Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE296746 Phenotypic patterns in feline heart failure: a natural model for understanding variable disease severity in humans June 5, 2026
  Contributors : Talitha C. F. Spanjersberg ; Alma H. Hulsman ; Guy C. M. Grinwis ; Babette Janssen ; C. Nina van der Wilt ; Rogier J. A. Veltrop ; Christian Snijders Blok ; Claudia Rozendom ; Paul Besseling ; Jolanda van der Velden ; Pim van der Harst ; Magdalena Harakalova ; Frank G. van SteenbeekSeries Type : Expression profiling by high throughput sequenci […]
• GSE249357 The effect of glutamine on EMT and lung cancer metastasis June 5, 2026
  Contributors : Yinrui LEI ; Zilong GengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the effect of glutamine on lung cancer cell EMT and metastasis, we used TGFbeta to treat A549 cells for 24 hours, which were cultured under glutamine depletion or 0.2 mM or 0.5 mM glutamine. RNA-seq was performed to ana […]
• GSE299512 Reconstitution of sex-determination process and testicular environment using mouse pluripotent stem cells June 5, 2026
  Contributors : Hayashi Katsuhiko ; Nakamura Tomonori ; Yoshino TakashiSeries Type : Expression profiling by high throughput sequencingOrganism : MusProper differentiation of gonadal somatic cells is crucial for sex determination and subsequent production of sex hormone and gametes. A proper reconstitution of the process in culture will provide not only an ap […]
• GSE299045 Arabidopsis aneuploidy mutant C30-81-as6, possesses enormous variations in multiple phenotypic characteristics June 5, 2026
  Contributors : Asanga Deshappriya Nagalla ; Kotaro Ishii ; Tomonari Hirano ; Sumie Ohbu ; Yuki Shirakawa ; Yusuke Kazama ; Tomoko AbeSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaThe mutant line of C30-81-as6 is an ion beam-generated, Arabidopsis Col-0 based, aneuploid mutant line confirmed by elevated DNA qua […]
• GSE300310 Human Endogenous Retroviruses Drive Type-I Interferon Signaling activation in Early Rheumatoid Arthritis June 5, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSubstantial reactivation of HERVs was observed in both synovial tissues and PBMCs from early RA patients. Differentially expressed HERVs regulate adjacent ISGs expression by providing cis-regulatory elements. Moreover, excessive cytoplasmic HERVs trigger a type I interfero […]
• GSE299981 Effect of METTL4 knockout on expression and splicing in HeLa S3 cells [Human M4] June 5, 2026
  Contributors : Andrey Buyan ; Anastasiia Bolikhova ; Olga Averina ; Alexander Mazur ; Petr SergievSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn this work we studied the role of U2 snRNA m6A(m)30 modification introduced by METTL4 methyltransferase on a model of METTL4 knockout human cell line. METTL4 gene inactivati […]
• GSE333235 Baseline interferon signaling in monocytes and antibody-mediated innate activation at injection site shape mRNA vaccine reactogenicity [human_RNAseq] June 5, 2026
  Contributors : Natacha Madelon ; Gustavo A Ruiz Buendía ; Arnaud M DidierlaurentSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe local and systemic symptoms that follow vaccination -collectively referred to as reactogenicity- are common, yet the mechanisms underlying individual variability remain poorly understood. T […]
• GSE304741 Cytotoxic CD39+ tumor-associated NK cells respond to NKG2A blockade in lung cancer (10X Multiome) June 5, 2026
  Contributors : Clara Serger ; Lucas Rebuffet ; Michael T Sandholzer ; Eric Vivier ; Andrea Romagnani ; Alfred ZippeliusSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiensNatural killer (NK) cell–targeting immunotherapies are emerging, yet the differentiatio […]
• GSE333510 Baseline interferon signaling in monocytes and antibody-mediated innate activation at injection site shape mRNA vaccine reactogenicity [NanoString nCounter dataset] June 5, 2026
  Contributors : Natacha Madelon ; Gustavo A Ruiz Buendía ; Arnaud M DidierlaurentSeries Type : Expression profiling by arrayOrganism : Mus musculusThe local and systemic symptoms that follow vaccination -collectively referred to as reactogenicity- are common, yet the mechanisms underlying individual variability remain poorly understood. Through longitudinal i […]
• GSE333438 Inherent tissue homeostasis of the juvenile metaphysis provides a foundation for osteosarcoma development [scRNAseq_p21] June 5, 2026
  Contributors : Masato Saito ; Sho Ohta ; Fumie Nakasuka ; Takuya Yamamoto ; Yasuhiro YamadaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusOsteosarcomas typically arise from the metaphyseal cells of juvenile long bones, in contrast to most cancers that develop in aged individuals. Here, we show that the cyclin-dependent […]
• GSE333534 Targeting KRAS in a TRP53/KRAS mouse and organoid model inhibits Barrett Esophagus to Gastroesophageal Adenocarcinoma progression June 5, 2026
  Contributors : Linus Schoemig ; Michael QuanteSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe lack of experimental systems that faithfully model the genetic and phenotypic progression from Barrett’s esophagus (BE) to gastroesophageal adenocarcinoma (GEAC) has limited mechanistic discovery and preclinical testing. He […]
• GSE333743 Modification of VE-cadherin signalling by ZEB1 in Lymphatic Endothelial Cells June 5, 2026
  Contributors : Nada S Ahmed ; Joseph L Horder ; Charles T Cresswell ; Poppy E Harris ; Amy P Lynch ; Zarah B Tabrizi ; Kathryn R Green ; James H Hallwood ; Anton C Smith ; Michael A Portelli ; Alexander J Fezovich ; Christos Spanos ; David S Gardner ; Alan McIntyre ; Sarah J Storr ; Daniel G Booth ; David O Bates ; Andrew V BenestSeries Type : Expression pro […]
• GSE333878 Comparative transcriptomic analysis of rice under cadmium and selenium nanoparticle treatments June 5, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Oryza sativaThis study investigated the role of biosynthesized selenium nanoparticles (SeNPs) derived from Chlorella sorokiniana SZ2-1 in alleviating cadmium (Cd) toxicity in rice (Oryza sativa L. cv. Quan Youde Zhan) under hydroponic conditions.The research focused on evaluating the […]
• GSE333952 Baseline interferon signaling in monocytes and antibody-mediated innate activation at injection site shape mRNA vaccine reactogenicity [ATAC-seq] June 5, 2026
  Contributors : Natacha Madelon ; Gustavo A Ruiz Buendía ; Arnaud M DidierlaurentSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThe local and systemic symptoms that follow vaccination -collectively referred to as reactogenicity- are common, yet the mechanisms underlying individual variability remain poorly […]
• GSE333230 The Transcription Factor IRF8 drives tumor-specific exhaustion in CD8 T cells June 5, 2026
  Contributors : Marco Ongaro ; Grégory Verdeil ; Jesus Corria-Osorio ; Yi-Chuan WangSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusT-cell exhaustion is a hallmark of chronic infection and cancer and constitutes a major barrier for successful immunotherap […]