Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE229172 Effect of LINC01535-204 (BLACAT3) knockdown on gene expression in bladder cancer T24 cells April 5, 2026
  Contributors : Jinbo Xie ; Bo PengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the target genes and biological functions regulated by BLACAT3, we constructed a T24 cell strain stably knocking down BLACAT3 by shRNA.
• GSE277310 Metastatic triple-negative breast cancer secretes heme metabolites to alter macrophage immune suppression and function April 5, 2026
  Contributors : Michelle M Williams ; Jennifer K Richer ; Andrew E Goodspeed ; Meher Preethi BoorgulaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusA promising approach to improve immunotherapy options for metastatic breast cancer is therapeutic inhibition of metabolic pathways that regulate both pro-tumorigenic and imm […]
• GSE264234 Transcriptome analysis of sham-operated, MI-injured and FGF17-treated MI mice hearts (MI) April 5, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusFibroblast growth factor (FGF) signal transduction plays essential roles in cardiac repair following myocardial infarction (MI). Among which, FGF17 was demonstrated to regulate epicardial epithelial-mesenchymal transition to provide new vasculature for muscle regeneration […]
• GSE288472 Multiple Myeloma Surviving T Cell Therapies Exhibits a CD45+ Immune Evasive Phenotype April 5, 2026
  Contributors : Alana Keller ; Dennis Kady ; Sarah E Parzych ; Zachary J Walker ; Amanda J Novak ; Catherine Pham-Danis ; Tanisha N Medha ; Jeremy T Rakhola ; Meher P Boorgula ; Eric M Kohler ; Daniel W SherbenouSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMultiple myeloma (MM) is an incurable plasma cell malignancy w […]
• GSE287798 Epigenetic modulation of polyamine biosynthetic pathways rectifies T cell dysfunction to enhance anti-tumor immunity in lung cancer [ATAC-seq] April 5, 2026
  Contributor : Hsing-Chen TsaiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensT cell exhaustion (TEX) represents a critical target for immunotherapy in cancer. Nevertheless, T cells exhibit diminished responsiveness to immune checkpoint inhibitors once they transition to a terminally-exhausted state. Here, […]
• GSE300617 Simulated microgravity models sex differences in knee osteoarthritis through a CD36-regulated mechano-metabolic circuit April 5, 2026
  Contributors : Zhiyao Ma ; Haiming Lin ; Daniel Young ; Aahil Ansari ; Melanie Kunze ; Maria Febbraio ; Daniel Graf ; Antoine Dufour ; Adetola AdesidaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusLeveraging the unique conditions of space microgravity, our research offers groundbreaking insights into osteoarthritis (OA […]
• GSE293892 HDAC5 Deficiency Induces Intrinsic Resistance to KRASG12D Inhibition by Disrupting c-Myc Acetylation-Ubiquitination Homeostasis April 5, 2026
  Contributors : Zhou Yingke ; Yu HaixinSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensWe found that HDAC5 deletion significantly enhances intrinsic resistance to MRTX1133 in KRASG12D mutant pancreatic cancer. Mechanistic studies show that HDAC5 deletion promotes resistance to KRASG12D inhibitors by sustain […]
• GSE305407 GPR35+ tumor-associated neutrophils promote tumor growth in hepatocellular carcinoma. April 5, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBulk RNA-seq profiling of tumor-associated neutrophils from Hepa1-6 mouse hepatocellular carcinoma (HCC) models. Neutrophils were isolated from mice HCC tissues and classified as GPR35+ or GPR35- subsets (n=3 per group). Differential expression analysis revealed significan […]
• GSE303719 SnRNAseq of tumors isolated from Apc cKO; Kras-mutant animals April 5, 2026
  Contributors : Amanda R Moore ; Sandra P Melo ; Frederic J de SauvageSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHere, we performed snRNAseq on flash frozen tumors isolated from VilCre; Apc fl/fl; Kras-mutant animals.
• GSE326538 Aqueous Artemisia argyi extract mitigates acute lung injury by coordinating gut microbiota, metabolic homeostasis, and pulmonary inflammatory signaling April 5, 2026
  Contributors : Huixiang Wang ; Haihong JiaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground: Artemisia argyi is a traditional medicinal herb with established anti-inflammatory and immunomodulatory properties. Its aqueous extract (AEAA), enriched in water-soluble bioactive constituents, exhibits favorable safet […]
• GSE318140 Posterior explants of Stage 26 embryos treated with picrotoxins April 5, 2026
  Contributors : Masaki Hachiman ; Hiroki KurodaSeries Type : Expression profiling by high throughput sequencingOrganism : Xenopus laevisThis dataset contains RNA-seq profiles from the posterior explants of Xenopus laevis embryos at stage 26. Explants were sectioned posterior to the otic vesicle and treated with 0.5 mM picrotoxin for 3 h to inhibit Gamma-Amino […]
• GSE326554 RNA-seq of wild-type human iPSC-derived retinal organoids at different developmental stages April 5, 2026
  Contributors : Srishti Silvano ; Rick-Lenze van Annika ; Jacob Sampson ; Milena Zitnik-Sergeant ; Jamie Ellingford ; Manning CerysSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHuman retinal organoids derived from pluripotent stem cells provide an in vitro system to model key aspects of early human retinal development […]
• GSE326561 Remembering heat: How the unicellular alga Cyanidioschyzon merolae establishes a molecular stress memory that boosts its thermotolerance April 5, 2026
  Contributors : Elise Kerckhofs ; Teresa Kowar ; Léa Faivre ; Martha R. Stark ; Ruth Lintermann ; Ana-Belen Kuhlmann ; Stephen D. Rader ; Daniel SchubertSeries Type : Expression profiling by high throughput sequencingOrganism : Cyanidioschyzon merolae ; Cyanidioschyzon merolae strain 10DA powerful way to enhance heat tolerance is by establishing a stress memo […]
• GSE326574 Effect of hydrolyzed corn starch treatment on the gene-expression profiles April 5, 2026
  Contributors : Hitomi Hagawa ; Eri Ichikawa ; Keiko OtakeSeries Type : Expression profiling by arrayOrganism : Homo sapiensThis study investigates the transcriptional response of normal human epidermal keratinocytes (NHEKs) to treatment with hydrolyzed corn starch containing maltotetraose.NHEKs were treated with 2.0% hydrolyzed corn starch for 24 h, and tota […]
• GSE326598 Molecular Characterization of auditory nerve with Versican deficiency [re-analysis] April 5, 2026
  Contributors : Hainan Lang ; Jeremy L BarthSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusOverall goal of the study is to identify molecular regulators of auditory nerve development and maintenance. A reanalysis was done for sequencing data (fastq files) deposited under GEO record GSE122045. These samples were prepared […]