Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE294863 Mechanistic target of rapamycin/blood test barrier mechanism mediates acceleration of sperm epigenetic aging by environmental factors. April 30, 2026
  Contributors : Olatunbosun Arowolo ; Oladele Oluwayiose ; Jiahui Zhu ; Oleg Sergeyev ; Emily Houle ; J R Pilsner ; Alexander SuvorovSeries Type : Methylation profiling by genome tiling arrayOrganism : Mus musculusOur previous research suggested that mechanistic target of rapamycin (mTOR)/blood-testis barrier (BTB) mechanism is involved in the regulation of t […]
• GSE295772 Mechanisms governing interaction of the chromosomal protein SMCHD1 with chromatin determined by live-cell and single molecule imaging April 30, 2026
  Contributors : Flavia Constantinescu ; Guifeng Wei ; Neil BrockdorffSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe chromosomal protein SMCHD1 is a GHKL-ATPase that plays important roles in epigenetic silencing, including on the inactive X chromosome (Xi) and at the D4Z4 macrosatellite linked to regulation of DUX4 e […]
• GSE295182 Metabolic-epigenetic reprogrammed splenic TRNP1hiCD8+ T cells exacerbate liver fibrosis April 30, 2026
  Contributors : Liyuan Zhang ; Yahui Wang ; Kai Wei ; Wen Nie ; Yayuan Feng ; Zhiwen Shi ; Jin HouSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusMASLD, especially its severe form MASH, progresses to liver fibrosis, leading to cirrhosis and liver cancer. The crosstalk between spleen and liver in MASLD/MASH […]
• GSE298361 Single cell RNA-seq analysis of PBMCs from mouse models of mevalonate kinase deficiency April 30, 2026
  Contributors : Michael Rogers ; Oliver Skinner ; Marcia Munoz ; Ryan Chai ; Andrew McCorkindaleSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe single cell RNA sequencing data here were used in the publication "NK cell dysfunction and interferon gamma production underlie autoinflammation in mevalonate kinase def […]
• GSE296096 GERANYLGERANIOL OVERCOMES THE DELETERIOUS EFFECT OF NITROGEN CONTAINING BISPHOSPHONATES ON OSTEOCLASTS BY PROMOTING G-PROTEIN EXPRESSION April 30, 2026
  Contributors : George Feldman ; Theresa Freemen ; Sankar Addya ; Carly Smith ; Paolo Fortina ; Daniel Taub ; Robert DiecidueSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe nitrogen containing bisphosphonates (NBP), pamidronate, is considered to be responsible for Medication Related Osteonecrosis of the Jaw, MRONJ. B […]
• GSE264576 Targeting LMO2-induced autocrine FLT3 signalling to overcome chemoresistance in early T-cell precursor acute lymphoblastic leukemia [ChIP-seq] April 30, 2026
  Contributors : Cedric S Tremblay ; Jesslyn Saw ; Feng Yan ; Shokoufeh Abdollahi ; Richard B Lock ; David J CurtisSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensEarly T-cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) is an immature subtype of T-cell acute lymphoblastic leukemia (T-ALL) characterised […]
• GSE231700 miRNA expression change in chronic cardiac pressure overload mouse April 30, 2026
  Contributor : Jiming LiSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Mus musculusTo investigate the miRNA expression change in chronic cardiac pressure overload, we established transverse aortic constriction (TAC) mouse model for 8 weeks.
• GSE329159 Widespread transcriptional memory shapes heritable states and functional heterogeneity in cancer and stem cells [RNA-Seq] April 30, 2026
  Contributors : Yongjie Lin ; Xiangru Chen ; Long Wu ; Yutong Zhou ; Yihan LinSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRecent studies show that non-genetic heterogeneity, particularly through heritable cell states, shapes cancer evolution and developmental trajectories. However, single-cell snapshots lack temporal […]
• GSE329158 Widespread transcriptional memory shapes heritable states and functional heterogeneity in cancer and stem cells April 30, 2026
  Contributors : Yongjie Lin ; Xiangru Chen ; Long Wu ; Yutong Zhou ; Yihan LinSeries Type : OtherOrganism : Homo sapiensRecent studies show that non-genetic heterogeneity, particularly through heritable cell states, shapes cancer evolution and developmental trajectories. However, single-cell snapshots lack temporal information to identify these states. We emp […]
• GSE329267 Nanostring nCounter Myeloid Innate Immunity analysis of CD8 T cells cultured with conditioned media April 30, 2026
  Contributors : Ou Peiqi ; Eres Ittai ; Zhao Junjie ; Han Chia-Jung ; Oh Jaehak ; Kim Aeryon ; Dong Jiayi ; Zhou Hong ; Yamawaki Tracy ; Li Chi-Ming ; Rankin Andrew ; Noubade Rajkumar ; Yu XinSeries Type : Expression profiling by arrayOrganism : Mus musculusThe immunosuppressive tumor microenvironment (TME) contributes to resistance against checkpoint inhibit […]
• GSE329266 Nanostring nCounter Mouse PanCancer Immune Profiling analysis of murine tumor tissues April 30, 2026
  Contributors : Ou Peiqi ; Eres Ittai ; Zhao Junjie ; Han Chia-Jung ; Oh Jaehak ; Kim Aeryon ; Dong Jiayi ; Zhou Hong ; Yamawaki Tracy ; Li Chi-Ming ; Rankin Andrew ; Noubade Rajkumar ; Yu XinSeries Type : Expression profiling by arrayOrganism : Mus musculusThe immunosuppressive tumor microenvironment (TME) contributes to resistance against checkpoint inhibit […]
• GSE329296 MURV-seq reveals the genome-wide diversity of 5’ termini and leader sequences across poxvirus transcripts April 30, 2026
  Contributors : Chorong Park ; Hannah L Serio ; Daniel Arango ; Derek WalshSeries Type : OtherOrganism : Homo sapiensViral RNA polymerases (vRNAPs) can slip on homopolymeric sequences to expand their coding potential in diverse ways. This includes poxviruses, whose vRNAP slips at thymidine-rich motifs to generate non-templated polyadenosine (polyA) leaders on […]
• GSE329335 Widespread transcriptional memory shapes heritable states and functional heterogeneity in cancer and stem cells [RRBS] April 30, 2026
  Contributors : Yongjie Lin ; Xiangru Chen ; Long Wu ; Yutong Zhou ; Yihan LinSeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensRecent studies show that non-genetic heterogeneity, particularly through heritable cell states, shapes cancer evolution and developmental trajectories. However, single-cell snapshots lack tempora […]
• GSE329336 Widespread transcriptional memory shapes heritable states and functional heterogeneity in cancer and stem cells [scRNA-seq] April 30, 2026
  Contributors : Yongjie Lin ; Xiangru Chen ; Long Wu ; Yutong Zhou ; Yihan LinSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensRecent studies show that non-genetic heterogeneity, particularly through heritable cell states, shapes cancer evolution and developmental trajectories. However, single-cell snapshots lack […]
• GSE293956 Mechanism of action of hDF-EVs on fibroblasts and keratinocytes [RNA-seq] April 30, 2026
  Contributors : Minjie Liu ; Ganqin Ye ; Ruiyang LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapienshDF-EVs miRNA array, hDFs and HaCaT cells were co-cultured with hDF-EVs for transcriptome sequencing