Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE307964 MiR-342 suppression of an E2F signaling network limits metastatic outgrowth of triple negative breast cancer [RNA-Seq] July 16, 2026
  Contributors : Philip A Gregory ; Katherine A Pillman ; John Toubia ; Kate Dredge ; Andrew G BertSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMetastasis occurs with high frequency in patients with triple negative breast cancer (TNBC) and its aetiology remains poorly understood. Through integrated analysis of metastat […]
• GSE307720 MiR-342 suppression of an E2F signaling network limits metastatic outgrowth of triple negative breast cancer [HITSCLIP] July 16, 2026
  Contributors : Philip A Gregory ; Katherine A Pillman ; John Toubia ; Kate Dredge ; Andrew G BertSeries Type : OtherOrganism : Homo sapiensMetastasis occurs with high frequency in patients with triple negative breast cancer (TNBC) and its aetiology remains poorly understood. Through integrated analysis of metastatic TNBC mouse models and patient datasets, we […]
• GSE308206 PAN2 Maintains mRNA Poly(A) Tail Homeostasis and Regulates RNA Degradation During Early Embryonic Development in Mice [PAIso-seq] July 16, 2026
  Contributors : Yuke Wu ; Xuan WuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRNA homeostasis regulators and surveillance factors function in the global transcriptome of oocytes and early embryos. Among them, the CNOT6L and CNOT7 proteins of the BTG4, PABPN1L, and CCR4-NOT subunits, as well as TUTs, are involved in th […]
• GSE307965 MiR-342 suppression of an E2F signaling network limits metastatic outgrowth of triple negative breast cancer July 16, 2026
  Series Type : Other ; Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
• GSE334778 RXRα Suppression Drives Hepatic Metabolic and Immune Dysfunction in Sepsis​: Differential gene expression in septic and non-septic dogs July 16, 2026
  Contributors : Matyas Jelinek ; Jolien Vandewalle ; Marah Heyerick ; Tineke Vanderhaeghen ; Céline Van Dender ; Steven Timmermans ; Madeleine Hellemans ; Daria Fijalkowska ; Martin Guilliams ; Karolien De Bosscher ; Claude LibertSeries Type : Expression profiling by high throughput sequencingOrganism : Canis lupus familiarisSepsis is a life-threatening condi […]
• GSE319489 Restored clearance of senescent neutrophils by tissue-resident macrophages limits organ aging July 16, 2026
  Contributors : Yuting Jessy Tan ; Travis E Conley ; Fuwen Yao ; Fernando J Garcia-Marques ; Damilola E Akinyemi ; Van V Dinh ; Qian Wang ; Abel Bermudez ; Jieun Kim ; Julia A Belk ; Oliver Soehnlein ; Sharon J Pitteri ; Katrin I AndreassonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSingle-cell RNA sequencing of sort […]
• GSE337619 Differential Transcriptomic Responses to MRQ 74 and MRQ 76 Rice Extracts in HT-29 Cells; Implications for Apoptosis and Cell Cycle Regulation July 16, 2026
  Contributors : Norhaslinda Ridzwan ; Mohd Adzim Khalili Rohin ; Norhayati Abd Hadi ; Mohd Fadzelly Abu Bakar ; Norazlina Saad ; Ruziana IshakSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensColorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, and resistance to conventional chemotherapy n […]
• GSE338465 Impact of SPOP mutations on gene expression in prostate cancer July 16, 2026
  Contributors : Di Zhao ; Yue LuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo determine SPOP mutations' effects on gene transcriptome in prostate cancer, we introduced wildtype versus F133V mutation of SPOP into DU145 cells, followed by RNA-sequencing
• GSE338354 PRMT1-mediated arginine methylation redirects a metastasis-promoting transcriptional output of SMAD4 in pancreatic cancer July 16, 2026
  Contributors : Yizhou Liu ; Xueyi Liang ; Ruozheng Wei ; Yuhan Zhao ; HeShui Wu ; Yingke ZhouSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPancreatic ductal adenocarcinoma (PDAC) is characterized by early metastatic dissemination and poor clinical outcomes. Although SMAD4 is frequently altered in PDAC, the majority of […]
• GSE338003 Transcriptomic Analysis Identifies Transient Mesendodermal State and Lineage Divergence in Human Pluripotent Stem Cell Differentiation July 16, 2026
  Contributors : Alice C Borges ; Mariana A Branco ; João P Cotovio ; Ana R Gomes ; Joana E Saraiva ; Leonilde M Moreira ; Joaquim M Cabral ; Domingos Henrique ; Maria M Diogo ; Tiago G FernandesSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHuman pluripotent stem cells serve as a vital model for studying early human lin […]
• GSE338387 Effect of TGF-beta on SMAD2/3 and YAP/TAZ in HOVX human vocal fold fibroblasts {ChIP-seq] July 16, 2026
  Contributor : Ryosuke NakamuraSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensSMAD2/3 and YAP/TAZ are activated by TGF-beta signaling in human vocal fold fibroblasts. This study provides ChIP-seq data regarding chromatin occupancy of SMAD2/3 and YAP/TAZ in these cells in response to TGF-beta treatment. […]
• GSE338388 Effect of TGF-beta and K-975 in HOVX human vocal fold fibroblasts [RNA-seq] July 16, 2026
  Contributor : Ryosuke NakamuraSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSMAD2/3 and YAP/TAZ are activated by TGF-beta signaling in human vocal fold fibroblasts. This study provides transcriptomic data regarding altered gene expression following TGF-beta treatment and YAP/TAZ inhibition.
• GSE338455 Transcriptome sequencing of wide type COS7 cell and ATL2/3 double knockout COS7 cells. July 16, 2026
  Contributors : Hanchi Miao ; Yuqi Wasng ; Yingying Huang ; Haoyang Zhang ; Lexin Zheng ; Xin Zhou ; Xiaoqun Wang ; Qing Xie ; Lei Xue ; Junjie HuSeries Type : Expression profiling by high throughput sequencingOrganism : Chlorocebus sabaeusTo investigate different gene expression in wide type COS7 cell and ATL2/3 double knockout COS7 cells, we carried out tra […]
• GSE299376 Regulation of neurogenesis and neuronal migration by Rrm2 and Timp3 following seizures July 16, 2026
  Contributors : Adebayo O Adeyeye ; Parul Varma ; Nico Enerlan ; Marissa Coppin ; Jenny HsiehSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTemporal lobe epilepsy is associated with aberrant neurogenesis and ectopic migration of adult-born granule cells (abGCs), yet the molecular mechanisms driving these changes remain […]
• GSE336917 Endotome as an Unrecognized Source of Human Peri-Aortic Brown Adipocytes July 16, 2026
  Contributors : Hao Yu ; Stephen Dalton ; Tianming WuSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensBrown adipose tissue (BAT) uncouples nutrient catabolism from ATP synthesis to dissipate energy as heat, making it a promising regenerative medicine appro […]