Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE262172 GSK-J4 treatment in ovarian cancer cell lines (ATAC-Seq) June 1, 2026
  Contributors : Marcos Quintela ; Agne Pociute ; Natalia Sikora ; David W JamesSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThe deregulation of histone methylation profiles has been implicated in the pathogenesis of multiple diseases, including ovarian cancer, on of the most lethal gynaecological maligna […]
• GSE234654 DDX6 reshapes the cancer RNA editome to suppress RNA-induced innate immunity June 1, 2026
  Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
• GSE284389 DNMT1 RFTS mutation alters RNA splicing and drives neurodegeneration via its RNA-binding function [RNA-BisSeq] June 1, 2026
  Contributors : Guoping Fan ; Ganlu HuSeries Type : OtherOrganism : Homo sapiensDNA Methyltransferase 1 (DNMT1) is a key enzyme in maintaining DNA methylation. Mutations in the RFTS domain of DNMT1 are associated with two neurodegenerative diseases: Hereditary sensory and autonomic neuropathy type 1E with dementia and hearing loss (HSAN1E) and Autosomal domin […]
• GSE270985 Myonuclear reprogramming underlies muscle denervation and weakness following knee injury [ChIP-Seq] June 1, 2026
  Contributors : Nicholas T Thomas ; Alexander R Keeble ; Allison M Owen ; Camille R Brightwel ; Christine M Latham ; Megan C Graham ; Kelsey A Reeves ; Jensen Goh ; Sara Gonzalez-Velez ; Douglas E Long ; Douglas A Harrison ; Phillip A Kern ; Gregory S Hawk ; Caitlin E Conley ; Jean L Fry ; Austin V Stone ; Katherine L Thompson ; Darren L Johnson ; Yuan Wen ; […]
• GSE295886 The gene expression of primitive macrophage derived from human induced pluripotent stem cells treated by PNU282987 June 1, 2026
  Contributors : Koki Harada ; Kazuyuki TakataSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMicroglia are immune cells in the brain originating from primitive macrophages, which developed in the yolk sac during embryonic development. We have previously found that stimulation of the nicotinic acetylcholine receptor α7 su […]
• GSE291284 Low-dose total body irradiation (LD-TBI) primes CD19-directed CAR T cells against large B-cell lymphoman (LBCL) June 1, 2026
  Contributors : Mohammad Alhomoud ; Michelle Foley ; Mayumi Sugita ; Takahiro Yamazaki ; Joshua A Fein ; Samuel Yamshon ; Leandro Martinez ; Alexandra Gomez-Arteaga ; Kai Rejeski ; Roni Shouval ; Paul Pagnini ; Maider Astorkia ; Doron Betel ; Tsiporah Shore ; Juliet N Barker ; Olivier Boyer ; Renier Brentjens ; Koen van Besien ; Lorenzo Galluzzi ; Silvia Form […]
• GSE333480 METTL3-mediated m6A modification controls Tcra recombination center formation and thymic T cell development June 1, 2026
  Contributors : Keyi Li ; Bingtso HaoSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing ; Methylation profiling by high throughput sequencing ; OtherOrganism : Mus musculusN6-methyladenosine (m6A) is the most prevalent internal modification of RNA, and METTL3 functions as the cat […]
• GSE299227 Pyruvate, lactate, and hypoxia reprogram murine CD8 T cell chromatin landscape June 1, 2026
  Contributors : Chang Chih-Hao ; Christopher L Baker ; Wei JianSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate how metabolic and environmental cues shape gene regulation and chromatin accessibility in T cells, CD8 T cells were isolated from […]
• GSE333494 Hippocampal CA3 Nex+ neuronal TNFR2 alleviates chronic neuropathic pain by sex-dependently engaging opioid and endocannabinoid pathways June 1, 2026
  Contributors : Sreejita Arnab ; Payam Fathi ; Erin Jones ; Aravind Meyyappan ; Kayla L Nguyen ; Valerie Bracchi-Ricard ; Shruti Gupta ; Roman Fischer ; Veronica J Tom ; John R BetheaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusChronic neuropathic pain develops due to persistant neuroinflammation and maladaptive synap […]
• GSE333489 Integrative multiomic analysis reveals how non-viral delivery system selection shapes CRISPR gene editing outcomes in stem cells. June 1, 2026
  Contributors : Josh Graham ; Tomas Gonzalez-FernandezSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe clinical translation of CRISPR gene editing is challenged by the lack of delivery systems that are both safe and efficient in therapeutically relevant cell types such as mesenchymal stem cells (MSCs). Non-viral deliv […]
• GSE333498 Transcriptomic profiling of Candida glabrata under eltrombopag (ETP) treatment June 1, 2026
  Contributors : Shih-Ju Wu ; Ying-Lien ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Nakaseomyces glabratusThis study aimed to investigate the transcriptional responses of Candida glabrata to eltrombopag (ETP) treatment. RNA sequencing analysis identified 122 differentially expressed genes under ETP treatment, including 44 upr […]
• GSE333520 The flame retardant triphenyl phosphate induces varying responses in genetically diverse mouse induced pluripotent stem cells June 1, 2026
  Contributors : Madison Armstrong ; Kathryn Janeczko ; Hannah B Dewey ; Anne Czechanski ; Qiongyu Chen ; Emily Swanzey ; Callan O’Connor ; Steven C Munger ; Laura G ReinholdtSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGenetic variation impacts the biological response to chemical and environmental exposures, contribut […]
• GSE333566 Emergence of Disease-relevant Aberrant Epithelial Cell States in Human Alveolar Organoids June 1, 2026
  Contributors : McCall A. Scott ; Kropski Jonathan A.Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSingle-cell RNA-sequencing of human lung epithelial cell organoids cultured with permutations of SFFFM and ADM media as well as pharmacologic activation and manipulation of hypoxia-inducible factors.
• GSE198499 Phf6 mutation induces leukemogenesis through altered chromatin state in mice (RNA-Seq) June 1, 2026
  Contributors : Ying Guo ; Pingpin Sui ; Feng-Chun YangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the effect of PHF6 mutations in leukemogenesis, we generated Phf6R274X transgenetic(Tg) and Phf6 KO mice. Then we purified the Lineage-cKit+Sca-1+ cells from bone marrow of Phf6R274XTg, Phf6 KO and WT mic […]
• GSE333181 Integration of zebrafish pineal transcriptomes reveals cell type-specific timing June 1, 2026
  Contributors : Wexler Yair ; Huang Dengfeng ; Yan Jun ; Gothilf YoavSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioThis study aimed at expanding our knowledge of the cellular composition of the zebrafish pineal gland and identify cellt ype-specific circadian rhythmicity and light response. This was accomplished by combi […]