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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE284998 Interplays between gene therapy vector and host cell genome January 21, 2026Series Type : Genome binding/occupancy profiling by high throughput sequencing ; OtherOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE283670 An EGR1-dependent cascade modulates genome architecture at the CSF1R locus [Capture-C] January 21, 2026Contributors : Sandra Deliard ; Elisa Barbieri ; Marco Trizzino ; Avery Zucco ; Francis Picone ; Alessandro GardiniSeries Type : OtherOrganism : Homo sapiensThe organization and dynamics of chromatin are key to regulating gene expression during myeloid cell differentiation. Sequence-specific transcription factors initiate and maintain a complex network of en […]
- GSE288778 MYRF Controls Mesothelium Specification, Signaling, and Plasticity [scRNA-Seq] January 21, 2026Contributors : Gidsela Luna ; Jamie M Verheyden ; Chunting Tan ; Estelle Kim ; Ziai Zhu ; Michelle Hwa ; Jugraj Sahi ; Yufeng Shen ; Wendy K Chung ; David J McCulley ; Xin SunSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe mesothelium is a squamous monolayer that ensheathes internal organs and lines the body cavitie […]
- GSE287653 Distinct molecular Sox9 dynamics characterize differentiation states and a Sox9 overexpression-induced morphology change in intestinal organoid models. January 21, 2026Contributors : Nike Walther ; Claudia CattoglioSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCellular gene expression programs are rewired during embryonic development to generate healthy tissues and during differentiation underlying the homeostasis of adult tissues. As aberrant gene expression is a hallmark of develo […]
- GSE297477 Highly effective combination of BRG1/BRM inhibitor with BET inhibitor or decitabine for high-risk MECOM-rearranged AML [ChIP-Seq] January 21, 2026Contributors : Warren Fiskus ; Kapil BhallaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensIn AML with 3q26.2 rearrangements (r) the distal GATA2 hematopoietic enhancer becomes aberrantly relocated leading to activation of EVI1 expression EVI1 is a transcriptional regulator that plays a role in proliferati […]
- GSE293519 Androgen Signaling in Type 2 Innate Lymphoid Cells Drives Sex Differences in Helicobacter-Induced Gastric Inflammation and Atrophy January 21, 2026Contributors : Benjamin C Duncan ; Maeve T Morris ; Jordan L Pascoe ; Jonathan T Busada ; Lei Wang ; Gangqing Hu ; Stuti KhadkaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGastric cancer is the fifth most common cancer worldwide. Men are disproportionately affected by gastric cancer, which ranks as the fourth most co […]
- GSE316823 Extracellular Vesicles from Cytokine-Treated Human Pancreatic Ductal Cells Enhance HLA Class I Expression in Beta Cells January 21, 2026Contributors : Neslihan Erdem ; Min-Hsuan Chen ; Hsun Teresa KuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIntroduction/Objective: Type 1 diabetes (T1D) is an autoimmune disease characterized by the loss of insulin-producing beta cells and has no cure. The role of cell-cell interactions in immune recognition of beta […]
- GSE242163 Genetic and Pharmacological Targeting of the EphA4/Tie2 Axis Results in Improved Pial Collateral Response following Ischemic Stroke January 21, 2026Contributors : Alexandra M Kaloss ; Yu Lin ; Hehuang Xie ; Michelle H TheusSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground: Pial collaterals are a major determinant of patient outcome following ischemic stroke, however, targeted treatments for enhancing these blood vessels remain elusive. EphA4, a receptor ty […]
- GSE316869 High Resolution Spatial Mapping of Microbiome-Host Interactions via in situ Polyadenylation and Spatial RNA Sequencing [bulk RNA-Seq] January 21, 2026Contributors : Ioannis Ntekas ; David W McKellar ; Lena Takayasu ; Iwijn De VlaminckSeries Type : Expression profiling by high throughput sequencingOrganism : mouse gut metagenomeInter-microbial and host–microbial interactions are thought to be critical for the functioning of the gut microbiome, but few substantive tools are available to measure these intera […]
- GSE316833 Spatiotemporal molecular profiling of macrophage-fibroblast crosstalk defines checkpoints orchestrating onset and resolution of inflammation [scRNA-seq] January 21, 2026Contributors : Katharina Weishaupt ; David Chambers ; Maria Dzamukova ; Ivana Androšević ; Jean-Philippe Auger ; Darleen Hüser ; Sébastien Trzebanski ; Andreas Ramming ; Anika Grüneboom ; Georg Schett ; Steffen Jung ; Markus H Hoffmann ; Gerhard KrönkeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe molecular details […]
- GSE316918 Spatiotemporal molecular profiling of macrophage-fibroblast crosstalk defines checkpoints orchestrating onset and resolution of inflammation [RNA-seq] January 21, 2026Contributors : Katharina Weishaupt ; David Chambers ; Maria Dzamukova ; Ivana Androšević ; Jean-Philippe Auger ; Darleen Hüser ; Sébastien Trzebanski ; Andreas Ramming ; Anika Grüneboom ; Georg Schett ; Steffen Jung ; Markus H Hoffmann ; Gerhard KrönkeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe molecular details […]
- GSE316957 Single-Cell RNA Sequencing Reveals Distinct Cellular and Molecular Features of Steroid-Induced Osteonecrosis of the Femoral Head Compared to Alcohol-Induced Osteonecrosis and Hip Osteoarthritis January 21, 2026Contributors : Jay R. Lieberman ; Arijita SarkarSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensOsteonecrosis of the femoral head (ONFH) remains a devastating complication of glucocorticoid therapy and alcohol abuse, yet the pathophysiology is poorly understood. Using single-cell RNA sequencing, we analyzed femoral head […]
- GSE316962 Mapping the total transcriptome at near cellular resolution January 21, 2026Contributors : Ioannis Ntekas ; David W McKellar ; Lena Takayasu ; Iwijn De VlaminckSeries Type : OtherOrganism : Mus musculusSpatial transcriptomics provides context to gene expression information, however most methods are only sensitive to a subset of the RNA species. Many noncoding and microbial RNA molecules lack the poly(A) tail which is used to capture […]
- GSE277903 Innate tissue immunosurveillance by γδ T cells has real-time dependence on the T cell receptor [RNA-seq] January 21, 2026Contributors : Miguel Munoz-Ruiz ; Nicolas Veland ; Adrian HaydaySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWith clonotypic potential to engage different ligands, T cell receptor (TCR) γδ fulfils a key tenet of adaptive immunity. Nonetheless, many γδ repertoires are non-circulating, display limited diversity, and a […]
- GSE316812 Single-cell RNA sequencing of thioglycollate-elicited peritoneal cells from myeloid-specific S1pr1 gain- and loss-of-function mice January 21, 2026Contributors : Yueh-Chien Lin ; Michel V Levesque ; Reed Crocker ; Timothy HlaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSphingosine-1-phosphate receptor 1 (S1pr1) plays an important role in myeloid cell trafficking and inflammatory responses. Here, single-cell RNA sequencing was performed on thioglycollate-elicite […]