Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE307223 Multimodal induction of hyperinflammation by IL-18 includes virus-specific NK immunodeficiency August 25, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
• GSE306511 Multimodal induction of hyperinflammation by IL-18 includes virus-specific NK immunodeficiency [NKstim_RNAseq] August 25, 2026
  Contributors : Han-Yu Shih ; Giuseppe Sciume ; Yohei Mikami ; Hong-Wei Sun ; Stephen R. Brooks ; Alejandro Villarino ; Yuka Kanno ; Scott Canna ; JJ O'SheaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHemophagocytic Lymphohistiocytosis (HLH) is a hyperinflammatory syndrome with multiple contributors and often an […]
• GSE312424 Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding August 25, 2026
  Contributors : Giulia Boezio ; Jasper Depotter ; Thomas Frith ; Arthur Radley ; Stephanie Strohbuecker ; Ana Cunha ; Michael Howell ; James Briscoe ; Ashley Libby ; Dimitris VolterasSeries Type : Expression profiling by high throughput sequencingOrganism : Gallus gallus ; Homo sapiensThe formation of neural circuits depends on the precise spatial and tempora […]
• GSE308856 Systematic dissection of co-regulator dependencies reveals conserved and divergent mechanisms of repression August 25, 2026
  Contributors : Jannis Stadager ; Linda Brandstädter ; Shari Heller ; Jana Kehl ; Chelsey Ellis ; Stefan Legewie ; Philipp RathertSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiensThe establishment and maintenance of epigenetic states depends on intricate c […]
• GSE344640 Single-cell RNA sequencing of a treatment-naive human high-grade serous ovarian carcinoma August 25, 2026
  Contributors : Feihong Dong ; Yueyue Zhang ; Yumin Xie ; Ke Wu ; Luna Zhang ; Huiyi Lv ; Ming ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensN6-methyladenosine (m6A) RNA modification has been studied extensively in tumour cells, but its role in the tumour microenvironment remains largely unexplored. To characteris […]
• GSE327308 Butyrate Counteracts Maternal Obesity-Induced Cardiac Defects by Promoting PLEKHG3-Actin Binding August 25, 2026
  Contributors : Xueyun Qin ; Laihai Zhang ; Mo Zhang ; Shiting Chen ; Siyi Wei ; Kexin Zou ; Yanqi Xia ; Guolian DingSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusMaternal obesity increases the risk of abnormal cardiac development during gestation. However, the underlying metabolic determinants contribut […]
• GSE344484 Human fetal and neonatal naïve CD4+ T cells are bound for intestinal migration and display a gut-associated activation-prone profile August 25, 2026
  Contributors : Elise S Saager ; Guillem Sánchez Sánchez ; Leonie Holland-van den Noort ; Maria Papadopoulou ; Moosa Rezwani ; Catherine Donner ; Anne Holoye ; Caroline De Coninck ; Marle E Lokerse ; Eveline M Delemarre ; Thom E Kusters ; Vera Middelkamp ; Theo van den Broek ; Victorien M Wolters ; Bas Oldenburg ; David Vermijlen ; Femke van WijkSeries Type : […]
• GSE303361 Epigenetic Disordering Drives Stemness, Senescence Escape and Tumor Heterogeneity [scRNAseq_hUHRF1] August 25, 2026
  Contributors : Kirsten C Sadler ; Elena Magnani ; Patrice M DelaneySeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioHeterogeneity is largely attributed to distinct genetic changes within each cell population but the widespread epigenome repatterning that characterizes most cancers is also highly heterogenous within tumors […]
• GSE344539 NCOR1 alleviates osteoarthritic cartilage degradation in vivo and in vitro via ERRα-RASSF1-Hippo/YAP pathway August 25, 2026
  Contributors : Junhong Li ; Yan Mou ; Xinran Wang ; Jianwen Li ; Shiheng Wang ; Cong Ma ; Hui Huang ; Meipeng ZhuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe significant socioeconomic burden of osteoarthritis (OA) coupled with limitations of current treatments underscores the critical need for discovering novel t […]
• GSE344508 RNA-seq analysis of human glioma LN229 cells treated with 17-hydroxyjolkinolide B August 25, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGlioma is a highly aggressive brain tumor for which effective therapeutic options remain limited. Although natural products represent an important source of anticancer agents, the anti-glioma activity of 17-hydroxyjolkinolide B (HJKB), a diterpenoid derived from Euphorbia […]
• GSE344578 EBV reactivation priming of the peripheral immune system in multiple sclerosis relapse [CD19+ B cell bulk RNA-seq] August 25, 2026
  Contributors : Devin A King ; Shrishti Saxena ; Danielle Caefer ; Hrishikesh Lokhande ; Tanuja ChitnisSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDespite decades of research, the cellular and molecular events preceding multiple sclerosis (MS) relapse remain incompletely understood. In this observational study of lon […]
• GSE344597 Identification of a facilitator involved in GJB2 regulation at DFNB1 locus [Hi-C] August 25, 2026
  Contributors : Valentine Min ; Stéphanie MoisanSeries Type : OtherOrganism : Homo sapiensTo study GJB2 gene regulation, we used HiC to analyse chromatin interactions inside DFNB1 locus
• GSE344611 Id2 orchestrates IL-33-driven metabolic reprogramming in pathogenic Th2 cells (ChIP-seq) August 25, 2026
  Contributors : Xiaojuan Han ; Huarong Huang ; Xi Wang ; Ping Gao ; Xiangwen Liu ; Chao Li ; Xiaoyu Zhai ; Xuyu Zhou ; Jianwei Wang ; Jian Song ; Fuping ZhangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThe transcription factor Id2 licenses the transition of stem‑like Th2 cells to pathogenic ST2⁺ Tpath2 […]
• GSE306392 iPSC-Derived Hepatocytes from Patients with MASLD Exhibit Early Mitochondrial Dysfunction August 25, 2026
  Contributors : Dounia Le Guillou ; Kevin Siao ; Chris L Her ; Caroline C Duwaerts ; Jacquelyn J MaherSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensiPSCs from 10 MASLD patients and 10 healthy control subjects genotyped for the I148M variant of PNPLA3 were differentiated to iPSC-Heps. Mitochondrial mass and function wer […]
• GSE344459 Optineurin-deficiency Collapses the Host Endolysosomal Network and Impairs Xenophagy to Accelerate Mycobacterium tuberculosis Growth August 25, 2026
  Contributors : Nalin Abeydeera ; Jeffrey Chin ; Angel Ruvalcaba ; Khushi Amin ; Vinh Q Nguyen ; Joshua Chang ; Katherine Yin ; Joel D Ernst ; Jonathan M BudzikSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSelective autophagy is a host defense mechanism against Mycobacterium tuberculosis (Mtb) that restricts bacterial […]