Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE291346 scRNA-seq analysis of lung metastatic microenvironment in Tmem175 KO and WT mice. January 19, 2026
  Contributors : Ziqi Zhang ; Lei Chen ; Xuejiao HanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusA 10X Genomics scRNAseq of Tmem175-/- and WT B16-F10 lung matastatic model. The main purpose of this research is to explore the transcriptome changes in different immune cells.
• GSE290089 Evolutionarily divergent transcriptomic programs in ovarian folliculogenesis across mice, monkeys and humans January 19, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Macaca fascicularis ; Mus musculusThis SuperSeries is composed of the SubSeries listed below.
• GSE297733 GLASS-OD primary – recurrent oligodendrogliomas January 19, 2026
  Contributors : Youri Hoogstrate ; Pim J FrenchSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensBackground: Treatment decisions in IDH-mutant oligodendrogliomas are shaped by tumor aggressiveness, underscoring the need for objective grading of these malignant brain tumors. Material and Methods: We collect 302 primary and recurr […]
• GSE294326 A PLETHORA3/7 transcription factor shapes cucumber shoot architecture [DAP-seq] January 19, 2026
  Contributors : Merijn Kerstens ; Kelvin Adema ; Olga Kulikova ; Florian Müller ; Magdalena Lastdrager ; Ben Scheres ; Viola WillemsenSeries Type : OtherOrganism : Cucumis sativusPLETHORA transcription factors (PLTs) are master regulators of plant development. In Arabidopsis, loss of shoot meristematic PLTs leads to destabilised phyllotaxis, but whether these […]
• GSE253001 CA1 significantly aggravats atherosclerosis and MTZ, a inhibitor of CA1, can alleviate the disease. January 19, 2026
  Contributors : Xiaotian Chang ; Kehua FangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAortic calcification is essential for atherosclerosis (AS). Carbonic anhydrase I (CA1) can promote calcification in aortic tissues to stimulate AS plaque formation, and methazolamide (MTZ), a CA inhibitor, can be used to treat AS b […]
• GSE316516 Projection-defined amygdala neurons encode emotional memory through distinct transcriptomic programs January 19, 2026
  Contributors : Lu Zhang ; Dongling Guo ; Xiangjia Zhu ; Yang YangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe amygdala is crucial for emotional memory, but the molecular programs that enable its distinct circuits to encode different memory features remain unclear. Combining single-cell RNA sequencing with retrogr […]
• GSE314097 Codonopsis pilosula polysaccharides mitigates Brucella abortus outer membrane protein 19-induced uterine damage via macrophage adhesion and calcium signaling January 19, 2026
  Contributor : xuxu wangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBrucellosis is a zoonotic disease caused by the Brucella species. Its pathogenesis is closely linked to bacterial evasion of macrophage-mediated killing, induction of a pro-inflammatory cytokine storm, and immune-mediated pathological damage. Accumul […]
• GSE273414 MRTFA-SRF driven gene expression promotes cellular stiffness by controlling cytoplasmic Ca2+ and K+ levels in cancer cells January 19, 2026
  Contributors : Alexa M Gajda ; Mark A Sanborn ; Ekrem E ErSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCellular stiffness, the inverse of compliance, is a biophysical property of cells that fundamentally impacts homeostatic functions and pathological states and understanding how these properties are controlled can pr […]
• GSE315799 CGRP signaling Links Tumor-Associated Pain to Immune Evasion in Oral Squamous Cell Carcinoma January 19, 2026
  Contributors : Amin Reza Nikpoor ; Maryam Ahmadi ; Sebastien Talbot ; Nicole ScheffSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPeripheral sensory nerves are thought to contribute to solid tumor growth, particularly in oral squamous cell carcinoma (OSCC); however, the link between pain and immunosuppression remains u […]
• GSE315580 NAT10 Promotes Tubular Epithelial Cell Senescence in Cisplatin-Induced Acute Kidney Injury by Regulating DDX17 January 19, 2026
  Contributors : Yuting Zhu ; Chun ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAcute kidney injury (AKI) is a severe clinical syndrome with high morbidity and mortality, yet its pathogenesis remains incompletely understood, and effective therapeutic strategies are still lacking. In this study, we observed signifi […]
• GSE316291 MOLECULAR SIGNATURE OF IN UTERO HYPERTHERMIA ON THE MAMMARY FAT PAD OF NEWBORN HEIFERS January 19, 2026
  Contributors : Maverick Guenther ; Bethany Dado-Senn ; Madison N Myers ; Jayasimha R Daddam ; G Andres Contreras ; Zhou Zheng ; Geoffrey E Dahl ; Jimena LaportaSeries Type : Expression profiling by high throughput sequencingOrganism : Bos taurusThis study investigated the effects of in utero heat stress on the microstructure and transcriptomic profile of the […]
• GSE316499 Propranolol overcomes vemurafenib resistance in melanoma by upregulating CDK11 and inducing cell cycle arrest January 19, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAcquired resistance to the BRAF inhibitor vemurafenib remains a major obstacle in melanoma therapy. Drug repurposing offers a promising strategy to overcome such resistance. Here, we investigated the β-blocker propranolol as a sensitizer to vemurafenib in resistant melanom […]
• GSE316515 A dorsal hippocampus-prodynorphinergic dorsolateral septum-to-lateral hypothalamus circuit mediates contextual gating of feeding January 19, 2026
  Contributors : Travis D Goode ; Mollie X Bernstein ; Michael S Totty ; Jason B Alipio ; Cinzia Vicidomini ; Devesh Pathak ; Antoine Besnard ; Delara Chizari ; Nina Sachdev ; Michael D Kritzer ; Ain Chung ; Xin Duan ; Evan Macosko ; Stephanie C Hicks ; Larry S Zweifel ; Amar SahaySeries Type : Expression profiling by high throughput sequencingOrganism : Mus m […]
• GSE290087 Evolutionarily divergent transcriptomic programs in ovarian folliculogenesis across mice, monkeys and humans January 19, 2026
  Contributors : Baku Nakakita ; Ken Mizuta ; Yoshitaka Katou ; Hidetaka Tasaki ; Tomonori Nakamura ; Yukihiro Yabuta ; Chizuru Iwatani ; Hideaki Tsuchiya ; Ikuo Kawamoto ; Tomoyuki Tsukiyama ; Xun Chen ; Guillaume Bourque ; Junko Otsuki ; Mikiya Nakatsuka ; Akihito Horie ; Masaki Mandai ; Mitinori Saitou ; Hiroshi OhtaSeries Type : Expression profiling by hig […]
• GSE313855 Hairy Vetch–Based Green Manure Improves Yield and Grain Appearance Quality in High-Yielding Japanese Rice Cultivars with Lodging Resistance Conferred by Functionally Weak GA20ox alleles January 19, 2026
  Contributors : Hirofumi Fukuda ; Toshihiro Sakamoto ; Akari Fukuda ; Daisuke OgawaSeries Type : Expression profiling by high throughput sequencingOrganism : Oryza sativaGreen manure is widely advocated as a sustainable alternative to chemical fertilizers in crop systems, yet the mechanisms underlying its yield benefits remain unclear. Moreover, vigorous vege […]