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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE278813 Intervertebral disc spheroids as an in vitro multicellular platform for recapitulating the microenvironment of intervertebral disc degeneration December 25, 2025Contributors : Tae-Won Kim ; An-Gi Kim ; Min-Ho Hwang ; Hyuk ChoiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIntervertebral disc (IVD) degeneration (IVDD) is a major contributor to chronic low back pain (LBP), representing a significant burden on the spinal healthcare system and a leading cause of long-term disabili […]
- GSE285487 Themis directs T cell exhaustion by promoting PD-1 signaling and regulating expression of transcription factors TCF-1 and TOX December 25, 2025Contributors : jian tang ; yuzhou baoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusT cell exhaustion is a protective mechanism during chronic viral infections, but it can impair anti-tumor immunity. Themis, a T cell-specific protein, is critical for CD8+ T cell homeostasis, cytokine responsiveness, and anti-Listeria r […]
- GSE285438 A Novel Murine Model of Sjögren's Syndrome Using Lacrimal Autoantigen December 25, 2025Contributors : Siyuan Li ; Yaqiong Li ; Peng Zhang ; Fengyang Lei ; Lei Tian ; Ying JieSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPurpose: Sjögren's syndrome (SS) is a group of chronic autoimmune diseases primarily targeting exocrine glands, including the lacrimal glands (LG). Involvement of the lacrimal gland […]
- GSE290883 Analysis of local mucosal immune dysregulation to guide pilot directed therapy for long-COVID olfactory loss [5' GEX] December 25, 2025Contributors : Sarah Kim ; Vincent M D'Anniballe ; John B Finlay ; Tiffany Ko ; Michael Wang ; Bradley J GoldsteinSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo further define local mechanisms impacting peripheral olfactory structures, we obtained olfactory biopsies from subjects with post-COVID olfactory loss […]
- GSE285991 Chemotherapy triggers immune evasion by fostering LEPR+ Kupffer cell differentiation in liver metastases December 25, 2025Contributors : Xuege Wang ; Qiang PanSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiens ; Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE245349 Transcriptomic responses of synovial and peripheral blood mononuclear cells in horses with naturally occurring osteoarthritis December 25, 2025Contributors : Lynn M Pezzanite ; Lyndah Chow ; Gabriella Piquini ; Ashana Patel ; Meagan Rockow ; Luke Bass ; Dean Hendrickson ; Steven DowSeries Type : Expression profiling by high throughput sequencingOrganism : Equus caballusOsteoarthritis (OA) is the most common disease affecting equine joints, and represents an important source of pain, reduced athleti […]
- GSE314718 DNA methylation of K562 and KU812 cells sensitive and resistant to imatinib. December 25, 2025Contributors : Shashi Kumari ; Rukmini Govekar ; Rahul Mojidra ; Mythreyi NarasimhanSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensCML-CP Patients showing resistance to Imatinib, due to Bcr-Abl mechanisms of resistance are treated with 2nd and 3rd generation TKIs but some non-responders shown Bcr-Abl independant mechanism of […]
- GSE313872 Genome-scale DNA methylome and transcriptome profiling of midgut of Bombyx mori infected with BmCPV December 25, 2025Contributors : Qunnan Qiu ; Chengliang Gong ; Zhe Liu ; Yuqing Huang ; Huilin Pang ; Liuyang Li ; Min Zhu ; Xiaolong HuSeries Type : Methylation profiling by high throughput sequencingOrganism : Bombyx moriDNA methylation, as well as histone modifications, is an important regulatory mechanism for altered gene expressions. Our previous study has shown that Bo […]
- GSE313791 Multi-Omics Integration Identifies a Prognostic Signature Guiding Precision Survival in Advanced HCC December 25, 2025Contributor : Fengna YanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality globally, with over 70% of patients diagnosed at intermediate or advanced stages where curative treatments are no longer feasible. Current prognostic tools are inadeq […]
- GSE314266 The Novel Nrf2 Agonist Neobavaisoflavone Attenuates Periodontitis by Inhibiting Osteoclastogenesis through Iron Homeostasis Regulation and Senescence Suppression December 25, 2025Contributor : Yilin LiaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe Novel Nrf2 Agonist Neobavaisoflavone Attenuates Periodontitis by Inhibiting Osteoclastogenesis through Iron Homeostasis Regulation and Senescence Suppression
- GSE314129 Transcriptomics of K562/S and K562/R, KU812/S and KU812/R of imatinib resistant cell using RNA-sequencing. December 25, 2025Contributors : Shashi Kumari ; Rukmini Govekar ; Rahul Mojidra ; Mythreyi NarasimhanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCML-CP Patients showing resistance to Imatinib, due to Bcr-Abl mechanisms of resistance are treated with 2nd and 3rd generation TKIs but some non-responders shown Bcr-Abl independant mechan […]
- GSE314496 Non-viral CISH locus-specific integrated FAPα CAR-T cells achieve potent anti-tumor efficacy in glioblastoma December 25, 2025Contributors : Xie guozhu ; Dong xinSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCAR-T cells have been used to treat patients with glioblastoma (GBM) in clinical trial settings, by targeting GBM-associated antigens. However, the efficacy of these CAR-T cells remain limited mainly due to heterogeneous expression of tu […]
- GSE314632 Transcriptional profiling of HLCZ01 cells with or without HBV infection. December 25, 2025Contributor : Yang SunSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo explore the biological processes affected by HBV infection, high throughput sequencing was performed in HLCZ01 cells with or without HBV infection.
- GSE314685 The Piezo1-ATF3-PPP1r15a axis transduces mechanical stress into apoptosis in glioma under low-intensity focused ultrasound December 25, 2025Contributors : Mingming Li ; Weidong Wang ; Jian Jiang ; Yingxuan Mao ; Mingwei Zhu ; Pengfei Liu ; Xiuhua YangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis study aims to evaluate the therapeutic effects of LIFU on GBM and investigate its mechanisms of action.
- GSE252078 Quantifying the effects of lack of Stim2 on neuronal origin cells at single cell resolution December 25, 2025Contributors : Shamba S Mondal ; Rishikesh K Gupta ; Jacek KuznickiSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioStromal interaction molecule (STIM) proteins reside on the endoplasmic reticulum (ER) membrane and regulate Ca2+ homeostasis and signaling. The stim2a and stim2b double-knockout zebrafish have problems with […]