Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE300492 Developmental programming of late-life proteostasis and longevity by NuA4 complex activity in early life [RNA-Seq] July 7, 2026
  Contributors : Yihan Wang ; Lianfeng WuSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansMaintaining proteostasis is essential for healthy aging and preventing neurodegenerative diseases like Alzheimer's disease, yet its collapse in late life leads to irreversible pathologies. It is unknown if there exists […]
• GSE240826 Transcriptional analysis of transposon mutants disrupted in glutathione or ergothioneine biosynthesis in Burkholderia thailandensis July 7, 2026
  Contributors : Rawat Mamta ; Van Laar Tricia ; Thomas JasonSeries Type : Expression profiling by high throughput sequencingOrganism : Burkholderia thailandensisIn this study we compare logrithmically grown Burkholderia thailadensis wildtype to a transposon mutant that is disrupted in gshA1, or gshA2, which are involved in glutathione biosynthesis or egtB, in […]
• GSE301790 RNA Sequencing Analysis of PFAS Impact on Liver Organoids July 7, 2026
  Contributors : You Lijuan ; Ying Yang ; Tian Yaru ; Zhuang Zhisen ; Qiannan Zhang ; Xudong Jia ; Hui YangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn order to gain a deep understanding of the effects of PFAS on liver organoids, we have constructed a liver organoid model based on human liver cells. We have treated […]
• GSE301622 RNA Sequencing of the Impact of CXCR3 receptor modulation on activated T cells function July 7, 2026
  Contributors : Ying Yang ; Xu Miao ; Tian Yaru ; Zhuang Zhisen ; Qiannan Zhang ; Xudong Jia ; Hui YangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensFirst, we used human PBMCs to establish a T - cell activation model, and activated T cells with the polyclonal stimulants PMA and Ionomycin. Before activating the PBMCs, w […]
• GSE309565 Morphological and Functional Diversity of Spatially Resolved Vestibular Ganglion Neuron Cell Types July 7, 2026
  Contributors : Ruiqi Liu ; Jingyue Liu ; Zhiyu Chen ; Jingying Li ; Zhiyong Liu ; Shuohao SunSeries Type : OtherOrganism : Mus musculusVestibular ganglion neurons (VGNs) are the primary sensory neurons of the vestibular system, a relatively understudied sensory modality that is essential for maintaining visual stability and postural balance. Compared with ot […]
• GSE301872 Therapy-persistent leukemia is selectively vulnerable to SLC23A1 restoration via targeting KHSRP (PDX samples from different disease statuses) July 7, 2026
  Contributors : Qingyu Luo ; Andrew LaneSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHuman PDX cells were enriched from mice treated with vehicle control or venetoclax + azacitidine
• GSE337395 Transcriptomic profiling of Rb1-treated DC2.4 dendritic cells July 7, 2026
  Contributors : Li Yuan ; Lu Yuxiang ; Zhou Shiling ; Lu Jiaxing ; Feng Yuanlong ; Ma Fen ; Zhang JiweiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGinsenoside Rb1 was investigated for its effects on dendritic cell function and antitumor immunity. Bulk RNA-seq was performed on murine DC2.4 dendritic cells treated with […]
• GSE330002 A High-Throughput Screen on Primary Glioblastoma-Associated Macrophages Identifies HDAC Inhibitors as Enhancers of Phagocytosis and Potent Partners for Immunotherapy [RNA-seq] July 7, 2026
  Contributors : Mona Khalaj ; Irving L WeissmanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study presents the first high-throughput chemical screen on primary tumor-associated macrophages (TAMs) freshly isolated from surgical glioblastoma (GBM) patient samples, testing 1,365 compounds to identify drugs that enha […]
• GSE337426 USP22 is a novel vulnerability regulating MEIS1 protein abundance and gene transcription in KMT2Ar acute leukemia July 7, 2026
  Contributor : Florian PernerSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensPatients with acute leukemias harboring translocations involving gene lysine methyltransferase 2A (KMT2A) have a poor prognosis due to chemotherapy resistance with rapid relapse following standard treatments. The resulting KMT2A fu […]
• GSE337417 16S rRNA gene amplicon sequencing of gut microbiota from APAP-induced acute liver injury mice treated with Polygonatum odoratum extract July 7, 2026
  Contributors : Huanghui Qin ; Runxiao Chen ; Ying Shi ; Caibin Li ; Yiming Bin ; Zhaoming Zeng ; Bin Deng ; Lanyu LiSeries Type : OtherOrganism : Mus musculus16S rRNA V3-V4 amplicon sequencing was performed on fecal samples from 12 male C57BL/6J mice across three groups (4 replicates each): Control (distilled water, 3 days), Model (distilled water, 3 days + […]
• GSE337438 Tumor-selective protein translation of mRNA drugs for targeted tumor therapy July 7, 2026
  Contributors : Xucong Teng ; Xiangdong Zhang ; Jinghong LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensmRNA-based therapies necessitate precise, specific, and patient-friendly control of therapeutic protein translation to ensure treatment safety and efficacy. However, achieving tumor-specific mRNA translation regulat […]
• GSE337450 RNA exosome-dependent transcriptional adaptation masks gene essentiality July 7, 2026
  Contributors : Sebastian Süsser ; Ronay Cetin ; Antonella Vera-Guapi ; Cosmin Tudose ; Chiara Becht ; Thomas Rohde ; Martin Wegner ; Florian Heigwer ; Jan Detleffsen ; Gabriel M. C. Longo ; Alessandro Vinceti ; Sweta Taylan ; Siu Wang Ng ; Anjan Venkatesh ; Yves Matthess ; Tabea Hoffmann ; Simone Schaubeck ; Koraljka Husnjak ; Jannik Lübke ; Colm Ryan ; Fran […]
• GSE337458 Circadian Clock Gene Modulation and Selective Reprogramming in Response to Copy-back Viral Genomes During Infection July 7, 2026
  Contributors : Nicole Rivera ; Emna Achouri ; Matthew Hackbart ; Maria F Gonzalez Aponte ; Yanling Yang ; Erik Herzog ; Carolina B. LópezSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe circadian clock regulates fundamental cellular processes that include the host response to infection. However, its intersection with […]
• GSE337460 Chlamydia serovars in uterus- scRNA-seq, CITE-seq and TCRab July 7, 2026
  Contributors : Andrea Lebron Figueroa ; David Zemmour ; Christophe BenoistSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusThis study is part of the immgenT Open Source Project, specifically from IGT33, which focuses on characterizing T cell populations in the uterus during Chlamydia trachomatis D and L2 infectio […]
• GSE337357 Single-cell transcriptomic profiling of pituitary adenoma from patient with Cushing's disease July 7, 2026
  Contributor : Cui ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe performed single-cell transcriptomic profiling of a pituitary adenoma from a patient with a rare subtype of Cushing's disease using the 10x Genomics platform. The analysis revealed the cellular landscape of the tumor, identifying distinct cel […]