Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE289108 Neurons undergo IFNγ-driven persistent epigenetic shifts and synaptic remodeling in the inflamed brain [ChIP-Seq] December 23, 2025
  Contributors : Shammas Ghazal ; Merkler DoronSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusOur study provides novel evidence that neuronal intrinsic epigenetic changes are established as a consequence of cytotoxic T cell-mediated immune attacks and persist long after the resolution of the inflammatory pr […]
• GSE285496 RBPscan: A Quantitative, In Vivo Tool for Profiling RNA-Binding Protein Interactions IV December 23, 2025
  Contributors : Dmitry A Kretov ; Owen Sanborn ; Thora McIssac ; Elaine Park ; Imrat Imrat ; Samuel Wu ; Daniel CifuentesSeries Type : OtherOrganism : Danio rerio ; Homo sapiensRNA-binding proteins (RBPs) are essential regulators of gene expression at post-transcriptional level, yet obtaining quantitative insights into RBP–RNA interactions in vivo remains a c […]
• GSE293530 A streamlined nanopore-compatible 5PSeq protocol for rapid phenotypic antimicrobial sensitivity testing (Fig4_PromethION) December 23, 2025
  Contributors : Honglian Liu ; Susanne Huch ; Ryan Hull ; Fabricio R Garcia ; Lilit Nersisyan ; Wei-Hua Chen ; Juan Du ; Vicent PelechanoSeries Type : OtherOrganism : Clostridioides difficileAntimicrobial resistance (AMR) poses a significant threat to public health. Rapid and accurate antimicrobial sensitivity testing is essential to guide effective treatment […]
• GSE293523 A streamlined nanopore-compatible 5PSeq protocol for rapid phenotypic antimicrobial sensitivity testing(Fig1_HT-5PSeq) December 23, 2025
  Contributors : Honglian Liu ; Susanne Huch ; Ryan Hull ; Fabricio R Garcia ; Lilit Nersisyan ; Wei-Hua Chen ; Juan Du ; Vicent PelechanoSeries Type : OtherOrganism : Bacillus subtilis ; Lactiplantibacillus plantarumAntimicrobial resistance (AMR) poses a significant threat to public health. Rapid and accurate antimicrobial sensitivity testing is essential to […]
• GSE169467 Epigenetic Signatures of Brain Aging by Single Nucleus Methylation Sequencing [NACB-9mo-m-012] December 23, 2025
  Contributors : Wei Tian ; Anna Bartlett ; Jordan Altshul ; Rosa Gomez Castanon ; Joseph R Nery ; Jacinta D Lucero ; Julia K Osteen ; Huaming Chen ; M M Behrens ; Joseph R EckerSeries Type : Methylation profiling by high throughput sequencingOrganism : Mus musculusIllustrating aging effects on the epigenomic features of brain is critical to understand brain f […]
• GSE295802 In Vivo Dual RNA-Seq identifies a novel AB Toxin-like as a key effector of Leptospira interrogans barrier disruption (or host colonization) December 23, 2025
  Contributors : Alexandre Giraud-Gatineau ; Georges Haustant ; Marc Monot ; Mathieu Picardeau ; Nadia BenaroudjSeries Type : Expression profiling by high throughput sequencingOrganism : Leptospira interrogans ; Mesocricetus auratusThe ability to evade host immune responses and disrupt epithelial barriers is essential for microbial pathogenesis, yet the underl […]
• GSE314360 Isw2-dependent chromatin remodeling at the CRZ1 promoter governs azole tolerance in Candida albicans December 23, 2025
  Contributors : Adnane Sellam ; Antony T. Vincent ; Maria Juliana Mantilla ; Faiza Tebbji ; Andrew Chatr-aryamontriSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Candida albicansHere, we conducted a quantitative analysis of transcription factor deletion mutants in C […]
• GSE272209 Functional and molecular characterization of exosomes secreted from mesenchymal stromal cells exposed to IFNg in the presence of autophagy modulators tamoxifen and chloroquine December 23, 2025
  Contributors : Vladimir Beljanski ; Julia M Hollweg ; Renee Potens ; Tanner Blaylock ; Andres B Irausquin ; Nikhila Paleati ; Lubov NathansonSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensBone marrow mesenchymal stromal cells (MSCs) are therapeutic cells which adopt an immunomodulatory phenotype when exposed to pro […]
• GSE314476 Sex-specific effects of exogenous asparagine on colorectal tumor growth, 17β-estradiol levels, and aromatase December 23, 2025
  Contributors : Oladimeji Aladelokun ; Katherine Benitez ; Yuying Wang ; Abhishek Jain ; Domenica Berardi ; Georgio Maroun ; Xinyi Shen ; Jatin Roper ; Joanna Gibson ; Kaelyn Sumigray ; Sajid A Khan ; Caroline H JohnsonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSex-related differences in asparagine metabolism are as […]
• GSE314454 From blood to pluripotency: Fibrocytes as a reprogrammable somatic cell source for bovine iPSCs December 23, 2025
  Contributors : Vimal Selvaraj ; Hannah Sylvester ; Prasanthi P KogantiSeries Type : Expression profiling by high throughput sequencingOrganism : Bos taurusFibrocytes represent a distinct somatic cell type derived from peripheral blood leukocytes, first described as spindle-shaped adherent cells with dual hematopoietic and mesenchymal features. Although fibro […]
• GSE314617 Shotgun metagenomic profiling of human fecal microbiota before and after aerobic exercise intervention December 23, 2025
  Contributors : Ci Song ; Chengxiao Yu ; Xin Xu ; Zhibin HuSeries Type : OtherOrganism : feces metagenomeLean nonalcoholic fatty liver disease (NAFLD) is increasingly recognized as a distinct clinical phenotype with limited evidence for effective non-pharmacological interventions and unclear mechanistic pathways. Aerobic exercise is recommended for NAFLD mana […]
• GSE314652 Targeting mTORC2-Dependent AKT/FOXO1/RNF125 Signaling Exploits a Therapeutic Vulnerability in c-MET-Activated and β-catenin-Mutated Hepatocellular Carcinoma December 23, 2025
  Contributors : Xue Wang ; Xin ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground and Aims: Approximately 10% of human hepatocellular carcinomas (HCC) exhibit concurrent c-MET activation and β-catenin gain-of-function mutations, representing a clinically relevant HCC subtype. This study aimed to investigate t […]
• GSE314714 Serine inhibits granulosa cell ferroptosis to maintain ovarian function December 23, 2025
  Contributors : Haocheng Gu ; Hongbo XinSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCyclophosphamide (CTX) is a primary medicine for curing breast cancer which often caused premature ovarian insufficiency (POI). Our recent publication revealed that CTX induced POI by promoting the expression of SLC1A4, a transporter […]
• GSE285312 RBPscan: A Quantitative, In Vivo Tool for Profiling RNA-Binding Protein Interactions. December 23, 2025
  Contributors : Dmitry A Kretov ; Owen Sanborn ; Thora McIssac ; Elaine Park ; Imrat Imrat ; Samuel Wu ; Daniel CifuentesSeries Type : OtherOrganism : Danio rerio ; Homo sapiensRNA-binding proteins (RBPs) are essential regulators of gene expression at post-transcriptional level, yet obtaining quantitative insights into RBP–RNA interactions in vivo remains a c […]
• GSE314331 Gene expression data from SW13 cells infected with Orthonairovirus hazaraense December 23, 2025
  Contributors : Keisuke Ohta ; Machiko NishioSeries Type : Expression profiling by arrayOrganism : Homo sapiensOrthonairovirus hazaraense (Hazara virus: HAZV) is a surrogate model for Orthonairovirus haemorrhagiae (Crimean-Congo hemorrhagic fever virus: CCHFV). Nucleoprotein of these viruses are multifunctional, and is thought to have a great influence on gen […]