Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE303768 Fetal erythropoiesis and hemoglobin regulation in the context of maternal obesity June 25, 2026
  Contributors : Zhongyun Kou ; Min DuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe employed single-cell RNA sequencing (scRNA-seq) to investigate the impact of maternal obesity (MO) on embryonic erythropoiesis across multiple hematopoietic organs during mouse development. Tissues including E13.5 placenta, yolk sac, […]
• GSE301891 RNA-Seq Analysis of Fibroblast-Like Synoviocytes Treated With Lutein in a Rheumatoid Arthritis Context June 25, 2026
  Contributors : Chi-Jen Chang ; Tsung-Ming Chang ; Ying-Sui Sun ; Ji-Fan Lin ; Chiang-Wen Lee ; Mei-Ling Fang ; Ju-Fang LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation and progressive joint destruction. Although lutein is […]
• GSE314257 Transcriptomic profiling of epigenetic regulators and metabolic reprogramming in human cholangiocarcinoma [HuCCT-1] June 25, 2026
  Contributors : Amaya Lopez-Pascual ; Jasmin Elurbide ; Emiliana Valbuena-Goiricelaya ; M Ujue Latasa ; Elena Anaya ; Elena Adan-Villaescusa ; Borja Castelló-Uribe ; Luz A Martínez-Pérez ; Iker Uriarte ; Maria Arechederra ; Sergio Ciordia ; Fernando J Corrales ; Sona Frankova ; Eva Sticova ; Ondrej Fabian ; Leticia Colyn ; Patricia Inacio ; Juan Bayo ; Meritx […]
• GSE308873 ZMAT3 alleviates cell death in Fanconi anemia via adaptation of sphingolipid metabolism June 25, 2026
  Contributors : Dominique Bluteau ; Camille LobrySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensFanconi anemia (FA) is characterized by defective DNA repair and chronic p53 activation, predisposing to acute myeloid leukemia through persistent genomic instability. The molecular adaptations enabling cell survival under ch […]
• GSE276749 Metadomain genome associations in mammalian T cells (CD4/CD8 data) June 25, 2026
  Series Type : OtherOrganism : Mus musculusThere is a paucity of information regarding 3-dimensional (3D) chromatin interactions and chromosomal organization in different mammalian cell types. For example, the relationships between different topologically associating domains (TADs) and sub-TAD regulatory loops are uncertain due to the lack of appropriate comp […]
• GSE237410 MyD88 Signaling in Trophoblasts is Necessary for Maternal High Fat Diet-Associated Developmental Programming of Obesity June 25, 2026
  Contributors : Kartik Shankar ; Meghan RuebelSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMaternal obesity contributes to persistent programming of offspring obesity. A causal role for placental inflammatory mechanisms in developmental programming remains to be established. We examined the role of the toll-like recep […]
• GSE336535 AAV-mediated gene therapy demonstrates phenotypic rescue in a mouse model of Cockayne Syndrome June 25, 2026
  Contributors : Ana Rita Batista ; Aine C Scholand ; William S Callahan ; McKenna K Watson ; Cassandra M Sion ; Tyler Mola ; Kennedy O'Hara ; Simon A Wentworth ; William S Sena-Esteves ; Oliver D King ; Robert M King ; Miguel Sena-EstevesSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCockayne Syndrome (CS) is an au […]
• GSE295747 CD44 IN MYELOID CELLS IS A MAJOR DRIVER OF LIVER INFLAMMATION AND INJURY IN ALCOHOL-RELATED LIVER DISEASE [CD44_KO_Ethanol] June 25, 2026
  Contributors : Déborah ROUSSEAU ; Stéphanie BONNAFOUS ; Frédéric SOYSOUVANH ; Dorian SARRAIL ; Manon BOURINET ; Axelle STRAZZULLA ; Stéphanie PATOURAUX ; Arnaud BORDERIE ; Bastien DOLFI ; Alexandre GALLERAND ; Marwin A FARRUGIA ; Véronique ORIAN-ROUSSEAU ; Yingzheng Xu ; Jesse W WILLIAMS ; Stoyan IVANOV ; Albert TRAN ; Rodolphe ANTY ; Carmelo LUCI ; Philippe […]
• GSE336548 Effect of intravenous poly(lactide-co-glycolide) nanoparticles on bleomycin pulmonary fibrosis June 25, 2026
  Contributors : Hannah Viola ; Bethany B Moore ; Lonnie SheaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusOrgan fibrosis presents a substantial disease burden with few therapeutic options. Innate immunity mediates fibrinogenesis, but also plays a major role in fibrinolysis. Here, we show that immunomodulatory nanoparti […]
• GSE336537 Transcriptome changes driving multiple regulatory pathways involved in TGF-β-induced Anterior Subcapsular Cataract June 25, 2026
  Contributors : Sarah Y Coomson ; Chirag Parsania ; Charles G Bailey ; Cynthia Metierre ; Mary Flokis ; Salil A Lachke ; Frank J LovicuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTransforming Growth Factor-beta (TGF-β) promotes lens epithelial-mesenchymal tran-sition (EMT) and fibrosis, contributing to anterior subca […]
• GSE336549 Effect of intravenous poly(lactide-co-glycolide) nanoparticles on M2-polarized bone-marrow derived macrophages June 25, 2026
  Contributors : Kate Griffin ; Hannah Viola ; Bethany B Moore ; Lonnie SheaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusOrgan fibrosis presents a substantial disease burden with few therapeutic options. Innate immunity mediates fibrinogenesis, but also plays a major role in fibrinolysis. Here, we show that immunomodul […]
• GSE336609 KRAS inhibition is an effective therapy for appendiceal adenocarcinoma June 25, 2026
  Contributors : John Paul Shen ; Ichiaki Ito ; Saikat ChowdhurySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusAppendiceal adenocarcinoma (AA) is a rare cancer with limited treatment options. KRAS is the most commonly mutated gene in AA and a promising therapeutic target, but its preclinical and translatio […]
• GSE336618 Spatiotemporal Transcriptomic Immune Responses to a Recombinant Hemagglutinin Protein Vaccine [CosMx SMI profiling] June 25, 2026
  Contributors : Laurelle Jackson ; Sarah M Williams ; James Sinclair ; Ana Kume ; Azadeh Bahadoran ; Ingeborg Langohr ; Hillary Danz ; Bin Lu ; Dinesh Bangari ; Amanda J Cox ; Laurence Macia ; Sudha Chivukula ; Nicholas P WestSeries Type : OtherOrganism : Mus musculusVaccination triggers coordinated immune responses that begin at the injection site and propag […]
• GSE300777 Spliceosomal proteins direct RNA methylation to modulate gene expression and silence retrotransposons [RNA-seq] June 25, 2026
  Contributors : Drisya Vijayakumari ; Xander Gottfried ; Brent Groubert ; Jothy Dhakshnamoorthy ; Shweta Jain ; Hua Xiao ; Anupa T Anil ; Martin Zofall ; David Wheeler ; Shiv GrewalSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Schizosaccharomyces pombeRNA modifications play indispensable roles in RNA processing and […]
• GSE336398 Transcriptional Effects of 6-Shogaol and 6-Gingerol in LPS-Stimulated BV2 Microglial Cells June 25, 2026
  Contributors : Insung Choi ; Tae Hyun Kim ; Yong-jun Jeon ; Jin Hee Kim ; Myung Sook Oh ; Inwha BaekSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study investigated the transcriptomic effects of the ginger-derived compounds 6-Shogaol and 6-Gingerol on inflammation-associated gene expression in LPS-stimulated BV2 […]