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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE306856 Venetoclax Enhances gamma-deltaT cell Antileukemia Activity via Fatty Acid Oxidation in Relapsed Acute Myeloid Leukemia. November 26, 2025Contributors : Xingchi Chen ; Xiaoyu Zhu ; Lin Zhang ; Bingbing Yan ; Yinqiang Sui ; Weiwei Ma ; Yining WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRelapse remains a leading cause of death in acute myeloid leukemia (AML), in part because host immune surveillance declines over time. Gamma delta (gamma-delta) T ce […]
- GSE293929 IPSC-Derived CAR-NK Extracellular Vesicles Remodel Macrophage Immunity and Enhance Tumor Eradication November 26, 2025Contributors : Hao Zhang ; Peng Xia ; Bin Jin ; Minghe Zhang ; Jie LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusChimeric antigen receptor (CAR) cell therapy has revolutionized the treatment of hematological malignancies; however, its efficacy in solid tumors remains limited due to dense stromal barriers and the im […]
- GSE311460 Rapid gain and loss of a chromosome drives key morphology and virulence phenotypes in Histoplasma, a fungal pathogen of humans November 26, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Histoplasma ohienseThis SuperSeries is composed of the SubSeries listed below.
- GSE310509 SREBP signaling regulates lung resident memory B cell metabolism to sustain allergic memory November 26, 2025Contributors : Wei Luo ; Alex MaldeneySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIgE drives allergic airway disease, yet the mechanisms sustaining IgE memory remain incompletely understood. Using a murine model of allergy, we identified CCR6⁺ CD69⁺ lung-resident memory B cells (BRM) that persist after sensitization […]
- GSE282949 Venom-gland transcriptomic analysis of the predatory stink bug, Picromerus lewisi (Hemiptera: Pentatomidae) November 26, 2025Contributors : Jinmeng Li ; Xu Tian ; Hancheng Wang ; Wenhong LiSeries Type : Expression profiling by high throughput sequencingOrganism : Picromerus lewisiComparative gene expression profiling analysis of RNA-seq data from six venom-gland samples belonging to the Ag and Ng groups. The transcriptome data of the venom gland of P. lewisi obtained in this study […]
- GSE270116 Lymphotoxin alpha is an endogenous repressor of acute myeloid leukemia November 26, 2025Contributor : Sebastian VosbergSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAcute myeloid (AML) is characterized by frequent relapse, which is driven by resistant leukemic stem cells (LSC)1, highlighting the necessity to target the malignant stem-cell pool for disease control. Here, we report a tumor suppressive mech […]
- GSE311073 Variability in intrinsic promoter strength underlies the temporal hierarchy of the Caulobacter SOS response induction November 26, 2025Contributors : Aditya Kamat ; Asha Joseph ; Deeksha Rathour ; Anjana BadrinarayananSeries Type : Expression profiling by high throughput sequencingOrganism : Caulobacter vibrioidesBacteria encode for gene regulatory networks crucial for sensing and repairing DNA damage. Upon exposure to genotoxic stress, these transcriptional networks are induced in a tempor […]
- GSE283060 Humanized Monoacylglycerol Acyltransferase 2 mice Become Obese and develop Metabolic Dysfunction-Associated Steatotic Liver Disease when fed a High Fat Diet November 26, 2025Contributors : Jose Corbalan ; Pranavi Jagadeesan ; Joseph NickelsSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusObjective: Elevated monoacylglycerol acyltransferase 2 (hMOGAT2) expression is seen in individuals having obesity and mice lacking mMGAT2 activity are resistant to diet-induced obesity. Whether hMOGAT2 inhib […]
- GSE311175 Single-cell Multiomics Analysis Reveals CTCF as a Key Regulator of Lung Morphogenesis and Progenitor Maintenance I November 26, 2025Contributors : Shenfei Sun ; Yamei Jiang ; Fujing Huang ; Wei Wei ; Mathias Hochgerner ; Tianmin Xu ; Xiaoting Wang ; Kaijun Lin ; Xinna Zhang ; Yanli Wang ; Hua He ; Miao Yu ; Xiaofang Tang ; Xinhua LinSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Mus musculusLun […]
- GSE311172 Transcriptional Response and Adaptive Evolution to Oxidative Stress in Synechococcus elongatus PCC 7942 November 26, 2025Contributors : Pavlo Bohutskyi ; Zachary Johnson ; Marci GarciaSeries Type : Expression profiling by high throughput sequencingOrganism : Synechococcus elongatus PCC 7942 = FACHB-805Cyanobacteria inhabit dynamic redox environments influenced by diurnal cycles, environmental fluctuations, and nutrient availability, necessitating tight redox regulation. This R […]
- GSE311331 Effect of depletion of ANAPC1P2 on OVCAR3 cells. November 26, 2025Contributors : Sharmila Bapat ; Jadhav AmrutaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensANAPC1P2 is a chimeric pseudogene that gives rise to a novel chimeric long non-coding transcript, vA-202 (RMND5A-ANAPC1). Notably, vA-202 functions as a γ-irradiation–responsive lncRNA, becoming induced under genotoxic stress co […]
- GSE311393 Protocol for Quantifying Silent Ribosome Induction using Polysome Profiling November 26, 2025Contributors : Sayanur Rahaman ; Samuel Mondal ; Nicole Schiffelholz ; Attila BecskeiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTranslationally silent ribosomes have become an important focus in RNA biology, yet their quantification remains challenging. Lacking mRNAs, they represent a hibernating ribosome state. Th […]
- GSE311458 Phase 1 study of chidamide in combination with venetoclax, azacitidine, aclarubicin, cytarabine and G-CSF for refractory/relapsed acute myeloid leukemia: Clinical safety, efficacy and correlative analysis November 26, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensFor scRNA-seq analysis, bone marrow mononuclear cells (BMMCs) from four consecutively enrolled patients (July–September 2023) were processed using the 10x Genomics platform. Patients selected for scRNA-seq analysis were consecutively enrolled during the study period to min […]
- GSE291257 Gene Expression Profiling Identifies Potential Biomarkers for Vaso-Occlusive Episodes in Sickle Cell Disease November 26, 2025Contributors : Varsha Bhat ; Justin J Yoo ; Srija Ponna ; Alka A Potdar ; Ashwin P Patel ; Guoying K Yu ; Greg Gibson ; Vivien A SheehanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensVaso-occlusive episodes (VOE) or acute pain events, involving complex interactions between sickle erythrocytes and other blood cells, are […]
- GSE311050 Chromatin folding principles underlying the generation of antibody diversity November 26, 2025Contributors : Noah Ollikainen ; Fei Ma ; Fatima Z Braikia ; Ranjan SenSeries Type : OtherOrganism : Mus musculusAchieving a diverse repertoire of antigen receptors for effective adaptive immunity requires rearrangement of gene segments into unique combinations via V(D)J recombination. To illuminate precise mechanisms underlying this process, we combined bio […]