Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE271310 Role of RXRg in NSC-derived OPCs and their differentiation July 2, 2026
  Contributor : Vito BaldassarroSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRXRg is positive regulator of oligodendrocyte progenitor (OPC) differentiation. To address molecular underpinnings of this regulation we performed analyses of the effects of RXRg deletion (RXRgKO) as a function of 24hrs T3 treatment (different […]
• GSE300504 ScRNA-Seq analysis of spontaneous regeneration of inner ear hair cells in a novel injury model revealed the key role of dlx5a July 2, 2026
  Contributors : Jie Gong ; Chao Yang ; Guiyi Zhang ; Chao Guo ; Xun Wang ; Ying Xu ; Fuping Qian ; Xin Wang ; Dong LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioWe established a hair cell injury model in the zebrafish inner ear by injecting neomycin at 5 dpf. To capture the key time points of hair cell damage and reg […]
• GSE282673 TIME-RESOLVED MORPHOLOGICAL AND TRANSCRIPTOMIC CHARACTERIZATION OF EARLY ENTERIC NEURON SUBTYPE EMERGENCE IN CHICK July 2, 2026
  Contributors : Maëlys André ; Guillaume Marcy ; Julien Falk ; Valérie CastellaniSeries Type : Expression profiling by high throughput sequencingOrganism : Gallus gallusThe genetic programs directing nascent enteric nervous circuits and their unique architecture remain poorly characterized. To gain insight, we combined manipulations in the chick embryo model, […]
• GSE309674 STING deficiency does not rescue short-telomere mediated aging phenotypes and longevity in TERC or TERT telomerase deficient mice July 2, 2026
  Contributors : Rosa M. Marión ; José Carlos González ; Maria A. BlascoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe c-GAS-STING pathway is proposed to have a key physiological role in the response to viral genomes and other types of endogenous DNA byproducts by inducing inflammatory pathways. More recently a role […]
• GSE307491 TGF-alpha/EGFR signalling mediates retinoic acid-induced lung repair July 2, 2026
  Contributors : Charlotte H Dean ; Sek-Shir Cheong ; David ChambersSeries Type : Expression profiling by arrayOrganism : Homo sapiensRetinoic acid (RA) signalling is an important regulator of lung development and repair. To investigate the molecular mechanisms underlying RA-mediated responses in lung endothelial cells, we profiled the gene expression of human […]
• GSE337384 Comparison of FOLR2-negative and FOLR2-positive human decidual macrophages at term July 2, 2026
  Contributors : Emilie O Paterson ; Katerina Rekopoulou ; Victoria MaleSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe initiation of human labour is associated with inflammatory activation at the maternal-fetal interface; however, the cellular mechanisms driving this process remain incompletely understood. Decidual m […]
• GSE311279 Analysis of pancreatitis-derived organoids and PDAC organoids cocultured with multi-stroma July 2, 2026
  Contributors : Giulia Biffi ; Wenlong Li ; Muntadher JihadSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe investigated the crosstalk between cocultures of pancreatitis (P)-derived organoids (P1 or P5) or PDAC organoids (T6-LOH or T13-LOH) and multi-stroma (pancreatic stellate cells PSC5, pancreatic fibroblasts FIBRO2 […]
• GSE337001 A novel High-Throughput Ligase-Independent Mapping method to detect Viral Integration Sites July 2, 2026
  Contributors : Manisha Kabi ; Guillaume J FilionSeries Type : OtherOrganism : Homo sapiensIntegrated DNA elements are central to virology, functional genomics, and gene therapy, but current insertion-site mapping methods often rely on restriction digestion, ligation, or complex sequencing workflows that introduce bias and limit recovery. Here, we present Ter […]
• GSE336861 ID2 secures cDC1 specification by antagonizing E proteins at a pleiotropic Zeb2 enhancer [scRNA-seq] July 2, 2026
  Contributors : Feiya Ou ; Kenneth M MurphySeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusThe transcriptional regulator ID2 is required for type 1 classical dendritic cell (cDC1) specification, yet the mechanism has remained obscure. We previously identified the Zeb2 -165-kb enhancer as key to normal hematopoies […]
• GSE337244 ChIP-seq profiling of RBBP4 and P300 occupancy after CSNK2B knockdown in small cell lung cancer cells July 2, 2026
  Contributors : Yuli Chen ; Qinnan Chen ; Jiahao Guo ; Ziwei Li ; Shaokun Yu ; Peng Huang ; Ming SunSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThis ChIP-seq dataset profiles genome-wide occupancy of RBBP4 and P300 in NCI-H69 human small cell lung cancer cells after siRNA-mediated CSNK2B knockdown. The […]
• GSE337180 Tbx3 controls retinal angiogenesis by driving retinogenesis July 2, 2026
  Contributors : Joao-Carlos Ribeiro-Silva ; Nikita Shah ; Mark L Derbyshire ; Sruti Akula ; Rachel Burt ; Zoe Boyd ; Carmen Lee-Bennett ; Anne S Moon ; Michael E Zuber ; Andrea S ViczianSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRetinal angiogenesis relies on a tightly coordinated sequence of retinogenesis, astrocyt […]
• GSE337245 Transcriptome profiling of SCRMP knockout and control NCI-H69 small cell lung cancer cells July 2, 2026
  Contributors : Yuli Chen ; Qinnan Chen ; Jiahao Guo ; Peng Huang ; Ming Sun ; Fengqi Nie ; Xianghua LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis series contains RNA-seq data from NCI-H69 small cell lung cancer cells with CRISPR/Cas9-mediated SCRMP knockout and corresponding negative control cells. SCRMP is a […]
• GSE337294 Development of a Gene Editing Strategy to Enhance CAR-T Therapy Through Inducible IL-15 Expression at the PD-1 Locus July 2, 2026
  Contributors : M Cortijo-Gutiérrez ; PP Jurado-Bascón ; P Carmona-Sáez ; F Martín ; K BenabdellahSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: Adoptive cell therapy (ACT) with genetically engineered T cells expressing chimeric antigen receptors (CARs) has emerged as a promising treatment option for refract […]
• GSE337354 Tissue-specific consequences of impaired RNA surveillance converge on mitochondrial homeostasis July 2, 2026
  Contributors : Lauryn A Higginson ; Xingjun Wang ; Derrick J MortonSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterRNA surveillance pathways maintain transcriptome integrity by eliminating aberrant, excess, and non-functional RNAs, yet it remains unclear whether distinct tissues exhibit equivalent requirement […]
• GSE266494 Genome-wide rotational and translational phasing of nucleosomes with human transcription factors July 2, 2026
  Contributors : Haining Chen ; Jordan E Krebs ; Olivia W Lang ; Jiayi Hu ; Devin C Mellini ; Judith Hyle ; Chunliang Li ; William KM Lai ; B Franklin PughSeries Type : OtherOrganism : Homo sapiensHow transcription factors (TFs) and their binding sites organize and engage nucleosomes at natural genomic locations remains poorly understood. Here we develop Benzo […]