Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE291923 ORCA-mediated Polycomb Repressive Complex stabilization maintains 3D-genome architecture and controls replication timing [NS-seq] May 20, 2026
  Contributors : Neha Chetlangia ; Bhushan L Thakur ; Christophe E redon ; Oraya J Zinder ; Lorinc S Pongor ; YouJin Song ; Darya Asoudegi ; Dazhen Liu ; Chris J Fields ; Kannanganattu V Prasanth ; Mirit I Aladjem ; Supriya G PrasanthSeries Type : OtherOrganism : Homo sapiensPolycomb bodies, also called Polycomb group (PcG) protein complexes, are implicated in […]
• GSE278956 SETD2 contributes to PAF1C interactions with the elongating RNA Pol II and is required for neuronal differentiation [ChIP-Seq] May 20, 2026
  Contributor : Tuncay BaubecSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusChromatin modifications are relevant for mammalian development, and their aberrant deposition is associated with human disease. While the mechanisms that deposit and remove these modifications have been largely elucidated, their rol […]
• GSE299462 REP-1 depletion causes altered mitochondrial energy metabolism in CHM disease, shifting from glycolysis to lipid oxidation May 20, 2026
  Contributors : Sara Buonocore ; Giuliana Giamundo ; Iolanda Caratù ; Chiara Barone ; Dario Antonini ; Ivan ConteSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe persistent supply of glucose in the retina is essential for underpinning ATP production to meet the retinal cell’s energy requirements essential for the visi […]
• GSE296461 N-terminal arginine anchor in BCL7A Fine-tunes Chromatin Remodeling and Drives Tumor Suppression in DLBCL [RNA-seq] May 20, 2026
  Contributors : Jingdong Xue ; Bing LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe hSWI/SNF (BRG1/BRM-associated factor) chromatin remodeling complex plays a critical role in regulating chromatin accessibility and gene expression, with its dysfunction linked to cancer. However, the specific mechanisms by which its […]
• GSE307114 Analysis of FMR1 splicing in FXS iPSCs May 20, 2026
  Contributors : Shaima Hourani ; Kagistia H Utami ; Maija L Castrén ; Mahmoud A PouladiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensFragile X syndrome (FXS) is a neurodevelopmental disorder caused by loss of FMRP that, with rare exceptions, results from CGG expansion in the promoter region of FMR1. The trinucleotide e […]
• GSE303446 Beyond CD30 Targeting: Brentuximab Vedotin Triggers Immunogenic Cell Death and Antitumor Immunity in Mycosis Fungoides, Overcoming Resistance via BCL2 Inhibition May 20, 2026
  Contributors : Yi Jiang ; Pan Lai ; Mingjia Li ; Yujie Wen ; Yu Xiao ; Zhuojing Chen ; Jingru Sun ; Yang WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: Mycosis fungoides (MF), the most common subtype of cutaneous T cell lymphoma (CTCL), has poor prognosis in advanced stages due to lack of effective ther […]
• GSE331446 Epicardial fat drives macrophage response in atrial cardiomyopathy May 20, 2026
  Contributors : Laure Crepin ; Abhilash Dasari ; Nathalie Mougenot ; Eva Trenquier ; Francois Lanthiez ; Maria Mihoc ; Ibrahim Abdou-Seini ; Alexandre Raymond-Cahuzac ; Maharajah Ponnaiah ; Caroline Chabbat ; Emmanuel Gautier ; Guillaume Lebreton ; Pascal Leprince ; Alexandre Boissonnas ; Stephane Hatem ; Nadine SuffeeSeries Type : OtherOrganism : Homo sapien […]
• GSE311380 Cellular composition of tissue-resident monocyte-lineage cells reveal heterogeneity during inflammatory arthritis, Figure 2 & 3 May 20, 2026
  Contributors : Yidan Wang ; Deborah R Winter ; Harris PerlmanSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusCITE-seq analysis of joint myeloid niche reveals the heterogeneity of tissue-resident monocyte-lineage cells at steady-state and 7 days post Clo-lip administration.
• GSE331502 Regulation of the histone H3K36 methyltransferase Set2 by the histone chaperone Spt6 [RNA-seq] May 20, 2026
  Contributors : Alexandra R Elchert ; Vanda Lux ; James L Warner ; Tereza Nešporová ; Václav Veverka ; Fred WinstonSeries Type : Expression profiling by high throughput sequencingOrganism : Saccharomyces cerevisiaeHistone H3 lysine 36 methylation is a conserved histone modification that is critical for maintaining eukaryotic transcriptional fidelity and genom […]
• GSE331465 Epicardial fat drives macrophage response in atrial cardiomyopathy [scRNA-Seq] May 20, 2026
  Contributors : Laure Crepin ; Abhilash Dasari ; Nathalie Mougenot ; Eva Trenquier ; Francois Lanthiez ; Maria Mihoc ; Ibrahim Abdou-Seini ; Alexandre Raymond-Cahuzac ; Maharajah Ponnaiah ; Caroline Chabbat ; Emmanuel Gautier ; Guillaume Lebreton ; Pascal Leprince ; Alexandre Boissonnas ; Stephane Hatem ; Nadine SuffeeSeries Type : Expression profiling by hig […]
• GSE331519 Synergistic effects of tRNA modification defects in Escherichia coli K12 May 20, 2026
  Contributors : Jo Marie Bacusmo ; Jill Babor ; Jennifer Hu ; Bo Cao ; Stefanie Kaiser ; Sierra Szkrybalo ; Yifeng Yuan ; Serena Sander ; Paul Kuipers ; Laura Sanchez ; Michael DeMott ; Hirotada Mori ; Peter Dedon ; Valérie de Crécy-LagardSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Escherichia coliTransfer RNAs (tRNAs) are e […]
• GSE331520 Conserved structural features of the lncRNA HOTAIR in breast cancer cells May 20, 2026
  Contributors : Zion R Perry ; Anish Beeram ; Logan Lee ; Anna Marie PyleSeries Type : OtherOrganism : Homo sapiens ; synthetic constructLong noncoding RNAs (lncRNAs) regulate diverse cellular processes and are frequently implicated in disease, but their functional mechanisms often remain elusive. One such lncRNA, HOTAIR (Hox transcript antisense intergenic R […]
• GSE332555 Regulation of the histone H3K36 methyltransferase Set2 by the histone chaperone Spt6 [ChIP-Seq] May 20, 2026
  Contributors : Alexandra R Elchert ; Vanda Lux ; James L Warner ; Tereza Nešporová ; Václav Veverka ; Fred WinstonSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Saccharomyces cerevisiaeHistone H3 lysine 36 methylation is a conserved histone modification that is critical for maintaining eukaryotic transcriptional fide […]
• GSE267948 Gene expression profiles in peripheral blood mononuclear cells of patients with pulmonary tuberculosis and lung cancer May 20, 2026
  Contributors : Jie Wu ; Yang ChenSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensLung cancer and pulmonary tuberculosis (PTB) are two common lung diseases with similar symptom, and pre-existing PTB poses an increased lung cancer risk, yet the detailed molecular mechanism is still not clear. The objective of this study was to identify di […]
• GSE331382 Inhibition of Salt-Inducible Kinases 2 and 3 reduces inflammatory signature in Psoriasis May 20, 2026
  Contributor : Steve De VosSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPsoriasis is a highly prevalent inflammatory skin disease for which good systemic therapeutic agents are available. However, there still is a great need for new treatment options, especially oral ones. Salt-inducible kinases (SIKs) are emerging as […]