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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE270098 Knockdown of chERVs block TLR3-IL-1β dependent inflammatory response in chicken macrophages December 9, 2025Contributors : Xuming Hu ; Xujing Chen ; Huixian Wu ; Hengmi CuiSeries Type : Expression profiling by high throughput sequencingOrganism : Gallus gallusChicken endogenous retroviruses (chERVs) are remnants of ancient retroviral infections and can profoundly affect the host antiviral innate immune response, although the mechanisms by which these changes occur […]
- GSE282222 Dysfunction of Unc119, a transducin-binding protein, leads to cone-rod dystrophy through activating JAK-STAT and NF-kB inflammatory pathways in the mouse retina December 9, 2025Contributors : Koki Kobayashi ; Taro Chaya ; Yamato Maeda ; Yuki Nakashima ; Ryotaro Tsutsumi ; Haruka Yamamoto ; Toshinori Tsujii ; Daisuke Motooka ; Takahisa FurukawaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTransducin is a heterotrimeric G protein that is a component of the phototransduction cascade in rod and […]
- GSE279909 Sequencing and bioinformatics analysis of exosome-derived miRNAs in mouse models of pancreatic injury induced by OSA December 9, 2025Contributors : Qingshi Chen ; Jiuhuang Lan ; Yaopeng Guo ; Dexin LiuSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Mus musculusThe role of exosomal miRNAs involved in the pathogenesis and development of pancreatic injury caused by obstructive sleep apnea (OSA) remains unclear. Here, miRNA sequencing (miRNA-seq) was used to inv […]
- GSE288404 Olfr2 drives abdominal aortic aneurysm by promoting monocyte recrutiment December 9, 2025Contributors : Patrik Schelemei ; Holger WinkelsSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusOlfactory receptor 2 is a G-protein coupled receptor expressed on vascular macrophages. Activation by its ligand octanal in conjuction with a toll like receptor 4 stimulus induces the NLRP3 inflammasome with subsequent IL-1al […]
- GSE285203 Transcriptome analyses of human corneal endothelial cell lines derived from patients with Fuchs Endothelial Corneal Dystrophy December 9, 2025Contributors : Ula Jurkunas ; Shazia AshrafSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe report differential gene expression profiles of the corneal endothelial cells from Fuchs dystrophy patients with or without the TCF4 gene mutation
- GSE227769 Rice Chromatin Protein OsHMGB1 Is a Transcriptional Facilitator that Regulates Phosphate Homeostasis and Plant Growth [ATAC-seq] December 9, 2025Contributors : Yan Wang ; Fei Wang ; Hong Lu ; Rongbin LinSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Oryza sativaAlthough phosphorus is one of the most important essential elements for plant growth and development, the epigenetic regulation of inorganic phosphate (Pi) signaling is poorly understood. In this study […]
- GSE290333 Whole transcriptome analysis of peripheral blood mononuclear cells from de novo and drug-naive sporadic Parkinson’s disease patients December 9, 2025Contributors : Navarrete Francisco ; Guillot-Fernández Marina ; Martínez-Hostyn Lorena ; Navarro Daniela ; Molina José A. ; López-Atalaya Jose P. ; Manzanares JorgeSeries Type : Expression profiling by arrayOrganism : Homo sapiensThis study investigated gene expression differences in Parkinson’s disease (PD) using blood samples from 23 newly diagnosed, drug- […]
- GSE312968 Cardiorenal heart failure with preserved ejection fraction is caused by a reversible rise of mineralocorticoid-induced fibroblast subtypes December 9, 2025Contributors : David Meral ; Argen Mamazhakypov ; Duygu Koca ; Ramona Emig ; Rémi Peyronnet ; Sebastian Preissl ; Achim LotherSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHeart failure with preserved ejection fraction (HFpEF) is driven by co-morbidities. While specific treatments to enable recovery of HFpEF are lacki […]
- GSE312800 To study the expression profile change after treatment of ZN-c5 and 4-OH Tamaxifen in MCF-7 cells December 9, 2025Contributors : Jianhui Ma ; Fernando Donate ; Ahmed SamatarSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEndocrine therapy has proven to be beneficial for patients with estrogen receptor (ER) positive, HER2 negative (ER+/HER2-) breast cancer; however, de novo or acquired resistance remains a major clinical challenge. […]
- GSE312984 Systems mapping of intra-donor cross-tissue T cell clonal expansion and tissue adaptation in the gut-liver-blood axis December 9, 2025Contributors : Ran Ran ; Merve Uslu ; Mohda F Siddiqui ; Douglas K Brubaker ; Martin TrapecarSeries Type : Other ; Expression profiling by high throughput sequencingOrganism : Homo sapiensSingle-cell RNA sequencing with paired TCR sequencing was performed on CD3+ T cells isolated from matched colon epithelium, colon lamina propria, liver, and peripheral bloo […]
- GSE312980 Single-Cell RNA Sequencing Analysis of Kidney Organoids derived in 2D or 3D from SCTi004-A hiPSC line using the STEMdiff™ Kidney Organoid Kit December 9, 2025Contributors : Nina Quiskamp ; Eloi Mercier ; Ryan Bailey ; Colleen UmaliSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensKidney organoids differentiated from human pluripotent stem cells are complex structures that capture glomerular, tubular and mesenchymal cell types of the developing human kidney. The STEMdiff™ Kidne […]
- GSE313006 Spatial transcriptomic profiling of human lung tissue in chronic obstructive pulmonary disease (COPD) [Xenium] December 9, 2025Contributors : Yuening Zhang ; Huanhuan Wei ; Jessica Nouws ; Maor SaulerSeries Type : OtherOrganism : Homo sapiensTo spatially contextualize and extend disease-associated cellular states, we generated Xenium spatial transcriptomics data from FFPE lung tissue of 38 participants spanning the COPD disease spectrum. Four tissue microarrays (TMA1–TMA4) were prof […]
- GSE313021 STING–IFN–CH25H lipid axis links innate immune activation to tau pathology [scRNA-seq] December 9, 2025Contributors : Hao Chen ; Li Fan ; Manying Wong ; Yohannes A. Ambaw ; Jingjie Zhu ; Kendra Norman ; Pearly Ye ; Nessa Foxe ; Daphne Zhu ; Yuansong Wan ; Mahalashmi Srinivasan ; Sue-Ann Mok ; Laura Beth J McIntire ; Tobias C. Walther ; Robert V. Farese Jr. ; Li Gan ; Wenjie LuoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musc […]
- GSE313022 STING–IFN–CH25H lipid axis links innate immune activation to tau pathology [RNA-seq] December 9, 2025Contributors : Hao Chen ; Li Fan ; Manying Wong ; Yohannes A. Ambaw ; Jingjie Zhu ; Kendra Norman ; Pearly Ye ; Nessa Foxe ; Daphne Zhu ; Yuansong Wan ; Mahalashmi Srinivasan ; Sue-Ann Mok ; Laura Beth J McIntire ; Tobias C. Walther ; Robert V. Farese Jr. ; Li Gan ; Wenjie LuoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musc […]
- GSE260452 Single-cell multidimensional profiling of tumor cell heterogeneity in supratentorial ependymomas December 9, 2025Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiens ; Rattus norvegicusThis SuperSeries is composed of the SubSeries listed below.