Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE123962 Hypoxia-inducible factor-1α-deficient adipose-tissue macrophages produce the heat to mediate lipolysis of white adipose tissue through uncoupling protein-1 December 21, 2025
  Contributors : Hoibin Jeong ; Hyeongrin Jeon ; Tae-Young Roh ; G-One AhnSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground: Uncoupling protein 1 (UCP1) is a proton uncoupler located across the mitochondrial membrane generally involved in thermogenesis of brown adipose tissues. Although UCP1 is known to be strong […]
• GSE192441 Pulmonary B lymphocytes ameliorate Alzheimer's disease-like neuropathology December 21, 2025
  Contributors : Weixi Feng ; Yanli Zhang ; Ming XiaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIncreasing evidences reveal that the peripheral immune system is involved in the pathogenesis of Alzheimer's disease (AD). Here, we report that pulmonary B lymphocytes mitigated beta-Amyloid (Aβ) pathology in 5xFAD mi […]
• GSE189886 GABPα2β2 tetramer deficiency alters transcriptional profiles in NK cells December 21, 2025
  Contributor : Shuyang YuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNatural killer (NK) cells are critical innate lymphocytes with the capacity to elicit the early defense against pathogens and the immune surveillance of tumor cells. The complex transcriptional network involved in NK cells is still many unknowns. By […]
• GSE290558 Mapping breakome of multiple cancer cell-lines December 21, 2025
  Contributors : Osama Hidmi ; Sara Oster ; Diala Shatleh ; Jonathan Monin ; Rami AqeilanSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; OtherOrganism : Homo sapiensCancer is characterized by uncontrolled proliferation accompanied by the hypertranscription of oncogenes, leading to transcription stress, a key source of DNA doubl […]
• GSE228309 RNA sequencing transcriptome analysis of lesional to perilesional cortex at 5 days after traumatic brain injury December 21, 2025
  Contributors : Michael K Schäfer ; Matthias Klein ; Irmgard TegederSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusC57BL6/N male mice (14-week-old) were subjected to a controlled cortical impact (CCI) to induce a unilateral traumatic brain injury (TBI). After surgery, mice were treated and monitored for 5 days after TBI […]
• GSE295270 NONO Deficiency Impairs HOXA1 Chromatin Association to Disrupt Wnt-Driven Cardiomyocyte Differentiation in Human iPSCs [ChIP-Seq] December 21, 2025
  Contributors : Wei Sheng ; Feizhen Wu ; Guoying Huang ; Zhiyu Feng ; Yuan GaoSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensNONO is recognized as a critical molecular scaffold involved in both transcriptional and posttranscriptional regulation. Mutations in NONO are frequently linked to congenital heart d […]
• GSE311977 Single-cell sequencing data of brain tissue in septic mice December 21, 2025
  Contributors : Jiayu Song ; Qile Ye ; Rong Tang ; Yuwen Wang ; Mengmeng Zhang ; Rui Zhao ; Jie LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo explore the specific molecular mechanisms underlying brain injury caused by sepsis, we conducted single-cell transcriptomic analysis on mouse brain tissues. In the experime […]
• GSE313561 RNA-seq data of the kidneys of diabetic nephropathy rats treated with TSK December 21, 2025
  Contributors : Na Zhao ; Ran Wei ; Nuan Wen ; Jian Ma ; Xicheng Jiang ; Huijun Chen ; Bingmei Wang ; Chuwen Feng ; Lei Zheng ; Shanshan Zheng ; Wei Zhou ; Zeyu YuSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusTSK (TangShenKang) is a compound traditional Chinese medicine. To explore the core corresponding program o […]
• GSE313986 Overactivation of Cdc42 GTPase Impairs the Cytotoxic Function of NK Cells from Old Individuals towards Senescent Fibroblasts December 21, 2025
  Contributor : Pallab MaitySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSenescent fibroblasts accumulate in the connective tissue of all organs and promote organ aging and aging-related diseases. The underlying mechanisms for the accumulation of senescent fibroblasts are poorly understood. Natural killer (NK) cells of […]
• GSE314005 TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure through PKN2 Ubiquitination December 21, 2025
  Contributors : Risheng Zhao ; Mengyang WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPathological cardiac hypertrophy is a key predisposing factor for heart failure (HF). This study investigates the role of the E3 ubiquitin ligase Tripartite Motif-Containing 40 (TRIM40) in cardiac hypertrophy. Using TRIM40 knockou […]