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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE256008 Single-cell multiomic study of zebrafish cranial neural crest [scRNA-seq (Direct Capture Perturb-seq)] May 11, 2026Contributors : Zhiyuan Hu ; Sarah Mayes ; Tatjana Sauka-SpenglerSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Single-cell multiomic study of zebrafish cranial neural crest
- GSE247748 Heterochromatin re-organization associated with the transcriptional reprogramming under viral infection in Arabidopsis May 11, 2026Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing ; Methylation profiling by high throughput sequencing ; Non-coding RNA profiling by high throughput sequencingOrganism : This SuperSeries is composed of the SubSeries listed below.
- GSE292485 Cancer stem cells are hyper-responsive sensors of tumor microenvironment in orchestrating metastasis dynamics May 11, 2026Contributors : Binwu Tang ; Howard Yang ; Maxwell Lee ; Lalage M WakefieldSeries Type : Expression profiling by high throughput sequencingOrganism : Cancer stem cells (CSCs) are key drivers of metastasis and therapy resistance but have been challenging to visualize and study in situ. Using a fluorescent CSC reporter, we observed very different population dyn […]
- GSE270113 Macrophage response and lung injury from thoacic RT is enhanced by subsequent influenza infection II May 11, 2026Contributor : Angela GrovesSeries Type : Expression profiling by high throughput sequencingOrganism : Infiltrating monocyte-derived macrophages (MDMs) have been found to drive radiation (RT) induced lung injury (RILI). RILI is enhanced by subsequent influenza A virus (IAV) infection, leading us to hypothesize that the irradiated lung microenvironment alters […]
- GSE300099 Control of CD8+ T central memory cell formation via ADAP regulation of TRIM21-mediated ubiquitination of ZEB2 May 11, 2026Contributors : Jiajia Lu ; Fan Yang ; Yanli Li ; Pengchao Zhang ; Tengfei Jia ; Hebin LiuSeries Type : Expression profiling by high throughput sequencingOrganism : The ADAP-SKAP1 signaling module plays a critical role in TCR-mediated activation and LFA-1-dependent adhesion; however, its regulatory function in balancing CD8+ T-cell effector differentiation, m […]
- GSE296597 Essential Role of Apoptosis in Immature B Cells for Preventing Autoimmune Disease in Mice May 11, 2026Contributor : Christian T MayerSeries Type : Protein profiling by protein arrayOrganism : Autoreactive B cells are generated through V(D)J recombination during development and somatic hypermutation during immune responses. Clonal deletion via programmed cell death is a key mechanism to eliminate these cells, as evidenced by autoimmune disease development in […]
- GSE330276 Suppressed cGAS-STING DNA Sensing Drives Immune Evasion in Anaplastic Thyroid Cancer May 11, 2026Contributors : Xuguang Zhu ; Manju Acharya ; Nathan Wong ; Sheue-yann ChengSeries Type : Expression profiling by high throughput sequencingOrganism : We used single-cell RNA sequencing to study the tumor immune microenvironment of thyroid tumors in a genetically engineered mouse model harboring triple mutations in Thrb1, Trp53, and Pten.
- GSE309174 Stem cell activation in organ culture reveals novel transcriptional programs underlying metabolic, fibrotic, vascular, and immune dysregulation in uterine leiomyomas May 11, 2026Contributors : Vázquez Paula ; Salas Ana ; Beltrán-Flores Silvia ; Montes de Oca Francisco ; Delgado Araceli ; Almeida A TeresaSeries Type : Expression profiling by high throughput sequencingOrganism : Background and objective: Uterine leiomyomas may arise from somatic stem or progenitor cells, leading to abnormal activation, proliferation, and clonal expans […]
- GSE330380 The effects of adiponectin knockout on hepatic gene expression in male and female C57BL/6NCrl mice fed ad libitum or undergoing caloric restriction May 11, 2026Contributors : William P Cawthorn ; Yoshiko M Ikushima ; Hiroshi Kobayashi ; Kuan-Chan ChenSeries Type : Expression profiling by high throughput sequencingOrganism : To understand the role of adiponectin under caloric restriction (CR) in the liver, we collected liver samples from male and female adiponectin KO mice and wild-type (WT) mice, on a C57BL/6NCrl b […]
- GSE330279 Fibroblast-derived CCL2 function in skin infection May 11, 2026Contributors : Tatsuya Dokoshi ; Richard L GalloSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : This dataset includes bulk RNA-seq, single-cell RNA-seq, and spatial transcriptomic analyses performed to investigate the role of fibroblast-derived CCL2 in cutaneous host defense against Staphylococcus aureus infection. Samples […]
- GSE330450 The single-nucleus RNA-seq of AAV-Abeta42 injected hippocampus of crab-eating macaque May 11, 2026Contributors : Laiqiang Chen ; Jiawei Zhang ; Zhifu Wang ; Xian-Jiang LiSeries Type : Expression profiling by high throughput sequencingOrganism : In our previous work, we found that hippocampal injection of AAV-Aβ42 induced robust Aβ deposition, increased abnormal phosphorylated tau (pTau) pathology, and neurodegeneration in the aged hippocampus, but not in […]
- GSE330451 IL-16 production is a mechanism of resistance to BTK inhibitors and R-CHOP in lymphomas May 11, 2026Contributors : Alberto J Arribas ; Cascione Luciano ; Bertoni FrancescoSeries Type : Expression profiling by high throughput sequencingOrganism : Resistance to Bruton tyrosine kinase (BTK) inhibitors remains a major clinical challenge in B-cell lymphomas and often occurs without BTK or PLCG2 mutations. Here, we investigated non-genetic mechanisms of ibrutini […]
- GSE330511 Uncoupling hyperphagia and fat storage by modulation of different serotonergic receptors May 11, 2026Contributors : Christina Clark ; Rizaldy Zapata ; Ian Newman ; Olivia Osborn ; Michael Petrascheck ; Alan ToSeries Type : Expression profiling by high throughput sequencingOrganism : Psychotropic drugs such as antipsychotics improve symptoms of psychiatric disorders. However, they are associated with severe metabolic side effects that remodel energy balance, […]
- GSE247744 Heterochromatin re-organization associated with the transcriptional reprogramming under viral infection in Arabidopsis [ChIP-seq] May 11, 2026Contributors : Maria L Annacondia ; Jinping Cheng ; Vasti T Juarez-Gonzalez ; Juan L Reig-Valiente ; German MartinezSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Epigenetic mechanisms are key regulators of genomic integrity and genic expression. Emerging evidence shows that epigenetic regulation is an important comp […]
- GSE330231 Divergent signaling profiles in mTOR gain-of-function Smith-Kingsmore syndrome and TSC2 deficiency May 11, 2026Contributors : Curtis R Carlson ; Yang Shen ; Hongzhi He ; Erwin K Gudenschwager ; Chunya Hou ; Junfeng Ma ; Joanna C Chiu ; Andrew C LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Smith-Kingsmore syndrome (SKS) is a rare neurodevelopmental disorder caused by gain-of-function mutations in MTOR, yet whether these mutations pheno […]