Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE269185 Effect of decitabine on gene expression in THP-1 or decitabine-resistant THP-1 leukemia cells June 28, 2025
  Contributors : Min Lu ; Xueqin Chen ; Jiale Wu ; Yuntong LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo globally evaluate transcriptome in THP-1 and decitabine-resistant THP-1 cells treated by decitabine, cells were treated with the IC90 dose of decitabine until 90% cell death was reached, then cultured in decitab […]
• GSE269742 LKB1-deficient NSCLC cells show vulnerability to high-dose AA-induced pyroptosis. June 28, 2025
  Contributors : Xiangyu Sun ; Xuejun Guo ; Xiaoting Cai ; Zhongyi Dong ; Dehua Wu ; Xue BaiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe deficiency of LKB1 in tumor cells impairs their ability to sense metabolic stress appropriately,ultimately leading to redox imbalance. LKB1-deficient NSCLC cells predominantly tak […]
• GSE269501 Applications for estimation of in vivo toxicity point of departure for discovery stage molecule predictive safety assessment June 28, 2025
  Contributors : Enrica Bianchi ; Eduardo Costa ; Joshua Harrill ; Andi DhrosoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Rattus norvegicusUtilization of in vitro (cellular) techniques, like Cell Painting and transcriptomics-based methods could provide powerful tools for risk assessment and regulatory decision-maki […]
• GSE301078 Targeting AEBP1 to mitigate pro-tumor activity of cancer-associated fibroblasts and increase therapeutic efficacy to anti-PD-1 June 28, 2025
  Contributors : Suchitra Natarajan ; Khoa Nguyen ; Heyuan Li ; Elysia Saputra ; Cindy Li ; Gukhan Kim ; Yu Liu ; Hong Sun ; Ramli Muhammad ; Ling Li ; William Monis ; Wendy Blumenschein ; Dewan Hossain ; Aleksandra Olow ; Xin YuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCancer-associated fibroblasts (CAFs) are one o […]
• GSE269916 RCOR2 downregulates RNF43 via LSD1-mediated histone demethylation in cancer cells June 28, 2025
  Contributors : Lei Bao ; Weibo LuoSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensRCOR2 and LSD1 directly co-binds to RNF43 gene. RCOR2 knockout does not affect LSD1 binding on RNF43 gene.
• GSE244572 Characterization of RPE subpopulation gene expression and cell surface protein composition using single cell sequencing June 28, 2025
  Contributors : Farhad Farjood ; Yue Wang ; Sally Temple ; Jeffrey Stern ; Nathan C BolesSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensThe retinal pigment epithelium (RPE) has traditionally been considered a homogenous monolayer, however differences in morphology, gene expression and disease susceptibility of R […]
• GSE207257 Effect of STING-TRIM29 interaction inhibitor SB24011 on gene expression upon solo or co-treatment with STING agonist in Raw264.7 murine macrophage-like cells. June 28, 2025
  Contributors : Wansang Cho ; Solchan Won ; Yoona Choi ; Sihyeong Yi ; Jong B Park ; Jun-Gyu Park ; Caroline E Kim ; Chintam Narayana ; Ju H Kim ; Junhyeong Yim ; Young I Choi ; Dong-Sup Lee ; Seung B ParkSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSB24011 upregulates cellular STING levels through inhibition of STING […]
• GSE290293 Overexpression of METTL3 leads to differential gene expression in the rat proximal tubular epithelial cell line NRK-52E June 28, 2025
  Contributors : Yanyan Sun ; Jia Ge ; Wei Zhang ; Junfeng Zhang ; Yuhui ZangSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusWe generated the NRK-52E sublines overexpressing METTL3 (referred as to lv_Mettl3), and performed transcriptome sequencing to identify the differentially expressed genes compared to the control […]
• GSE285984 Multi-omic characterization of human sural nerves across polyneuropathies [Xenium] June 28, 2025
  Contributors : Heming Michael ; Meyer zu Hörste GerdSeries Type : OtherOrganism : Homo sapiensDiseases of peripheral nerves termed polyneuropathies (PNPs) are common, mechanistically heterogeneous, and challenging to diagnose. Here, we integrated single nucleusi transcriptomics of peripheral nerves from 33 human PNP patients and four controls (365,708 nuclei […]
• GSE300626 Cycloheximide resistant ribosomes reveal adaptive translation dynamics in C. elegans [RNA-Seq] June 28, 2025
  Contributor : Qiuxia ZhaoSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansProtein translation regulation is critical for cellular responses and development, yet how disruptions during the elongation stage shape these processes remains incompletely understood. Here, we identify and validate a single amino acid s […]
• GSE296151 Identifying and Exploiting Combinatorial Synthetic Lethality by Characterizing Adaptive Kinome Rewiring of EGFRvIII-driven Glioblastoma June 28, 2025
  Contributors : Benjamin Lin ; Abigail K Shelton ; Erin Smithberger ; Julia Ziebro ; Kasey R Skinner ; Ryan E Bash ; Richard Kirkman ; Allie Stamper ; Madison Butler ; Alex Flores ; Steven P Angus ; Michael P East ; Timothy F Cloughesy ; Timothy C Howton ; Brittany N Lasseigne ; Christopher D Willey ; Gary L Johnson ; Anita B Hjelmeland ; Frank B Furnari ; C. […]
• GSE300705 Ferulic acid ameliorates TLR4-mediated macrophage activation by irreversibly binding to Peroxiredoxin 1 to inhibit its dimerization and secretion June 28, 2025
  Contributors : Jie Gao ; Jin Yan ; Xingwang Zu ; Yanyan Xu ; Shilong Wang ; Yue Li ; Yuanyuan HouSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study was designed to investigate whether Ferulic acid (FA) alleviates LPS-induced inflammation, and to identify associated transcriptional changes and signaling pathways. […]
• GSE300994 Huangqin Decoction Exerts Antifungal Effects by Interfering with Energy Metabolism of Trichophyton rubrum with Glyoxylate Cycle as a Potential Target June 28, 2025
  Contributors : Su-Qing Yang ; Yi-Can He ; You-Jin Ge ; Bao-De Shen ; Chen-Ying ShenSeries Type : Expression profiling by high throughput sequencingOrganism : Trichophyton rubrumBackground: The dermatophyte Trichophyton rubrum (T. rubrum) is a highly specialized filamentous fungus that infects keratinized tissues and is the most common pathogen isolated from […]
• GSE301016 Microglial Replacement as a Drug Delivery Method for the Brain June 28, 2025
  Contributors : Rohan Hofland ; Tiago GonçalvesSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMicroglia, the central nervous system's (CNS) resident immune cells, show promise as vehicles for treating intractable neurological disorders. Microglia can be transiently ablated using a Colony Stimulating Factor 1 (CSF1r […]
• GSE263749 RNA sequencing of mouse cardiac neutrophils after myocardial ischemia and reperfusion injury model June 28, 2025
  Contributors : N Nishiyama ; T Sugasawa ; C Nakahashi-Oda ; A ShibuyaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe performed bulk RNA-seq of cardiac neutrophils from the heart of WT and Cd300a-/- mice 3 days after myocardial ischemia and reperfusion.