Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE267477 Endothelial Cells Exhibit Persistent Inflammation-Mediated Immunological Memory, affecting Infectious and Vascular Disease-Associated Pathways [ATAC-Seq] May 14, 2025
  Contributors : Kieu T Le ; Nick Keur ; Heleen Middelkamp ; Thuy L Do ; Albert van den Berg ; Valeria Orlova ; Leo A Joosten ; Mihai G Netea ; Iris Jonkers ; Sebo Withoff ; Andries D Van der Meer ; Vinod KumarSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensChronic inflammation characteristic for infectious […]
• GSE267462 Gene expression profiles at single cell level of CD4 T Cells infected with HIV Nano Cre May 14, 2025
  Contributors : Donald V Doanman ; Gerrit Schmidt ; Benjamin K ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo study the mechanisms of early HIV latency establishment, we used EHILT to infect primary CD4+ T cells and test the ability of the system to track similar EHILT phenotypes in primary CD4+ T cells
• GSE267688 Autism-associated mutations in Kdm6b affect its role as a chromatin regulator in brain development May 14, 2025
  Contributors : Rebecca Li ; Urann Chan ; Vijyendra Ramesh ; Andrew Aldridge ; Anne WestSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe regulation of gene expression in the developing brain is coordinated by changes in chromatin regulation. Chromatin regulation involves the deposition and removal of molecular modific […]
• GSE267578 The role of the 3D genome organization on platinum drug induced DNA damage susceptibility May 14, 2025
  Contributors : Ye Wang ; Frank Alber ; Xianghong J ZhouSeries Type : OtherOrganism : Homo sapiensPlatinum drugs (Pt drugs) are one of the most widely used chemotherapy drugs in cancer treatment. Although the cytotoxic and resistant mechanisms of Pt drugs have been thoroughly explored, it remains elusive what factors affect the receptiveness of DNA to Pt drug […]
• GSE230203 Analysing environmentally induced genome-wide frameshift in S. cerevisiae using ribosome profiling May 14, 2025
  Contributors : Yujie Zhang ; Vicent PelechanoSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Saccharomyces cerevisiaeIn this study, we examine the impact of poor nutrient conditions on -1 ribosome frameshifting and its effect on mRNA degradation. To explore this process, we utilized Ribosome profiling (Ingolia, et.al 2009, […]
• GSE297027 Abundance of tRNA fragments in Tau-RNA complexes from Tau-mutant PS19 (human P301S Tau transgenic) mice hippocampus May 14, 2025
  Contributor : Ami KobayashiSeries Type : Non-coding RNA profiling by arrayOrganism : Mus musculusWe report the binding between tRNA fragments and Phosphorylated Tau pS396 from the hippocampus of WT controls and Tau-mutant PS19 (human P301S Tau transgenic) mice. We show tRNA fragments abundance in Tau-RNA complexes changes between the two groups. Specific tRN […]
• GSE279513 Developmental features and unique characteristics of peptide-specific PLZF+ innate-like T cells May 14, 2025
  Contributor : Ahmed HassanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusInnate-like T cells are considered a family of T lymphocytes capable of mounting quick responses, yet restricted to conserved antigens of non-peptide nature. Here, we performed single-cell transcriptomic analyses of peptide-specific PLZF+ innate-l […]
• GSE230205 Analysing environmentally induced genome-wide frameshift May 14, 2025
  Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Bacillus subtilis ; Saccharomyces cerevisiaeThis SuperSeries is composed of the SubSeries listed below.
• GSE284716 The energy-saving metabolic switch underlies survival of extremophilic red microalgae in extremely high nickel levels May 14, 2025
  Contributors : Sergio Santaeufemia ; Francesca Marchetto ; Patrizia Romano ; Dorota Adamska ; Krzysztof Goryca ; Jeffrey Palatini ; Ilaria Corsi ; Joanna KargulSeries Type : Expression profiling by high throughput sequencingOrganism : Cyanidioschyzon merolaeThe red microalga Cyanidioschyzon merolae inhabits extreme environments of high temperature, high acid […]
• GSE282047 Clec12a is a potential therapeutic target in NUP98-NSD1 AML May 14, 2025
  Contributors : Sagarajit Mohanty ; Fiorella Charles Cano ; Razif Gabdoulline ; Michael HeuserSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNUP98-NSD1 is one of the most recurring nucleoporin 98 (NUP98) fusions in acute myeloid leukemia (AML). NUP98-NSD1 AML is associated with adverse outcomes and poor response to conv […]
• GSE290897 Identification of key genes associated with circadian rhythm as potential diagnostic biomarkers for cytomegalovirus infection in very low birth weight infants May 14, 2025
  Contributors : Qianqian Li ; Junmei YanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAfter HCMV infection, most individuals have no obvious symptoms. However, HCMV infection in very low birth weight infants can cause liver function damage, thrombocytopenia, hearing damage, cholestasis and so on. Cytomegalovirus is gen […]
• GSE292774 Comparing the Effects of Taurine and 3-Sulfopropanoic Acid, a Metabolite of Tramiprosate, on ApoE4 Pathological Aggregation: Implications for Alzheimer's Disease May 14, 2025
  Contributors : Anthony Legrand ; Katerina Amruz Cerna ; Sérgio M. Marques ; Naina Verma ; Jakub Kopko ; Tereza Vanova ; Madhumalar Subramanian ; Jaroslav Bendl ; Tomas Henek ; Pavel Vanacek ; Josef Kucera ; Joan Planas-Iglesias ; Jiri Sedmik ; Veronika Pospisilova ; Petr Kouba ; Aneta Vaskova ; Marketa Nezvedova ; Jiri Sedlar ; Jiri Damborsky ; Stanislav Maz […]
• GSE296535 Genetic and Phenotypic correlates of clinical outcomes with Venetoclax in Acute Myeloid Leukemia: The GEN-PHEN-VEN study May 14, 2025
  Contributors : Curtis A Lachowiez ; Theodore Braun ; Anupriya AgrawalSeries Type : OtherOrganism : Homo sapiensResistance to venetoclax-based therapy in acute myeloid leukemia (AML) includes genetic (i.e., mutations in N/KRAS, FLT3-ITD, TP53) and phenotypic (i.e., monocytic differentiation) features. Whether monocytic differentiation contributes to clinical […]
• GSE267418 Endothelial Cells Exhibit Persistent Inflammation-Mediated Immunological Memory, affecting Infectious and Vascular Disease-Associated Pathways [RNA-Seq] May 14, 2025
  Contributors : Kieu T Le ; Nick Keur ; Heleen Middelkamp ; Thuy L Do ; Albert van den Berg ; Valeria Orlova ; Leo A Joosten ; Mihai G Netea ; Iris Jonkers ; Sebo Withoff ; Andries D Van der MeerSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensChronic inflammation characteristic for infectious and inflammatory disease is […]
• GSE278654 Mgat4b mediated selective N-glycosyl modification regulates melanocyte development and melanoma progression [scRNA-seq] May 14, 2025
  Contributors : Babita Sharma ; Keerthic Aswin ; Tanya Jain ; Ayesha Nasreen ; Ayush Aggarwal ; Yogaspoorthi Subramaniam ; Jeyashri Rengaraju ; Srashti Jyoti Agrawal ; Mayank Bhatt ; Bhaskar Paul ; Koushika Chandrasekaran ; Aanchal Yadav ; Jyoti Soni ; Rajat Ujjainiya ; Md Quasid Akhter ; Shantanu Sen Gupta ; Rajesh Pandey ; Shruthy Suresh Aggarwal ; Srinivas […]