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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE277350 Single-cell transcriptomic changes in oligodendroglial lineage cells derived from Parkinson’s disease patient-iPSCs with LRRK2-G2019S mutation February 17, 2026Contributors : Dehestani Mohammad ; Kessler Wiebke ; Karmali Nasser ; Sun Wenhua ; Volos Polina ; Tsitkov Stanislav ; Dhingra Ashutosh ; Rodriguez-Nieto Salvador ; Tietz Julia ; Schafflick David ; Fernandes Noémia ; Fitzgerald Julia ; Fraenkel Ernest ; Gasser Thomas ; Rafiq Nisha Mohd ; Kuhlmann Tanja ; Bansal VikasSeries Type : Expression profiling by high […]
- GSE174547 Vascular mitohormesis couples Mfn2 with improved systemic metabolism and healthspan February 17, 2026Contributors : Iñigo Chivite ; Alicia G Gómez-Valadés ; Macarena Pozo ; Erika Monelli ; Luis Varela ; Sara Ramírez ; Roberta Haddad-Tóvolli ; Daniel Beiroa ; Anne Abot ; Oscar Osorio-Conles ; José A Valer ; Arnaud G Obri ; Maria Milà-Guasch ; Pilar Villacampa ; Elena Eyre ; Miriam Toledo ; Jordi Altirriba ; Xavier Remesar ; Antonio Zorzano ; Francesc Ventura […]
- GSE289806 Effect of interferon gamma on wild type and SORL1 knockout iPSC-derived microglia February 17, 2026Contributors : Imdadul Haq ; Jason C Ngo ; Nainika Roy ; Falak SherSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis study investigates the transcriptomic response of wild-type (WT) and SORL1 knockout (KO) iPSC-derived microglia following treatment. For microglia differentiation protocol please see PMID: 38600587. Bu […]
- GSE285229 Understanding the effect of milk fat containing diet in the gut epithelial homeostasis. February 17, 2026Contributors : Chen Chongtham ; Raunak Kar ; Dr Veena S Patil ; Dr G Aneeshkumar ArimbasseriSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe employed single-cell RNA sequencing using 10X Genomics technology to investigate the effect of milk fat diet on gut homeostasis. We have observed that mice with dextran sodium su […]
- GSE289832 Splenic nerves NE-β2AR axis exacerbate septic acute kidney injury via modulating neutrophilic immunosuppression [RNA-seq] February 17, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSepsis is characterized by chronic inflammation and immunosuppression, two immune states that hinder effective infection control and significantly contribute to renal pathological damage. Recent studies have underscored the crucial role of splenic neuroimmune interactions […]
- GSE289831 Splenic nerves NE-β2AR axis exacerbate septic acute kidney injury via modulating neutrophilic immunosuppression [scRNA-seq] February 17, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSepsis is characterized by chronic inflammation and immunosuppression, two immune states that hinder effective infection control and significantly contribute to renal pathological damage. Recent studies have underscored the crucial role of splenic neuroimmune interactions […]
- GSE297569 The Conserved Non-Coding Sequence CNS11 Is A Master Control Region for Rorc Transcription in Type 17 Immune Cells [4C-Seq] February 17, 2026Contributors : Hao Zhang ; Ruifeng Li ; Chen DongSeries Type : OtherOrganism : Mus musculusAs the master transcription factor, RORγt controls the development and function of all type 17 immune cells. Although the trans-regulatory mechanisms governing Rorc expression have been extensively studied, the cis-regulatory mechanisms that differentially regulate Ror […]
- GSE297567 The Conserved Non-Coding Sequence CNS11 Is A Master Control Region for Rorc Transcription in Type 17 Immune Cells [CUT&Tag] February 17, 2026Contributors : Hao Zhang ; Ruifeng Li ; Chen DongSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusAs the master transcription factor, RORγt controls the development and function of all type 17 immune cells. Although the trans-regulatory mechanisms governing Rorc expression have been extensively studied, the […]
- GSE304500 N,N Dimethylacetamide attenuates LPS induced neuroinflammation in a murine model February 17, 2026Contributors : Acosta Teeshavi D ; Wu Jiaqi ; Khairnar Rhema ; Reznik Sandra ESeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNeuroinflammation is a central driver of cognitive decline in many neurodegenerative diseases and is marked by persistent activation of pro-inflammatory pathways. N,N-Dimethylacetamide (DMA), an […]
- GSE305167 Müller glial and microglial responses coupled to recovery of cone photoreceptors following limited cone ablation in zebrafish retina February 17, 2026Contributors : Halle Weimar ; Ashley Farre ; Jordan Rumford ; Diana MitchellSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioWe treated gnat2:nfsb-mCherry transgenic adult zebrafish with 24-hour 10 mM Mtz immersion exposure, triggering transient cone stress and subsequent glial and microglial responses.
- GSE319431 RNA-seq of Human nasopharyngeal carcinoma cells in BALF2-LR and BALF2-HR overexpress group February 17, 2026Contributor : Wei XiongSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the biological function of EBV BALF2-HR in NPC pathogenesis, we constructed overexpression vectors for BALF2-HR and BALF2-LR (used as a control) and transfected them into the EBV-negative NPC cell line HK1 [Fig. S1D]. Differential gene […]
- GSE319460 Transcriptomic Profiling on Intestine of Diabetic and Septic Mice [miRNA-seq] February 17, 2026Contributors : Xinjin Chi ; Fang Tan ; Lei ZhengSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Mus musculusSepsis is a severe clinical syndrome related to an exaggerated host immune response to infection as well as systematic inflammation and serious tissue damage. Sepsis-induced intestine injury is one of the most frequent an […]
- GSE319500 Predictability of progression free survival in ovarian cancer February 17, 2026Contributors : Lucy B Kleunen ; Grace Bowman ; Sarah E Stockman ; Logan Barrios ; Hope A Townsend ; Kimberly R Jordan ; Rebecca J Wolsky ; Kian Behbakht ; Matthew J Sikora ; Benjamin G Bitler ; Aaron ClausetSeries Type : Expression profiling by arrayOrganism : Homo sapiensGiven the interrelated mechanisms by which changes to the tumor microenvironment (TME) […]