces japonicus yFS275The growth control of Fusarium species and modification of their harmful mycotoxins are of paramount importance. In this study, we used an in silico […]
• GSE319960 Plasma miR-98-5p as a diagnostic biomarker for oxaliplatin-induced neuropathic pain related to NGF and catecholamine dysregulation February 24, 2026
  Contributors : Yeongdon Ju ; Aelee JangSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensThis study aimed to identify differentially expressed microRNAs in plasma samples from patients with gastrointestinal cancer treated with oxaliplatin to elucidate the association between the expression levels of miRNA, nerve growt […]