Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE283935 Differential Enrichment of MAPK and Wnt Signaling Pathways in metastatic CRC tumors January 8, 2026
  Contributors : Melanie Heinlein ; Ginny X Li ; Robert PiskolSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusColorectal cancer, a leading cause of cancer-related mortality due to distant metastases, is driven by activating mutations in the Wnt and MAPK pathways. Understanding the interplay between these crucial pathways […]
• GSE266254 Inflammation Rewires the Enteric Nervous System Through Neurogenic Monocyte Recruitment January 8, 2026
  Contributors : Monalee Saha ; Qian Li ; Preston White ; Sushma Nagaraj ; Ken Liu ; Subhash Kulkarni ; Lauren Peters ; Yu Liu ; Miliena Bogunovic ; Pankaj J PasrichaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe proper organization of the enteric nervous system (ENS) is critical for normal gastrointestinal (GI) phys […]
• GSE285789 The effects and mechanisms of exosomal miRNAs derived from TGF-β-induced M2-polarized TAMs in prostate cancer. January 8, 2026
  Contributors : Rui-feng Deng ; Lu Cheng ; Yu-lin Zhou ; Yuan-ling Liu ; Wen-cong Jiang ; Song Wan ; Min-yao Jiang ; Ming XiSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensRecent research indicates that exosome-derived miRNAs play a crucial role in disease progression and may serve as potential candidates for therape […]
• GSE283937 A high MAPK, low WNT cell state drives metastatic dissemination in colorectal cancer January 8, 2026
  Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
• GSE287735 A Multi-omic approach reveals iron availability influences hepatocyte cell fate I January 8, 2026
  Contributors : Athena Jessica Ong ; Andrew Cox ; Kristin BrownSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRecent evidence has highlighted the importance of employing cell culture media designed to reproduce the physiological metabolic environment in vitro. Here, we utilize the physiological medium Plasmax to examine […]
• GSE286196 High fidelity detection of endogenous GPCR-G protein activity with a versatile mouse biosensor platform January 8, 2026
  Contributors : Remi Janicot ; Sabrina S Shoily ; Mikel Garcia-MarcosSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusActivation of heterotrimeric G-proteins (Gαβγ) by G-protein-coupled receptors (GPCRs) is a quintessential mechanism of transmembrane signal transduction in eukaryotes with major biomedical implications in […]
• GSE312105 Assessing the impact of epigenetic inhibitors on reversion of the chromatin landscape from metastatic to non-metastatic organoids January 8, 2026
  Contributors : Melanie Heinlein ; Amanda R Moore ; Ginny X Li ; Robert PiskolSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusColorectal cancer, a leading cause of cancer-related mortality due to distant metastases, is driven by activating mutations in the Wnt and MAPK pathways. Understanding the interplay […]
• GSE315860 DAXX governs the silencing of LINE1 during spermatogenesis in mice [ChIP-seq] January 8, 2026
  Contributors : Zejia Li ; Chaoyang Xiong ; Jin Shen ; Chen Tan ; Dupeng Ma ; Jun Chen ; Rong Liu ; Qi Sun ; Weihao Gong ; Wenming Yuan ; Mengya Huang ; Li Huang ; Yueqiu Tan ; Guohong Li ; Mengcheng LuoSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThe suppression of transposable elements in germline is c […]
• GSE315518 Daphnetin sensitizes hepatocellular carcinoma cells to chemotherapeutics and suppresses malignant phenotypes through modulating DDIT3-associated stress-response January 8, 2026
  Contributors : Guangchao Sui ; RAZA ALI ; Guangyue LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMany natural products can both suppress tumor growth and promote human health. Daphnetin (DAP) is a natural coumarin and possesses suppressive activities against various cancers, but the molecular mechanisms underlying i […]
• GSE315077 KDM5 protein mediated cisplatin resistance in ovarian cancer. [ChIP-Seq] January 8, 2026
  Contributors : Jung Yoo ; So Hee KwonSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensHigh recurrence and relapse rates of ovarian cancer (OVC) make it one of the deadliest gynecological cancers and the 5th most common cause of death in women. It is well recognized that acquired resistance is accompanied by […]
• GSE315521 Lactate-Mediated Cross-Talk between KRT15 and GPR68 drives Type 2 Immunity in ECRSwNP January 8, 2026
  Contributors : Hongjie Du ; Ming XiaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP) is a refractory inflammatory disease driven by type 2 immunity, yet the mechanistic link between epithelial stress and immune activation remains elusive. Here, we identify a […]
• GSE315687 Antitumor effects of anti-CD4-depleting antibody in lung fibrosis through CD8+ T cell activation and regulatory T cell inhibition in mice January 8, 2026
  Contributors : Tatsuki Nishioka ; Takehiro Sakabe ; Masahiro Kitabatake ; Noriko Ouji-Sageshima ; Atsushi Hara ; Ichiro Sato ; Nobuhiro Fujioka ; Ryutaro Furukawa ; Tomoko Kasamatsu-Nishimura ; Shigeto Hontsu ; Shigeo Muro ; Toshihiro ItoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackgroundLung cancer (LC) as a com […]
• GSE315815 KLHDC4 serves as a novel prognostic biomarker and drives tumor progression via PI3K/AKT signaling in clear cell renal cell carcinoma January 8, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : HomoThe clinical significance and molecular mechanisms of KLHDC4 in malignancies, particularly in clear cell renal cell carcinoma (ccRCC), remain poorly understood. In this study, we integrated multi-omics data—including tran-scriptomic, proteomic, and single-cell RNA sequencing—to sy […]
• GSE252879 Upstream open reading frame inactivation augments GATA4 translation and cardiomyocyte hypertrophy in mice January 8, 2026
  Contributors : Omar M Hedaya ; Feng Jiang ; Peng YaoSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusUpstream open reading frames (uORFs) are short peptide-encoding sequences residing in the 5' untranslated region (5' UTR) of mRNAs enabling tran […]
• GSE311723 Nuclear MBL-1 modulates mitochondrial morphology through carnitine palmitoyltransferase in C. elegans with toxic trinucleotide repeats January 8, 2026
  Contributors : Joana Teixeira ; Mikko J Frilander ; Ove Eriksson ; Susana M GarciaSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansExpansion of nucleotide repeat sequences is linked to a growing number of neuromuscular degenerative disorders. Metabolic changes, including disruptions in mitochondrial function an […]