Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE275073 Chimeric Oncoproteins Enhance Native Kinase Activity to Drive Tumorigenesis via Phase-separated Cytoplasmic Condensates August 11, 2026
  Contributors : Xiaoping Wu ; Xiaohua HuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGene fusions involving receptor tyrosine kinases (RTKs) are potent oncogenic drivers, yet the underlying mechanisms by which these chimeric proteins induce tumorigenesis remain largely elusive. Here we demonstrate that recurrent FGFR3 […]
• GSE240703 The effect of Sphingosine-1-Phosphate Receptor 1 and Complement Component 3 conditional knockouts on primary tumors in MMTV-PyMT mice. August 11, 2026
  Contributor : Alhaji H JannehSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSphingolipid metabolism has been shown to regulate intracellular complement activation via sphingosine-1-phosphate receptor 1 (S1PR1) signaling to stimulate NLRP3 inflammasome-induced cancer metastasis. Here, the transcriptomic effects of S1PR1 […]
• GSE305261 The loss of glucocorticoid receptor accelerates ovarian ageing in zebrafish August 11, 2026
  Contributors : Vijayan Mathilakath ; Devan MeeraSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioOvarian aging and reproductive decline are key indicators of mid-life aging in females, with stress and elevated glucocorticoids (GCs) being significant contributors to the acceleration of this process. GCs act through both th […]
• GSE302292 PAX3-SIX2 muscle stem cell heterogeneity drives muscle-specific repair dynamics diversification August 11, 2026
  Contributors : Virginia Zoglio ; Sarah Chebouti ; Fayez Issa ; Benjamin Polin ; Sylvie Manin ; Pascal Maire ; Joana Esteves de Lima ; Frédéric RelaixSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe human body contains around 640 distinct muscles, each capable of regeneration following injury through the action of mus […]
• GSE314035 Protective efficacy of AAV-expressed bNAbs co-delivered with PD-L1 August 11, 2026
  Contributors : Michael Kuipa ; Abubakarr A Koroma ; Isai Leguizamo ; Priya Dhole ; Yash Barot ; Michelle Y Lee ; Gregory K Tharp ; Shan Liang ; Magdalen Chouinard ; Stephanie Ehnert ; Stacey Weissman ; Casey Whitehead ; Rachelle L Stammen ; Jennifer S Wood ; Elizabeth H Curran ; Deepa Machiah ; Evan D Dessasau ; Yoshiaki Nishimura ; Jun Xie ; Guangping Gao ; […]
• GSE309078 Ultrasound-Amplified Exosome Secretion and Antibody-Free SERS Profiling for APOE Genotype-Dependent Signatures August 11, 2026
  Contributors : Won Jong Yu ; Jinhee Yoo ; Youngjun Kim ; Seongmin Kim ; Inki Kim ; Byullee Park ; Jong-Chan ParkSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensExosomes offer a promising platform for non-invasive diagnosis of neurodegenerative diseases by encapsulating multiple biomarkers and crossing the blood–brain ba […]
• GSE343057 Draft hybrid assembly and annotation of the Drosophila palustris genome August 11, 2026
  Contributors : William Dion ; Emily Washeleski ; Tessa E. Steenwinkel ; Emily Taylor ; Prajakta P. Kokate ; Aidan VanDrie ; Thomas Werner ; Paul D. GoetschSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila palustrisSpecies within the Drosophila quinaria group are models for ecological genetic studies on topics that include […]
• GSE320532 Cryo-EM structure, enzymatic activity and genome targeting of canonical PRC1 August 11, 2026
  Contributors : Martina Cafiso ; Jürg Müller ; Jacques BonnetSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Drosophila melanogasterCanonical Polycomb Repressive Complex 1 (cPRC1) preserves cell fate decisions by repressing inappropriate transcription of developmental regulator genes. We report the cryo–electron micros […]
• GSE343154 Molecular Determinants of Functional Bacterial sRNA–mRNA Interactions Revealed by Integrating RNA Interactomes and Interpretable Machine Learning [Hfq-CLASH] August 11, 2026
  Contributors : Daniel Mediati ; Fatemeh Safari ; Fatemeh Vafaee ; Jai TreeSeries Type : OtherOrganism : Escherichia coli str. K-12 substr. MG1655Bacterial small RNAs (sRNAs) regulate gene expression by base pairing with target mRNAs, yet transcriptome-wide interactome mapping has shown that many sRNA–mRNA interactions detected in vivo have modest or not regu […]
• GSE343058 Draft hybrid assembly and annotation of the Drosophila subpalustris genome August 11, 2026
  Contributors : William Dion ; Emily Washeleski ; Tessa E. Steenwinkel ; Emily Taylor ; Prajakta P. Kokate ; Aidan VanDrie ; Thomas Werner ; Paul D. GoetschSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila subpalustrisSpecies within the Drosophila quinaria group are models for ecological genetic studies on topics that inclu […]
• GSE343161 Bulk RNA sequencing of Hspa1a knockdown in GM-CSF-driven bone marrow-derived monocyte/dendritic cell cultures August 11, 2026
  Contributors : Zeping Gui ; Neda Feizi ; Berkay Demirors ; Canxiang Lin ; Hehua Dai ; Mouhamad Al Moussawy ; Andrew Friday ; Steven M Sanders ; Latha Halesha ; Amanda L Williams ; Faruk Sacirbegovic ; Parmjeet S Randhawa ; Khodor I Abou-Daya ; Martin H OberbarnscheidtSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe pe […]
• GSE343347 Transcriptomic profiling of cancer cells treated with COF-Tpy-Se-Cu August 11, 2026
  Contributor : Yuantong LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study profiled the transcriptional response of murine oral squamous cell carcinoma MOC1-R cells to COF-Tpy-Se-Cu combined with ionizing radiation. MOC1-R cells were maintained under control conditions or treated with COF-Tpy-Se-Cu (30 μg mL−1 […]
• GSE343355 Transcriptomic profiling of MOC1 cells treated with fractionated irradiation to inform the application of COF-Tpy-Se-Cu August 11, 2026
  Contributor : Yuantong LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study compared the transcriptomes of control MOC1 murine oral squamous cell carcinoma cells and MOC1 cells subjected to repeated fractionated irradiation. Three biologically independent samples from each group were analyzed by paired-end RNA […]
• GSE336866 Genetic and chemical interrogation of methionyl-tRNA synthetase reveals a shared vulnerability across diverse mycobacteria August 11, 2026
  Contributors : Dan Luo ; Weile Xie ; Longlong Wang ; Jijie Jiang ; Guocheng Zhao ; Mengke Hou ; Keyu Xiao ; Lan Qian ; Jianming Zhang ; Guanghui Dang ; Siguo Liu ; Zhe WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis dataset contains host–pathogen dual RNA-seq profiles from RAW264.7 macrophages infected with Myc […]
• GSE343008 Smart-seq profiling of border-associated alveolar macrophages in fibrotic mouse lungs August 11, 2026
  Contributors : Jing Wang ; Jin Wang ; Wenying Zhao ; Yeke Huang ; Jiangxue LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusFibrosis is commonly viewed as a pathological endpoint of persistent tissue injury and failed repair. Yet chronically injured tissues do not scar uniformly, indicating that local adaptive programs […]