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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE269572 Generation of Stable Chambered Cardioids from human Pluripotent Stem Cells [scRNA-seq] April 14, 2026Contributors : XINLE ZOU ; FANWEN WANG ; HUILING ZHENGSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe human heart is a vital organ under intense investigation for the hope to improve health and longevity. Recent advances to generate cardiac organoids (cardioids) provide unprecedented opportunities to cardiac researc […]
- GSE292011 Adaptor protein CIN85 potentiates migration of osteosarcoma cells April 14, 2026Contributors : Iryna Horak ; Lucia KnopfováSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe adaptor protein CIN85, encoded by the SH3KBP1 gene, is a member of the CIN85/CMS family of adaptor molecules involved in many signaling pathways. CIN85 functionally contributes to different biological processes in normal and c […]
- GSE276024 Mitochondrial metabolism regulates the immunogenic responsiveness of dendritic cells [RNA-seq] April 14, 2026Contributors : Ignacio Heras-Murillo ; Stefanie K Wculek ; David SanchoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusActivation of dendritic cells (DCs) is linked to increased glycolysis. However, the role of the mitochondrial electron transport chain (ETC) in conventional DC subset function is poorly defined. Here, w […]
- GSE294594 The bone derived from scl-progenitors micromass forms bone marrow [scRNAseq] April 14, 2026Contributors : Yanhui Deng ; Jingfei Xiong ; Zhonghan LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSclerotomal progenitors derived from pluripotent stem cells hold promises for modeling skeletal development and recreating embryonic bone microenvironment to restore hematopoiesis and immunity in ageing. Current strat […]
- GSE294562 Characterization of a panel of mouse primary cell lines from Myc-driven mammary gland tumours and lung metastasis derived from them April 14, 2026Contributors : Josep Tarrago-Celada ; Michael Kossifos ; Ersa Gjelaj ; Yulia Panina ; Tegan Gilmore ; Mariia YunevaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTriple negative breast cancer (TNBC) represents 15% of all breast cancer subtypes. It is the most aggressive type, with limited treatment options and is often […]
- GSE304151 Systems-level investigation of mucopolysaccharidosis IIIA identifies deficient synaptic activity as a key driver of disease progression April 14, 2026Contributors : Alon M Douek ; Abbas Salavaty ; Jan Kaslin ; Mirana Ramialison ; Peter D CurrieSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioMucopolysaccharidoses are lysosomal storage diseases that collectively represent a major cause of lethal, treatment-refractory childhood dementias. Clinically-useful interventions […]
- GSE300363 https://www.ncbi.nlm.nih.gov/geo/ April 14, 2026Contributors : Tomás J Steeman ; Mercedes Torres ; Andrea M Weiner ; Juan A Rubiolo ; Laura E Sánchez ; Gabriela Coux ; Nora B CalcaterraSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Danio rerioNeural crest cells are a transient, multipotent population that gives rise to diverse structures during vertebrate embryonic developm […]
- GSE327496 Single-cell transcriptomic analysis of synovial tissues from aged mice April 14, 2026Contributors : Rui Peng ; Bo Yu ; Lutian Yao ; Lei Zhang ; Tao GuiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe employed a single‑cell RNA sequencing approach using the 10x Genomics platform to profile synovial tissues from aged (24‑month‑old) wilt-typt mice. This study aims to delineate cell‑type‑specific transcri […]
- GSE327495 Targeting STAT3-Mediated Lipid Metabolism Reprogramming Overcomes Chemoresistance in Acute Myeloid Leukemia April 14, 2026Contributors : Keren Peng ; Jianshan Mo ; Zhenjiao Yang ; Wen DingSeries Type : Expression profiling by high throughput sequencingOrganism : HomoChemotherapy resistance and intolerance pose significant challenges in the effective treatment of leukemia. Among the distinctive features associated with chemoresistance, metabolic reprogramming emerges as a key fa […]
- GSE327517 Targeting UBE2F induces a resilience program enhancing CD8 T cell immunity April 14, 2026Contributor : Xiaonan MaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCD8 memory T cells (TMEM) and exhausted T cells (TEX) are essential for host defense against infection and cancer, yet their therapeutic potential is often limited by insufficient persistence and sustained functional capacity. Strategies to enhance […]
- GSE327514 High-throughout sequencing of ovarian cancer cells treated with YY-15 April 14, 2026Contributors : Yeying He ; Jiaying TONG ; Xiaohui ZhengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAfter treating human ovarian cancer cells A2780 and ES2 with YY-15, high-throughput sequencing technology was employed. The transcriptome analysis revealed that YY-15 does not exert its anti-tumor effect solely through […]
- GSE327564 In planta transcriptome analysis of Pseudomonas syringae pv. tomato DC3000 two component regulator mutant cvsR during early infection and early exposure to pattern-triggered immunity in Arabidopsis thaliana April 14, 2026Contributors : Hsiao-Chun Chen ; Brian Howard KvitkoSeries Type : Expression profiling by high throughput sequencingOrganism : Pseudomonas syringae pv. tomato str. DC3000We extracted P. syringae transcriptome from infected A. thaliana tissue under naive or PTI preactivated tissue by flg22 treatment, through physical separation by low speed centrifugation at […]
- GSE327567 Heat shock factor 5 is indispensable for pachynema progression and LINE1 silencing during spermatogenesis in mice [RNA-seq] April 14, 2026Contributors : Qi Sun ; Yuming Cao ; Zhiyi Chen ; Jin Shen ; Zejia Li ; Binyi Wang ; Muyang Cheng ; Jiemin Chen ; Weihao Gong ; Mengcheng Luo ; Yuanzhen Zhang ; Rong LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPachytene spermatocytes were isolated from adult wild-type and Hsf5 knockout mouse testes using STA-PUT […]
- GSE327576 Transcriptomic and Metabolic Basis of Volatile Compound Dynamics in Apricot Fermentation April 14, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Wickerhamomyces anomalusAroma is one of the most important qualities that defines the appeal and value of the fermented fruit products. This study provides the first integrative analysis of volatile compound dynamics and transcriptomic regulations during apricot fermentation by Wicker […]
- GSE327577 Faecalibacterium prausnitzii EXL01 for the Maintenance of Steroid-induced Clinical Response or Remission in Patients with Crohn’s Disease: a first in human trial April 14, 2026Contributors : Perle Guarino-Vignon ; Edouard Louis ; Hang-Phuong Pham ; Giovanna Orianne ; Emma Tkacz ; Loic Brot ; Eolia Mazzetti ; Delphine Sedda ; Pauline Ruffié ; Nathalie Rolhion ; Geert D’Haens ; Benjamin Hadida ; Philippe Langella ; Harry SokolSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensA marked decrease in […]