Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE334097 Identification of genomic features that uniquely impact estrogen receptor alpha binding and its effects on gene expression in endometrial cancer [ChIP-seq] June 3, 2026
  Contributors : Alexandra Richey ; Noel Kitchen ; Craig Rush ; Jason GertzSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensEstrogen receptor alpha (ER) is an established oncogenic transcription factor in breast and endometrial cancer; however, more is known about the mechanisms controlling ER behavior in bre […]
• GSE307137 Spaceflight multi-omics reveals vulnerabilities of human germ cell development June 3, 2026
  Contributors : Ying Li ; Hui Gao ; Jie Xiong ; Nan Wang ; Yongchun Yuan ; Linjun Wang ; Jinzhong Xu ; Wenze Huang ; Gikin Tan ; Xiaojuan He ; Qiangfeng Zhang ; Tao Zhang ; Kehkooi KeeSeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensExposure to microgravity, cosmic radiation, and other spaceflight conditions induces sign […]
• GSE278667 Effect of MbovP475 on gene expression in BoMac cells June 3, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Bos taurusMbovP475 of M. bovis is a nucleomodulin and has the ability to enter into cells nucleus during infection. Recently, we verifed that MbovP475 can regulate the hostone PTMs. To detect the effect of MbovP475 of M. bovis on gene expression in BoMac cells, we constructed BoMac ce […]
• GSE264083 Mycobacterium abscessus infection in fetal liver derived alveolar-like macrophages activates distinct inflammatory responses compared to myeloid-derived macrophages June 3, 2026
  Contributors : Haleigh N Gilliland ; Soledad Soverina ; Kayla N Conner ; Taryn Vielma ; Andrew J OliveSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPulmonary infections caused by Mycobacterium abscessus (Mab), a rapidly growing nontuberculous mycobacterium (NTM), are on the rise in patients with chronic or acquired lu […]
• GSE291239 Glial-specific and inducible full body C3 deficiency does not affect amyloid pathology in the AppNL−G−F mouse model of Alzheimer’s disease June 3, 2026
  Contributors : Pieter Dujardin ; Clint De Nolf ; Roosmarijn VandenbrouckeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackgroundAlzheimer's disease (AD) is intricately linked with neuroinflammation, with the complement system, particularly C3, emerging as a critical player. However, research has been hampered by […]
• GSE286403 B cell CD19 is widely transferred between immune cells [CD11b+] June 3, 2026
  Contributors : Ochs Jasmin ; Schweineberg Pia ; Thode Jacqueline ; Blenkle Alica ; Husseini Leila ; Klein Matthias ; Bopp Tobias ; Schindler patrick ; Paul Friedemann ; Weber MartinSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWhen immune cells interact, they frequently exchange membrane-bound antigens. Our evolving u […]
• GSE333807 Single-nucleus multiomic profiling of hippocampus and frontal cortex in a C9orf72 knockout mouse model June 3, 2026
  Contributors : Paul M. McKeever ; Janice RobertsonSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThis project contains single-nucleus multiomic sequencing data generated from hippocampal and frontal cortex tissue collected from wild-type, heterozygous, […]
• GSE298289 Transcriptomic Insights into Exogenous Putrescine-Mediated Cold Adaptation in Cannabis sativa L. [miRNA-Seq] June 3, 2026
  Contributors : Byeong-Ryeol Ryu ; Min-Jun Kim ; Min-Ji Kang ; Sang-Hyuck Park ; Jung-Dae LimSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Cannabis sativaLow temperature is a major abiotic stress factor that promotes oxidative stress and disrupts cellular homeostasis, ultimately impairing plant physiological functions. This st […]
• GSE334083 Arginine methylationof BAF155 regualtes interactions with RNA processing machinery [ATAC-seq] June 3, 2026
  Contributor : Jesse RaabSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensPost-translational modifications (PTMs) of chromatin remodelers are abundant but functionally understudied. Here we investigate the role of asymmetric dimethylation of arginine 1064 (BAF155me2a) on the SWI/SNF core subunit BAF155, a ma […]
• GSE334029 EpiFat Coverage: integrative multiomics analysis and machine learning modelling for heart disease June 3, 2026
  Contributors : Andrei Alexandru Mircea ; Stephen Schwenderer ; Eric Rytkin ; Tatiana Efimova ; Zoltan Kutalik ; Keith Crandall ; Kedar Aras ; Igor EfimovSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: Epicardial adipose tissue (EAT) has emerged as a key factor in the pathogenesis of cardiovascular diseases, […]
• GSE334084 Arginine methylationof BAF155 regualtes interactions with RNA processing machinery [CUT&RUN] June 3, 2026
  Contributor : Jesse RaabSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensPost-translational modifications (PTMs) of chromatin remodelers are abundant but functionally understudied. Here we investigate the role of asymmetric dimethylation of arginine 1064 (BAF155me2a) on the SWI/SNF core subunit BAF155, a ma […]
• GSE334085 Arginine methylation of BAF155 regulates interactions with RNA processing machinery [TT-seq] June 3, 2026
  Contributor : Jesse RaabSeries Type : OtherOrganism : Homo sapiensPost-translational modifications (PTMs) of chromatin remodelers are abundant but functionally understudied. Here we investigate the role of asymmetric dimethylation of arginine 1064 (BAF155me2a) on the SWI/SNF core subunit BAF155, a mark deposited by CARM1/PRMT4 that has been linked to tumor p […]
• GSE334086 Arginine methylationof BAF155 regualtes interactions with RNA processing machinery [RNA-seq] June 3, 2026
  Contributor : Jesse RaabSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPost-translational modifications (PTMs) of chromatin remodelers are abundant but functionally understudied. Here we investigate the role of asymmetric dimethylation of arginine 1064 (BAF155me2a) on the SWI/SNF core subunit BAF155, a mark deposited b […]
• GSE303294 Transcriptomic Characterization of Doxorubicin Resistance in Bone Sarcoma Organoids June 3, 2026
  Contributors : René Rodríguez ; Borja GallegoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTumor organoids have emerged as the most promising avatar to model cancer in vitro and to be used as drug testing platform in personalized medicine protocols. The derivation of organoids from epithelial tumors is well establishe […]
• GSE333763 Targeting YAP1 Attenuates Persistent Oxidative Stress-Driven Tubular Cell Senescence June 3, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPersistent oxidative stress induced by hydrogen peroxide (H2O2) upregulates the expression of YAP1 and triggers cellular senescence in HK-2 (human kidney-2) cells. Conversely, knockdown of YAP1 not only downregulates the Hippo signaling pathway but also suppresses genes in […]