Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE299993 Transcriptomics of Neurochondrin (NCDN)-depleted and control U251 glioblastoma cells July 11, 2026
  Contributors : Tingrong Ren ; Gaigai Wei ; Haiping Zhao ; Huiling Zhang ; Yuqi Zhang ; Jingjing Yi ; Zhihan GuoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPre mRNA splicing is orchestrated by the spliceosome; a dynamic and highly regulated ribonucleoprotein complex composed of five small nuclear ribonucleoprotein pa […]
• GSE302352 Dual response of wheat roots to ABA and nitrate [dataset2] July 11, 2026
  Contributor : Junyi MuSeries Type : Expression profiling by high throughput sequencingOrganism : Triticum aestivumFor analysis of ABA and nitrogen treated transcriptome, wild-type wheat JW1 at 3 days after germination was removed endosperm and cultured on wheat nutrient culture medium containing 2 mM nitrate for 3 days, and then transferred to a nitrogen-fre […]
• GSE302351 Dual response of wheat roots to ABA and nitrate [dataset1] July 11, 2026
  Contributor : Junyi MuSeries Type : Expression profiling by high throughput sequencingOrganism : Triticum aestivumFor analysis of ABA and nitrogen treated transcriptome, wild-type wheat JW1 at 3 days after germination was removed endosperm and cultured on wheat nutrient culture medium containing 2 mM nitrate for 3 days, and then transferred to a nitrogen-fre […]
• GSE302434 Bromodomain Inhibitors to Prevent Development of Resistance to Targeted Kinase Inhibitors in Schwannomas [RNA-seq] July 11, 2026
  Contributors : Christina Fernandez-Valle ; Haley Hardin ; Anna NagelSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNeurofibromatosis type 2 (NF2) is an inherited disorder that promotes tumor growth on nerves throughout the nervous system. NF2 affects around 1 in 33,000 individuals worldwide and is caused by loss of fun […]
• GSE302409 Dynamic single-cell mapping of cerebrospinal fluid unveils immune suppressive states during cryptococcal meningitis July 11, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe have employed a single cell sequencing approach and single-cell T cell receptor sequencing employing the Singleron Matrix® platform to study the cerebrospinal fluid of patients with cryptococcal meningitis. Cryptococcal meningitis (CM), caused by Cryptococcus spp., rank […]
• GSE338233 Transcriptomic profiling of MIA PaCa-2 cells treated with hydroxyprogesterone caproate July 11, 2026
  Contributors : Jinyuan Lu ; Weishan Liang ; Saisai Tian ; Yiwen ShenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPancreatic ductal adenocarcinoma (PDAC) remains refractory to targeted therapy. This RNA-sequencing study characterizes transcriptional changes in the human PDAC cell line MIA PaCa-2 following treatment wi […]
• GSE302435 Bromodomain Inhibitors to Prevent Development of Resistance to Targeted Kinase Inhibitors in Schwannomas [ChIP-seq] July 11, 2026
  Contributors : Christina Fernandez-Valle ; Haley HardinSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensNeurofibromatosis type 2 (NF2) is an inherited disorder that promotes tumor growth on nerves throughout the nervous system. NF2 affects around 1 in 33,000 individuals worldwide and is caused by loss of fu […]
• GSE326578 Menin-RelA complex antagonizes cancer cell-intrinsic and tumour microenvironment-induced NF-κB hyperactivation to suppress pancreatic neuroendocrine tumorigenesis July 11, 2026
  Contributors : Claire Wen Ying Neo ; Jun Wei Chan ; Gokce Oguz ; Adaikalavan Ramasamy ; Adrian Kee Keong TeoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPancreatic neuroendocrine tumours (PNETs) are rare neuroendocrine cancers with high mortality rates and an immense unmet medical need. While the genetic and immune l […]
• GSE312785 RNA-seq analysis of splenic IgG1 or IgM plasma cells July 11, 2026
  Contributors : Yuki Tai ; Takuya Koike ; Tomohiro KurosakiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn a typical primary immune response, the BCR is brought about by IgM to IgG isotype switching, wherein B cells switched to IgG give rise to more long-lived plasma cells (LLPCs). How such isotype-driven bias takes p […]
• GSE337671 Dysregulated thymus-ovary axis promotes virtual memory T cell polarization to aggravate PCOS pathology July 11, 2026
  Contributors : Yaruo Qiu ; Weixuan Wang ; Chenlei Xu ; Yao Feng ; Dan LvSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPolycystic ovary syndrome (PCOS) is characterized by androgen excess, ovarian dysfunction and polycystic ovarian morphology and is classically considered as a disorder of the hypothalamic-pituitary-gon […]
• GSE329027 Menin-RelA complex antagonizes cancer cell-intrinsic and tumor microenvironment-induced NF-κB hyperactivation to suppress pancreatic neuroendocrine tumorigenesis July 11, 2026
  Contributors : Claire Wen Ying Neo ; Jun Wei Chan ; Elhadi Iich ; Tomomi Taguchi ; Nikita Bora ; Gokce Oguz ; Si Rong Heng ; Xinyi Zhang ; Jet Yee Ng ; Alvin Wei Tian Ng ; Kally Sze Mien Tan ; Wei Xuan Tan ; Adaikalavan Ramasamy ; Takeshi Miyatsuka ; Tatsuya Kin ; James Shapiro ; Khek-Yu Ho ; Joanne Yuen Yie Ngeow ; Adrian Kee Keong TeoSeries Type : Genome b […]
• GSE337704 IL-33 as a component of NETs mediates CIAKI by promoting ferroptosis in tubular epithelial cells July 11, 2026
  Contributors : Mengqing Ma ; Hao Zhang ; Weijuan Deng ; Xia Du ; Ting Chen ; Zhaowei Wang ; Chuxian Chen ; Mengxing Chen ; Binbin Pan ; Dawei Chen ; Qing Sun ; Mengting Lu ; Yimin Li ; Wenjuan Huang ; Rui Tang ; Zhibin Qiu ; Xin Wan ; Changchun CaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study performed bulk […]
• GSE337807 Expanding the ASXL1 Mutation Spectrum: Transcriptomic and Metabolic Dysregulation Underlying Overgrowth Phenotype in Inherited ASXL1 Missense Mutations July 11, 2026
  Contributors : Isabella Lin ; Valerie ArboledaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMutations in genes associated with chromatin remodeling, such as Additional sex combs-like 1 (ASXL1), underlie a spectrum of congenital abnormalities and neurodevelopmental disorders. Pathogenic variants in ASXL1 are classicall […]
• GSE337810 Bulk RNA-sequencing of killifish retina-RPE across aging July 11, 2026
  Contributors : Lajoyce Mboning ; Matteo PellegriniSeries Type : Expression profiling by high throughput sequencingOrganism : Nothobranchius furzeriBulk RNA sequencing was performed on retina-retinal pigment epithelium (retina-RPE) tissue collected from male Nothobranchius furzeri (GRZ background) at four ages (1.5, 3.0, 4.5, and 6.0 months). Total RNA was is […]
• GSE272072 Effects of dexamethasone and desisobutyryl ciclesonide on gene expression in liver and lung of neonatal rats July 11, 2026
  Contributors : Donald B DeFranco ; Julian Jaumnotte ; Jiefei Wang ; Uma R ChandranSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusInfants born before 30 weeks gestation are at risk of developing bronchopulmonary dysplasia (BPD), a prevalent chronic lung disease of prematurity. Glucocorticoids (GCs) such as dexameth […]