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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE301788 Uncovering glioblastoma (GBM) origin cells: Isolation and characterization from the subventricular zone (SVZ). August 18, 2026Contributors : Seok-Gu Kang ; Hoon Kim ; Sang-Woo KimSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis study identifies GBM origin cells in the SVZ of humans, highlighting their distinct features, and suggests that these cells could serve as target cells for future GBM treatments.
- GSE288238 A genome-wide map of the genetic network in monocytes that regulates type I interferon induction by the cGAS-STING pathway August 18, 2026Contributors : Emil Aagaard Thomsen ; Jian Zhao ; Ryo Narita ; Luther J Davis ; David Olagnier ; Søren Riis Paludan ; Jacob Giehm MikkelsenSeries Type : OtherOrganism : synthetic constructType I interferons (IFNs) are induced by pattern recognition receptors (PRRs) of the innate immune system to protect against foreign pathogens and malignant transformation, […]
- GSE310802 Morphological and Single-Cell Analyses of En Bloc Resected Non-Muscle invasive Bladder Cancer Reveal Structural and functional disruption of Tertiary lymphoid Structures August 18, 2026Contributors : Sarah Péricart ; Marie Tosolini ; Bernard Malavaud ; Camille LaurentSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTertiary lymphoid structures (TLS) have emerged as critical immune niches within the tumor microenvironment across various cancers. However, their structural organization and functional role […]
- GSE305898 Uncovering the transcriptional hallmarks of endothelial cell aging via integrated single-cell analysis [RNA-Seq 2] August 18, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEndothelial cells (ECs) are critical regulators of vascular function and exhibit specialized, organ-specific roles across tissues. During aging, these cells become dysfunctional, resulting in increased susceptibility to cardiovascular disease and its associated mortality. […]
- GSE325805 mRNA stability in response to m6A placement is linked to cell identity in planarians [Actinomycin D assay] August 18, 2026Contributors : Constantin Höhn ; Andreas Pittroff ; Anne-Sophie Gribling-Burrer ; Lisa Hülsmann ; Redmond P Smyth ; Claus-D. KuhnSeries Type : Expression profiling by high throughput sequencingOrganism : Schmidtea mediterraneaTo test the effect of m6A on mRNA stability, we performed an Actinomycin D assay to monitor mRNA decay kinetics over time in wildtype, […]
- GSE313363 SUMO2 Deletion Changes Chromatin Accessibility and Enhances Cytotoxic T Cell Activation and Tumor Infiltration [mouse_RNAseq] August 18, 2026Contributors : Mohottige D Neranjan Tharuka ; Dai-Hua Chen ; Maria Luisa Jurgensen Amaral ; Tianchen Ren ; Yixuan Kuang ; Shih-Ting Huang ; Nikhil Chilakapti ; Shih-Ting Huang ; Bing Ren ; Stephen P. Schoenberger ; Ye Zheng ; Yuan ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCytotoxic T cells (CTL) are crucial fo […]
- GSE344060 Sex-related differences in gene expression contribute to recurrence in the post-operative ileum August 18, 2026Contributors : Kyle Gettler ; Christopher Tastad ; Ksenija Sabic ; Judy ChoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensQuestion: How does gene expression in CD patients change after ileal resection, and what factors impact these expression changes? Findings: This study assessed RNA-seq and genetic components of 339 […]
- GSE327952 Deep FLASH-seq profiling of purified canine sensory neurons uncovers species-specific signatures relevant to pain and itch August 18, 2026Contributors : Paula Ledesma Fernandez ; Brandi Butler ; Heidi Theis ; Stefan Paulusch ; Elena De Domenico ; Greg A Weir ; Andrew M BellSeries Type : Expression profiling by high throughput sequencingOrganism : Canis lupus familiarisNaturally occurring pain and itch disorders in the domestic dog represent an important and underexploited opportunity for trans […]
- GSE344124 Omega-seq: ultra-low-background RNA sequencing with faithful molecular counting and precise transcript-end capture August 18, 2026Contributors : Hui-Min Chen ; Jui-Chun Kao ; Ching-Po Yang ; Christabel Tan ; Tzumin Lee ; Ken SuginoSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogaster ; Homo sapiens ; synthetic constructPCR-based RNA sequencing generates phantom unique molecular identifiers (UMIs) when residual UMI-bearing oligonucleotides re […]
- GSE344087 Single-cell multimodal immune profiling in MASLD [scRNA-seq] August 18, 2026Contributors : Raju Kumar ; William AlazawiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMetabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease worldwide, yet the cellular mechanisms driving disease progression remain poorly characterised. We performed single-cell CIT […]
- GSE344155 Multi-organ RNA sequencing in TSOD mice August 18, 2026Contributors : Makito Oku ; Keiichi Koizumi ; Kazutaka AkagiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis is a bulk RNA-seq dataset covering 13 organs from male TSOD (Tsumura Suzuki Obese Diabetes) mice aged 3 to 10 weeks. TSOD mice are a model animal for metabolic syndrome. This dataset will be useful for elucid […]
- GSE344164 RNA sequencing data: The effect of early and late erythropoietin in an anemic OIR rat model August 18, 2026Contributor : Ellen C IngolfslandSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusExogenous erythropoietin (Epo) is administered to preterm infants to mitigate anemia and reduce red blood cell transfusions, yet its impact on retinopathy of prematurity (ROP) remains unclear. The objective of this study was to investi […]
- GSE344174 Multi-Omic Analyses of Dietary Fatty Acid-Microbe-Host Interactions Reveal Metaorganismal Lipid Metabolic Crosstalk Impacting Cardiometabolic Disease August 18, 2026Contributors : Nour Mouannes ; Amy C Burrows ; Anthony J Horak ; Venkateshwari Varadharajan ; Sumita Dutta ; Kala Mahen ; Rakhee Banerjee ; William J Massey ; Xiayan Ye ; Marko Mrdjen ; Amanda L Brown ; Olumuyiwa Awoniwi ; Kehey Kitao ; Adarsh Sandhu ; Chiaki Tomimoto ; Kowa Tsuji ; Yasunori Yonejima ; Isaac Ampong ; Renliang Zhang ; Yunguang Qiu ; Belinda W […]
- GSE273833 TRAF7 Mutations Stabilize K/NRAS and Hyperactivate MAPK Signaling to Cause CAFDADD Neurodevelopmental Defects August 18, 2026Contributors : Man Xiao ; Yang Liu ; Maosen Dou ; Shengnan WuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe MAPK-ERK1/2 pathway plays a crucial role in neurodevelopment during embryogenesis, and the hyperactivation of this signaling cascade serves as a pathological hallmark for various neurodevelopmental disorders. […]
- GSE343958 Bulk RNA-seq of HCT116 colorectal cancer 3D spheroids treated with 5-fluorouracil or olaparib August 18, 2026Contributors : Christa Ringers ; David Holmberg ; Anders Larsson ; Bomi Jung ; Malin Jarvius ; Anna Luchniak ; Dan Rosen ; Martin Johansson ; Polina Georgiev ; Brinton Seashore-Ludlow ; Torkild Visnes ; Asmund Flobak ; Jordi Carreras-Puigvert ; Ola SpjuthSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis study accompa […]