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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE278295 RNA sequencing of Panc-1 cells co-cultured with CAF overexpressing PAI-1 March 29, 2026Contributors : Xuan Zhou ; Yu Ren ; Jihui HaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the effect of CAF overexpressing PAI-1 on tumor cells, CAF overexpressing PAI-1 was used to co-culture with Panc-1 cells, and then gene expression profiling of Panc-1 cells was performed using RNA-seq.
- GSE282248 Single-cell multi-omic analysis of post-transplant mesenchymal cells reveals molecular signatures and regulators of lung fibrosis (scRNA-seq) March 29, 2026Contributors : Lu Lu ; Aidan P McLinden ; Natalie M Walker ; Ragini Vittal ; Michael P Combs ; Joshua D Welch ; Vibha N LamaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensChronic lung allograft dysfunction (CLAD) is a critical challenge in lung transplantation. Dysregulated gene expression and epigenomic states in lung […]
- GSE281481 Single-cell multi-omic analysis of post-transplant mesenchymal cells reveals molecular signatures and regulators of lung fibrosis (RNA-seq) March 29, 2026Contributors : Lu Lu ; Aidan P McLinden ; Natalie M Walker ; Ragini Vittal ; Michael P Combs ; Joshua D Welch ; Vibha N LamaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensChronic lung allograft dysfunction (CLAD) is a critical challenge in lung transplantation. Dysregulated gene expression and epigenomic states in lung […]
- GSE309633 Sex-Dependent Effects of Glutamatergic Disruption on Dopaminergic Neuron Subtype Vulnerable in Parkinson’s Disease March 29, 2026Contributors : Kathleen F Carmichael ; Gavin Riccobono ; Victor M Martinez Smith ; Jinhui Ding ; Lisa Chang ; Lixin Sun ; Lupeng Wang ; Huaibin CaiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAldehyde dehydrogenase 1A1-positive (ALDH1A1+) dopaminergic neurons are selectively vulnerable in Parkinson’s disease (PD), ye […]
- GSE292789 Role of CARM1 in Glioblastoma March 29, 2026Contributors : Dejauwne Young ; Ronald Cutler ; Simone SidoliSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensOne driving factor of Glioblastoma (GBM) heterogeneity and therapy resistance is the capacity of glioma stem-like cells (GSCs) to hijack developmental signaling programs. However, it remains unclear how glioma st […]
- GSE325004 Distinct phases of immune system programming during ART-suppressed immunodeficiency virus infection March 29, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Macaca mulattaThis project contains rhesus macaque immune cell single-cell RNA-seq data, from SIV/ART studies.
- GSE316863 Modular Scalable Synthetic Gene Circuits for Complex Functions Within Minimal Computational Layers in Human Cells March 29, 2026Contributors : Keren Roas ; Ilanit Kovalski ; Odelia Mouhadeb ; Tamar Aminov ; Hadas Weinstein-Marom ; Lior NissimSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEngineering mammalian cells to execute complex genetic programs remains a significant challenge in synthetic biology. Synthetic gene circuits typically implem […]
- GSE325783 Ketogenesis promotes leukemia development by inhibiting ferroptosis in leukemic stem cells [ATAC-Seq] March 29, 2026Contributors : Xue Han ; Kexin Wang ; Weiwei Ma ; Songqi Zhu ; Jingjing Guan ; Xiaobin Tian ; Zhuangzhhuang Zhao ; Linjia JiangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusHepatic ketogenesis generates ketone bodies as an alternative energy source during carbohydrate restriction or ketogenic diets, yet […]
- GSE325782 Ketogenesis promotes leukemia development by inhibiting ferroptosis in leukemic stem cells [RNA-Seq] March 29, 2026Contributors : Xue Han ; Kexin Wang ; Weiwei Ma ; Songqi Zhu ; Jingjing Guan ; Xiaobin Tian ; Zhuangzhhuang Zhao ; Linjia JiangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHepatic ketogenesis generates ketone bodies as an alternative energy source during carbohydrate restriction or ketogenic diets, yet its role in no […]
- GSE325787 Photoactivatable CRISPR/Cas13d via upconversion nanoparticles for deep tissue RNA engineering and orthopedic therapy March 29, 2026Contributors : Jie Zhao ; Jun Jiao ; Miaomiao Gao ; Jingyu Zhang ; Jinbin Pan ; Xinlong MaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo overcome the limited tissue penetration of blue light, we engineer polyethylenimine-functionalized upconversion nanoparticles (UCNPs-PEI) that serve dual roles as gene carriers and […]
- GSE325843 Immune-remodeling mRNAs expressing IRF8 or NIK generate durable anti-tumor immunity in multiple cancer models March 29, 2026Contributors : Akash Gupta ; Riddha Das ; Kaelan Reed ; Taewon Jeon ; Quang Trung Chinh Nguyen ; Arnab Rudra ; Xinying Ge ; Suthathip Trongjit ; Yann S Vanrobaeys ; Robert Langer ; Ralph Weissleder ; Christopher Garris ; Daniel G AndersonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAlthough immunotherapy has a subset […]
- GSE325876 Butyrylcholinesterase alleviates hepatic stellate cell activation via paracrine muscarinic signaling. March 29, 2026Contributors : Le Tao ; Nuoya Liu ; Wei Zhang ; Zongguo Yang ; Jianrong Xu ; Guang Ji ; Cheng LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground & Aims: Butyrylcholinesterase (BuChE) is an enzyme involved in Alzheimer’s disease (AD), detoxification and depression. While BuChE expression is reduced in live […]
- GSE325923 Intratumoral CD40 agonist sotigalimab in combination with pembrolizumab induces rapid activation of antigen presenting cells and drives anti-tumor responses in non-injected tumors in metastatic melanoma: Results of a phase 1/2 study March 29, 2026Contributors : Jingjing Liu ; Jianhua Zhang ; Barbara Pazdrak ; Heather Sonnemann ; Adi Diab ; Gregory LizeeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCheckpoint inhibitors (CPIs) benefit metastatic melanoma (MM) patients, but resistance remains a challenge. This phase 1/2 (NCT02706353) study evaluated intratumoral […]
- GSE326035 Foliar iron application delays flavonoid degradation during the later grain-filling stage and regulates sugar metabolism in colored rice March 29, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Oryza sativaIntroduction Colored rice is recognized for nutritious function due to its flavonoid compounds. Flavonoid aglycones are conjugated with various sugar moieties. Iron (Fe) is an essential mineral nutrient for plants; however, the regulatory mechanisms by which Fe influences […]