Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE288574 Convergence of aging- and rejuvenation-related epigenetic alterations on PRC2 targets [ChIP-Seq] February 2, 2026
  Contributors : Oscar Camacho ; Michael A. Koldobskiy ; Andrew P. FeinbergSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusRejuvenation of tissues in physiologically aging mice can be accomplished by long-term partial reprogramming via expression of reprogramming factors (Oct4, Sox2, Klf4 and c-Myc). To inve […]
• GSE287531 The effects of ATP and CD39 inhibition in monocyte-derived dendritic cells. February 2, 2026
  Contributors : Rebecca Fuchs ; Ke Jin ; Christine E Bowman ; Jenna L Pappalardo ; Soonweng ChoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensExtracellular ATP (eATP) is a damage associated molecular pattern (DAMP) that may be released by cancer cells as a result of chemotherapy-induced immunogenic cell death (ICD). We […]
• GSE145757 DNA Methylation Profiles in Soybean Pol IV and V Mutants February 2, 2026
  Contributors : Brandon H Le ; Xuemei ChenSeries Type : Methylation profiling by high throughput sequencingOrganism : Glycine maxWe profiled the small RNA-ome, transcriptome, and DNA methylome of RNAi lines to study the molecular and biological functions of Pol IV and V in soybean.
• GSE295405 Induction of anergy in human T lymphocytes by exposure to single amino acid mutated antigens is stochastic February 2, 2026
  Contributor : Yoko Nakai-FutatsugiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensA single RNA sequencing approach using 10x Genomics scRNAseq was employed to stuudy induction of anegy in hunam T lymphocytes. Anergy is a condition of immune T cells becoming sustainably inactive. Theoretically, it occurs when a T cell re […]
• GSE223114 Sex differences in Yap1 oncogene function in immune evasion [EndPoint_Bulk RNA-seq] February 2, 2026
  Contributors : Nourhan Abdelfattah ; Kyuson YunSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe incidence of many human cancers differs according to sex, but little is known about the interplay between oncogenic events and sex as a variable in tumorigenesis. Here we report that the oncogene Yap1 is sexually dimorphic […]
• GSE221833 Next Generation Sequencing Analysis of Breast Cancer Cell Line MCF-7 And MDA-MB-231 After PI3K Inhibition February 2, 2026
  Contributors : Xin Xie ; Pu-Ste LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensmRNA profiles of MCF7 and MDA-MBA-231 cells treated with 1μM GDC-0941 or DMSO for 24 hours
• GSE317882 RNA transcriptome sequencing analysis of SNU-668 Erastin-resistant cells transfected with shRNA-ALKBH3 or control shRNA February 2, 2026
  Contributors : Mingzhe Ma ; Hui YangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensa RNA transcriptome sequencing analysis was performed in SNU-668 erastin-resistant cells that were transfected with shRNA-ALKBH3 or control shRNA
• GSE226608 Balb/c mouse lung tissue RNA-Seq in mouse OVA asthma model with and without anti-mouse-IL-4Ra antibody treatment. February 2, 2026
  Contributor : Jonathan PhillipsSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPurpose: Identify genes disregulated in Balb mouse lung tissue in the Ovalbumin (OVA) asthma disease model and genes disregulated by OVA challenged mice treated with with an Anti-mouse-IL-4Ra mAb
• GSE317886 m1A enrichment analysis of SNU-668 Erastin-resistant cells transfected with shRNA-ALKBH3 or control shRNA February 2, 2026
  Contributors : Mingzhe Ma ; Hui YangSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensAn m1A enrichment analysis was conducted to investigate the epigenetic landscape and RNA modification profiles within SNU-668 Erastin-resistant gastric cancer cells following the experimental manipulation of ALKBH3 expression. Sp […]
• GSE317885 Ribo-seq analysis analysis of SNU-668 Erastin-resistant cells transfected with shRNA-ALKBH3 or control shRNA February 2, 2026
  Contributors : Mingzhe Ma ; Hui YangSeries Type : Other ; Expression profiling by high throughput sequencingOrganism : Homo sapiensThis study presents a comprehensive ribosome profiling (Ribo-seq) analysis conducted on SNU-668 gastric cancer cells with acquired resistance to Erastin. These cells were genetically modified through stable transfection with eith […]
• GSE317888 RNA transcriptome sequencing analysis of SNU-668 Erastin-resistant cells transfected with shRNA-SPIN1 or control shRNA February 2, 2026
  Contributors : Mingzhe Ma ; Hui YangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAn RNA transcriptome sequencing analysis was performed in SNU-668 erastin-resistant cells to investigate their molecular profile. To assess the specific role of the SPIN1 protein, a comparative approach was undertaken. This involved tran […]
• GSE317899 Age-related molecular and functional remodeling of the choroid plexus in the mouse lemur February 2, 2026
  Contributors : Mariano Avino ; Benoit Laurent ; Fabien PifferiSeries Type : Expression profiling by high throughput sequencingOrganism : Microcebus murinusAging is accompanied by complex alterations in brain structure and functions, with growing evidence implicating the choroid plexus (CP) as a key regulator of cognitive and motor function. Here, we investig […]
• GSE317945 Rational design of immune gene therapy combinations via in vivo CRISPR activation screening of tumor microenvironment modulators [APCM_Screen_CLCG4I] February 2, 2026
  Contributors : Feifei Zhang ; Chuanpeng Dong ; Ryan D Chow ; Shan Xin ; Emily He ; Lvyun Zhu ; Daniyal Mirza ; Yanzhi Feng ; Xinyu Ling ; Qin Han ; Guangchuan Wang ; Sidi ChenSeries Type : OtherOrganism : Mus musculusThe hostile tumor microenvironment (TME) is major challenge for cancer immunotherapies. Here, we design and perform TME-targeted in vivo CRISPR […]
• GSE285749 The COMPASS subunit Bre2 targets CRF Arp9 to regulate the bio-synthesis of secondary metabolite AFB1 and virulence in Aspergillus flavus February 2, 2026
  Contributors : Minghui Sun ; Zhenhong ZhuangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Aspergillus flavusIn this study, To determine the chromatin distribution pattern of Bre2-regulated H3K4me3 at the genome-wide level, we used the BRE2 knockout strain constructed in this study as a control; Chip-sequencing (ChIP […]
• GSE317793 Profiling of CSDE1-bound RNAs under MKRN2-mediated ubiquitination February 2, 2026
  Contributors : Zi Wang ; Min Zhu ; Ronggui HuSeries Type : OtherOrganism : Homo sapiensThis study aims to elucidate how MKRN2-mediated ubiquitination regulates the RNA-binding capacity of CSDE1. By overexpressing CSDE1 in MKRN2 knockout (KO) SHSY5Y cells and complementing with MKRN2 for comparison, we systematically analyzed the alterations in the RNA-bindin […]