Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE175822 Parathyroid hormone 1 receptor signaling links to craniosynostosis by regulating calvaria cartilage and the suture formation February 13, 2026
  Contributors : Katsuhiko Amano ; Mikihiko Kogo ; Daisuke OkuzakiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusOur study uncovered a unique factor causing craniosynostosis studying calvaria chondrocyte differentiation and the regulation by Pth1r/Ihh signaling.
• GSE288513 Scap Stabilizes PKM2 to Promote Glycolysis and Enhance Antifungal Immunity in Macrophages February 13, 2026
  Contributors : Jiaqi Huang ; Zhihua ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusFungal infection induces substantial but poorly understood metabolic reprogramming in macrophages. We demonstrate that fungal stimulation reduces Scap levels in human monocytes and murine bone-marrow-derived macrophages (BMDMs), and […]
• GSE255679 Does three copies of App contribute to amplified basal interferon signaling in the brain of the Dp1Tyb mouse model of Down syndrome February 13, 2026
  Contributors : Frances Wiseman ; Cliona FarrellSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe have previously found that the Dp1Tyb mouse model of Down syndrome exhibits amplified basal interferon signaling in the brain but that the Dp2Tyb mouse does not unless challenged with interferon. The Dp1Tyb model carries an […]
• GSE305324 Protective efficacy and related mechanism of deinoxanthin in experimental animal and cell models of periodontitis February 13, 2026
  Contributor : Jung-Chae LeeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAs periodontitis is a chronic inflammatory disease resulting in periodontal tissue destruction and tooth loss, studies have tried to development the biomaterials that effectively prevent inflammatory response and oxidative stress without side eff […]
• GSE289711 Regulation of Epstein–Barr Virus latency by histone variant H2A.Z [ChIP-seq] February 13, 2026
  Contributors : Leonardo J Castro-Muñoz ; Davide Maestri ; Leena Yoon ; Bhanu C Karisetty ; Italo Tempera ; Paul LiebermanSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensChromatin structure plays a central role in the regulation of Epstein-Barr Virus (EBV) latency. The histone variant H2A.Z.1 has been impli […]
• GSE309901 Reduced levels of inositol hexakisphosphate kinase (IP6K) impair life-cycle transitions and the intracellular development of Trypanosoma cruzi within human cardiomyocytes February 13, 2026
  Contributors : Bryan E Abuchery ; Thaise L Teixeira ; Vitor L da Silva ; Rauni B Marques ; Fernanda M Gerolamo ; Carolina M Catta-Preta ; Bruno A Santarossa ; Marija Krasilnikova ; Craig Lepslay ; Yete G Ferri ; Maria Cristina M Motta ; Samuel C Teixeira ; Miguel A Chiurrilo ; Noelia M Lander ; Simone G Calderano ; Eduardo M Reis ; Richard McCulloch ; Marcel […]
• GSE307982 PTMA Safeguards Mitochondrial Integrity to Sustain Metabolic Function and Antitumor Persistence of CD8+ T Cells February 13, 2026
  Contributors : Keling Huang ; Xiaoxue LI ; Feng WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWhile immune checkpoint blockade (ICB) has revolutionized cancer treatment, its clinical efficacy remains constrained by the progressive exhaustion of tumor-reactive CD8+ T cells - a dysfunctional state intimately linked […]
• GSE314708 Microglia TFEB Activation Attenuates Alzheimer’s Disease Pathology by Enhancing Autophagy-Lysosomal Function February 13, 2026
  Contributors : Yeji Kim ; Tae-Young Ha ; Oksana Kondaurova ; Myung-Shik Lee ; Keun-A ChangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAlzheimer’s disease (AD) is characterized by amyloid-β (Aβ) accumulation, neuroinflammation, synaptic dysfunction, and cognitive decline. Impairment of microglial autophagy-lysosomal […]
• GSE314031 miR126-mediated alteration of vascular integrity in Rett syndrome February 13, 2026
  Contributors : Tatsuya Osaki ; Zhengpeng Wan ; Koji Haratani ; Ylliah Jin ; Marco Campisi ; David A Barbie ; Roger D Kamm ; Mriganka SurSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in methyl-CpG binding protein 2 (MeCP2). MeCP2 is a non-cell typ […]
• GSE318537 Identification of target genes and regulatory networks for bone mineral density GWAS loci through systematic targeting and inhibition [hFOB ATAC-seq] February 13, 2026
  Contributors : Larry Mesner ; Mohammadjavad Kahlani ; Vedavathi Madhu ; Lucia Wagner ; Kristyna Kupkova ; Hannah Pitas ; Ana Mello ; Samuel Ghatan ; Tuuli Lappalainen ; Neville Sanjana ; John A Morris ; Charles R FarberSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensOsteoporosis is characterized by low bon […]
• GSE315711 Bulk RNA sequencing of interfollicular Tfh cells isolated from the palatine tonsils of recurrent tonsillitis and IgA nephropathy. February 13, 2026
  Contributors : Taiki Sugaya ; Ippei Ikegami ; Shingo IchimiyaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensImmunoglobulin A nephropathy (IgAN) is a chronic glomerular disease characterized by mesangial IgA deposition, which can progress to end-stage renal failure. Tonsillectomy is used as a therapeutic intervention to […]
• GSE318830 LncRNA NAS1 deficiency drives cisplatin resistance in non-small cell lung cancer February 13, 2026
  Contributors : Xianrong Lin ; Wenjun TaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCisplatin resistance remains a major obstacle in non-small cell lung cancer (NSCLC) treatment. Long non-coding RNAs (lncRNAs) have been implicated in chemotherapy resistance, yet their specific roles and mechanisms are not fully unde […]
• GSE318864 Eurycomanone from Eurycoma longifolia Jack roots regulates dopamine secretion via transsynaptic GABA signalling in differentiated SH-SY5Y human neuroblastoma cells: a transcriptomic study February 13, 2026
  Series Type : Expression profiling by arrayOrganism : Homo sapiensWe employed microarray-based transcriptomic analysis to uncover potential molecular pathways associated with the dopaminergic effect of the quassinoid compound from the plant. The transcriptomic insights generated from this work may provide a deeper molecular basis for the long-debated aphrodi […]
• GSE318881 RNA-Seq quantitative analysis of the regulatory effects of plasma exosomes from CML patients on CML cell transcriptomes February 13, 2026
  Contributors : Fei Li ; Qing ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDrug resistance frequently results in treatment failure for leukemia and leads to the progression of chronic myeloid leukemia (CML) into an accelerated or blast phase. Although new tyrosine kinase inhibitors (TKIs) and combined TKI therapi […]
• GSE319266 Identification of target genes and regulatory networks for bone mineral density GWAS loci through systematic targeting and inhibition [hFOB BMD STING-seq] February 13, 2026
  Contributor : John A MorrisSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensOsteoporosis is characterized by low bone mineral density (BMD) and elevated fracture risk. Most BMD-associated GWAS variants lie in noncoding regions, complicating efforts to identify causal genes and mechanisms. To overcome this variant […]