Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE284279 Diverse impact of neutrophils on cancer cells of different epithelial/mesenchymal phenotypes leads to distinct tumor microenvironment and metastatic behavior [3] May 21, 2026
  Contributors : Ling Wu ; Xiang ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNeutrophils play complicated roles in tumor progression. Examination of several murine triple negative breast cancer (TNBC) models revealed nearly opposite impact of neutrophils on epithelial-like vs. mesenchymal-like cancer cells (ECCs […]
• GSE268011 High Multiplex Translocation sequencing (HMTS) detect translocation in MCF7 and HEK293T with different treatments and in NCAPH2 deficinecy cells treated with ETO. May 21, 2026
  Contributors : Wubin Ma ; Guofeng Zhao ; Tan Wu ; Yajing Hao ; Michael G RosenfeldSeries Type : OtherOrganism : Homo sapiensChromosomal translocations play pivotal roles in various physiological and pathological processes, such as immunoglobulin production and tumor progression; however, the infrequency of chromosomal translocation events has impeded the exp […]
• GSE286557 Nitric oxide drives proteomic diversity through alternative splicing May 21, 2026
  Contributors : Joseph C Schindler ; Puneet Seth ; Alfred Hausladen ; Ricky Chan ; Jun Yang ; Jun Qin ; Zhaoxia Qian ; Divya Seth ; Kathleen Lundberg ; Joseph M Luna ; Richard T Premont ; Jonathan S StamlerSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusThis SuperSeries is composed of the SubSeries listed […]
• GSE286543 Nitric oxide drives proteomic diversity through alternative splicing [CLIP-Seq] May 21, 2026
  Contributors : Joseph C Schindler ; Puneet Seth ; Alfred Hausladen ; Ricky Chan ; Jun Yang ; Jun Qin ; Zhaoxia Qian ; Divya Seth ; Kathleen Lundberg ; Joseph M Luna ; Richard T Premont ; Jonathan S StamlerSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRedox signaling by nitric oxide (NO) is estimated to control the lar […]
• GSE297828 Oxygen-Tolerant Hydrogenase-Ag Nanoclusters-Peptide Hydrogel for Light-Driven H₂ Therapy in Diabetic Wound Healing May 21, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDiabetic wound healing is hindered by excessive reactive oxygen species (ROS), while conventional hydrogen (H₂) delivery methods lack localized efficacy. Escherichia coli [NiFe]-hydrogenase 2 (Hyd-2), though promising for H₂ production, suffers from oxygen sensitivity. Her […]
• GSE297761 Cytosolic sodium accumulation is a common danger signal triggering NLRP3 inflammasome activation May 21, 2026
  Contributors : Matthew Mangan ; Marius Jetzsch ; Jonathan Schmid-BurgkSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDetecting noxious molecules within the endo/lysosomal system is essential for maintaining cellular integrity. Here, we identify acute cytosolic sodium accumulation as a key trigger for NLRP3 inflammasome […]
• GSE328627 Clinically approved HIF‑PHIs modulate redox metabolism, cell growth, and angiogenesis independent of HIF‑1α/HIF‑2α May 21, 2026
  Contributor : Daniela MennerichSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHIF-prolyl hydroxylase inhibitors are used to treat anemia in chronic kidney disease. These drugs stabilize hypoxia-inducible factors HIF-1α and HIF-2α, which activate erythropoiesis and iron metabolism pathways. Clinically approved HIF-PHIs […]
• GSE298522 A temporal single-nucleus atlas of the hippocampus in temporal lobe epilepsy mice unveils neuroprotective IGF1+ microglia May 21, 2026
  Contributors : Fei Xiao ; Ziwei Yuan ; Yan Liu ; Ran Duan ; Xiaogang Zhang ; Liqin Hu ; Fei Song ; Yuan Meng ; Pingyang KeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusEpilepsy is a complex chronic disease characterized by intricate interactions between neurons and various types of glial cells during its pathogenesis. […]
• GSE329254 A telomerase-SUCLG2 signaling axis drives drug resistance by protecting persister cells May 21, 2026
  Contributors : Yu Liu ; Kejia Zhao ; Zhenyu Yang ; Gao Zhang ; Lunxu LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe evolution of drug-tolerant persister (DTP) cells into resistant clones remains a major obstacle to targeted therapies. Transcriptomic profiling across melanoma (A375, SK-MEL-28), non-small cell lun […]
• GSE329222 Transcriptional landscape of mouse adipose tissue transfected with LHX8 siRNA May 21, 2026
  Contributor : Röszer TamásSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe have studied the role of LHX8 (Lim Homeobox 8) in adipocyte development. Mouse 3T3-L1 adipcoytes were used for our analyses. Cells were cultured in high glucose DMEM, supplemented with 10% FCS, 1% glutamine and 1% penicillin/streptomycin. Cells […]
• GSE331127 A telomerase-SUCLG2 signaling axis drives drug resistance by protecting persister cells [ATAC-Seq] May 21, 2026
  Contributors : Yu Liu ; Kejia Zhao ; Zhenyu Yang ; Gao Zhang ; Lunxu LiuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThe evolution of drug-tolerant persister (DTP) cells into resistant clones remains a major obstacle to targeted therapies. Transcriptomic profiling across melanoma (A375, SK-MEL-28), non- […]
• GSE331198 Retinal scRNAseq revelas cell-type-specific responses to bacterial infection May 21, 2026
  Contributors : Sierra Foshe ; Helen Rossmiller ; Jacob K Sterling ; Ellen White ; Michelle C Callegan ; Yuyan Cheng ; Elizabeth Grice ; Joshua L DunaiefSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPurpose: Endophthalmitis is a serious complication of intraocular surgery due to the risk of irreversible retinal damage. […]
• GSE331226 Metabolic–Epigenetic Rewiring of CCR5 hi Monocytes Sustains Long-Term Trained Immunity Against Lethal Sepsis [scRNA-seq] May 21, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTrained immunity enhances innate host defense by endowing monocytes with memory-like properties, yet the underlying integrated metabolic and epigenetic mechanisms remain elusive. Here, we demonstrate that co-immunization with Bacillus Calmette–Guérin (BCG) and bacterial li […]
• GSE203633 Development of small molecule miR-17-92 inhibitors [miRNA-Seq] May 21, 2026
  Contributors : Romina Matter-Marone ; Emmanuelle Landmann ; Denis Seyres ; Anna Toebak ; Lukas JekerSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Mus musculusMicroRNAs (miRNAs) are conserved small non-coding RNAs that regulate gene expression at the posttranscriptional level by pairing to the 3’ UTR of other genes. miR-17-92 […]
• GSE326675 Resf1 is required for normal placental development and configuration of trophoblast cell-specific heterochromatin May 21, 2026
  Contributors : Kei Fukuda ; Yoichi ShinkaiSeries Type : Methylation profiling by high throughput sequencingOrganism : Mus musculusResf1 (Retroelement silencing factor 1) is involved in retroelement silencing cooperated with H3K9 methyltransferase SETDB1 by regulating H3K9 methylation in mouse embryonic stem cells (mESCs). However, it remains unknown whether […]