Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE267230 RNA Editing for the Treatment of Alpha-1 Antitrypsin Deficiency January 12, 2026
  Contributors : Prashant Monian ; Chikdu Shivalila ; Genliang Lu ; Keith Bowman ; Marissa Bylsma ; Michael Byrne ; Megan Cannon ; Jigar Desai ; Alyse Faraone ; Frank Favaloro ; Anamitra Ghosh ; Jack Godfrey ; Nidia Hernandez ; Olivia Huth ; Naoki Iwamoto ; Tomomi Kawamoto ; Jayakanthan Kumarasamy ; Pachamuthu Kandasamy ; Anthony Lamattina ; Muriel Lemaitre ; […]
• GSE243714 Analysis of three-dimensional enhancer network regulated by CTCF in CD4+ T cells [HiChIP] January 12, 2026
  Contributors : Eun-Chong Lee ; Woong-Jae Jung ; Sugyung KimSeries Type : OtherOrganism : Mus musculusPurpose: We aim to analyze genome-wide changes in RNA expression, histone modifications, chromatin structure, and 3D genome organization in CD4+ T cells following CTCF depletion.Conclusions: CTCF controls gene expression via 3D enhancer network in CD4+ T cell […]
• GSE284101 Functional gene regulatory networks and broad applications of the human expandable pancreatic progenitor-islet system [scRNA-Seq] January 12, 2026
  Contributors : Xiaojie Ma ; Guo Chen ; Liling Jiang ; Saiyong ZhuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensInvestigating the precise gene regulatory programs directing pancreatic differentiation provides insights into the mechanisms of pancreatic development and diabetes progression. Here, we performed integrated […]
• GSE277267 Renal tubular VMP1 protects against acute kidney injury via facilitating autophagic flux January 12, 2026
  Contributors : Wenwen Yang ; Fenglian ZhouSeries Type : OtherOrganism : Homo sapiensAcute kidney injury (AKI) is intricately linked to autophagy. Our study investigates the pivotal role of the autophagy-associated protein VMP1 in the pathogenesis and progression of AKI.
• GSE289618 LncRNA WEE1-AS coordinates oxidative fatty acid metabolism through the activation of mitochondrial Cdk1/Cyclin B1 January 12, 2026
  Contributors : Hyeon-Ji Kim ; Cheolhee Jeong ; Sang-Heon Lee ; Mi-Ock LeeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMetabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly prevalent with life-threatening complications, underscoring the need for new therapeutic targets. In this study, we ide […]
• GSE286507 Transcriptomic analysis of RNA (mRNA/ lncRNA/ circRNA) expression and epitranscriptomic profiling of N4-acetylcytidine-related RNA (mRNA/ lncRNA/ circRNA) acetylation in renal cortex from mice with ischemia reperfusion injury January 12, 2026
  Contributors : Peng Wang ; Tongtong MaSeries Type : Other ; Expression profiling by high throughput sequencingOrganism : Mus musculusN4-acetylation of cytidine (ac4C) in RNA are crucial for regulating the expression level and promoting the translate efficiency of mRNA. However, epitranscriptomic profiling of ac4C-related RNA (mRNA/ lncRNA/ circRNA) acetylati […]
• GSE315985 Uncovering a Key Metabolic Role of the GATA1 N-Terminus in Red Blood Cell Development [CUT&RUN] January 12, 2026
  Contributors : Te Ling ; Rashid Mehmood ; John D CrispinoSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusMutations in GATA1 that result in skipping of exon 2, which encodes the N-terminus, are associated with the myeloid leukemia of Down syndrome and Diamond-Blackfan anemia (DBA). To elucidate the molecula […]
• GSE292326 Development, validation, and clinical utility of a novel methylation classifier for recurrence risk prediction in meningiomas [dataset 2] January 12, 2026
  Contributors : Drew Duckett ; Lucas Santana-Santos ; Matthew McCord ; Vanessa Smith ; MB Lopes ; Mark Youngblood ; Stephen Magill ; James Chandler ; Rimas Lucas ; Ditte Primdahl ; Roger Stupp ; Rudolph Castellani ; Craig Horbinski ; Daniel Brat ; Lawrence J Jennings ; Madina Sukhanova ; Pouya JamshidiSeries Type : Methylation profiling by genome tiling array […]
• GSE316098 Spatial Transcriptomic Landscape of Invasion Patterns in Human Papillomavirus-Associated Endocervical Adenocarcinoma January 12, 2026
  Contributors : Margaret Axelrod ; Lulu SunSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHuman papillomavirus (HPV)-associated endocervical adenocarcinoma is the second-most common cancer of the uterine cervix. HPV-associated endocervical adenocarcinoma can be classified into histologic Silva patterns of invasion, whic […]
• GSE315986 Uncovering a Key Metabolic Role of the GATA1 N-Terminus in Red Blood Cell Development [CUT&RUN Human] January 12, 2026
  Contributors : Te Ling ; Rashid Mehmood ; John D CrispinoSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensMutations in GATA1 that result in skipping of exon 2, which encodes the N-terminus, are associated with the myeloid leukemia of Down syndrome and Diamond-Blackfan anemia (DBA). To elucidate the molecula […]
• GSE316100 The accumulation of methylglyoxal and acrolein leads to arginine depletion causing hyperglycemia and renal abnormalities January 12, 2026
  Contributors : Shu Li ; Hao Li ; Jens KrollSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioThere is growing evidence to support the idea that the accumulation of reactive carbonyl species plays a significant causal role in the pathogenesis of ageing, cardiovascular diseases, diabetes and its complications. Among reactive […]
• GSE316130 Cell Type-Specific Hormonal Signaling Configures Hypothalamic Circuits for Parenting January 12, 2026
  Contributors : Brandon L Logeman ; Patricia M Horvath ; Mustafa Taly ; Vikrant Kapoor ; Harris S Kaplan ; Catherine DulacSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusParenting behavior emerges from hormonally sensitive circuits, but how distinct circu […]
• GSE316142 Gsx2 Regulates Oligodendrocyte Precursor Formation in the Zebrafish Spinal Cord January 12, 2026
  Contributors : Kimberly Arena ; Christina Kearns ; Rebecca O'Rourke ; Bruce AppelSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Danio rerioIn the spinal cord, neural progenitor cells (NPCs) of the pMN domain produce neurons in early development followed by oli […]
• GSE223331 Molecular characterization of glioblatoma tissue samples January 12, 2026
  Contributors : Salvador Alejo ; Yidong Chen ; Gangadhara R SareddySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPatient-derived glioblastoma tissues were collected from discarded specimens obtained from GBM patients undergoing surgery at UT Health San Antonio under an IRB approved biorepository. The specimens were col […]
• GSE315981 Uncovering a Key Metabolic Role of the GATA1 N-Terminus in Red Blood Cell Development [Bulk RNA-seq] January 12, 2026
  Contributors : Te Ling ; Rashid Mehmood ; John D CrispinoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMutations in GATA1 that result in skipping of exon 2, which encodes the N-terminus, are associated with the myeloid leukemia of Down syndrome and Diamond-Blackfan anemia (DBA). To elucidate the molecular functions of […]