Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE253827 Psychological Stress-Induced Systemic Corticosterone Directly Sabotages Intestinal Stem Cells Activity March 14, 2025
  Contributors : Xiaole Sheng ; Lanfei Jin ; Zhengrong Yao ; Longtao Zhu ; Jiaji Gu ; Junxuan Peng ; Xin Xu ; Xiaolong Ge ; Wei Zhou ; Jinghao Sheng ; Zhengping Xu ; Rongpan BaiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusStress exerts profound impacts on the gastrointestinal tract, yet its effects on intestinal stem c […]
• GSE207192 Two-Stage CAR T-Cell Differentiation in Patients with Large B-Cell Lymphoma March 14, 2025
  Contributors : Jun Huang ; Justin P Kline ; Guoshuai Cao ; Yifei HuSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensTo investigate the CAR T-cell differentiation in vivo, we performed single-cell, multi-omics analyses of CD28-costimulated CAR T cells from patients with DLBCL who were successfully treated with axi […]
• GSE263524 Inhibition of MBTPS1 reprograms cold into inflamed tumors and potentiates anti-PD-1 immunotherapy [scRNA-seq] March 14, 2025
  Contributors : Yi-Yu Wang ; Zhe Fu ; Jin-Fei Lin ; Yan HuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDespite notable advancements in cancer immunotherapy, the overall response rate among cancer patients remains low. Therefore, exploring strategies combining immunotherapy with adjuvant approaches to augment adaptive […]
• GSE261629 PRMT5 inhibition by SCR-6920 leads to downregulation of HIF-1α and exhibits synergistic antitumor activity with bevacizumab in ovarian cancer March 14, 2025
  Contributors : Guimei Yang ; Huixia Dou ; Weijie Chen ; Feng ZhouSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensProtein arginine methyltransferase 5 (PRMT5) is a desirable anticancer target due to its extensive involvement in cellular processes associated with tumor initiation and progression. This study describes an o […]
• GSE268066 Memory-like natural killer cell and CD19-antibody based immunotherapy in combination with tyrosine-kinase inhibition of Ph(-like) acute lymphoblastic leukemia March 14, 2025
  Series Type : Expression profiling by high throughput sequencing ; Methylation profiling by arrayOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
• GSE267523 CREM is a regulatory checkpoint of CAR and IL-15 signaling in NK cells March 14, 2025
  Contributor : Katayoun RezvaniSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiensThis is a preclinical study investigating the role of CREM transcription factor in CAR NK cells. We found thata CREM is a regulatory checkpoint induced by CAR CD3z signaling an […]
• GSE291583 IQGAP3 bridges matrix stiffness with cancer stem cell maintenance and radioresistance by stabilizing SOX2 II March 14, 2025
  Contributors : Po Zhang ; Xujia Wu ; Donghai Wang ; Jeremy RichSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDrivers of therapeutic resistance in cancer include evolution of tumor cell heterogeneity and the tumor microenvironment (TME). Here, we found that increased matrix stiffness promotes radioresistance in gliobla […]
• GSE273735 Dietary oleic acid drives obesogenic adipogenesis via modulation of LXR⍺ signaling March 14, 2025
  Contributors : Allison Wing ; Elise Jeffery ; Chris Church ; Jennifer Goodell ; Rocio D Saavedra-Peña ; Brandon Holtrup ; Maud Voisin ; Zenan Wang ; Thomas E Zapadka ; Michael J Garabedian ; Rohan Varshney ; Michael C Rudolph ; Matthew S RodehefferSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDietary fat composition h […]
• GSE291659 A TFEB-TGFβ axis systemically regulates diapause, stem cell resilience and protects against senescence. March 14, 2025
  Contributor : Jennifer MakSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansDiapause is a long-lived state of resilience that allows organisms to outlast adversity. C. elegans can endure months in a fasting-induced adult reproductive diapause (ARD) and, upon refeeding, regenerate and reproduce. Here, we find tha […]
• GSE291628 Shaking culture attenuates circadian rhythms in induced pluripotent stem cells during osteogenic differentiation through the YAP-TEAD axis March 14, 2025
  Contributors : Yunyu Fu ; Hiroko Okawa ; Hiroshi EgusaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCircadian rhythms synchronize cellular activities with the Earth’s 24-hour cycle, primarily regulated by clock genes that influence metabolism, physiology, and osteogenesis. While genetic regulation of circadian rhythms […]
• GSE291835 Radiation and anti-PD-L1 synergize by stimulating a stem-like T cell population in the tumor-draining lymph node [TCR-Seq] March 14, 2025
  Contributors : Buchwald Zach ; Shen Yang ; Connolly ErinSeries Type : OtherOrganism : Mus musculusRadiotherapy (RT) and anti-PD-L1 synergize to enhance local and distant (abscopal) tumor control. However, clinical results in humans have been variable. With the goal of improving clinical outcomes, we investigated the underlying synergistic mechanism focusing […]
• GSE291836 Radiation and anti-PD-L1 synergize by stimulating a stem-like T cell population in the tumor-draining lymph node March 14, 2025
  Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
• GSE291852 Effect of naphthalene on gene expression of C57BL/6J mouse lung cells March 14, 2025
  Contributors : Hye-Jeong Han ; Amartuvshin Baasankhuu ; Bogun Kim ; Angela Prameswari ; Karina Kalani ; Sangwoo Lee ; Woo-Keun Kim ; In-Geol Choi ; Cheol-Hee Kim ; Hyun-Taek KimSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTranscriptomic analysis on naphthalene exposed mouse lung cells was performed to discover molecu […]
• GSE198784 Single cell RNA sequencing of human normal and failing heart March 14, 2025
  Contributors : Si Zhang ; Ting-Ting Tang ; Xiang Cheng ; Nian-Guo DongSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapienswe performed single cell RNA sequencing (scRNA-seq) in human normal and failing hearts. Heart tissues from 3 ICM and 2 DCM patients, as well as heart tissues from 3 donors were used for scRNA/TCR-seq. […]
• GSE291564 Characterization of a gene expression biomarker predictive of hypoxia-inducible factor-1 modulation March 14, 2025
  Contributor : Chris CortonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe describe here a gene expression biomarker that can accurately identify chemicals and genetic conditions that perturb hypoxia-inducible factor-1 (HIF-1), a transcription factor critical for the cellular response to hypoxia involved in the pathop […]