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Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE262956 CRIPTO regulates EV uptake and fibroblast activation in breast cancer [scRNAseq] March 7, 2026
  Contributors : David W Freeman ; Brooke W Gates ; Mauri D Spendlove ; H E Gulbahce ; Ben T SpikeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensInhibition of CRIPTO blocks the serial passage capacity of breast cancer organoids. Here, we sequenced control MDA-MB-468 organoids and organoids expressing a CRIPTO inhibitor, […]
• GSE249068 Targeting Mettl8-Tcf1 axis promotes CD8+ TPEX differentiation and antitumor immunity March 7, 2026
  Series Type : Other ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusCD8+ T cell exhaustion represents a major obstacle to effective cancer immunotherapy. While stem-like progenitor exhausted T (TPEX) cells can differentiate into intermediate (Int-TEX) and terminally exhausted (TEX) subsets, the epigenetic regulation o […]
• GSE291548 Epigenetic Regulation During Flatfish Metamorphosis: Integrative Omics Analysis of DNA Methylation and Gene Expression in Turbot Brain March 7, 2026
  Contributors : Laura Guerrero-Peña ; Paula Suarez-Bregua ; Núria Sánchez-Baizán ; Francesc Piferrer ; Juan J Tena ; Josep RotllantSeries Type : Methylation profiling by high throughput sequencingOrganism : Scophthalmus maximusThe regulation of gene expression plays a pivotal role in the complex metamorphic process of flatfishes, which oversees the dynamic al […]
• GSE283125 Transcriptomic study of the Drosophila midgut during larval development March 7, 2026
  Contributors : Gilles Storelli ; Clara Lefranc ; Ali AbdallahSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterThe main goal of this study was to characterize the transcriptome of the Drosophila midgut during larval development. Larval midguts were collected on three different days during development for RNA ex […]
• GSE315710 Characterization of the effect of hepatocyte nuclear factor 4 (Hnf4) silencing in enterocytes on gene expression in the developing Drosophila larval midgut March 7, 2026
  Contributors : Gilles Storelli ; Clara Lefranc ; Arnaud FichantSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterThe main objective of this study was to characterize the effects of Hnf4 silencing in enterocytes (ECs) on the Drosophila midgut during larval development. Larval midguts from control animals and ani […]
• GSE307463 BASIC PENTACYSTEINE 1 (BPC1) is involved in the epigenetic suppression of camalexin biosynthesis in Arabidopsis March 7, 2026
  Contributors : Adji Baskoro Dwi Nugroho ; Dasom Choi ; Heewon Moon ; Eojin Cho ; Dong-Hwan KimSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaCamalexin is one of indolic phytoalexins protecting plants against biotic challenges like pathogen attack. However, molecular mechanism on how camalexin accumulation is mo […]
• GSE322659 Nitric Oxide Synthase 2-Dependent Metabolic Dysregulation, Immunosuppression, and Genomic Instability in Metastatic Triple-Negative Breast Cancer March 7, 2026
  Contributor : William R MontfortSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusChronic inflammation drives many diseases, including cancer, where inflammation is associated with metastasis, the cause of death in 90% of cancer fatalities. Tumor inflammation drives inducible nitric oxide synthase (NOS2 or […]
• GSE317232 Dual mechanisms for the antagonistic crosstalk between H3 glycation and H3K4me3 [CUT&Tag] March 7, 2026
  Contributors : Yang Xiao ; John Pettingill ; Tessa Firestone ; Alli Hickman ; Lu Sun ; Michael Keogh ; Yujin Choi ; Richard Koche ; Yael DavidSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensCancer cells undergo profound metabolic reprogramming that elevates the intracellular levels of reactive byproducts s […]
• GSE322669 Exploring the mechanism of Jia Wei Xing Bi Gel nasal drops on Children with Allergic Rhinitis based on Transcriptomics and Network Pharmacology March 7, 2026
  Contributors : Si Ai ; Zhuoyang Jiang ; Shiwei Kang ; Xueqi Fan ; Yuqin Zhang ; Xiong Lin ; Jian ZhengSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensObjective: This study combines transcriptomics and network pharmacology to explore the mechanism of action of Jia Wei Xing Bi Gel nasal drops in treating allergic rhin […]
• GSE322668 A Positive Feedback Loop Between TKT and c-Myc Drives TACE Resistance In Hepatocellular Carcinoma March 7, 2026
  Contributor : Yifu XiaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHepatocellular carcinoma (HCC) often receives transarterial chemoembolization (TACE), yet clinical benefit is limited by resistance driven by ischemia-induced adaptations. This study explains how transketolase (TKT) in the pentose phosphate pathway ( […]
• GSE322673 Mild cold exposure mitigates ischemic heart injury through indole-3-acetamide–AHR-mediated SMAD2 proteolysis March 7, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAmbient temperature profoundly influences organismal metabolism, physiology, and disease. While cold exposure is a well-recognized risk factor for the onset of myocardial infarction (MI), its impact on the injured heart after MI remains unexplored. Here, we demonstrate tha […]
• GSE322713 Evolutionary expansion of the corticospinal system is linked to dexterity in Peromyscus mice March 7, 2026
  Contributor : Kelsey M TyssowskiSeries Type : Expression profiling by high throughput sequencingOrganism : Peromyscus maniculatus bairdii ; Peromyscus maniculatus nubiterraeWhile the central nervous system is perpetually reshaped by evolution, the principles governing how such changes promote ecologically relevant behaviors without breaking established funct […]
• GSE322732 CCAAT‐enhancer binding protein delta functions as a tumor suppressor gene in acute myeloid leukemia March 7, 2026
  Contributors : Francine Garrett-Bakelman ; Subhash PrajapatiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThere is a continued need for identification of novel disease drivers of acute myeloid leukemia (AML) as many patients experience relapse and have poor clinical outcomes. Using genomic analyses of a study dataset […]
• GSE322741 Two mycorrhiza-responsive MADS transcription factors, OsMADS61 and OsMADS26, regulate both direct and mycorrhizal nitrate transport pathways March 7, 2026
  Contributors : Yuhan Ren ; Congfan Yang ; Haoyan Ji ; Kun Xie ; Haoran Mao ; Dechao Zeng ; Lingxiao WangSeries Type : Expression profiling by high throughput sequencingOrganism : Oryza sativaMost land plants have evolved both a direct root uptake pathway and a symbiotic pathway, via association with arbuscular mycorrhizal (AM) fungi, to facilitate nutrient a […]
• GSE322634 LIF induced tumor plasticity establishes an immunosuppressive myeloid niche in LKB1 mutant lung cancer [antiLif_CITEseq] March 7, 2026
  Contributors : Ray Pillai ; Ali Rashidfarrokhi ; Yuan Hao ; Aristotelis Tsirigos ; Sergei Koralov ; Thales PapagiannakopoulosSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusSingle Cell RNA-seq analysis (5' CITE-seq) of immune Cells from Murine Lkb1 mutant KP Lung Tumors with deletion of Lif or Lifr (Figure […]