Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE236530 Enzyme-mediated methylation and alkynylation enables transcriptome-wide identification of pseudouridine modifications February 15, 2026
  Contributors : Yuru Wang ; Kinga Pajdzik ; Yutao Zhao ; Chang Ye ; Talbot Stone ; Lisheng Zhang ; Wen Zhang ; Mahdi Assari ; Wenxin Zhao ; Caraline Sepich-Poore ; Qing Dai ; Ke Wang ; Minkui Luo ; Tao Pan ; Chuan HeSeries Type : Other ; Expression profiling by high throughput sequencingOrganism : Pseudouridine (Ψ) is one of the most abundant chemical modific […]
• GSE319173 Transcriptomic atlas of POSA mice versus normoxic controls February 15, 2026
  Contributors : Williamson Michael ; Chandrakantan Arvind ; Serin Harmanci AkdesSeries Type : Expression profiling by high throughput sequencingOrganism : We exposed p14 mice to 56 day of forced intermittent hypoxia as a proxy stimlulus for pediatric OSA. After this exposure, we performed sn-RNA seq of the hippocampus of both normoxic controls and IH exposed […]
• GSE263002 Gene expression profiles in pancreatic cancer cells with high or low baseline autophagy flux levels [Low-Auto_High-Auto_RNASeq] February 15, 2026
  Contributors : Mohamad Assi ; Alec KimmelmanSeries Type : Expression profiling by high throughput sequencingOrganism : In this study, we characterize the transcriptional signature of pancreatic cancer cells with different autophagy flux levels.
• GSE263000 Effects of constitutive YAP1 activation on gene expression in pancreatic cancer spheroids [EV_YS6A_RNASeq] February 15, 2026
  Contributors : Mohamad Assi ; Alec KimmelmanSeries Type : Expression profiling by high throughput sequencingOrganism : In this study, we investigate the role of YAP1 in regulating autophagy flux in pancreatic cancer spheroids.
• GSE274444 Estrogen receptor β target gene expression reveals novel repressive functions in aggressive breast cancer [sRNA-Seq] February 15, 2026
  Contributors : Spyros Tastsoglou ; Ilias Karagounis ; Marios Miliotis ; Harika Nagandla ; Kristina Zambo ; Maria Liousia ; Naoto Ueno ; Amit Maity ; Artemis G Hatzigeorgiou ; Christoforos ThomasSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Inflammatory breast cancer (IBC) is a highly metastatic breast carcinoma with high freq […]
• GSE263163 Identify positive and negative regulators of autophagy in pancreatic cancer spheroids. February 15, 2026
  Contributors : Mohamad Assi ; Alec KimmelmanSeries Type : OtherOrganism : In this study, we reveal the regulators of autophagy in 3D culture and 2D starvation conditions in pancreatic cancer.
• GSE317401 A pioneering single-nucleus multi-omic atlas of Dermatophagoides farinae defines allergen origins and transcriptional regulators February 15, 2026
  Contributors : Yubao Cui ; Ying Zhou ; Ximeng Ma ; Xinhui Gong ; Cunyin Yuan ; Pavel B. Klimov ; Jing Du ; Dongmei ZhouSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : The cellular origins and transcriptional regulation of allergens from house dust mites (HDMs), a pr […]
• GSE274448 Estrogen receptor β target gene expression reveals novel repressive functions in aggressive breast cancer [ChIP-Seq] February 15, 2026
  Contributors : Spyros Tastsoglou ; Ilias Karagounis ; Marios Miliotis ; Harika Nagandla ; Kristina Zambo ; Maria Liousia ; Naoto Ueno ; Amit Maity ; Artemis G Hatzigeorgiou ; Christoforos ThomasSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Inflammatory breast cancer (IBC) is a highly metastatic breast carcinoma with […]
• GSE318977 Intraperitoneal BSN-37 activates peritoneal macrophages in Balb/c mice and reshapes the circRNA–mRNA transcriptome February 15, 2026
  Contributors : Xiaojing Xia ; Xujie Zhao ; Yanhe Lv ; Bingze Jiao ; Haipeng Li ; Ke Ding ; Jianhe HuSeries Type : Expression profiling by high throughput sequencingOrganism : Our preliminary work indicates that the antimicrobial peptide BSN-37 exhibits immunostimulatory activity; however, its in vivo molecular mechanisms remain insufficiently defined. Here, […]
• GSE318385 Cohesin prevents local mixing of condensed euchromatic domains in living human cells February 15, 2026
  Contributors : Le Xiong ; Liangqi XieSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : The human genome is folded into chromatin loops by the cohesin complex, forming functional chromatin domains that underlie transcription and DNA replication/repair. However, the physical properties of these domains in living cells, es […]
• GSE319147 RNA-seq analysis of Tabanus nipponicus Salivary Glands February 15, 2026
  Contributors : Noboru Inoue ; Keisuke Suganuma ; Ercha HuSeries Type : Expression profiling by high throughput sequencingOrganism : Tabanus nipponicus is a hematophagous insect species with high activity in summer, and its salivary gland secretions play a critical role in mediating successful blood-feeding. In this study, pooled salivary gland samples from t […]
• GSE319154 HER2d16 promotes breast cancer metastasis through integrin-driven signaling February 15, 2026
  Contributors : Philippe P Roux ; Guillaume de Lhoneux ; Jonathan BoucherSeries Type : Expression profiling by high throughput sequencingOrganism : The HER2d16 splice variant, generated by skipping exon 16 of the ERBB2 transcript, is frequently detected in aggressive HER2-positive breast tumors and has been associated with enhanced tumorigenicity. However, th […]
• GSE319166 Anaerobic riboflavin degradation by human gut Lachnospiraceae February 15, 2026
  Contributors : Christian J Quiles-Pérez ; Ami Fofana ; Kamal Deep ; Calissa Carlisle ; Justin A North ; Patrick H BradleySeries Type : Expression profiling by high throughput sequencingOrganism : Vitamins mediate a web of cross-feeding interactions in the human gut. Many Gram-positive gut microbes, in particular, are predicted to be vitamin auxotrophs. Previ […]
• GSE289716 Longitudinal zone- and cell-type-specific immune responses sustain Arabidopsis roots against pathogen infections February 15, 2026
  Contributors : Lahong Xu ; Fausto Andres Ortiz Morea ; Yan Yan ; Derui Liu ; Xiangpei Kong ; Camilla Ferrari ; Daniel Osorio ; James J. Cai ; Klaas Vandepoele ; Libo Shan ; Ping HeSeries Type : Expression profiling by high throughput sequencingOrganism : The immunity is dynamically regulated to balance growth and defense. Roots consisting of diverse cell typ […]
• GSE316394 Aberrant medial ganglionic eminence (MGE) GABAergic neurogenesis contributes to Huntington’s disease pathogenesis February 15, 2026
  Contributors : Aldrin E Molero ; Gnanapackiam S Devakanmalai ; Yagiz M Altum ; Teresa Jover-Mengual ; Junya Zhang ; Nusrat Khan ; Mark F MehlerSeries Type : Expression profiling by high throughput sequencingOrganism : This study used single-cell RNA sequencing to characterize early transcriptional alterations in medial ganglionic eminence (MGE) development c […]